Nina Ivanoska, D.Sc., Professor
Head of Department
Tel: (+359 2) 979 31 95
E-mail: nina@microbio.bas.bg
1958
Born February 1
1981
MS Faculty of Biology, Sofia University ‘St. Kliment Ohridski’
1987
PhD in Immunology, Institute of Epidemiology and Microbiology,
Moscow
1995
Associate Professor, Institute of Microbiology, BAS
2006
DSc in Immunology, Institute of Microbiology, BAS
2009
Professor in Immunology, Institute of Microbiology, BAS
Teaching: Faculty of Biology, Sofia University ‘St. Kliment Ohridski’
Head of the Department of Immunology, Institute of Microbiology
Since 2000 Supervisor of 5 PhD Students
STAFF
Laboratory of Immunopathology and Experimental Immunotherapy
Tchavdar
Vassilev,
M.D.,
vassilev@microbio.bas.bg
DSc,
Professor,
Head
of
Laboratory
Andrey Tchorbanov, PhD, Associate Professor, tchorban@microbio.bas.bg
Anastas Pashov, PhD, Associate Professor, a_pashov@microbio.bas.bg
Iglika Djoumerska-Alexieva, MD, PhD, Research Scientist, joumer@microbio.bas.bg
Niklolina Mihaylova, PhD, Research Scientist, mihaylova_n@microbio.bas.bg
Kalina Nikolova, MS, nikolova_k@microbio.bas.bg
Stela Petkova, MS, Research Assistant, petkova_stela@yahoo.com
Nikola Kerekov, PhD, nikolakerekov@gmail.com
Vera Gesheva, PhD, veragesheva@gmail.com
Stela Chausheva, Student, stella.chausheva@gmail.com
Ilian Manoilov, Student, iliom@abv.bg
Laboratory of Immunomodulators
Nina Ivanovska, DSc, Professor, Head of Laboratory nina@microbio.bas.bg
Petya Dimitrova, PhD, Associate Professor, petya_dimitrova@web.de
Victoriya Milanova, MS, Research Assistant, v.milanova8@gmail.com
Valeriya Gyurkovska, PhD, vali_lqs@yahoo.com
Laboratory of Nonspecific Resistance
Hristo Neychev, VMD,
neychev@microbio.bas.bg
PhD,
Associate
Professor,
Head
of
Laboratory
Tsvetanka Stefanova, PhD, Research Scientist, tsvetankastefanova@yahoo.com
Petya Stoyanova, VMD, Research Assistant
MAIN RESEARCH TOPICS

Autoimmunity

New generation of vaccines and immunoglobulin preparations

Relationships between infections and rheumatic diseases

Immunomodulatory properties of natural substances and their synthetic analogs
ONGOING PROJECTS
DDVU 10-250 “Functional elimination of autoreactive T cells by antibody therapy in murine
and humanized SCID models of Systemic lupus erythematosus and Multiple sclerosi” Project
leader: Assoc. Prof. Andrey Tchorbanov
DRNF 02/11 “Biologic response of neoplastic and auto-immune B-cells to chimeric proteinengineered antibodies: flow cytometry analysis of apoptosis using novel cyanine nucleic acid
dyes” Project leader: Assoc. Prof. Petya Dimitrova
PIRG05-GA-2009-248289: “Translational study on the antigen presenting properties of
human vs mouse B cell subpopulations”. Principle investigator: Assoc. Prof. Anastas
Pashov
VUH 11/07 “Creation of engineered chimeric molecules by protein technology for therapy of
autoimmune diseases” Project leader: Assoc. Prof. Andrey Tchorbanov
VU 704/07 “New approach for selective suppression of autoreactive B cells by a chimeric
anti-CD35 antibody” Project leader: Assoc. Prof. Andrey Tchorbanov
DO 02-312/08 “Suppression of allergen-specific B lymphocytes in humanized SCID mice
using Chimeric protein-engineered antibodies” Project leader: Assoc. Prof. Andrey
Tchorbanov
DTK 02/19 “DNA vaccines: Viral Antigen Targeting by Genetically Engineered Chimeric
Molecules” Project leader: Assoc. Prof. Andrey. Tchorbanov
DTK 02/78 “Antitumor activity of Gastropodan hemocyanins” Project leader: Assoc. Prof.
Andrey. Tchorbanov
TK 317/07 “Generation of gene-engineered chimeric DNA molecules by recombinant
technologies for specific therapy of autoimmune diseases” Project leader: Assoc. Prof.
Andrey Tchorbanov
MOST IMPORTANT RESULTS

Pathological DNA-specific B and T cells in SLE are logical targets for a selected
therapeutic intervention. We have constructed chimeric molecules by coupling of
different epitope-specific peptides to monoclonal antibodies. Our data show that it is
possible to suppress selectively the activity of targeted autoreactive B and Tlymphocytes and to change the natural course of an autoimmune disease in mouse
models or humanized transfer models of lupus by administering chimeric molecules
that cross-link the inhibitory receptors with the immunoglobulin B cell receptor.

Introduction of DNA vaccines is a new approach to vaccination. Such a hybrid DNA
molecules were constructed by us, encoding a T and B cell epitope-containing
influenza hemagglutinin peptide and a scFv antibody fragment binding to mouse
complement receptors I and II or human FcγRI. A single or double immunization with
a plasmid containing the described construct induced a strong anti-influenza cytotoxic
response lasting for more than six months and a weak antibody response.

We have worked on new therapeutic strategies in sepsis as there is an urgent unmet
medical need for new treatments for this disease. Our therapeutic approach consists of
the development and use of improved immunoglobulins “next generation”
immunoglobulin preparations with enhanced anti-inflammatory activity.

We have characterised the role of properdin, a positive regulator of the complement
system, in experimental models of sepsis and arthritis. Our studies demonstrate that
properdin deficiency attenuates the symptoms of Zy-induced shock and exacerbates
LPS-induced shock. It uncovers, for the first time, a relationship between properdin
and macrophage as well as platelet functions in models of nonspetic shock. Our data
showed that properdin, appeared to have a protective role in the processes of joint
erosion which suggest that alternative pathway of complement might be actively
involved in the chronic inflammation in rheumatoid arthritis. Another strand of our
work characterises the antiinflammatory action of tyrosine kinase inhibitors in models
of sepsis, particularly via STAT signaling

We have contributed to osteoimmunology research by determining on a molecular
level the manner in which inflammation impairs bone formation and the extent to
which signalling pathways are altered as a consequence. The investigations are carried
out in patients with osteoarthritis and in a murine model of collagenase-induced
osteoarthritis. Current work is focused on application of glucosamine as a potential
antiarthritic agent. The mechanism of its action is studied with regard to neutrophils,
key cytokines and chemokines and also RANKL signaling in relation to events leading
to osteoclastogenesis.
Recent Publications
Djoumerska I., Tchorbanov A., Donkova-Petrini V., Pashov A., Vassilev T. (2005):
Serum IgM, IgG and IgA block by F(ab’)2 dependent mechanism the binding of natural
IgG autoantibodies from therapeutic immunoglobulin preparations to self-antigens.
Eur.J.Haematol. 74, 101-110.
Yordanov M., Tchorbanov A., Ivanovska N. (2005). Candida albicans cell wall
fraction exacerbates collagen-induced arthritis in mice. Scand. J. Immunol., 61, 301-308.
Yordanov M., Dimitrova P., Danova S., Ivanovska, N. (2005): Candida albicans
dsDNA can participate in the host defence against disseminated candidiasis. Microbes and
Infection, 7: 178-86.
Yordanov M., Dimitrova P., Patkar S., Falcocchio S., Xoxi E., Saso L., Ivanovska N.
(2005): Ibogaine reduces organ colonization in murine systemic and gastrointestinal
Candida albicans infections. J. Med. Microbiol., 54: 647-53.
Djoumerska A. Tchorbanov A. Pashov A., Vassilev T. (2005): The autoreactivity of
therapeutic intravenous immunoglobulin (IVIg) preparations depends on the fractionation
methods used. Scand. J. Immunol., 61, 357–363.
Voynova E., Tchorbanov A., Todorov T., Vassilev T. (2005): Breaking of tolerance to
native DNA in nonautoimmune mice by immunization with natural protein/DNA
complexes. Lupus, 14, 543-550.
Wen Y. J., Mancino A., Pashov A., Whitehead T., Stanley J., Kieber-Emmons T.
(2005): Antigen binding of human IgG Fabs mediate ERK-associated proliferation of
human breast cancer cells. DNA and Cell Biology. 24,73-84
Pashov A., Perry M., Dyar M., Chow M., Kieber-Emmons T. (2005): Carbohydrate
mimotopes in the rational design of cancer vaccines. Curr. Top. Med. Chem. 5, 11711185.
Pashov A., MacLeod S., Saha R., Perry M., VanCott T. C., Kieber-Emmons T.
(2005): Concanavalin A binding to HIV envelope protein is less sensitive to mutations in
glycosylation sites than monoclonal antibody 2G12. Glycobiology 15,994-1001.
Pashov A., Canziani G., Monzavi-Karbassi B., Kaveri S. V., Macleod S., Saha R.,
Perry M., Vancott T. C., Kieber-Emmons T. (2005): Antigenic properties of peptide
mimotopes of HIV-1-associated carbohydrate antigens. J. Biol. Chem. 280, 28959-28965.
Pashov A., Canziani G., Macleod S., Plaxco J., Monzavi-Karbassi B., T. KieberEmmons T. (2005): Targeting carbohydrate antigens in HIV vaccine development.
Vaccine 23, 2168-2175.
Djoumerska I. K., Tchorbanov A. I., Donkova-Petrini V. D., Pashov A. D., Vassilev
T. (2005): Serum IgM, IgG and IgA block by F(ab')-dependent mechanism the binding of
natural IgG autoantibodies from therapeutic immunoglobulin preparations to self-antigens.
Eur. J. Haematol. 74, 101-110.
Djoumerska, I., Tchorbanov A., Pashov A., VassilevT. (2005): The Autoreactivity of
Therapeutic Intravenous Immunoglobulin (IVIg) Preparations Depends on the
Fractionation Methods Used. Scand. J. Immunol. 6, 357-363.
Toshkova, R., Ts. Stefanova, N. Nikolova, J. Serkedjieva. (2006). A plant polyphenol
extract ameliorates the disfunctions of alveolar macrophages in influenza virus-infected
mice. Pharmacologyonline, 3:778-784.
Yordanov M., Golkocheva E., Najdenski H. (2006): Modulation of complement activity
in vitro and in vivo by Yersinia wild and mutant strains. Folia Microbiol (Praha), 51, 2732.
Dimitrova P., Ivanovska N. (2006): Host resistance to Candida albicans infection of
mice with collagen-induced arthritis treated with leflunomide. Res. Microbiol., 15, 525530.
Dimitrova P., Ivanovska N. (2006): Influence of leflunomide on gastrointestinal
Candida albicans infection induced in naive and arthritic newborn mice. Int.
Immunopharmacol., 6: 1682-1689.
Shalova I.N., Cechalova K., Rehakova Z., Dimitrova P., Ognibene E., Caprioli A.,
Schmalhausen, E.V., Muronetz V.I., Saso, L. (2006): Decrease of dehydrogenase
activity of cerebral glyceraldehyde-3-phosphate dehydrogenase in different animal models
of Alzheimer’s disease. BBA-GEN Subjects General 1760, 636-651.
Pashov A. D., Plaxco J., Kaveri S. V., Monzavi-Karbassi B., Harn D., KieberEmmons T. (2006): Multiple antigenic mimotopes of HIV carbohydrate antigens: relating
structure and antigenicity. J. Biol. Chem. 28, 29675-29683.
Monzavi-Karbassi B., Pashov A., Jousheghany F., Artaud C., Kieber-Emmons T.
(2006): Evaluating strategies to enhance the anti-tumor immune response to a
carbohydrate mimetic peptide vaccine. Int. J. Mol. Med. 17, 1045-1052.
Dimitrov J.D., Ivanovska N.D., Lacroix-Desmazes S., Doltchinkova V.R., Kaveri
S.K., Vassilev T.L. (2006): Ferrous ions and reactive oxygen species increase antigenbinding and anti-inflammatory activities of immunoglobulin G. J.Biol.Chem., 281, 439446.
Ivanovska N., Tchorbanov A., Prechl J., Maximova V., Voynova E., Vassilev T.L.,
(2006): Immunization with a DNA chimeric molecule encoding a hemagglutinin peptide
and a scFv CD21-specific antibody fragment induces long-lasting IgM and CTL responses
to influenza virus. Vaccine, 24, 1830-1837.
Vassilev T., Mihaylova N., Voynova E., Nikolova M., Kazatchkine M., Kaveri S.,
(2006): IgM-enriched human intravenous immunoglobulin suppresses T lymphocyte
functions in vitro and delays the activation of T lymphocytes in hu-SCID mice. Clin. Exp.
Immunol., 145, 108-115.
Dimitrov, J.D. Lacroix-Desmazes, S., Kaveri, S.K., and Vassilev, T.L. (2007):
Transition towards antigen-binding promiscuity of a monospecific antibody.
Molec.Immunol., 44, 1864-1873.
Ivanovska N., Kalfin R., Lazarova M., Dimitrova P. (2007): Exogenous VIP limits
zymosan-induced generalized inflammation (ZIGI) in mice. Immunol. Lett., 110, 126-132.
Pashov A., Monzavi-Karbassi B., Raghava G., Kieber-Emmons T. (2007). Peptide
mimotopes as prototypic templates of broad-spectrum surrogates of carbohydrate antigens
for cancer vaccination. Crit. Rev. Immunol., 27, 247-270.
Pashov A., Monzavi-Karbassi B., Chow M., Cannon M., Kieber-Emmons T. (2007):
Immune surveillance as a Rationale for Immunotherapy? Hun. Vaccin, 3, 224-228.
Monzavi-Karbassi, B., L. J. Hennings, C. Artaud, T. Liu, F. Jousheghany, A. Pashov,
R. Murali, L. F. Hutchins, and T. Kieber-Emmons. 2007. Preclinical studies of
carbohydrate mimetic peptide vaccines for breast cancer and melanoma. Vaccine 25:30223031.
Pashov A., Perry M., Dyar M., Chow M., Kieber-Emmons T. (2007): Defining
carbohydrate antigens as HIV vaccine candidates. Curr. Pharm. Des. 13, 185-201.
Dimitrov J.D., Roumenina L.T., Doltchinkova V.R., Vassilev T.L. (2007): Iron Ions
and Heme Modulate the Binding Properties of Complement Subcomponent C1q and of
Immunoglobulins. Scand.J.Immunol., 65, 230-239.
Dimitrov J., Roumenina, L., Doltchinkova V., Mihaylova N., Desmazes S.-L., Kaveri
S., Vassilev T. (2007): Antibodies use heme as a cofactor to extend their pathogeneliminating activity and to acquire new effector functions. J.Biol.Chem., 282, 2669626706.
Stefanova T., Nikolova N., Michailova A., Mitov I., Iancov I., Zlabinger G, Neychev
O. (2007): Enhanced resistance to Salmonella enterica serovar Typhimurium infection in
mice after coumarin treatment. Microbes Infect., 9: 7-14.
Stefanova, T., N. Nikolova, R. Toshkova, H. Neychev. (2007). Antitumor and
immunomodulatory effect of coumarin and 7-hydroxycoumarin against Sarcoma 180 in
mice. J. Exp. Ther. Oncol., 6:107-115.
Serkedjieva, J., R. Toshkova, S. Antonova-Nikolova, T. Stefanova, A. Teodosieva, I.
Ivanova. (2007). Effect of a plant polyphenol-rich extract on the lung protease activities
of influenza virus infected mice. Antivir. Chem. Chemother., 18:75-82.
Tchorbanov A., Voynova E., Mihaylova N., Todorov T., Nikolova M., Yomtova V.,
Chiang B.-L., Vassilev T. (2007): Selective silencing of DNA-specific B lymphocytes
delays lupus activity in MRL/lpr mice. Eur. J. Immunol., 37, 3587-3596.
Mihaylova N., Dimitrov J., Djoumerska-Alexieva I., Vassilev T. (2008): Inflammationinduced enhancement of IgG immunoreactivity. Inflamm. Res., 57, 1-3.
Mihaylova N., Voynova E., Tchorbanov A., Nikolova M., Michova A., Todorov T.,
Srebreva, L., Taskov H., Vassilev T. (2008): Selective silencing of disease-associated Blymphocytes by chimeric molecules targeting their FcγRIIb receptor. Int. Immunol., 20,
165-175.
Dolashka-Angelova P., Stefanova T., Livaniou E., Velkova L., Klimentzou P.,
Stevanovic S., Salvato B., Neychev H., Voelter W. (2008): Immunological potential of
Helix vulgaris and Rapana venosa hemocyanins. Immunol. Invest., 37, 822-840.
Remichkova M., Yordanov M., Dimitrova P. (2008): Etoposide attenuates zymosaninduced shock in mice. Inflammation, 31, 57-564.
Ivanovska N., Dimitrova P., Luckett J., El-Rachkidy Lonnen R., Schwaeble, W.,
Stover C. (2008): Properdin deficiency in murine models of nonseptic shock. J. Immunol.,
180, 6962-6969.
Dimitrova P., Yordanov M., Danova S., Ivanovska N. (2008): Enhanced resistance
against systemic Candida albicans infection in mice treated with C. albicans DNA. FEMS
Immunol. Med. Microbiol., 53, 231-6.
Yordanov M., Dimitrova P., Patkar S., Saso L., Ivanovska N. (2008): Inhibition of
Candida albicans extracellular enzyme activity by selected natural substances and their
application in Candida infection. Can. J. Microbiol., 54, 435-440.
Dimitrova P., Ivanovska N. (2008): Tyrphostin AG-490 inhibited the acute phase of
zymosan-induced inflammation. Int. Immunopharmacol., 8, 1567-1577.
Voynova Е., Tchorbanov A., Prechl J., Nikolova M., Baleva M., Erdei A., Vassilev T.
(2008): Вi-specific antibody targeting CR1(CD35) selectively suppresses human
autoreactive disease-associated B lymphocytes. Immunol.Lett., 116, 168-173.
Dimitrov J.D., Lacroix-Desmazes S., Kaveri S.K., Vassilev T.L. (2008): Insight into
the mechanism of the acquired antibody autoreactivity. Autoimm.Rev. 7, 410-414.
Dimitrov J.D., Vassilev T.L., Andre S., Kaveri S.K., Lacroix-Desmazes S. (2008):
Functional variability of antibodies upon oxidative processes. Autoimmun.Rev.: 7, 574578.
Tchorbanov A., Idakieva K., Mihaylova N., Doumanova L. (2008): Modulation of the
immune response using Rapana thomasiana hemocyanin. Int. Immunopharmacol. 8,
1033–1038.
Mihaylova N., Voynova E., Tchorbanov A., Dolashka-Angelova P., Bayry J.,
Devreese B., Kaveri S., Vassilev T. (2009): Simultaneous engagement of FcγIIb and
CD22 inhibitory receptors silences targeted B cells and suppresses autoimmune disease
activity. Molec. Immunol. 2009: 47, 123-130.
Djoumerska-Alexieva I., Dimitrov J., Nacheva J., Kaveri S., Vassilev T. (2009):
Protein-destabilizing agents induce polyreactivity and enhanced immunomodulatory
activity in IVIg preparations. Autoimmun., 43, 365-367.
Krumova E.Z., Pashova S.B., Dolashka-Angelova P.A., Stefanova T., Angelova M.B.
(2009). Biomarkers of oxidative stress in the fungal strain Humicola lutea under copper
exposure. Proc. Biochem., 44, 288-295.
Kostova, I., Ts. Stefanova. (2009). Synthesis, characterization and cytotoxic/cytostatic
activity of Sm(III) and Gd(III) complexes. J. Coord. Chem., 62:3187-3197.
Pashov A., Monzavi-Karbassi B., Kieber-Emmons T. (2009). Immune surveillance and
immunotherapy: lessons from carbohydrate mimotopes. Vaccine, 27, 3405-3415.
Pashov A., Garimalla S., Monzavi-Karbassi B., Kieber_Emmons T. (2009):
Carbohydrate targets in HIV vaccine research: lessons from failures. Immunotherapy, 1,
777-794.
Toncheva A., Remichkova M., Ikonomova K., Dimitrova P., Ivanovska N. (2009):
Inflammatory response in patients with active and inactive osteoarthritis. Rheumatol. Int.,
29, 1197-1203.
Remichkova M., Dimitrova P., Philipov S., Ivanovska N. (2009): Toll-like receptormediated anti-inflammatory action of glaucine and oxoglaucine. Fitoterapia, 80, 411-414.
Dimitrova P., Gyurkovska V., Shalova I., Saso L., Ivanovska N. (2009): Inhibition of
zymosan- induced kidney dysfunction by tyrphostin AG-490. J. Inflam., 6, 13.
Nikolova K., Tchorbanov A., Djoumerska-Alexieva I., Nikolova, M., Vassilev T.
(2009): Intravenous immunoglobulin up-regulates the expression of the inhibitory FcγIIB
receptor on B cells. Immunol.Cell.Biol., 87, 529-533.
Dimitrov J.D., Vassilev T.L. (2009): Cofactor-mediated protein promiscuity. Nat.
Biotechnol., 27, 892.
Kostova, I., Ts. Stefanova. (2010). Synthesis, characterization and cytotoxic/cytostatic
activity of La(III) and Dy(III) complexes. J. Trace Elem. Med. Biol., 24:7-13.
Stefanova, Ts. H., I. Ratcheva, N. J. Nikolova. H.O. Neychev. (2010). Effect of yeast
superoxide dismutase treatment on some mediators of inflammation during adjuvantinduced arthritis in mice. Z. Naturforsch., 65c:141-147.
Serkedjieva J., Ts. Stefanova, E. Krumova. (2010). A fungal Cu/Zn-containing
superoxide dismutase enhances the therapeutic efficacy of a plant polyphenol extract in
experimental influenza virus infection. Z. Naturforsch., 65c:419-428.
Dimitrova P., Ivanovska N., Schwaeble W., Gyurkovska V., Stover C. (2010): The
role of properdin in murine zymosan-induced arthritis. Mol. Immunol., 47, 1458-1466.
Djoumerska-Alexieva I., Dimitrov J., Voynova E., Lacroix-Desmazes S., Kaveri S.,
Vassilev, T. (2010): Exposure of IgG to an acidic environment results in molecular
modifications and in enhanced protective activity in sepsis. FEBS J., 277, 3039-3050.
Gesheva V, Idakieva K, Kerekov N, Nikolova K, Mihaylova N, Doumanova L,
Tchorbanov A. (2010): Marine gastropod hemocyanins as adjuvants of non-conjugated
bacterial and viral proteins. Fish Shellfish Immunol., 30, 135-142.
Dimitrov J.D., Planchais C., Kang J., Pashov A., Vassilev T.L., Kaveri S.V., LacroixDesmazes S. (2010): Heterogeneous antigen recognition behavior of induced polyspecific
antibodies. Biochem.Biophys.Res.Commun., 398, 266-271.
Nikolova K.A., Mihaylova N.M., Voynova E.N., Tchorbanov A.I., Voll R.E., Vassilev
T.L. (2010): Selective silencing of autoreactive B lymphocytes – following the Nature’s
way. Rev.Autoimmun., 9, 775-779.
Todorova V. K., Klimberg V. S., Hennings L., Kieber-Emmons T., Pashov A. (2010):
Immunomodulatory effects of radiofrequency ablation in a breast cancer model. Immunol.
Invest., 39, 1-19.
Pashov A., Monzavi-Karbassi B., Raghava G., Kieber-Emmons T. (2010): Bridging
Innate and Adaptive Antitumor Immunity Targeting Glycans. J. Biomed. Biotech. online
2010 June 15. doi: 10.1155/2010/354068
Dimitrova I., Gesheva V., Nikolova K., Mihaylova N., Todorov T., Nikolova M.,
Tchorbanov A. (2010): Target silencing of disease-associated B-lymphocytes by
chimeric molecules in SCID model of pristane-induced autoimmunity. Lupus, 19, 12611271.
Nikolova K, Mihaylova N, Voynova E, Kerekov N, Gesheva V, Prechl J, Nikolova M,
Tchorbanov A. (2010): Re-establishing tolerance to DNA in humanized and murine
models of SLE. Autoimmun Rev., 9, 499–450.
Papp K., Végh P., Miklós K., Tchorbanov A., Vassilev T., Erdei A., Prechl J. (2010):
Anti-DNA IgG antibodies tilt the balance from smothered classical pathway complement
activation to abundant C3 generation. Rheumatology, 49, 2273-2280.
Pavlovic S., Zdravkovic N., Dimitrov J., Djukic A., Arsenijevic N., Vassilev T., Lukic
M. (2010): Intravenous immunoglobulins exposed to heme (heme IVIG) are more
efficient than IVIG in attenuating autoimmune diabetes. Clin.Immunol.
doi:10.1016/j.clim.2010.10.010, 2010.
Dimitrova, P., Toncheva, A., Gyurkovska, V., Ivanovska, N. (2011): Involvement of
soluble receptor activator of nuclear factor B ligand (sRANKL) in collagenase-induced
murine osteoarthritis and human osteoarthritis. Rheum. Internat., DOI: 10.1007/s00296010-1723-8.
Ivanovska N., Dimitrova P. (2011): Bone resorption and remodeling in murine
collagenase-induced osteoarthritis after administration of glucosamine. Arth. Res. Ther.,
13, R44.