Oxidative Coupling: Chemistry between Two Nucleophiles1
Prof. Dr. Aiwen Lei,
College of Chemistry and Molecular Sciences, Wuhan University, Hubei, P.R. China,
430072; aiwenlei@whu.edu.cn
Our research focuses on developing novel and efficient bonds formation methods
catalyzed by transition metals. Currently, we are interested in the oxidative coupling,
which avoided difficult oxidative addition and made bonds between two nucleophiles. [1-6]
As an important character of our research, understanding toward the reactions is the
other focus. Recently, we revealed a second transmetallation reaction, which could
occur in the Pd-catalyzed coupling reaction as a fundamental step. [7] In addition, kinetic
studies in our laboratory quantitatively disclosed the rate of reductive elimination of
Csp2-Ni-Csp2. [8,9]
References:
[1] Liu Q., Li G., He J., Liu J., Li P., Lei A., Angew. Chem., Int. Ed. 2010, 49, 3371. [2] Chen M., Zheng X., Li W., He J.,
Lei A., J. Am. Chem. Soc. 2010, 132, 4101. [3] Zhao Y., Wang H., Hou X., Hu Y., Lei A., Zhang H., Zhu L., J. Am.
Chem. Soc. 2006, 128, 15048. [4] Zhao Y., Jin L., Li P., Lei A., J. Am. Chem. Soc. 2008, 130, 9429. [5] He C., Chen
C., Cheng J., Liu C., Liu W., Li Q., Lei A., Angew. Chem., Int. Ed. 2008, 47, 6414. [6] Yin W., He C., Chen M., Zhang
H., Lei A., Org. Lett. 2009, 11, 709. [7] Liu Q., Lan Y., Liu J., Li G., Wu Y-D., Lei A., J. Am. Chem. Soc. 2009, 131,
10201. [8] Jin L., Zhang H., Li P., Sowa J. R., Lei A., J. Am. Chem. Soc. 2009, 131, 9892. [9] Jin L., Liu C., Liu J., Hu
F., Lan Y., Batsanov A. S., Howard J. A. K., Marder T. B., Lei A., J. Am. Chem. Soc. 2009, 131, 16656.
Supported by the National Natural Science Foundation of China and the Start-up Grant of Wuhan University