CHINESE MEDICINAL BIOTECHNOLOGY Bimonthly Established in December 2006 Responsible Institution Ministry of Health of the People’s Republic of China Sponsor China Medicinal Biotech Association 7B Zaojunmiao Road, Haidian District, Beijing 100081, China Editing Editorial Board of Medicinal Biotechnology Chinese Tel: 0086-10-62135779 Fax: 0086-10-62115976 Email: cmbj01@126.com http://www.cmbp.net.cn Editor-in-Chief ZHAO Kai(赵铠) Managing Director WEN Jian-ping(文建平) Publishing China Medicinal Biotech Association 7B Zaojunmiao Road, Haidian District, Beijing 100081, China Tel: 0086-10-62135779 Fax: 0086-10-62115976 Email: cmba@cmba.org.cn Printing Beijing Zhongke Printing Limited Company Overseas Distributor China International Book Trading Corporation P. O. Box 399, Beijing, China Code No. BM4275 Mail-Order Editorial Department of Chinese Medicinal Biotechnology 7B Zaojunmiao Road, Haidian District, Beijing 100081, China Tel: 0086-10-62135779 Fax: 0086-10-62115976 Email: cmbj01@126.com CSSN ISSN 1673-713X CN 11- 5512 / R Copyright© 2008 by the China Medicinal Biotech Association All articles published represent the opinions of the authors, not reflecting the official policy of the China Medicinal Biotech Association or the Editorial Board of Chinese Medicinal Biotechnology, unless this is clearly specified. Volume 3, Number 6 December 10, 2008 CONTENTS OF SELECTED ARTICLES Editorials Biological therapy: new hope for cancer treatment ………………………… 401 HAO Xi-shan Stem cell researchers blazing new paths for pharmaceutical industry … 402 ZHAO Gui-ying, ZHANG Shu-yong Biotherapies Efficacy of activated haploidentical allogeneic hematopoietic stem cells on advanced intractable carcinoma ………………………………………… 404 WANG Yun-liang, KANG Hong-gang, YU Jin-pu, CAO Shui, REN Bao-zhu, ZHANG Xin-wei, ZHANG Wei-hong, HAN Ying, REN Xiu-bao Microscopic study of the alginate-chitosan-alginate microcapsules cryopreservation ……………………………………………………………… 409 YE Ping, CHEN Er-tong, XU Bin-kai, PENG Cheng-hong, SHEN Bai-yong, LI Hong-wei, DU Zhi-yong, ZHANG Rui, WANG Zhao-hai, HAN Bao-san Expressions and significance of CD80, CD86 and ICAM-1 on acute leukemic cells ……………………………………………………… 415 WEI Jing, LI Yang, GUO Hai-xia, WU Yan-feng, FANG Jian-pei, WANG Xiao-ping, ZHOU Dun-hua, HUANG Ke, CHEN Chun, LIN Yong-chao Phase I clinical trial of granulocyte macrophage colony-stimulating factorsecreting allogeneic cellular immunotherapy for advanced cancer …… 420 KANG Hong-gang, WANG Yun-liang, YU Jin-pu, CAO Shui, REN Bao-zhu, ZHANG Xin-wei, ZHANG Wei-hong, HAN Ying, REN Xiu-bao Empirical study of enhancing anti-tumor biotherapy through fludarabine and tumor vaccine ……………………………………………………………… 425 CHAI Xiao-fei, GAO Quan-li, XU Lin-ping, MAI Ling Mechanism and influence of a truncated mutation of Axin2 on cell proliferation …………………………………………………………… 430 WANG Feng-wei, WEN Ling, ZHU Si-wei, WANG Xin-zhuo, YIN Xiao-dong, ZHANG Chao, WANG He-tong, LIU Wan-guo Original Articles Proliferative effect of keratinocyte growth factor on thymocyte ………… 435 LIU Yan-long, ZHAO Yong, LIN Hong, XIAO Jian, LI Xiao-kun The study on preparation and quality of DATS microemulsion ………… 440 XU Yun-feng, LIU Qing-fei, CHEN Xi, LUO Guo-an, WANG Yi-ming Cloning, expression and biological characterization of the first kunitz-type domain of human tissue factor pathway inhibitor-2 …………………… 445 SHI Hui-ning, DING Ri-gao, ZHONG Yu-xu, LIU Hong-yan, XU Qi-shou, MA Feng-zhong, LIAO Ming-yang Reviews Role of transcriptional activator of cdr gene TAC1 in resistance of Candida albicans to antifungal agents …………………………………… 451 LI Li-juan, LI Ruo-yu, LIU Wei Research advances in improving the pharmacokinetics of protein drugs by utilizing human serum albumin as a carrier ………………………… 454 SHI Yi-feng, BIAN Lei Research advances in several natural analgesic polypeptides …………… 457 YU Yan, CHEN Jian-hua Research advances in targeted drug delivery system for antitumor drugs …………………………………………………………… 461 SUN Xi-yang, REN Chang-shan, CAO Xin-ke, LI Ning Research advances in cellular protection of trehalose molecule ………… 465 ZHANG Lan-xin, ZHANG Bu-chang