International Wound Journal ISSN 1742-4801 LETTER TO THE EDITOR Cleansing of wounds by tap water? An evidence-based systemic analysis Dear Editors, Tap water therapy has been used for several decades (1) in wound cleansing for the treatment of many conditions, such as lacerations, incisions, open fractures and episiotomy (2 – 5). The infection rate and outcome of wounds cleansed with tap water are commonly believed to be the same as those cleaned with normal saline solution (2 – 5). Even though this alternative treatment is considered safe, a contrary opinion has always existed. There is still no evidence-based consensus on the contribution of tap water therapy to the treatment of wound cleansing and treatment results have not always achieved patient satisfaction. Thus, the aim of this study is to explore the safety of tap water irrigation in wound cleansing and to develop a specific recommendation based on the review of medical literature. PubMed data up to May 2013 was searched for studies in English evaluating the outcome of tap water therapy in wound cleansing. The words used in the search were ‘tap water’, ‘running water’, ‘normal saline solution’, ‘irrigation’ and ‘wound’. Reference lists of obtained articles were searched as well. Studies including any laboratory values were excluded from this data analysis. One investigator selected the articles for inclusion. Two investigators independently extracted data from all eligible studies using a standardised Excel file. These authors retrieved data on study design, study period, study size, patient demographics and treatment outcome. Relevant studies were assigned a level of evidence according to the Oxford Centre for Evidence-Based Medicine 2011 levels of evidence. The search performed in May 2013 yielded six articles pertinent to the topic (Table 1) – five randomised controlled trials (RCTs, level I evidence) (1 – 5), and one case series (level IV evidence) (6). Four RCTs showed that the infection rates and status of wound healing in tap water therapy were similar to the normal saline solution group (P > 0·05) and the culture results from the wounds in both groups showed no significant finding in colony counts (P > 0·05). Furthermore, tap water therapy may be more cost-effective (2 – 5). Only one RCT revealed that the infection rates in tap water therapy were significantly lower than that in normal saline solution group (P < 0·05) and suggested that sterile saline should be replaced by tap water in patients with acute traumatic soft-tissue wounds (1). There was no significant difference between the two groups in colony counts of microorganisms in the case series, but its number of participants could not be obtained (6). The studies that met our inclusion criteria for eligibility were all of evidence level I or IV. All of them used normal saline solution as control group for evaluating the efficacy of wound cleansing and revealed the superiority of tap water therapy, but there was no consistency in mechanism and degree of contamination of wounds, amount of tap water and normal saline or pressure of irrigation. In addition, most articles were written in developed countries such as America and Sweden where sterilisation of tap water equipment is well-established. Only few data could be reviewed from other countries. Thus, further comparative studies are both justified and necessary to provide more information on the best technique for wound cleansing and more rigorous evidence on effectiveness and safety are required. Chia-Yu Huang1,2 , Mun-Yau Choong2,3 & Tzong-Shiun Li2,3 1 Department of Plastic Surgery China Medical University Hospital Taichung, Taiwan 2 School of Medicine China Medical University Taichung, Taiwan 3 Department of Plastic Surgery Tainan Municipal An-Nan Hospital Tainan, Taiwan Email: li.tsa2@msa.hinet.net Table 1 The studies with evidence levels I and IV Studies Number (total, intervention group, control group) P -value Level of evidence Location Angeras et al . (1) 627, 295 (tap water), 332 (normal saline solution) <0·05 Level I Ostra (Sweden) Valente et al . (2) 530, 259 (tap water), 271 (normal saline solution) >0·05 Level I NY (America) Bansal et al . (3) 45, 21 (tap water), 24 (normal saline solution) >0·05 Level I TX (America) Griffiths et al . (4) 49, 23 (tap water), 26 (normal saline solution) >0·05 Level I Macarthur (Australia) Moscati et al . (5) 634, 334 (tap water), 300 (normal saline solution) >0·05 Level I NY (America) Riyat et al . (6) * * Level IV Leicester (Britain) *, unclear data. © 2013 The Author International Wound Journal © 2013 John Wiley & Sons Ltd and Medicalhelplines.com Inc doi: 10.1111/iwj.12113 1 Letter to the Editor C.-Y. Huang et al. References 1. Angeras MH, Brandberg A, Falk A, Seeman T. Comparison between sterile saline and tap water for the cleaning of acute traumatic soft tissue wounds. Eur J Surg 1992;158(6 – 7):347 – 50. 2. Valente JH, Forti RJ, Freundlich LF, Zandieh SO, Crain EF. Wound irrigation in children: saline solution or tap water? Ann Emerg Med 2003;41:609 – 16. 3. Bansal BC, Wiebe RA, Perkins SD, Abramo TJ. Tap water for irrigation of lacerations. Am J Emerg Med 2002;20:469 – 72. 2 4. Griffiths RD, Fernandez RS, Ussia CA. Is tap water a safe alternative to normal saline for wound irrigation in the community setting? J Wound Care 2001;10:407 – 11. 5. Moscati RM, Mayrose J, Reardon RF, Janicke DM, Jehle DV. A multicentre comparison of tap water versus sterile saline for wound irrigation. Acad Emerg Med 2007;14:404 – 10. 6. Riyat MS, Quinton DN. Tap water as a wound cleansing agent in accident and emergency. J Accid Emerg Med 1997;14:165 – 6. © 2013 The Author International Wound Journal © 2013 John Wiley & Sons Ltd and Medicalhelplines.com Inc