Course Outline:
Title:
Heterocyclic Chemistry (341 Chem.)
Instructor:
Dr. Nahed Nasser El-Sayed
email: nelsayed@ksu.edu.sa
Webpage: http://faculty.ksu.edu.sa/77563
Contact hours: 2h/ week
Lectures:
Class GA009051115, Monday & Wednesday 08-08:50
Office Hours: Sunday 9-11, Monday 10-11- Wednesday 9-10 & Thursday
11-12 or by
appointment.
Office: Building 5- 3rd floor, office T 253
.
Brief course description:
Nomenclature, Aromaticity, Five-membered heterocycles: pyrrole, furan, thiophen
indole, diazoles Six-membered heterocycles: pyridine, quinoline &isoquinoline;
basicity; synthesis, reactions, cycloaddition reactions. Heterocyclic compounds
versus microbes: antibiotics, antitumors and as dyes. Biologically important
heterocycles, uracils, purins, Carbohydrates; definition, nomenclature,
classification, monosaccharide: absolute configuration, cyclic structures, oxidation,
reduction, osazones, ascorbic acid, amino sugars. Oligosaccharides and
polysaccharides; cellulose technology, Amino acids; proteins, natural amino acids:
properties, synthesis and reactions, synthesis of peptides, protein classification.
Lipids; classification, waxes, oils and fats (glycerides), synthesis and properties of
glycerides, glycolipids.
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Detailed outline of lectures:
Introduction to heterocyclic chemistry
 Definition of H.C., natural sources, examples and importance.
Chap. 1: Aromaticity and hetrocyclic compounds:
 Criteria for aromaticity; aromatic and non aromatic heterocycles.
Chap. 2: Nomenclature of heterocyclic compounds
 Different methods of naming heterocyclic compounds: common nomenclature,
modified replacement nomenclature and Hantzsch Widman nomenclature (IUPAC)
 Nomenclature of fused heterocyclic compounds (benzofused heterocycles and two or
more fused heterocycles)
Chap. 3: 5-Membered heterocyclic compounds
 Synthesis and reactions of pyrrole furan, thiophene, indole, and diazoles (imidazole
and pyrazole)
Chap. 4: 6-Membered heterocyclic compounds
 Synthesis, reactions and basicity of pyridine, quinoline & isoquinoline, and diazines
(uracils and purins).Structure of nucleic acids (DNA & RNA).
Chap. 5: Carbohydrates
 Definition and classification.
 Monosaccharide: nomenclature, examples, stereochemistry, different methods of
drawing of monosaccharide, physical properties, chemical properties: oxidation,
reduction, glycosides formation, ether formation, ester formation, osazones, degradation
and synthesis.
 Structure, properties and importance of di, oligo and polysaccharides.
Chap 6: Amino acids and proteins
 Naturally occurring amino acids: classification, properties, configuration, synthesis and
reactions.
 Synthesis of peptides and protein
Chap 7: Lipids and fatty acids
 Structure and main characteristics of fatty acids
 Classification of lipids: waxes, oils and fats (triglycerides).
 Synthesis and properties of triglycerids and glycolipides.
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Throughout the course we categorized and accumulated concepts for
review such as:
Meaning and criteria for aromaticity, electronic configuration, hybridization
(sp2 & sp3) , resonance, electronegativity, basicity, acidity, electrophile,
nucleophile, major reactions of carbonyl group & substitution reaction ,
addition reactions, cycloaddition reactions, hydrogen bonding and its effects on
physical properties, isomers, chiral carbons.
Course lectures: available on Learning management system (LMS)
Textbook:
(Recommended, available in bookstores and university library)
‫ دار الخريجى للنشر‬،‫ سهام العيسى‬،‫ ناصر العندس‬،‫ حسن الحازمى‬.‫د‬.‫ أ‬، ‫ المركبات الحلقية غير المتجانسة‬.1
. 1211 ، ‫ الطبعة األولى‬،‫و التوزيع‬
1211 ،‫ دار الخريجى للنشر و التوزيع‬،‫ حسن الحازمى‬.‫د‬.‫ أ‬, ‫ حمد الخثالن‬.‫د‬.‫ أ‬، ‫ تسمية المركبات العضوية‬.1
.
3. Heterocyclic chemistry, J.A. Joule and K. Mills, 4th ed., Blackwell Publishing 2000
Other Sources:
Internet
Evaluation: Assignments: There will be a total of 4 assignments handed out
throughout the semester. They will be due one week from the day they are
handed out, at the end of class. Late assignments will not be accepted.
The top 3 assignments will be counted.
Quizzes: There will be a total of 3 quizzes will be given throughout the
semester. The top 2 quizzes will be counted.
Midterm Exams: Mid 1 and Mid2 (1h)
Final Exam (3 hr) will cover material from the entire course
Important Dates:
Mid 1 Exam: Monday 17/1/1436 (12-1)
Mid 2 Exam: Monday 22/2/1436 (12-1)
Notes: Any assignments, tests or exams written in pencil will not be eligible for
regarding.
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Mark Breakdown (subjected to change)
Assignments and web based research:
Homework & Quizzes
Mid Term Exams:
Final Exam:
10%
10%
40% (20 % each)
40 %
Getting Help: If you need extra help with the course, feel free ask me during office
hours or by email to arrange for extra class.
Academic Dishonesty:
The following illustrates only three forms of academic dishonesty:
1. Plagiarism, e.g. the submission of work that is not one’s own or for which other
credit has been obtained.
2. Improper collaboration in group work.
3. Copying or using unauthorized aids, tests, and examinations.
Feedback
I am always open to suggestions and constructive criticism for improving my
performance
Technology used
Dear student you are expected to access my website and LMS on a frequent basis to
down load files in addition to find out about your marks.
Also information may be sent by email to your email account so please look at group
email account on a frequent basis.
Good Luck
Dr. Nahed Nasser El-Sayed September/ 2014
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