DOWNRIVER CARDIOLOGY CONSULTANTS PATIENT EDUCATION INFORMATION: REGARDING: CORDARONE OR PACERONE (AMIODARONE) This drug is utilized to treat heart rhythm problems. It was originally approved by the FDA for the treatment of life-threatening ventricular arrhythmias. These are heart rhythm problems originating in the lower or pumping chamber of the heart that frequently can be fatal. More recently it has also been utilized in the treatment of arrhythmias in the atrial chambers or top chambers of the heart. Although it is the best medication for heart rhythm problems that exists, as far as effectiveness, its multiple and sometimes serious side effects limit its use. Many of these side effects are dose related, meaning that there are more frequent side effects as higher dosages are utilized. Generally higher doses are needed in the ventricular arrhythmias (approximately 400 mg/day) versus the lower doses with atrial arrhythmias (150-200 mg/day). The most common use in atrial arrhythmias is for atrial fibrillation. Amiodarone has an extremely slow onset and duration of action. Generally it requires a loading or higher dose to obtain benefits earlier and it can be expected to have continued effects for several months after stopping the drug. The most common side effect of Amiodarone is nausea and vomiting which may occur in up to 1/3 of patients. This symptom is alleviated when the loading dose is reduced. Additionally, splitting the pill and/or taking it with meals may be helpful. Many of the other side effects of Amiodarone are also dose related, meaning that they are more frequent at the higher doses required for ventricular arrhythmias than they are at the lower doses used in treating atrial fibrillation. The most important complication is inflammation of the lungs, which may lead to pulmonary fibrosis or scarring in the lungs. If you notice any shortness of breath you should notify your physician. Many patients taking Amiodarone develop shortness of breath from other reasons and it is important that your physician differentiates the shortness of breath from these other diseases from the effects of Amiodarone. Lung status should be followed with chest x-rays and pulmonary function studies (including diffusion capacity). Elevations of the blood tests associated with liver disease are seen frequently in patients on Amiodarone. If this level increased three times above normal or doubles in a patient with elevated liver functions to start with, the medication should be discontinued. Any visual changes that develop while on Amiodarone should receive immediate attention and an eye examination. Small eye deposits occur in the majority of patients on Amiodarone and are usually seen during an eye examination. They might cause some visual halos or blurred vision. In the absence of any symptoms, these small deposits do not require discontinuation of medication. Amiodarone affects thyroid function in many patients and may cause either symptoms of an over-active or under-active thyroid. This should be followed by periodic testing of thyroid function. If you notice any increased heart rhythm problems, you should also notify your physician in case this is either an effect from the Amiodarone or in the event it has caused an over-active thyroid. Amiodarone may have interactions with other medications. Generally it increases the effect of other medications. You should make your physician aware of your use of Amiodarone prior to him or her instituting other medications. In particular, cyclosporin may have a markedly increased effect. Suggestions for use with other medications are listed below: DCC, December 2007 Coumadin (Warfarin) – reduce Coumadin dose by 1/3 to 1/2 Lanoxin (Digoxin) – reduce Lanoxin dose by 1/2. Quinidine – reduce Quinidine dose by 1/3 to ½ or discontinue. Procainamide – reduce Procainamide dose by 1/3 or discontinue Dilantin – may need to reduce dose. Amiodarone may have many nonspecific symptoms and side effects which should be reported to your physician. This includes but is not limited to: rash, muscle weakness, involuntary movements, lack of coordination, abnormal gait, dizziness, slow heart rate, or sleep disorders. FOLLOW UP INITIAL 3 MONTHS 6 MONTHS DATE DATE 12 MONTHS OFFICE VISIT DATE DATE CBC. LYTES, MG, BUN, CREATININE DATE DATE DIGOXIN OR OTHER DRUG LEVELS DATE DATE 18 MONTHS ONLY WITH SYMPTOMS DATE WHICH MAY INCREASE THYROID PROFILE DATE DATE DATE DATE LIVER ENZYMES CHEST X-RAY DATE DATE PULMONARY FUNCTION WITH DIFFUSION DATE DATE ELECTROCARDIOGRAM DATE OPHTHALMOLOGIC EXAM DATE DATE DATE Including funduscopic and slit lamp examinations. DATE DATE Treatment of hypothyroidism may not be necessary until TSH exceeds 2 times normal value. However, an elevated TSH warrants closer follow up of lab and heart rate. Adapted from Singh, BN: Clin Cardiol 20:608-618, 1997. EKG: BASELINE DATE ATRIAL FIBRILLATION 3 6 MONTHS MONTHS DATE DATE 12 MONTHS DATE VENTRICULAR TACHYCARDIA 3 6 12 BASELINE MONTHS MONTHS MONTHS DATE DATE DATE DATE CHEST X-RAY/PULMONARY FUNCTION WITH DIFFUSION CAPACITY BASELINE DATE DCC, December 2007 ATRIAL FIBRILLATION 6 MONTHS 12 MONTHS DATE DATE BASELINE DATE VENTRICULAR TACHYCARDIA 3 MONTHS 6MONTHS 9 MONTHS DATE DATE DATE THYROID FUNCTION/LIVER FUNCTION LAB INITIAL DATE T3 FREE T4 TSH AST (SGOT) ALT (SGPT) BILIRUBIN ALK PHOS POTASSIUM/MAGNESIUM INITIAL DCC, December 2007 6 MONTHS 12 MONTHS 12 MONTHS 18 MONTHS