CIRM CENTER of Excellence in Stem Cell Genomics
CESCG Call 2: Collaborative Research Program (CRP)
Research Proposal (Part A)
Use this template to complete Part A of the Collaborative Research Program application, the
Research Proposal. The proposal may include tables and figures.
Before you begin, please complete the Project Information table below.
Please observe the indicated page limits for each section as applications that exceed these
limits will not be accepted. No appendices are allowed. Do not modify typeface (Arial), font
size (11 pt), or margins (1” all around).
When you have finished the Research Proposal, please fill in the appropriate page numbers
for each section listed in the Table of Contents. You must then convert the document into a PDF
file (and combine it with all other required documents into a single PDF file) for email
submission.
All application materials must be received by CESCG at cescg@salk.edu no later than 12:00
pm PDT on October 30, 2015. No exceptions to this deadline will be made.
Project Information
Fill in the fields below
PI Name:
Email:
Project Title:
CESCG Call 2: CRP Research Proposal
Instructions for Completing the Research Proposal
The Part A Proposal includes the following sections 1-4 (up to 10 pages total):
1. Abstract (1/2 page)
State the goals of the proposal. Summarize the overall plans for the proposed research
project and how these will meet the stated objectives of this Call.
2. Research Plan
CRP projects include both small and large-scale, data-intensive, transformative
genomics research projects focused on substantive problems in human stem cell
biology and regenerative medicine. The goal of the CRP program is to accelerate
fundamental understanding of human biology and disease mechanisms, enhance cell
and tissue production and advance personalized cellular therapeutics through the
development and/or application of innovative genomic and epigenomic approaches in
regenerative medicine.
Provide the following information:
a. Rationale and Significance (up to 1/2 page)
Summarize the context and background of the project and the specific rationale for the
work proposed. Specifically identify the gaps in the current knowledge base that the
project is intended to fill and why a genomics/bioinformatics approach can best address
them. If the aims of the project are achieved, state how the findings will make a critical
contribution to the field of human stem cell genomics and biology or regenerative
medicine in support of the CIRM mission to accelerate treatments for patients with
unmet medical needs.
b. Specific Aims (up to 1 page)
State the goal of the specific research proposed. Identify and enumerate each specific
aim of the project in a concise and step-wise fashion, and describe how each aim will
support the goal of this research.
c. Preliminary Data (up to 2 pages)
Provide preliminary data or cite published results to support the concepts, hypotheses
and/or approaches proposed for the project. New projects, lacking preliminary data, are
welcome but need to be adequately described and convincingly justified to enable
reasonable evaluation.
d. Research Design, Methods, and Project Timeline (up to 4 pages)
Describe concisely, but in sufficient detail to permit evaluation of the merit of the
research, the experimental design, methods and techniques to be employed to achieve
the goals specified for this project. Use clear and consistent terminology to identify the
various cell types, cell lines and genomics technologies that may be employed
throughout the project. Identify the new or risky aspects of the research, anticipated
pitfalls, and plans to overcome or circumvent difficulties that may arise. Describe the
CESCG Call 2: CRP Research Proposal
methods of analysis of results; note that because these are genomics based projects
we expect a significant emphasis on genomics technologies. Describe specific criteria
for success of the project including meaningful quantitative measure(s) to determine if
the project objective has been achieved. Provide a realistic timetable for completing
each proposed specific aim of the project; provide specific criteria for evaluating the
achievement of each specific aim. If you request more than 25% of direct costs be
allocated to your laboratory / institution (Translational/Clinical CRP projects only, prior
approval from CIRM staff required), please provide a scientific justification, keeping in
mind that CRP projects are designed to support investigator access to CESCG
technologies, resources, and expertise.
3. References (up to 1 page)
List all references cited in the body of the proposal.
4. Key Personnel (1 page in Part A, also included in Part C)
List all key personnel and briefly describe their roles on and significance to the project.
Key personnel are defined as individuals who contribute to the scientific development or
execution of the project in a substantive, measurable way, whether or not they receive
salaries or compensation under the grant. Key personnel may include any technical
staff, trainees, co-investigators (collaborators), or consultants who meet this definition.
Key personnel who are not part of the applicant organization should be identified as
subcontractors. Personnel who are not key, such as technical support staff, may be
supported by grant funds but not named.
A minimum of one percent effort is required for each key person.
For each key person listed, except for technical staff and students, provide a two- page
biographical sketch using the template provided under Part C. The sketch should
highlight prior relevant experience, accomplishments and/or special skills related to the
proposed research. Include relevant publications and/or patents or patent applications.
Following the biographical sketch for the PI include all remaining biographical sketches
in alphabetical order.
CESCG Call 2: CRP Research Proposal
CRP Research Proposal
When you have finished the Research Proposal, please fill in the appropriate
page numbers for each section listed in the Table of Contents below.
Page
Table of Contents
1
Abstract................................................................................................................. <enter page #>
Rationale and Significance .................................................................................... <enter page #>
Specific Aims ........................................................................................................ <enter page #>
Preliminary Data ................................................................................................... <enter page #>
Research Design, Methods, and Project Timeline ................................................. <enter page #>
References ........................................................................................................... <enter page #>
Key Personnel....................................................................................................... <enter page #>
CESCG Call 2: CRP Research Proposal
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Abstract and Rationale & Significance (up to 1 page, excess pages will be discarded):
CESCG Call 2: CRP Research Proposal
2
Specific Aims (up to 1 page, excess pages will be discarded):
CESCG Call 2: CRP Research Proposal
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Preliminary Data (up to 2 pages, excess pages will be discarded):
CESCG Call 2: CRP Research Proposal
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Research Design, Methods and Project Timeline (up to 4 pages, excess pages will be discarded):
CESCG Call 2: CRP Research Proposal
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References (up to 1 page, excess pages will be discarded):
CESCG Call 2: CRP Research Proposal
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Key Personnel (up to 1 page, excess pages will be discarded):
CESCG Call 2: CRP Research Proposal
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CESCG Call 2: CRP Research Proposal
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