DEPARTMENTAL POLICY AND PROCEDURE Program: University of Michigan Cardiovascular Pulmonary Hypertension Procedure Title: Antibiotic Prophylaxis Procedure Written: July 2011 Reviewed/ Revised: July 2011 Procedure Statement / Purpose: To provide guidelines for timely and safe prescriptions for the cardiology patient that needs antibiotic prophylaxis for subacute bacterial endocarditis (SBE) I. GUIDELINES A. Under the direction of the cardiologist at Cardiovascular Medicine, the nurse assumes responsibility for the management of established Cardiovascular Medicine Patients requesting antibiotics for SBE prophylaxis. B. For a patient to receive antibiotics as part of this protocol they must have the following conditions documented in their medical record. 1. Prosthetic cardiac valves 2. A history of having had infective endocarditis 3. Unrepaired or incompletely repaired cyanotic congenital heart disease, including those with palliative shunts and conduits. 4. Any repaired congenital heart defect with residual defect at the site of adjacent to the site of a prosthetic patch or a prosthetic device 5. A completely repaired congenital heart defect with prosthetic material or device, whether placed by surgery or by catheter intervention during the first six months after the procedure ie Amplatzer device. Prophylaxis is recommended for 6 months only because endothelialization of the prosthetic material occurs within six months after the procedure. 6. Non-coronary vascular grafts need prophylaxis for 6 months post procedure. C. Patients with conditions under B or with documented need for prophylaxis in the medical record by the cardiologist will need antibiotics before the following procedures. 1. All dental procedures that involve manipulation of gingival tissue or the periapical region of teeth or perforation of the oral mucosa. 2. Procedures on the respiratory tract or infected skin, tissues just under the skin or musculoskeletal tissue. Revised: 07/2011 D. Antibiotic prophylaxis is not recommended for the following conditions 1. Congenital Heart Disease such as ventricular septal defect, atrial septal defect and hypertrophic cardiomyopathy 2. Previous CABG 3. Mitral Valve Prolapse 4. Functional heart murmurs 5. Cardiac Pacemakers or defibrillators 6. Placement of coronary stents 7. Rheumatic Heart disease 8. Bicuspid Aortic Valve 9. Calcified Aortic Stenosis E. Prophylaxis is not recommended for the following procedures 1. Endotracheal intubation 2. Bronchoscopy with flexible bronchoscope, with or without biopsy 3. Tympanostomy tube insertion 4. Transesophageal echo 5. Endoscopy with or without gastrointestinal biopsy 6. Vaginal hysterectomy 7. Vaginal childbirth 8. Uncomplicated Cesarean Section 9. GI or GU procedures II. PROPHYLACTIC REGIME THE NURSE WILL REASSESS THE PATIENT FOR ANY DRUG ALLERGIES BEFORE USING THIS PROTOCOL A. Standard: Amoxicillin 2.0 gm orally 1 hour before procedure Note: RX should read Amoxicillin 500 mg tabs po 1 hour before procedure quantity 4. Needs for refills should be assessed based on the number of procedures patient is anticipating having. B. Penicillin Allergy: If the patient has an allergy to penicillin the patient should be given 1. Clindamycin 600 mg po 1 hour before procedure Or 2. Cephalexin or Cefadrxil 2.0 grams 1 hour before procedure Or 3. Azithromycin or Clarithromycin 500 mg po 1 hour before procedure. Note: Cephalasporins should not be used in individuals with immediate type of hypersensitivity reaction to penicillins (urticaria, angioedema, and anaphylaxis. Revised: 07/2011 III. REFERENCES Prevention of Infective Endocarditis. Guidelines From the American Heart Association. A Guideline From the American Heart Association Rheumatic Fever, Endocarditis, and Kawasaki Disease Committee, Council on Cardiovascular Disease in the Young, and the Council on Clinical Cardiology, Council on Cardiovascular Surgery and Anesthesia, and the Quality of Care and Outcomes Research Interdisciplinary Working Group Circulation 2007: published online before print April 19, 2007, 10.1161/CIRCULATIONAHA.106.183095. MD Signature: ___________________________ Date: ____________ Val McLaughlin, MD Medical Director, CVM Pulmonary Hypertension Program Nurse Signature: ___________________________ Date: ____________ Janice Norville, MSN, MSBA, RN Director of Clinical Operations – CVM – Special Programs Revised: 07/2011