1562; Poster, cat: 4
ASSOCIATION BETWEEN THE SEVERITY OF ANGIOGRAPHIC
CORONARY ARTERY DISEASE AND PARAOXONASE-1 PROMOTER GENE
POLYMORPHISM T(-107)C IN IRANIAN POPULATION
E. Javadi1, A. Jalilian1, E.B. DJavadi2, M. Doosti1, P. Amiri2, A. Mohaghegh2,
B. Shariati1
1
Tehran university of medical sciences, Tehran, Iran, 2Shariati hospital, Tehran, Iran
BACKGROUND: The oxidation of LDL is believed to play an integral role in the
development of coronary artery diseases(CAD).Paraoxonase-1(PON1)protects LDL from
oxidative modification. The present study tested the hypothesis that PON1 promoter
polymorphism T(-107)C could be a risk factor for severity of CAD in Iranian population.
METHODS: PON1 promoter genotypes were determined in 300 consecutive
subjects(over 40 years old)who underwent coronary angiography (150 with more than
50% stenosis served as cases[CAD+] and 150 with less than 20% stenosis served as
controls[CAD-]. PON1 promoter genotypes were determined by PCR and BSTU1
restriction enzyme digestion.
RESULT: CAD+ subjects didnt show any significant differences in the distribution of
PON1 promoter genotypes as compared to CAD- subjects(p=0.075).However the
analysis of PON1 promoter genotypes distribution showed an higher percentage of
(-107)TT among CAD+ compared with CAD-(p=0.027).After controlling for other risk
factors, the T(-107)C polymorphism had interaction with age(p=0.12),but didnt show any
interaction with other risk factors such as BMI,gender, smoking, diabetes, level of
HDL-C, LDL, TG, total cholestrol.
CONCLUSION: These data suggest that the TT genotype may represent a genetic risk
factor for coronary artery diseases in Iranian population.