Curriculum vitae
Claudia Waskow, Ph.D.
Homepage: http://tu-dresden.de/Members/claudia.waskow
Professor for Immunology, Regeneration in Hematopoiesis and Animal Models in
Hematopoiesis, Faculty of Medicine, TU Dresden, Germany
claudia.waskow@tu-dresden.de
Phone: +49 351 458 6448
Fax: +49 351 458 6309
Summary
The aim of my studies is the identification of cell-autonomous and -extrinsic factors
governing maintenance of hematopoietic stem cells and differentiation of immune
cells, including the understanding of their homeostasis, e.g. their generation and turnover during steady-state and under inflammatory conditions. Thus, the research of
my laboratory focuses on uncovering basic mechanisms that regulate hematopoietic
stem cell biology, and this understanding may pioneer novel translational
approaches.
Academic Career
2014 to date
2008-2014
2005-2008
2002-2005
1998-2002
Professor for Regeneration in Hematopoisis and Animal
Models in Hematopoiesis, Institute for Immunology, Faculty of
Medicine, TU Dresden, Dresden, Germany.
Group Leader ‘Regeneration in Hematopoiesis’
CRTD / DFG Center for Regenerative Therapies
Faculty of Medicine, TU Dresden, Dresden, Germany.
Postdoc the Laboratory of Molecular Immunology, M.
Nussenzweig, The Rockefeller University, New York, USA
Postdoc in the Department of Immunology, H.R. Rodewald,
University Clinics Ulm, Germany
PhD thesis at the University of Basel, Switzerland
July 2002, Summa Cum Laude
Education
1997-1998
1995-1998
1994-1995
1991-1994
Diploma Thesis at the Basel Institute for Immunology,
Hoffmann-La Roche AG Basel, Switzerland
Diploma in Biology, Johannes Gutenberg University Mainz
Department for Biology
BSc in Immunology, University of Glasgow, UK
Department for Immunology
Prediploma in Biology, Johannes Gutenberg University Mainz
Department for Biology
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Bibliography
Kourtzelis, I, Ferreira A, Mitroulis I, Ricklin D, Bornstein SR, Waskow C, Lambris JD,
and Chavakis T, 2015. Complement inhibition in a xenogeneic model of
interactions between human whole blood and porcine endothelium. Horm.
Metab. Res. 47:36-42.
Muller, E, Grinenko T, Pompe T, Waskow C, and Werner C, 2015. Space constraints
govern fate of hematopoietic stem and progenitor cells in vitro. Biomaterials
53:709-715.
Rahmig, S, Bornstein SR, Chavakis T, Jaeckel E, and Waskow C, 2015. Humanized
mouse models for type 1 diabetes including pancreatic islet transplantation.
Horm. Metab. Res 47:43-47.
Cosgun* KN, Rahmig* S, Mende N, Reinke S, Hauber I, Schäfer C, Petzold A,
Weisbach H, Heidkamp G, Purbojo A, Cesnjevar R, Platz A, Bornhäuser M,
Schmitz M, Dudziak D, Hauber J, Kirberg J, Waskow C, 2014. Kit Regulates
HSC Engraftment across the Human-Mouse Species Barrier. Cell Stem Cell,
15:227-238. *Co-first authors.
Grinenko T, Arndt K, Portz M, Mende N, Günther M, Cosgun KN, Alexopoulou D,
Lakshmanaperumal N, Henry I, Dahl A, Waskow C, 2014. Clonal expansion
capacity defines two consecutive developmental stages of long-term
hematopoietic stem cells. J Exp Med. 211:209-215.
Prewitz M, Seib PF, von Bonin M, Niehae C, Friedrichs J, Stißel A, Müller K,
Anastassiadis K, Waskow C, Hoflack B, Bornhäuser M, Werner C. 2013.
Tightly anchored tissue-mimetic matrices as instructive stem cell
microenvironments. Nature Methods. 10:788-794.
Singh RP, Franke K, Kalucka J, Mamlouk S, Mutschter A, Gembarska A, Grinenko T,
Willam C, Naumann R, Anastassiadis K, Stewart AF, Bornstein S, Chavakis
T, Breier G, Waskow C, Wielockx B. 2013. HIF-prolyl hydroxylase 2 (PHD2)
is a critical regulator of hematopoietic stem cell maintenance during steadystate and stress. Blood, 121:5158-5166.
Von Bonin M, Wermke M, Cosgun KN, Thiede C, Bornhauser M, Wagemaker G,
Waskow C. 2013 In vivo expansion of co-transplanted T cells impacts on
tumor re-initiating activity of human acute myeloid leukemis in NSG mice.
PLoS One. 8:e60680. Doi: 10.1371.
Arndt K, Grinenko T, Mende N, Reichert D, Portz M, Ripich T, Carmeliet P, Corbeil D,
Waskow C. 2013. CD133 is a modifier of hematopoietic progenitor
frequencies but is dispensable for the maintenance of mouse hematopoietic
stem cells. Proc Natl Acad Sci U S A. 110:5582-5587.
Ross K, Sedello AK, Todd GP, Paszkowski-Rogacz M, Bird AW, Ding L, Grinenko T,
Behrens K, Hubner N, Mann M, Waskow C, Stocking C, and Buchholz F.
2012. Polycomb group ring finger 1 cooperates with Runx1 in regulating
differentiation and self-renewal of hematopoietic cells. Blood 119:4152-4161.
Dudeck A, Dudeck J, Scholten J, Petzold A, Surianarayanan S, Kohler A, Peschke K,
Vohringer D, Waskow C, Krieg T, Muller W, Waisman A, Hartmann K,
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Gunzer M, and Roers A. 2011. Mast Cells Are Key Promoters of Contact
Allergy that Mediate the Adjuvant Effects of Haptens. Immunity. 34:973-84.
Gerbaulet A, Wickenhauser C, Scholten J, Peschke K, Drube S, Horny HP, Kamradt
T, Naumann R, Muller W, Krieg T, Waskow C, Hartmann K, and Roers A.
2011. Mast cell hyperplasia, B cell malignancy, and intestinal inflammation in
mice with conditional expression of a constitutively active kit. Blood.
117:2012-2021.
Waskow C, Madan V, Bartels S, Costa C, Blasig R, and Rodewald HR. 2009.
Hematopoietic stem cell transplantation without irradiation. Nat Methods.
6:267-9.
Waskow C, Liu K, Darrasse-Jeze G, Guermonprez P, Ginhoux F, Merad M,
Shengelia T, Yao K, and Nussenzweig M. 2008. The receptor tyrosine kinase
Flt3 is required for dendritic cell development in peripheral lymphoid tissues.
Nat Immunol. 9:676-83.
Liu K, Waskow C, Liu X, Yao K, Hoh J, and Nussenzweig M. 2007. Origin of
dendritic cells in peripheral lymphoid organs of mice. Nat Immunol. 8:578-83.
Waskow C, Bartels S, Schlenner SM, Costa C, and Rodewald HR. 2007. Kit is
essential for PMA-inflammation-induced mast-cell accumulation in the skin.
Blood. 109:5363-70.
Stumpf M, Waskow C, Krotschel M, van Essen D, Rodriguez P, Zhang X, Guyot B,
Roeder RG, and Borggrefe T. 2006. The mediator complex functions as a
coactivator for GATA-1 in erythropoiesis via subunit Med1/TRAP220. Proc
Natl Acad Sci U S A. 103:18504-9.
Terszowski G, Waskow C, Conradt P, Lenze D, Koenigsmann J, Carstanjen D,
Horak I, and Rodewald HR. 2005. Prospective isolation and global gene
expression analysis of the erythrocyte colony-forming unit (CFU-E). Blood.
105:1937-45.
Kroll J, Shi X, Caprioli A, Liu HH, Waskow C, Lin KM, Miyazaki T, Rodewald HR, and
Sato TN. 2005. The BTB-kelch protein KLHL6 is involved in B-lymphocyte
antigen receptor signaling and germinal center formation. Mol Cell Biol.
25:8531-40.
Agosti V, Corbacioglu S, Ehlers I, Waskow C, Sommer G, Berrozpe G, Kissel H,
Tucker CM, Manova K, Moore MA, Rodewald HR, and Besmer P. 2004.
Critical Role for Kit-mediated Src Kinase But Not PI 3-Kinase Signaling in Pro
T and Pro B Cell Development. J Exp Med. 199:867-878.
Waskow C, Terszowski G, Costa C, Gassmann M, and Rodewald HR. 2004. Rescue
of lethal c-KitW/W mice by erythropoietin. Blood. 104:1688-95.
Waskow C, Paul S, Haller C, Gassmann M, and Rodewald HR. 2002. Viable cKit(W/W) mutants reveal pivotal role for c-kit in the maintenance of
lymphopoiesis. Immunity. 17:277-88.
Rodewald HR, Waskow C, and Haller C. 2001. Essential requirement for c-kit and
common gamma chain in thymocyte development cannot be overruled by
enforced expression of Bcl-2. J Exp Med. 193:1431-7.
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Rodewald HR, Ogawa M, Haller C, Waskow C, and DiSanto JP. 1997. Prothymocyte expansion by c-kit and the common cytokine receptor gamma
chain is essential for repertoire formation. Immunity. 6:265-72.
Reviews & Book Chapters:
Waskow C and Calegari F (eds.) 2014. Stem Cells: from Basic Research to Therapy:
Volume 1: Basic Stem Cell Biology, Tissue Formation During Development,
and Model Organisms.
Volume 2: Tissue Homeostasis and Regeneration during Adulthood,
Applications, Legislation and Ethics.
Science Publisher, Enfield, NH, USA and Taylor & Francis Group, London,
UK.
Glauche I, Bystrykh L, Eaves C, Roeder I, Baum C, Brugman M, Bystrykh L, de
Carvalho KA, Cornils K, Eaves C, Fehse B, Florian C, Galle J, Geiger H,
Gerdes S, Glauche I, Grosselin J, Grinenko T, de Haan G, Knapp D, von Laer
D, Leboulch P, Loeffler M, Lu R, Modlich U, Buske P, Roeder I, Schmidt M,
Schwarzer A, Shapiro E, Thielecke L, Traulsen A, Verovskaya E, Waskow C,
Wermke M, Werner B. 2013. Stem cell clonality – theoretical concepts,
experimental techniques, and clinical challenges. Blood Cells Mol Dis.
50:232-240.
Roeder I, Loeffler M, Glauche I, Bornhaeuser M, Buske P, Clarke G, Cross M, Efroni
S, Ilan B, Essers M, Galle J, Giangreco A, Glauche I, Griessinger E, Hoppe P,
Kobel S, Krinner A, Lauffenburger D, Lemischka I, LoCelso C, Loeffler M,
Lutolf M, Moore K, Nazareth E, Oostendorp R, Palmer M, Pompe T,
Rocheteau P, Roeder I, Scherf N, Schroeder T, Tajbakhsh S, Vilne B, van der
Wath R, Waskow C, Werner C, Yaromina A, Zandstra P. 2011. Towards a
quantitative understanding of stem cell-niche interactions: experiments,
models, and technologies. Blood Cells Mol Dis. 46:308-317.
Waskow C 2010. Generation of parabiotic mice for the study of DC and DC
precursor circulation. Methods Mol Biol. 595:413-28.
Waskow C and Rodewald HR. 2002. Lymphocyte development in neonatal and adult
c-Kit-deficient (c-KitW/W) mice. Adv Exp Med Biol. 512:1-10.
Collaborative Research
CRTD/Cluster of Excellence
http://www.crt-dresden.de/
EU/FP7 CELL-PID
http://cell-pid.eu/index.pl
DFG/SFB/TRR 127
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http://www.klinikum.uni-muenchen.de/SFB-TRR-127/de/index.html
DFG/SFB 655
https://www.sfb655.de/START-EN/sonderforschungsbereich655?set_language=en
DFG/FOR 2033
http://www.dfg.de/en/research_funding/programmes/list/projectdetails/index.js
p?id=232863826
Else Kröner Fresenius Stifung
http://www.ekfs.de/de/start.html
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