Publications of C.J.P. Grimmelikhuijzen
(Abstracts of congress proceedings are not included)
1.
C.J.P. Grimmelikhuijzen and E.C. Slater (1972). The redoxstate of respiratory-chain
components in ratliver mitochondria. III. Cross-over points in site III. Biochim. Biophys.
Acta, 256, 24-31.
2.
C.J.P. Grimmelikhuijzen and E.C. Slater (1973). Antimycin-insensitive mutants of
Candida utilis. I. Isolation and characterization of mutant 28. Biochim. Biophys. Acta,
305, 67-79.
3.
C.J.P. Grimmelikhuijzen, C.A.M. Marres and E.C. Slater (1975). Antimycin-insensitive
mutants of Candida utilis. II. The effects of antimycin on cytochrome b. Biochim.
Biophys. Acta, 376, 533-548.
4.
C.J.P. Grimmelikhuijzen (1975). The mitochondrial respiratory chain. Studies on state
3-state 4 cross-overs and antimycin-resistant yeast mutants. Ph.D. Thesis, University
of Amsterdam, Krips-Repro, Meppel.
5.
C.J.P. Grimmelikhuijzen and E.C. Slater (1975). The use of antimycin-resistant yeast
mutants. In: "Electron-transfer chains and oxidative phosphorylation" (eds. E.
Quaglariello, S. Papa, F. Palmieri, E.C. Slater and N. Siliprandi), North-Holland
Publishing Company, Amsterdam, 201-206.
6.
C.J.P. Grimmelikhuijzen and E.C. Slater (1976). Models for antimycin binding in wild
type Candida utilis and antimycin-resistant mutants. In: "Genetics, biogenesis and
bioenergetics of mitochondria" (eds. W. Bandlow, R.J. Schweyen, D.Y. Tomas, K. Wolf
and F. Kaudewitz), W. de Gruyter and Co., Berlin, 389-397.
7.
C.J.P. Grimmelikhuijzen and H.C. Schaller (1977). Isolation of a substance activating
foot formation in hydra. Cell Diff., 6, 297-305.
8.
H.C. Schaller, T. Schmidt, K. Flick and C.J.P. Grimmelikhuijzen (1977). Analysis of
morphogenetic mutants of hydra. I. The aberrant. Wilhelm Roux's Archives, 183, 193206.
9.
H.C. Schaller, T. Schmidt, K. Flick and C.J.P. Grimmelikhuijzen (1977). Analysis of
morphogenetic mutants of hydra. II. The non-budding mutant. Wilhelm Roux's
Archives, 183, 207-214.
10. H.C. Schaller, T. Schmidt, K. Flick and C.J.P. Grimmelikhuijzen (1977). Analysis of
morphogenetic mutants of hydra. III. Maxi and mini. Wilhelm Roux's Archives, 183,
215-222.
11. H.C. Schaller, T. Schmidt and C.J.P. Grimmelikhuijzen (1979). Separation and
specificity of action of four morphogens from hydra. Wilhelm Roux's Archives, 186, 139149.
12. C.J.P. Grimmelikhuijzen (1979). Properties of foot activator from hydra. Cell. Differ., 8,
267-273.
13. C.J.P. Grimmelikhuijzen and H.C. Schaller (1979). Hydra as a model-organism for the
study of morphogenesis. Trends in Biochem. Sci., 4, 265-267.
14. H.C. Schaller, C.J.P. Grimmelikhuijzen, T. Schmidt and H. Bode (1979). Morphogenetic
substances in nerve-depleted hydra. Wilhelm Roux's Archives, 187, 323-328.
15. H.C. Schaller, T. Schmidt, C.J.P. Grimmelikhuijzen, T. Rau, H. Bode and R.D.
Campbell (1980). Morphogenetic substances in nerve-free hydra. In: "Developmental
and cellular biology of coelenterates" (ed. P. Tardent and R. Tardent), Elsevier,
Amsterdam, 389-394.
16. C.J.P. Grimmelikhuijzen, F. Sundler and J.F. Rehfeld (1980). Gastric/CCK-like
immunoreactivity in the nervous system of coelenterates. Histochemistry, 69, 61-68.
17. C.J.P. Grimmelikhuijzen, J. Lepault, A.W. MacDowall, S.W. de Laat, L.G.J. Tertoolen
and C.J. Weijer (1980). The gap junctions in hydra do not permit electrical and
chemical transmission. In: "Developmental and cellular biology of coelenterates" (ed. P.
Tardent and R. Tardent), Elsevier, Amsterdam, 453-458.
18. T. Schmidt, C.J.P. Grimmelikhuijzen and H.C. Schaller (1980). Morphogenetic
substances in hydra. In: "Developmental and cellular biology of coelenterates" (ed. P.
Tardent and R. Tardent), Elsevier, Amsterdam, 395-399.
19. J. Lepault, A.W. MacDowall and C.J.P. Grimmelikhuijzen (1980). Cellular junctions in
nerve-free hydra. Cell Tissue Res., 209, 217-224.
20. S.W. de Laat, L.G.J. Tertoolen and C.J.P. Grimmelikhuijzen (1980). No junctional
communication between epithelial cells in hydra. Nature, 288, 711-713.
21. C.J.P. Grimmelikhuijzen, A. Balfe, P.C. Emson, D. Powell and F. Sundler (1981).
Substance P-like immunoreacivity in the nervous system of hydra. Histochemistry, 71,
325-333.
22. C.J.P. Grimmelikhuijzen, R. Carraway, A. Rökaeus and F. Sundler (1981).
Neurotensin-like immunoreactivity in the nervous system of hydra. Histochemistry, 72,
199-209.
23. S. Falkmer and C.J.P. Grimmelikhuijzen (1981). Phyletic aspects of the tumor
pathology of the liver and the gastro-entero-pancreatic neuroendocrine system. In:
"Phyletic Approaches to Cancer" (eds. C.J. Dawe), Japan Sci. Soc. Press, Tokyo, 333346.
24. C.J.P. Grimmelikhuijzen, G.J. Dockray and N. Yanaihara (1981). Bombesin-like
immunoreactivity in the nervous system of hydra. Histochemistry, 73, 171-180.
25. C.J.P. Grimmelikhuijzen, K. Dierickx and G.J. Boer (1982). Oxytocin/vasopressin-like
immunoreactivity is present in the nervous system of hydra. Neuroscience, 7, 31913199.
26. C.J.P. Grimmelikhuijzen, G.J. Dockray and L.P.C. Schot (1982). FMRFamide-like
immunoreactivity in the nervous system of hydra. Histochemistry, 73, 499-508.
27. C.J.P. Grimmelikhuijzen (1983). Coexistence of neuropeptides in hydra. Neuroscience,
9, 837-845.
28. H.C. Schaller, C.J.P. Grimmelikhuijzen and T. Schmidt (1983). Assay and purification
of morphogenetic substances from hydra. In: "Hydra: Research Methods" (ed. H.M.
Lenhoff), Plenum Press, New York, 311-324.
29. C.J.P. Grimmelikhuijzen (1983). FMRFamide immunoreactivity is generally occurring in
the nervous systems of coelenterates. Histochemistry, 78, 361-381.
30. J. Triepel and C.J.P. Grimmelikhuijzen (1984). A critical examination of the occurrence
of FMRFamide immunoreactivity in the brain of guinea pig and rat. Histochemistry, 80,
63-71.
31. H.C. Schaller, H. Bodenmüller and C.J.P. Grimmelikhuijzen (1984). Neurohormones
and their function in hydra. Nova Acta Leopoldina, 56, 85-97.
32. C.J.P. Grimmelikhuijzen (1984). Peptides in the nervous system of coelenterates. In:
"Evolution and tumor pathology of the neuroendocrine system" (eds. S. Falkmer, R.
Hakanson, F. Sundler), Elsevier, Amsterdam, 39-58.
33. J. Triepel and C.J.P. Grimmelikhuijzen (1984). Mapping of Neurons in the central
nervous system of the guinea pig using specific antisera to FMRFamide. Cell Tissue
Res., 237, 575-586.
34. C.J.P. Grimmelikhuijzen and A.N. Spencer (1984). FMRFamide immunoreactivity in the
nervous system of the medusa Polyorchis penicillatus. J. Comp. Neurol., 230, 361-371.
35. G. Jirikowski, G. Erhart, C.J.P. Grimmelikhuijzen, J. Triepel and R.A. Patzner (1984).
FMRFamide-like immunoreactivity in the brain and pituitary of the hagfish Eptatretus
burgeri (Cyclostomata). Cell Tissue Res., 237, 363-366.
36. C.J.P. Grimmelikhuijzen (1985). Antisera to the sequence Arg-Phe-amide visualize
neuronal centralization in hydroid polyps. Cell Tissue Res., 241, 171-182.
37. P. Verhaert, C.J.P. Grimmelikhuijzen and A. de Loof (1985). Distinct Localization of
FMRFamide-and bovine pancreatic polypeptide-like material in the brain, retrocerebral
complex and suboesophageal ganglion of the cockroach Periplaneta americana. Brain
Res., 348, 331-338.
38. C.J.P. Grimmelikhuijzen and D. Graff (1985). Arg-Phe-amide like peptides in the
primitive nervous systems of coelenterates. Peptides, 6, Supplement 3, 477-483.
39. C.J.P. Grimmelikhuijzen (1986). FMRFamide-like peptides in the primitive nervous
systems of coelenterates and in the complex nervous systems of higher animals. In:
"Handbook of comparative opioid and related peptides mechanisms" (ed. G. Stefano),
C.R.C. Press, New York, 103-115.
40. C.J.P. Grimmelikhuijzen, A.N. Spencer and D. Carré (1986). Organization of the
nervous system of physonectid siphonophores. Cell Tissue Res., 246, 463-479.
41. C.J.P. Grimmelikhuijzen and D. Graff (1986). Isolation of <Glu-Gly-Arg-Phe-amide
(Antho-RFamide), a neuropeptide from sea anemones. Proc. Natl. Acad. Sci. USA, 83,
9817-9821.
42. C.J.P. Grimmelikhuijzen and A. Groeger (1987). Isolation of the neuropeptide pGlu-GlyArg-Phe-amide from the pennatulid Renilla köllikeri. FEBS Lett., 211, 105-108.
43. C.J.P. Grimmelikhuijzen, D. Graff, A. Groeger and I.D. McFarlane (1987).
Neuropeptides in invertebrates. In: "Nervous systems in Invertebrates" (ed. A.M. Ali),
Plenum Press, New York, 105-132.
44. I.D. McFarlane, D. Graff and C.J.P. Grimmelikhuijzen (1987). Excitatory actions of
Antho-RFamide, an anthozoan neuropeptide, on muscles and conduction systems in
the sea anemone Calliactis parasitica. J. Exp. Biol., 133, 157-168.
45. Q. Bone, C.J.P. Grimmelikhuijzen, A. Pulsford and K.P. Ryan (1987). Possible
transmitter function of acetylcholine and a RFamide-like substance in chaetognaths.
Proc. Roy. Soc. London, B230, 1-14.
46. C.J.P. Grimmelikhuijzen, D. Graff, A. Groeger and I.D. McFarlane (1987). Structure,
action and location of coelenterate Arg-Phe-amide peptides. Bull. Serb. Acad. Sci. Arts,
96 (Nr. 29), 13-24.
47. P.M. Bode, T.A. Awad, O. Koizumi, Y. Nakashima, C.J.P. Grimmelikhuijzen and H.R.
Bode (1988). Development of the two-part pattern during regeneration of the head in
hydra. Development, 102, 223-235.
48. D. Graff and C.J.P. Grimmelikhuijzen (1988). Isolation of <Glu-Ser-Leu-Arg-Trp-NH2, a
novel neuropeptide from sea anemones. Brain Res., 442, 354-358.
49. C.J.P. Grimmelikhuijzen, D. Graff and A.N. Spencer (1988). Structure, location and
possible actions of Arg-Phe-amide peptides in coelenterates. In: "Neurohormones in
Invertebrates" (eds. M.C. Thorndyke, G.J. Goldsworthy), Cambridge University Press,
199-217.
50. C.J.P. Grimmelikhuijzen, M. Hahn, K.L. Rinehart and A.N. Spencer (1988). Isolation of
<Glu-Leu-Leu-Gly-Gly-Arg-Phe-NH2
(Pol-RFamide),
a
novel
neuropeptide
from
hydromedusae. Brain Res., 475, 198-203.
51. D. Graff and C.J.P. Grimmelikhuijzen (1988). Isolation of <Glu-Gly-Leu-Arg-Trp-NH2
(Antho-RWamide II), a novel neuropeptide from sea anemones. FEBS Lett., 239, 137140.
52. D.R. Nässel, L.G. Ohlsson, K.U.I. Johansson and C.J.P. Grimmelikhuijzen (1988). Light
and electron microscopic immunocytochemistry of neurons in the blowfly optic lobe
reacting with antisera to RFamide and FMRFamide. Neuroscience, 27, 347-362.
53. D. Zitnan, P. Verhaert, A. De Loof and C.J.P. Grimmelikhuijzen (1988). Differences in
the distribution of immunoreactivity to FMRFamide and bovine pancreatic polypeptide
antisera in the larval and imaginal central nervous system of Galleria mellonella (Lepidoptera). In: "Endocrinological Frontiers in Physiological Insect Ecology" (eds. F.
Sehnal, A. Zabza, D.L. Denglinger), Wroclaw Technical Press, 847-857.
54. O. Koizumi, J.F. Wilson, C.J.P. Grimmelikhuijzen and J.A. Westfall (1989).
Ultrastructural localization of RFamide-like peptides in neuronal dense-cored vesicles
in the peduncle of Hydra. J. Exp. Zool., 249, 17-22.
55. M. Anctil and C.J.P. Grimmelikhuijzen (1989). Excitatory action of the native
neuropeptide Antho-RFamide on muscles in the pennatulid Renilla köllikeri. Gen.
Pharmac., 20, 381-384.
56. C.J.P. Grimmelikhuijzen, D. Graff and I.D. McFarlane (1989). Neurones and
neuropeptides in coelenterates. Arch. Histol. Cytol., 52 (Suppl.), 265-276.
57. C.J.P. Grimmelikhuijzen, D. Graff, O. Koizumi, J.A. Westfall and I.D. McFarlane (1989).
Neurones and their peptide transmitters in coelenterates. In: "Evolution of the First
Nervous Systems" (ed. P.A.V. Anderson), Plenum Press, New York, 95-110.
58. I.D. McFarlane, D. Graff and C.J.P. Grimmelikhuijzen (1989). Evolution of conducting
systems and neurotransmitters in the Anthozoa. In: "Evolution of the First Nervous
Systems" (ed. P.A.V. Anderson), Plenum Press, New York, 111-127.
59. C.J.P. Grimmelikhuijzen, K.L. Rinehart, E. Jacob, D. Graff, R.K. Reinscheid, H.P.
Nothacker and A.L. Staley (1990). Isolation of L-3-phenyllactyl-Leu-Arg-Asn-NH2
(Antho-RNamide), a sea anemone neuropeptide containing an unusual amino-terminal
blocking group. Proc. Natl. Acad. Sci. USA, 87, 5410-5414.
60. K.L. Rinehart, T.G. Holt, N.L. Fregan, P.A. Keifer, G.R. Wilson, T.J. Perun, R. Sakai,
A.G. Thompson, J.G. Stroh, L.S. Shield, L.H. Li, C.J.P. Grimmelikhuijzen and G. Gäde
(1990). Bioactive compounds from aquatic and terrestrial sources. J. Nat. Products, 53,
771-792.
61. M. Reuter, M.K.S. Gustafsson, J. Lang and C.J.P. Grimmelikhuijzen (1990). The
release sites and targets of nerve cells immunoreactive to RFamide - an ultrastructural
study of Microstomum lineare and Diphyllobothrium dendriticum (Plathyhelminthes).
Zoomorphol., 109, 303-308.
62. K.L. Rinehart, T.G. Holt, N.L. Fregan, A.L. Staley, A.G. Thompson, K.I. Harada, J.M.
Curtis, L.S. Rong, F. Sun, L.S. Shield, G. Gäde, C.J.P. Grimmelikhuijzen, C.C. Doughty
and C.E. Grimshaw (1990). Application of high resolution tandem FAB mass
spectrometry. In: "Biological Mass Spectrometry" (eds. A.L. Burlingame, J.A.
McCloskey), Elsevier, Amsterdam, 233-257.
63. I.D. McFarlane and C.J.P. Grimmelikhuijzen (1991). Three anthozoan neuropeptides,
Antho-RFamide and Antho-RWamide I and II modulate spontaneous tentacle
contractions in sea anemones. J. Exp. Biol., 155, 669-673.
64. D. Darmer, C. Schmutzler, D. Diekhoff and C.J.P. Grimmelikhuijzen (1991). Primary
structure of the precursor for the sea anemone neuropeptide Antho-RFamide (<GluGly-Arg-Phe-NH2). Proc. Natl. Acad. Sci. USA, 88, 2555-2559.
65. I.D. McFarlane, P.A.V. Anderson and C.J.P. Grimmelikhuijzen (1991). Effects of three
anthozoan neuropeptides Antho-RWamide I, II and Antho-RFamide, on slow muscles
from sea anemones. J. Exp. Biol., 156, 419-431.
66. C.J.P. Grimmelikhuijzen, D. Graff, O. Koizumi, J.A. Westfall and I.D. McFarlane (1991).
Neuropeptides in coelenterates: a review. Hydrobiol., 216/217, 555-563.
67. K.L. Rinehart, M. Namikoshi, A.G. Thompson, L.S. Shield, G. Gäde, C.J.P.
Grimmelikhuijzen, H.-P. Nothacker, W.W. Carmichael, K. Sivonen, C.C. Doughty and
C.E. Grimshaw (1991). Tandem mass spectrometry (FABMS/MS) studies of peptides
and proteins. In: "Studies in Natural Products Chemistry, Vol. 9, Structure and
Chemistry (Part B)" (ed. A. Rahman), Elsevier, Amsterdam, 487-509.
68. H.-P. Nothacker, K.L. Rinehart and C.J.P. Grimmelikhuijzen (1991). Isolation of L-3phenyllactyl-Phe-Lys-Ala-NH2 (Antho-KAamide), a novel neuropeptide from sea
anemones. Biochem. Biophys. Res. Commun., 179, 1205-1211.
69. H.-P. Nothacker, K.L. Rinehart, I.D. McFarlane and C.J.P. Grimmelikhuijzen (1991).
Isolation of two novel neuropeptides from sea anemones: The unusual, biologically
active L-3-phenyllactyl-Tyr-Arg-Ile-NH2 and its des-phenyllactyl fragment Tyr-Arg-IleNH2. Peptides, 12, 1165-1173.
70. C.J.P. Grimmelikhuijzen, K.L. Rinehart and A.N. Spencer (1992). Isolation of the
neuropeptide
<Glu-Trp-Leu-Lys-Gly-Arg-Phe-NH2
(Pol-RFamide
II)
from
the
hydromedusa Polyorchis penicillatus. Biochem. Biophys. Res. Commun., 183, 375-382.
71. C.J.P. Grimmelikhuijzen, K. Carstensen, D. Darmer, A. Moosler, H.-P. Nothacker, R.K.
Reinscheid, C. Schmutzler, H. Vollert, I.D. McFarlane and K.L. Rinehart (1992).
Coelenterate neuropeptides: Structure, action and biosynthesis. Amer. Zool., 32, 1-12.
72. C.J.P. Grimmelikhuijzen, D. Darmer, C. Schmutzler, K. Carstensen, A. Moosler, H.-P.
Nothacker, R.K. Reinscheid, H. Vollert, K.L. Rinehart and I.D. McFarlane (1992). The
peptidergic nervous system of coelenterates. In: "Progress in Brain Res.", Vol. 92, (eds.
J. Joosse, R.M. Buijs, F.J.H. Tilders), Elsevier, Amsterdam, 137-148.
73. I.D. McFarlane, R.K. Reinscheid and C.J.P. Grimmelikhuijzen (1992). Opposite actions
of Antho-RNamide on antagonistic muscle groups in sea anemones. J. Exp. Biol., 164,
295-299.
74. O. Koizumi, M. Itazawa, H. Mizumoto, S. Minobe, L.C. Javois, C.J.P.Grimmelikhuijzen
and H.R. Bode (1992). The nerve ring in the hypostome of Hydra.I. Its structure,
development and maintanance. J. Comp. Neurol., 326, 7-21.
75. P.A.V. Anderson, A. Moosler and C.J.P. Grimmelikhuijzen (1992). The presence and
distribution of Antho-RFamide-like material in scyphomedusae. Cell Tissue Res., 267,
67-74.
76. K. Carstensen, K.L. Rinehart, I.D. McFarlane and C.J.P. Grimmelikhuijzen (1992).
Isolation
of
Leu-Pro-Pro-Gly-Pro-Leu-Pro-Arg-Pro-NH2
(Antho-RPamide),
an
N-
terminally protected, biologically active neuropeptide from sea anemones. Peptides, 13,
851-857.
77. C. Schmutzler, D. Darmer, D. Diekhoff and C.J.P. Grimmelikhuijzen (1992).
Identification of a novel type of processing sites in the precursor for the sea-anemone
neuropeptide Antho-RFamide (<Glu-Gly-Arg-Phe-NH2) from Anthopleura elegantissima.
J. Biol. Chem., 267, 22534-22541.
78. K. Carstensen, I.D. McFarlane, K.L. Rinehart, D. Hudman, F.G. Sun, and C.J.P.
Grimmelikhuijzen (1993). Isolation of <Glu-Asn-Phe-His-Leu-Arg-Pro-NH2 (AnthoRPamide II), a novel, biologically active neuropeptide from sea anemones. Peptides,
14, 131-135.
79. J.A. Westfall and C.J.P. Grimmelikhuijzen (1993). Antho-RFamide immunoreactivity in
neuronal synaptic and nonsynaptic vesicles of sea anemones. Biol. Bull., 185, 109-114.
80. I.D. McFarlane, D. Hudman, H.-P. Nothacker and C.J.P. Grimmelikhuijzen (1993). The
expansion behaviour of sea anemones may be coordinated by two inhibitory
neuropeptides, Antho-RIamide and Antho-KAamide. Proc. Roy. Soc. Lond. B., 253,
183-188.
81. H.-P. Nothacker and C.J.P. Grimmelikhuijzen (1993). Molecular cloning of a novel,
putative G protein-coupled receptor from sea anemones structurally related to members
of the FSH, TSH, LH/CG receptor family from mammals. Biochem. Biophys. Res.
Commun., 197, 1062-1069.
82. R.K. Reinscheid and C.J.P. Grimmelikhuijzen (1994). Primary structure of the precursor
for the anthozoan neuropeptide Antho-RFamide from Renilla köllikeri: Evidence for
unusual processing enzymes. J. Neurochem., 62, 1214-1222.
83. C.J.P. Grimmelikhuijzen, D. Darmer, C. Schmutzler, R.K. Reinscheid and K.
Carstensen (1994). Biosynthesis of neuropeptides in the Cnidaria: new discoveries of
old principles. In: Perspectives of Comparitive Endocrinology (eds. D.G. Davey and S.S.
Tobe) National Research Council of Canada, Ottawa, pp 97-108.
84. C. Schmutzler, D. Diekhoff and C.J.P. Grimmelikhuijzen (1994). The primary structure
of the Pol-RFamide neuropeptide precursor protein from the hydromedusa Polyorchis
penicillatus indicates a novel processing proteinase activity. Biochem. J., 299, 431-436.
85. I. Leviev and C.J.P. Grimmelikhuijzen (1995). Molecular cloning of a preprohormone
from sea anemones containing multiple copies of a metamorphosis inducing
neuropeptide: a likely role for dipeptidyl aminopeptidase in neuropeptide precursor
processing. Proc. Natl. Acad. Sci. USA, 92, 11647-11651.
86. C.J.P. Grimmelikhuijzen and J. A. Westfall (1995). The nervous systems of cnidarians.
In: "The Nervous Systems of Invertebrates - A Comparative Approach" (eds. O.
Breidbach and W. Kutsch), Experientia 72, pp. 7-24.
87. J.A. Westfall, K.L. Sayyar, C.F. Elliott and C.J.P. Grimmelikhuijzen (1995).
Ultrastructural localisation of Antho-RWamides I and II at neuromuscular synapses in
the gastrodermis and oral sphincter muscle of the sea anemone Calliactis parasitica.
Biol. Bull., 189, 280-287.
88. M. Reuter, M.K.S. Gustafson, K. Mäntylä and C.J.P. Grimmelikhuijzen (1996). The
nervous system of Tricladida.III. Neuroanatomy of Dendrocoelum lacteum and Polycelis
tenuis (Plathelmintes, Paludicola): An immunocytochemical study, Zoomorphol. 116,
112-122
89. C.J.P. Grimmelikhuijzen and I. Leviev (1996). Biosynthesis of neuropeptides in
cnidarians: evidence for unusual neuropeptide precursor processing enzymes. In: "The
Peptidergic Neuron" (eds. B. Krisch and R. Mentlein), Birkhäuser Verlag, Basel, pp. 3946.
90. A. Moosler, K.L. Rinehart and C.J.P. Grimmelikhuijzen (1996). Isolation of four
neuropeptides, the Hydra-RFamides I-IV from Hydra magnipapillata. Biochem. Biophys.
Res. Commun., 229, 569-602
91. C.J.P. Grimmelikhuijzen, I. Leviev and K. Carstensen (1996). Peptides in the nervous
systems of cnidarians: Structure, function and biosynthesis. Int. Rev. Cytol., 167, 37-89.
92. F. Hauser, H.-P. Nothacker and C.J.P. Grimmelikhuijzen (1997) Molecular cloning,
genomic organization and developmental regulation of a novel receptor from Drosophila
melanogaster structurally related to members of the TSH, FSH, LH/CG receptor family
from mammals. J. Biol. Chem., 272, 1002-1010.
93. I. Leviev, M. Williamson and C.J.P. Grimmelikhuijzen (1997) Molecular cloning of a
preprohormone from Hydra magnipapillata containing multiple copies of Leu-Trp-NH2
(LWamide) neuropeptides: Evidence for processing at Ser and Asn residues. J.
Neurochem., 68, 1319-1325.
94. A. Moosler, K.L. Rinehart and C.J.P. Grimmelikhuijzen (1997) Isolation of three novel
neuropeptides, the Cyanea-RFamides I-III, from scyphomedusae. Biochem. Biophys.
Res. Commun, 236, 743-749.
95. C.J.P. Grimmelikhuijzen and F. Hauser (1997) Neurohormones and neurohormone
receptors in invertebrates. In: "Neuroendocrinology - Retrospect and Perspectives"
(eds. H.-W. Korf and K.H. Usadel), Springer Verlag, Heidelberg, pp. 25-42.
96. C.J.P. Grimmelikhuijzen and I. Leviev (1997). Function and biosynthesis of cnidarian
neuropeptides.
In:
"Coelenterate
Biology"
(ed.
J.C.
den
Hartog),
Nationaal
Natuurhistorisch Museum, Leiden, pp. 215-226.
97. F. Hauser, M. Williamson and C.J.P. Grimmelikhuijzen (1997) Molecular cloning of a
peptidylglycine -hydroxylating monooxygenase from sea anemones. Biochem.
Biophys. Res. Commun., 241, 509-512.
98. F. Hauser, L. Søndergaard and C.J.P. Grimmelikhuijzen (1998). Molecular cloning,
genomic organization and developmental regulation of a novel receptor from Drosophila
melanogaster structurally related to Gonadotropin-Releasing Hormone receptors from
mammals. Biochem. Biophys. Res. Commun., 249, 822-828.
99. D. Darmer, F. Hauser, H.-P. Nothacker, T. Bosch, M. Williamson and C.J.P.
Grimmelikhuijzen (1998). Three different prohormones yield a variety of Hydra-RFamide
(Arg-Phe-NH2) neuropeptides in Hydra magnipapillata. Biochem. J., 332, 403-412.
100. N. Vibede, F. Hauser, M. Williamson and C.J.P. Grimmelikhuijzen (1998). Genomic
organization of a receptor from sea anemones, structurally and evolutionarily related to
glycoprotein hormone receptors from mammals. Biochem. Biophys. Res. Commun.,
252, 497-501.
101. C. Mitgusch, F. Hauser and C.J.P. Grimmelikhuijzen (1999). Expression and
developmental regulation of the Hydra-RFamid and Hydra-LWamid preprohormone
genes in Hydra. Evidence for transient phases of head formation. Develop. Biol., 207,
181-203.
102. C.J.P. Grimmelikhuijzen, F. Hauser, K. Krageskov Eriksen and M. Williamson (1999).
Invertebrate neurohormones and their receptors. In: "Results and Problems in Cell
Differentiation“, Vol 26, (ed. D. Richter), Springer Verlag, Heidelberg, pp. 339-362.
103. C.J.P. Grimmelikhuijzen (2000). Developmental endocrinology of Cnidaria and
Ctenophora. In: "Reproductive Biology of Invertebrates, Vol. X, Progress in
Developmental Endocrinology“, (eds. A. Dorn, K.G. Adiyodi and R.G. Adiyodi), WileyLiss, New York, pp. 45-71.
104. C. Lenz, L. Søndergaard and C.J.P. Grimmelikhuijzen (2000). Molecular cloning and
genomic organization of a novel receptor from Drosophila melanogaster structurally
related to mammalian galanin receptors. Biochem. Biophys. Res. Commun., 269, 9196.
105. K. Krageskov Eriksen, F. Hauser, M. Schiøtt, K.-M. Pedersen, L. Søndergaard and
C.J.P.
Grimmelikhuijzen
(2000).
Molecular
cloning,
genomic
organization,
developmental regulation, and a knock-out mutant of a novel Leu-rich repeatscontaining G protein-coupled receptor (DLGR-2) from Drosophila melanogaster.
Genome Res., 10, 924-938.
106. G. N. Hansen, M. Williamson and C.J.P. Grimmelikhuijzen (2000). Two-color double
labeling in situ hybridization of whole mount Hydra using RNA probes for five different
Hydra neuropeptide preprohormones: evidence for colocalisation. Cell Tissue Res.,
301, 245-253.
107. C. Lenz, M. Williamson and C.J.P. Grimmelikhuijzen (2000). Molecular cloning and
genomic organization of a second probable allatostatin receptor from Drosophila
melanogaster. Biochem. Biophys. Res. Commun., 273, 571-577.
108. C. Lenz, M. Williamson and C.J.P. Grimmelikhuijzen (2000). Molecular cloning and
genomic organization of an allatostatin preprohormone from Drosophila melanogaster.
Biochem. Biophys. Res. Commun., 273, 1126-1131.
109. M. Williamson, F. Hauser and C.J.P. Grimmelikhuijzen (2000) Genomic organization
and splicing variants of a peptidylglycine -hydroxylating monooxygenase from sea
anemones. Biochem. Biophys. Res. Commun. 277, 7-12.
110. M. Williamson, C. Lenz, Å.M.E. Winther, D.R. Nässel and C.J.P. Grimmelikhuijzen
(2001) Molecular cloning, genomic organization, and expression of a B-type (crickettype) allatostatin preprohormone from Drosophila melanogaster. Biochem. Biophys.
Res. Commun., 281, 544-550.
111. T. Secher, C. Lenz, G. Cazzamali, G. Sørensen, M. Williamson, G.N. Hansen, P. Svane
and C.J.P. Grimmelikhuijzen (2001). Molecular cloning of a functional allatostatin
gut/brain receptor and an allatostatin preprohormone from the silkworm Bombyx mori. J.
Biol. Chem., 276, 47052-47060.
112. M. Williamson, C. Lenz, Å.M.E. Winther, D.R. Nässel and C.J.P. Grimmelikhuijzen
(2001) Molecular cloning, genomic organization, and expression of a C-type (Manduca
sexta-type) allatostatin preprohormone from Drosophila melanogaster. Biochem.
Biophys. Res. Commun., 282, 124-130.
113. C. Lenz, M. Williamson, G.N. Hansen and C.J.P. Grimmelikhuijzen (2001). Identification
of four Drosophila allatostatins as the cognate ligands for the Drosophila orphan
receptor DAR-2. Biochem. Biophys. Res. Commun., 286, 1117-1122.
114. C.J.P. Grimmelikhuijzen, M. Williamson and G.N. Hansen (2002). Neurohormones in
cnidarians. In: "Cell signalling in procaryotes and lower metazoa" (ed. I. Fairweather),
Kluwer Academic Publishers, Dordrecht, in press.
115. G.N. Hansen, M. Williamson and C.J.P. Grimmelikhuijzen (2002). A new case of
neuropeptide coexpression (RGamide and LWamides) in Hydra found by whole mount,
two color double labeling in situ hybridization. Cell Tissue Res., 308, 157-165.
116. C.J.P. Grimmelikhuijzen, M. Williamson and Georg N. Hansen (2002). Neuropeptides in
cnidarians. Can. J. Zool. 80, 1690-1702.
117. F. Staubli, T.J.D. Jørgensen, G. Cazzamali, M. Williamson, C. Lenz, L. Søndergaard, P.
Roepstoff and C.J.P. Grimmelikhuijzen (2002). Molecular identification of the insect
adipokinetic hormone receptors. Proc. Natl. Acad. Sci. USA, 99, 3446-3451.
118. G. Cazzamali and C.J.P. Grimmelikhuijzen (2002). Molecular cloning and functional
expression of the first insect FMRFamide receptor. Proc. Natl. Acad. Sci. USA, 99,
12073-12078.
119. G. Cazzamali, N.P.E. Saxild and C.J.P. Grimmelikhuijzen (2002). Molecular cloning and
functional expression of a Drosophila corazonin receptor. Biochem. Biophys. Res.
Commun., 298, 31-36.
120. A. Iversen, G. Cazzamali, M. Williamson, F. Hauser and C.J.P. Grimmelikhuijzen
(2002). Molecular cloning and functional expression of a Drosophila receptor for the
neuropeptides capa-1 and capa-2. Biochem. Biophys. Res. Commun., 299, 628-633.
121. A. Iversen, G. Cazzamali, M. Williamson, F. Hauser and C.J.P. Grimmelikhuijzen
(2002). Molecular identification of the first insect ecdyssis triggering hormone receptors.
Biochem. Biophys. Res. Commun., 299, 924-931.
122. G. Cazzamali, F. Hauser, S. Kobberup, M. Williamson and C.J.P. Grimmelikhuijzen
(2003). Molecular identification of a Drosophila G protein-coupled receptor specific for
crustacean cardioactive peptide. Biochem. Biophys. Res. Commun., 303, 146-152.
123. K. Egerod, E. Reynisson, F. Hauser, M. Williamson, G. Cazzamali and C. J. P.
Grimmelikhuijzen (2003). Molecular identification of the first insect proctolin receptor.
Biochem. Biophys. Res. Commun., 306, 437-442.
124. K. Egerod, E. Reynisson, F. Hauser, G. Cazzamali, M. Williamson and C. J. P.
Grimmelikhuijzen (2003). Molecular cloning and functional expression of the first two
specific insect myosuppressin receptors. Proc. Natl. Acad. Sci. USA, 100, 0000-0000.
125. C. Rosenkilde, G. Cazzamali, M. Williamson, F. Hauser, L. Søndergaard, R. Delotto, G.
Nachman and C. J. P. Grimmelikhuijzen (2003). Molecular cloning, functional
expression, and gene silencing of two Drosophila receptors for the Drosophila
neuropeptide pyrokinin-2. Submitted.
Master Degree and Ph.D. Theses from the reaserch group of C.J.P. Grimmelikhuijzen
1.
D. Graff (1985). Lokalisierung RFamid- und Vasopressin/Oxytocin immunreaktiver
Neurone in Calliactis parasitica, und Reinigung einer RFamide-ähnlichen Substanz aus
Anthopleura elegantissima. Master Degree thesis, University of Heidelberg.
2.
B.
Mader
(1986).
Lokalisierung
Arg-Phe-amid
immunreaktiver
Neurone
in
Hydromedusen und Reinigung einer Arg-Phe-amid-ähnlichen Substanz aus der
Hydromeduse Polyorchis pennicillatus. Master Degree thesis, University of Heidelberg.
3.
A.
Groeger
(1988).
Reinigung
und
Sequenzierung
von
RFamid-ähnlichen
Neuropeptiden der Seefeder Renilla köllikeri. Master Degree thesis, University of
Heidelberg.
4.
D. Graff (1988). Isolierung und Sequenzierung von Neuropeptiden aus Seeanemonen.
Ph.D. thesis, University of Heidelberg.
5.
E. Jacob (1989). Isolierung und Sequenzierung des Neuropeptids Antho-RNamid aus
der Seeanemone Anthopleura elegantissima. Master Degree thesis, University of
Heidelberg.
6.
R.K. Reinscheid (1993). Isolierung und Sequenzierung neuer Neuropeptide aus der
Seeanemone
Anthopleura
elegantissima
und
Klonierung
eines
Neuropeptid-
vorläuferproteins aus der Seefeder Renilla köllikeri. Ph.D. thesis, University of
Hamburg.
7.
K. Carstensen (1993). Struktur, Wirkungsweise und Biosynthese von Antho-RPamiden,
einer neuen Neuropeptidfamilie aus der Seeanemone Anthopleura elegantissima. Ph.D.
thesis, University of Hamburg.
8.
H.-P. Nothacker (1993). Isolierung neuer Neuropeptide und Klonierung der cDNA eines
neuartigen G-Protein gekoppelten Rezeptors aus der Seeanemone. Ph.D. thesis,
University of Hamburg.
9.
H. Vollert (1994) Isolierung und Funktion neuer Neuropeptide sowie Aufklärung der
genomischen Organisation eines Neuropeptidvorläufers aus der Seeanemone
Anthopleura Elegantissima Brandt.
Ph. D. thesis, University of Hamburg.
10. A. Moosler (1995) Struktur und Biosynthese von Neuropeptiden aus Hydro- und
Scyphozoen. Ph. D. thesis, University of Hamburg.
11. K.
Krageskov Eriksen (1998)
Molecular
cloning,
genomic
organization
and
developmental expression pattern of a second putative glycoprotein hormone receptor
from Drosophila melanogaster. Master Degree thesis, University of Copenhagen.
12. P. Svane (2000) Molecular cloning, genomic organization and developmental and
tissue expression of a novel leucine-rich repeats containing G protein-coupled receptor
from Bombyx mori. Ph.D. thesis, University of Copenhagen.
13. T. Secher (2001) Molecular cloning of a functional allatostatin gut/brain receptor and an
allatostatin preprohormone from the silkworm Bombyx mori. Master Degree thesis,
University of Copenhagen.
14. M. Torp (2001) Molecular cloning, genomic organization, and developmental and tissue
expression of two novel orphan G protein-coupled receptors (DGPR & DSR) from
Drosophila melanogaster. Master Degree thesis, University of Copenhagen.
15. N.P.E. Saxild (2002) Molecular cloning and expression of a putative somatostatin
receptor from Drosophila melanogaster. Master Degree thesis, University of
Copenhagen.
16. L. Bohn (2002) Molecular cloning and expression of a third Leu-rich containing G
protein-coupled receptor from Drosophila melanogaster. Master Degree thesis,
University of Copenhagen.
17. C. Lenz (2002) Cloning and functional expression of neuropeptide receptors and their
ligands in Drosophila melanogaster and Bombyx mori. Ph.D. thesis, University of
Copenhagen.
18. K. Bay Jensen (2002) Kloning og sekvensering af et nyt preprohormon kodende for et
formodet nyt neuropeptid i Hydra magnipappilata. Master Degree thesis, University of
Copenhagen.
19. L. Arler (2003) Molecular cloning of a second capa receptor and an orphan G proteincoupled receptor from Drosophila melanogaster. Master Degree thesis, University of
Copenhagen.
20. A. Iversen (2003) Molecular cloning and identification of three novel G protein-coupled
receptors
in
Drosophila
melanogaster.
Master
Degree
thesis,
University
of
Copenhagen.
21. C. Rosenkilde (2003) Identification of two Drosophila melanogaster pyrokinin receptors.
Master Degree thesis, University of Copenhagen.
22. E. Reynisson (2003) Molecular cloning and functional expression of a specific
myosuppression receptor from Drosophila melanogaster. Master Degree thesis,
University of Copenhagen.
Supervision of theses carried out externally
1.
L. Jønson (1997) Evolution of the gastrin/CCK family: Cloning of the cDNAs and genes
of the dogfish, Squalus acanthias, gastrin and CCK, as well as the gastrin cDNA of the
turtle, Pseudemys scripta. Master Degree thesis, University of Copenhagen (the
experimental part of the work was carried out at Rigshospitalet, Copenhagen).
2.
H. Husum (1998) Effects of chronic Citalopram, lithium and electroconvulsive shock
treatments on the rat hippocampal Neuropeptide Y system. Master Degree thesis,
University of Copenhagen (the experimental part of the work was carried out at
Lundbeck A/S, a pharmaceutical company in Copenhagen).
3.
J. U. Fog (1999) Genomic cloning and promotor analysis of the mouse -synuclein
gene. Master Degree thesis, University of Copenhagen (the experimental part of the
work was carried out at Lundbeck A/S, a pharmaceutical company in Copenhagen).
4.
N.I. Bech (2000) Elektrofysiologisk karakterisering af kainsyrereceptorer. Master
Degree thesis, University of Copenhagen (the experimental part of the work was
carried out at NeuroSearch A/S, a pharmaceutical company in the neighbourhood of
Copenhagen).
5.
A. Zedeler (2001) Human NT2 neuroner og hippocampale neuroner fra rotte som
partielle modeller for amyloid  peptide medierede oxidative forandringer ved
Alzheimers
sygdom.
Master
Degree
thesis,
University
of
Copenhagen (the
experimental part of the work was carried out at Rigshospitalet, Copenhagen).
6.
L. Hummelshøj Mogensen (2001) Constitutively active mutant NK1 receptors. Master
Degree thesis, University of Copenhagen (the experimental part of the work was
carried out at Lundbeck A/S, a pharmaceutical company in Copenhagen).
7.
Sidrah Qureshi (2002) Development of adeno-associated viral vector for in vivo gene
delivery into the central nerveous system. Master Degree thesis, University of
Copenhagen (the experimental part of the work was carried out at the University of
California, San Diego).
8.
Sadia Asghar Butt (2003) the role of Ca2+ and Ca2+/calmodulin kinases in NCAMmediated neural differentiation. Master Degree thesis, University of Copenhagen (the
experimental part of this work was carried out at the Panum Institute, University of
Copenhagen).