Supplementary data
Patients: Between October 2010 and September 2011, a total of 175 consecutive patients
with suspected or known coronary artery disease were included in a validation data set.
During a median follow-up period of 25 months (interquartile range, 19 to 30 months),
coronary events were observed in 18 out of the 175 patients.
1
Supplementary Table 1. Comparison of the Clinical Profile of Patients with or without
Coronary Events in the Validation Data Set
Coronary event
No coronary event
p value
(n = 18)
(n = 157)
Age, yrs
67 ± 8
64 ± 10
0.312
Male
17 (94.4%)
124 (78.9%)
0.076
Hypertension
17 (94.4%)
88 (56.1%)
0.002
Current smoker
5 (27.8%)
48 (30.6%)
0.806
Hyperlipidemia
12 (66.7%)
93 (59.2%)
0.538
Diabetes mellitus
8 (44.4%)
55 (35.0%)
0.436
BMI, kg/m2
24 ± 4
24 ± 3
0.790
SBP, mmHg
137 ± 22
134 ± 20
0.515
T-chol, mg/dl
206 ± 35
199 ± 36
0.362
LDL, mg /dl
122 ± 30
116 ± 31
0.289
HDL, mg/dl
47 ± 11
56 ± 16
0.017
TG, mg/dl
157 (114, 218)
109 (80, 153)
0.007
HbA1c, %
6.3 ± 1.4
5.8 ± 1.03
0.023
PMR
1.47 (1.38, 2.01)
1.14 (1.01, 1.31)
<0.001
Proven CAD
14 (77.8%)
42 (26.8%)
<0.001
Multivessel disease
5 (27.8%)
13 (8.28%)
0.025
Previous MI
5 (27.8%)
12 (7.69%)
0.019
Aspirin
12 (66.7%)
35 (22.3%)
<0.001
Beta-blocker
5 (27.8%)
8 (5.1%)
0.004
Medications
2
Statin
12 (66.7%)
59 (37.6%)
0.018
ACEI or ARB
10 (55.6%)
44 (28.0%)
0.021
Values are means ± SD, n (%), or medians (first quartile, third quartile). Abbreviations as in
Table 1.
3
Supplementary Table 2. Univariate Cox Regression Analysis of Risk Factors for All
Coronary Events in the Validation Data Set
Univariate Analysis
Hazard
p value
95% CI
Ratio
Age, yrs
1.03
0.005
1.01
– 1.04
Male
0.95
0.802
0.65
– 1.39
Hypertension
1.43
0.024
1.05
– 1.96
Current smoker
0.95
0.780
0.68
– 1.34
Hyperlipidemia
1.01
0.935
0.74
– 1.39
Diabetes mellitus
1.71
0.002
1.23
– 2.39
BMI, kg/m2
1.03
0.233
0.98
– 1.09
SBP, mmHg
1.01
0.080
1.00
– 1.01
T-chol, mg/dl
0.99
0.006
0.99
– 1.00
LDL, mg /dl
0.99
0.012
0.99
– 1.00
HDL, mg/dl
0.99
0.060
0.98
– 1.00
TG, mg/dl
1.00
0.435
1.00
– 1.00
HbA1C, %
1.27
0.002
1.09
– 1.48
PMR
3.95
<0.001
2.32
– 6.72
PMR ≥ 1.4
2.68
<0.001
1.77
– 4.07
Proven CAD
2.44
<0.001
1.71
– 3.50
Multivessel CAD
3.61
<0.001
2.09
– 6.24
Previous MI
3.42
<0.001
1.87
– 6.26
Medications
–
4
Aspirin
2.65
<0.001
1.81
– 3.88
Beta-blocker
1.61
0.167
0.82
– 3.18
Statin
1.16
0.354
0.84
– 1.61
ACEI or ARB
1.18
0.349
0.84
– 1.65
CI, confidence interval. Abbreviations as in Table 1.
5
Supplementary Table 3. Risk Factors in the Best Predictive Model for All Coronary
Events in the Validation Data Set Selected by Stepwise Cox Regression Analysis
Multivariate Analysis
Hazard Ratio
p value
95% CI
Age
1.02
0.031
1.00
– 1.04
HbA1c
1.21
0.058
0.99
– 1.48
Proven CAD
1.75
0.016
1.11
– 2.78
Multivessel CAD
2.09
0.035
1.05
– 4.15
LDL
0.99
0.048
0.99
– 1.00
PMR ≥ 1.4
2.61
<0.001
1.63
– 4.18
Abbreviations as in Tables 1 and 2.
6