Lesson 3, Upper GI – The Stomach and Pancreas Heal Your Gut with Lydia Shatney, NTP Many dysfunctions in the body will resolve themselves once the upper GI has been ironed out. Believe it or not, getting things ironed out in the upper GI is a top priority in the very foundation of your health. It is not really possible to expect to resolve problems further along in the digestive system without addressing stomach acidity. It is possible to repair the small and large intestine by simply getting your stomach acid levels back in line. Though, many will need to do further healing of an already damaged gut lining as well. Proper and adequate HCl production is KEY to the entire digestive process. This will be a key place for everyone to assess and work on if they want to see the issues in the south of digestion get ironed out. The stomach produces between 1 and 2 liters of gastric juices daily. This helps us break down our food. The most important jobs of the stomach are to act as a reservoir, storing food until it can be transported to the duodenum (the first portion of the small intestine), to mix food with gastric secretions, forming a semifluid mixture called chyme, and to slow the emptying of food into the small intestine at a rate suitable for its proper digestion and absorption. Do you have any of the following symptoms? Rate them 0 for never, 1 for minor or rarely, 2 for moderate or weekly and 3 for severe or daily Further Signs and symptoms you may be having that relate to issues in the upper GI Belching or gas within one hour after eating heartburn or acid reflux bloating within one hour after eating, a vegan diet bad breath loss of taste for meat sweat has a strong odor stomach upset by taking vitamins sense of excess fullness after meals feel like skipping breakfast feel better if you don't eat sleepy after meals fingernails chip, peel or break easily anemia unresponsive to iron stomach pains or cramps diarrhea (chronic) diarrhea shortly after meals black or tarry colored stools undigested food in stool Though these are not the only possible symptoms or signs that show you are not adequate in either stomach acid or pancreatic enzymes, they are the most commonly understood signs. What was your score? A score of 3-9 indicates a low priority, but you likely need some stomach acid and maybe digestive enzymes. A score of 10-14 is a moderate priority meaning you're on your way to worse things if you don't get it ironed out, you definitely need hydrochloric acid and digestive enzymes, 15 and above is a high priority and should become your top priority to work on. I am going to teach you a million things in this course. Please do not try to implement everything all at once. Don't even try to do more than a couple of new things while you are taking this class. Why? Because you didn't get to where you are overnight and you're not going to heal overnight either. It will be important to take your time working on things little by little. One key piece will be finding a dietary game plan that will work to further your healing. Add to that some basic supplements starting in the northern most parts of digestion and tackle that first. Most of us will need some time to see the benefits happen. Let's talk about heartburn and GERD for a bit Heartburn occurs when acid from the stomach irritates the tissue that lines the esophagus. Since acid does not belong in the esophagus it is very irritating, it is not made to handle the acid. The stomach however, is lined to deal with the extremely acid environment. The stomach is an acid producing machine. The acid in the stomach is secreted at about 0.8 if you took a drop of this acid and dropped it on the floor it would burn a hole in the floor. Acid reflux can be caused by many things including obesity, smoking, eating fried foods (fast foods), coffee, alcohol, and carbonated beverages. These foods or conditions end up causing acid reflux by increasing pressure in the abdomen and this causes the gastric contents to be forced up into the esophagus. This can irritate the esophageal sphincter and cause there to be a decrease in muscle tone. Frequent or chronic heartburn may have a structural piece to it. Hiatal hernias are associated with frequent or chronic heartburn. (Hiatal hernias are an out pouching of the stomach lining through the diaphragm.) I believe the main reason most of us are 'impaired' in this way is due to the standard American diet full of lifeless processed sugar and starch ridden foods. Hydrochloric acid is needed for protein breakdown. Not chewing thoroughly, eating excessive amounts in a given meal, or overcooking our meats puts a strain on us in this area. Gluten, casein in pasteurized dairy products, and heavily processed soy can also lead to issues. Our diet, how we eat ( not in a relaxed state), stress, and anxiety can contribute to lack of HCl production as well . How well we chew, and the quality of our proteins as well as consuming some raw and not always well done or reheated etc. can go a long way to correcting issues with low stomach acid. Hydrochloric acid is only produced in the presence of proteins (another anatomy piece showing us we were indeed intended to eat proteins), BUT it's also inhibited by sugars and starches. High carbohydrate diets are all too common today, and actually contribute to acid deficiency. This is why I really like a Paleo/GAPS dietary template. If you are not familiar with Paleo or GAPS check out the GAPS book or GAPS related sites. A great, great cookbook that I just reviewed is called 'Primal Cuisine: Cooking for the Paleo Diet' by Pauli Halstead. Pauli is a former chef/caterer and she became a client of Nora Gedgaudas (one of my nutrition heroes - who also attended the Nutritional Therapy association and wrote one of my favorite books; 'Primal Body-Primal Mind'. ) Thanks to what she learned from Nora she was able to heal and her cookbook has a great amount of information on proper diet and sourcing foods. I highly recommend this book! Dietary game plans are a great starting point for anyone wanting to heal. Then you can take it further as needed by removing other common allergens, such as eggs, gluten cross contamination foods, nightshades, and maybe even high oxalate foods, or FODMAPS - depending on your specific health situation. Often problems with heartburn are due to a LACK of stomach acid, not too much stomach acid as what mainstream medicine claims. There are those that may be hyper acidic, but it is VERY rare. This can be ruled out by a Heidelberg capsule test and may not necessarily mean that someone is always hyper secreting acid. The majority of Americans today produce too little stomach acid. Often the issue can just be inappropriate timing of acid secretion. Low stomach acid secretion (also known as hypochlorhydria) can lead to irritated and inflamed mucosa in the stomach. This condition sets up the ideal environment for infection by Helicobacter pylori. You see the stomach acid is your body’s first line of defense against pathogens. It kills bacteria, viruses, pathogens, parasites and more, but only when it is adequately produced. Helicobacter pylori is an opportunistic bacterium that seems to prefer the chronically irritated environment of the gastric mucosa. H. pylori is also associated with gastric ulcers. If you have had a history of acid reflux or heartburn you may want to get tested for H. pylori, especially if you have been on acid blockers for any length of time. H. Pylori 90% of people with duodenal ulcers and stomach ulcers actually have an H. Pylori infection. It's also associated with GERD, gastritis, stomach cancer, and stomach lymphoma. For the most part, the information you will learn throughout this course will go a long way towards healing issues with H. pylori. Probiotics and probiotic rich foods, cabbage juice, properly fermented sauerkraut (no mason jar short ferments -the real deal), cranberry juice (unsweetened) about 2 cups per day, green teas, onions, yogurt (properly fermented - if you tolerate it or try coconut yogurt), and even red wine can all have an anti-bacterial effect. Aloe vera juice, as I've mentioned for other purposes, taken 3 times daily after meals and oil of oregano are also helpful. I like a product called ADP by Biotics, I think everyone should have some of this on hand in their holistic medicine cabinets. This can be taken for 4-5 weeks 3 times per day about 3-4 tablets. We do need some H. Pylori in our guts as it plays a role with leptin. Often doctors will try to fully eradicate it with heavy duty antibiotics this is not necessary and can have some serious side effects. Acid Neutralizers/Acid Blockers/PPI's Antacids - Tums, Rolaids, Maalox and Mylanta (partially reduce acid) H2 Acid Blockers- Tagamet, Pepcid, Axid and Zantac (partially block acid) Proton Pump Inhibitors - Prilosec, Prevacid and Nexium (these block the acid completely - NOT GOOD NEWS!) PPI's are a huge money maker they are the 3rd highest of all drugs sold worldwide! They were designed for only very short term use while ironing out the underlying problem. Now they can be purchase over the counter, this is alarming! If you have been on acid blockers and want to get off of them, I recommend you do it gradually, never cold turkey. You can wean off acid blockers and use antacids in place while you work to heal the issue and add in whole foods/supplements that support the underlying issue. Taking acid blockers long term can erode the esophagus, it can lead to cancer, leaky stomach, decreased levels of calcium, magnesium, zinc, iron deficiency, vitamin B12 deficiency, and an increased risk of developing osteoporosis, depression, IBS, pneumonia and more. Blocking stomach acid increases your risk of SIBO. It is has found that people on PPIs have higher levels of IgE antibodies after 3 months of usage. Women over 50 increase risk of hip fracture. The longer anyone takes a PPI the higher the risk of fracture due to poor mineral absorption. This is scary since there are now so many people on acid blockers unmanaged by any practitioner. They never are told that it's dangerous to their long term health. Hydrochloric acid Test Precautions: If you are taking acid and too much of it, can cause a burning sensation. If any discomfort arises, stop taking it immediately. If you have a known peptic ulcer do not take acid. Start by healing the ulcer first. HCL can irritate sensitive tissue and be corrosive to teeth. Capsules should not be emptied into food or dissolved in beverages. Spend 1-2 months using support other than the HCL to heal the sensitive tissues in the stomach if needed, then try the HCL test. This process tends to be self-weaning, your stomach should tell you when you need to back off with a warming sensation. If your dose is not decreasing over time then it's time to look at deeper issues, such as H. Pylori overgrowth, poor thyroid function, or other pituitary issues. It's best to work with a qualified practitioner to help you evaluate the possible deeper reasons you are not seeing progress. Self-testing for stomach acid: I have included two ways for you to do this assessment. One is a gradual slow approach and one is an approach to find out your dose in just one meal. I will just say that the approach you use to find your dose in one meal can cause a lot of potential die off reactions and can be unpleasant for some. I've seen some people very sensitive even to one pill and some people not have any noticeably uncomfortable reactions from several. Everyone will be different. However, if you have been on enzymes, probiotics, and a real food diet with broth and ferments for some time or have used an acv tonic some time, the one meal loading dose test may be tolerable without any reactions. If you are concerned, go with the slow but steady approach. Realize if you have anything going on in your stomach, such as H. Pylori or have had a low pH for a time taking even just a little bit of acid could really cause a reaction. Please don't think this means you don't need the acid or shouldn't take it. The only reason to NOT take it or stop immediately is if you have any ulcerations in the stomach. You will know because it will be very painful. If you suspect you have any ulcerations or have been on acid blockers for a long time you may want to spend 2-4 weeks working on your stomach health before trying the acid supplementation. People with ulcers, or acute reflux should take some time to heal prior to starting acid supplementation. To heal the stomach first: Make sure to chew slowly at every meal, relax, support with herbal bitters before and/or after meals, licorice (DGL - deglycyrrhizinated), digestive/pancreatic enzymes, Gastrazyme (gut healing nutrients), and maybe some Aloe Vera Juice if there are ulcerations. Cabbage juice, several ounces daily, could be very helpful and start to help the parietal cells of the stomach to make its own HCL (this is only if you do not have a thyroid problem - goitrogenic foods such as cabbage are contraindicated in thyroid issues). Vitamins A & D and even L-glutamine may also help. Supplemental B1, methylated B12 and zinc - nutrients support acid production. Then add the HCL, keep using probiotics and enzymes daily. Working to add properly fermented foods daily would be optimal, aim to have a small serving with each meal. Zinc Test To start this test you should not have had anything to eat or drink (except water within 30 minutes). Swish with 1 TBS. liquid zinc around in your mouth for up to 30 seconds and note the second you taste something other than water. Write down whether it tastes like one of the following descriptions: -Strong unpleasant taste -definite taste that gets stronger -no immediate taste but slightly minerally, dry or furry -no specific taste after 30 seconds -sweet taste after 30 seconds Since zinc helps to build HCL it would be a good thing to get a gauge on whether you are deficient or not. Supplement with a few bottles of liquid zinc while working to rebuild your stomach acid. The liquid is more readily absorbed, since zinc is only pulled out of your food/supplements with adequate HCL, it is a good approach to help bypass digestion. Zinc is required as a cofactor involved in more than 300 enzymatic activities. These zinc metalloenzymes account for virtually every aspect of the metabolism of animal and plant foods. Zinc assists the various enzymes that metabolize carbohydrates, alcohol, and essential fatty acids. It works with the enzymes that synthesize proteins. Zinc also works with pancreatic enzymes. These enzymes have some pretty important jobs and they can't do them without the assistance of zinc. Zinc is a common deficiency in our modern culture. It took me 10 months of dedicated supplementing with HCl before I could stop taking it with every meal. And when I started out my dose was pretty low compared to many people. Now, I don't recommend long term supplementation of HCl, 6 months max for all my clients. If it does not start to resolve then deeper issues may need to be addressed. You want your body to be able to make its own stomach acid and it should over time with the supplementation regime . When it doesn't make quite enough on its own, that's when looking at other pieces with a practitioner may be necessary. For the most part, daily supplementation at every meal will take you a long way. The Pancreas One of the main functions of the pancreas is to produce digestive enzymes to break down fat, carbohydrate, and protein. It also produces bicarbonate to neutralize stomach acid once the food moves from the stomach to the duodenum. The main health problems with the pancreas related to our topic today are insufficiency of enzymes and possibly acute or chronic pancreatitis. If your pancreas cannot secrete enough enzymes you have pancreatic insufficiency , this is rather common. Signs of this would be abdominal discomfort, a tendency towards bleeding, bloating, can't gain weight, failure to thrive in children, fatigue for no obvious reasons, food sensitivities, gas, hypoglycemia, malabsorption, pale colored stools, stools that float and undigested food in your stools. Pancreatic insufficiency is common in people who have celiac disease, psoriasis, cirrhoses, pancreatitis, and cystic fibrosis. Other triggers are parasites, bacterial overgrowth, inflammatory bowel disease, dermatitis heretiformis, stress (mental and physical), getting older, nutritional deficiencies, poor diet, eating only cooked food with no enzymes from raw foods, exposure to radiation or toxins, hereditary weaknesses, drugs, and infection. The specific digestive enzymes manufactured by the pancreas are: Pancreatic amylase - digests starches and sugars Protein splitting enzymes - trypsin, chymotrypsin, carboxypeptidase, and elastase Pancreatic lipase and collapse break fats into fatty acids and glycerol. Ribonuclease and deoxyribonuclease digest old RNA & DNA Pepsin digests proteins A word on pepsin (gastric protease) - The peptic and mucous cells secrete several different types of pepsinogen which initially have no digestive activity. However, as soon as pepsinogen comes in contact with hydrochloric acid, it is immediately activated forming pepsin. This is actually a safety factor, because if pepsin were secreted in its active form, it would digest the protein in the very cells that produced it. Pepsin is an active proteolytic enzyme with an optimal pH of 1.8 to 3.5. Pepsin becomes completely inactivated in a short amount of time and has little proteolytic activity above a pH of about 5. Hydrochloric acid is as necessary as pepsin for protein digestion in the stomach. So, if you don't have enough hydrochloric acid, the pepsinogen secreted cannot be turned into pepsin, and in turn, the proteins you eat will not be properly digested. Here is an excellent summation of the enzyme secretion/function through digestion by Dr. Anthony J. Chicoke: Salivary glands secrete saliva (full of salivary amylase) in response to the presence of food in the mouth. Salivary amylase breaks down carbohydrates. Hydrochloric acid in the stomach converts pepsinogen to pepsin. Pepsin breaks down proteins. Rennin breaks down casein in milk products. Mucus protects the stomach from hydrochloric acid. Lipase breaks down fat and initiates the digestion of triglycerides. Amylase breaks down carbohydrates. Intrinsic factor bonds with B12 and is necessary for intestinal absorption. Enterokinase in the small intestine activates trypsinogen to form trypsin, which breaks down protein peptides. It is converted into chymotrysinogen and breaks down protein peptides. Converted by trypsin from proelastaste to elastase - breaks down peptides. Carboxypeptidase is activated by trypsin (from procarboxypeptidase). Amylase from the pancreas further breaks down starch and glycogen. Lipase breaks down fats and Ribonuclease breaks down deoxyribonucleic acid. Deoxyribonuclease breaks down deoxyribonucleic acids. Cholesterol ester hydrolase breaks down cholesterol esters. Phospholipase A breaks down phospholipids. In the small intestine amino peptidase breaks down polypeptide. Dipeptidases break down dipeptides. Sucrase breaks down sucrose. Maltase breaks down maltose. Lactase breaks down lactose. Phosphatase breaks down organic phosphates. Isomaltase breaks down glucosides. Polynucleotidase breaks down nucleic acid. Nucleosidases break down purine or pyramidine nucleosides. Trehalas breaks down trehalose. This is fascinating to me and shows just how hard our body is working for us. We can help ourselves by understanding the process and further support ourselves. Low secretion of pancreatic enzymes can lead to nutritional deficiencies - vitamin B12 requires protein-splitting enzymes to separate it from its carrier molecule, so poor pancreatic function can lead directly to vitamin B12 deficiencies. Pancreatic enzymes on an empty stomach can further assist in digestion if you lack the natural production. Normalizing HCl output and the pH of the stomach can also help to normalize pancreatic output. Some have deficiency of lipase which is a fat digesting enzyme. This may be more prevalent in those prone to diabetes and glucose dysregulation. Lipase can also help to ward off allergic conditions, infectious viruses, and cushion our bodies against traumatic blows and bruises. In addition, gastric lipase's initiate the digestion of triglycerides. Taking additional lipase to what may already be in a digestive enzyme supplement (there are specific brands that have extra lipase or only lipase and that are enterically coated to get through the stomach acid in the stomach) can help to restore healthy fat digestion for some. Although lipase can and does attack large fat globules, its action is much more effective when fats are first emulsified (split into tiny particles) by the action of bile salts from the gall bladder (if you don't have a gall bladder you will need to supplement for the rest of your life). Cool fact - lipolytic enzymes can break down up to 175 grams of fat per hour. What does this have to do with absorption? Well, if you are not producing the components needed, such as adequate HCL and pepsin in the stomach, enzymes and bicarbonate from the pancreas, you will not be able to properly digest your food. It won't break down, it will rot/putrefy and rancidity and cause a whole host of problems further on down the line. You will not benefit from the nutrients in your food to supply your body with adequate building materials. Again, it's going to be critical to iron out any issues in the north - the stomach and pancreas to further iron out digestive problems in the south. Enzymes play a decisive role in food absorption from the gut to the bloodstream and are essential in the transport of nutrients. Without digestive enzymes, 1/3 to 1/2 of the carbohydrates, proteins, and the majority of fats entering the small intestine will not be absorbed. There are chronic forms of pancreatitis and this means that tissue destruction is irreversible. This usually is due to alcoholism. It is believe that drinking more than 100 grams of alcohol per day for several years may cause obstruction of pancreatic ducts. Over time this obstruction becomes more widespread and causes additional abnormalities. Acute pancreatitis is when you suffer severe abdominal pain that radiates through to the back. If you think you have this condition see your doctor immediately. Chronic pancreatitis is from alcoholism, only rarely does this develop from other issues. Excessive consumption of refined carbohydrates and alcohol puts a great strain on the pancreas and can decrease the amount of enzymes produced. So, now what? How do you supplement with enzymes ? When should you? For how long? Practical advice on the use of enzymes: Eating more enzyme rich foods can aid your digestion and take a burden off the pancreas. Since we eat so many foods that are cooked and have lost their enzyme activity we really need to consider how to adjust our diets to remedy this. I don't recommend an all raw diet like is trendy in some circles, but pay attention to the amount of raw foods you eat. What percentage is it? Is it 10%, 20%, 50%? If it's less than 50% you may need to change that or use digestive enzymes. Consider when you eat foods like cooked proteins that are more difficult to digest that you pair it with plenty of enzyme rich foods. Fresh herbs, greens, or even some lacto-fermented foods like sauerkraut. If you are not getting enzyme rich foods with your meals, it's a really good idea to take enzymes before your meal. According to Dr. Edward Howell, in his book 'Enzyme Nutrition', a diet without enzymes can result in enlargement of the pancreas. He believes that eating fresh or raw foods (rich in enzymes) can inhibit the pancreas, preventing its enlargement. He says an enlarged pancreas is correlated to an increase in chronic degenerative diseases and cancer. Dr. Weston Price, during his travels studied healthy indigenous people groups, he found that one of the key pieces to their health was that they ate a large portion of their foods raw, including meats/dairy. If you are not consuming enough raw foods try to change that. I make sure we eat something raw or fermented at every meal and include some meals that are heavier on the raw foods. My boys eat fresh fruit for breakfast every day and likely a fermented beverage to get their day started out right. Dinner includes at least one raw veggie or ferment and a fermented beverage. Lunches are a bit harder, but I include fruit or veggie slices and raw cheese and dehydrated seaweed as I can. If you make it a habit now for you and your kids you can help them instill a good habit for life. Please make sure your produce is organic and not sprayed with pesticides as they are ruined by pesticide toxins. Also, you will want to learn how to properly soak and prepare your seeds, nuts, legumes, and grains as they contain enzyme inhibitors. Price found that traditional cultures took great efforts to prepare these foods to make them more digestible. I don't recommend grains and legumes while you are healing your gut, BUT if you do eat these foods be sure to prepare them properly. You can find some posts on my site on how to do this, or check out GNOWFGLINS and Cooking Traditional Foods, both of their sites have lots of education on how to properly prepare these foods. Fresh juices, fruits, vegetables, raw dairy, soaked & sprouted seeds, legumes, nuts, raw meats, brined meats like ceviche, and air cured meats are all going to contain various enzymes. Try to get some of these foods into every meal you eat. 50% or more of your diet should optimally be from raw foods. This is not always possible and that is when supplemental enzymes will come into play. Also, include lots of onions and garlic. I like to have a jar of lacto-fermented onions and garlic in my fridge at all times. The GAPS protocol includes fresh juices for a reason. Enzymes help the following digestive problems: Hypochlorhydria Achlorhydria Pancreatic insufficiency Acute pancreatics Chronic pancreatitis Cystic fibrosis Celiac Disease Lactose intolerance Intestinal toxemia Malabsorption Steatorrhea Food allergies Foods and supplements for Upper GI/digestive support Supplements Supplements to build acid: -Hydrozyme -Tthis is a combo low dose of HCL and digestive enzymes (time released) the enzyme component of the tablet does the work first then the hydrochloric acid. -Betaine Plus HP- A high dose stomach acid at 700 mg per capsule, this is where most people need to start to avoid taking a million tablets at every meal. These contain pepsin as well pepsin is essential for protein digestion which is why it is often paired with the HCl. Supplement to heal stomach: -Gastrazyme - A supplement that contains gut healing nutrients to oppose inflammation in the gastrointestinal tract. It's good for gastric inflammation, heartburn, acid reflux, ulcers or hiatal hernia. This product can be chewed. Supplements to help with pancreatic function: Pancreatic enzymes work well as a digestive aid. Glandular based supplements are directed to specific tissues, helping to initiate repair. Proteases help digest proteins, lipases help digest fats and amylase helps digest carbohydrates. Pancreatic enzymes also help to restore the balance of the GI flora and continued use of them can help with repair of pancreatic tissue. -Bio 6 Plus from Biotics is a great product , it is a broad spectrum pancreatic enzyme and includes all of the above. This is good for those who have maldigestion issues, bloating, problems in the distal small intestines, illeocecal valve problems or diarrhea. Take before the meal. -Other great enzymes are from Premier Research Labs, Theramedix has a lot of varied blends, Klaire Labs, Tri Enza (I've used their chewables for my kids). Also Enzymedica has good enzyme products. -TriEnza -from Houston Enzymes comes in good powder form, chewables, and pills. It is a high quality enzyme and is great for kids. -Bromelain Plus - good for inflammation and digestive problems (take on empty stomach coated to get through stomach's acidity). Papain from papaya, which is found in this product is excellent for treating those with celiac, it is used to help absorption in an already damaged gut. Foods -Cabbage juice can help the parietal cells of the stomach to create stomach acid it is good for people who can't swallow pills (children). A small amount before meals or a few ounces a day can be very supportive. -Good quality sea salt is also need to help produce hydrochloric acid. -Digestive acid replacement - use the malic acid in apple cider vinegar 1-2 tablespoons in water, sip before meals. -Properly prepared ferments, such as sauerkraut, kimchi, beet kvass, kombucha etc. We will cover more on ferments in a couple weeks. -Enzymes in food can replace digestive enzymes in the body. Some examples include cultured foods like yogurt and kefir. A chutney made from papaya and pineapple would be good to get bromelain and papain. -If you need to heal before starting with stomach acid take some aloe. George's aloe vera juice is an excellent brand. -Chlorophylls from green juices and cabbage juice can be very healing to the gut and are rich in enzymes. (only if you do not have hypothyroid or have oxalate issues) -Fresh fruits and vegetables contain enzymes and antioxidants.