REGULATION OF PROKARYOTIC & EUKARYOTIC
Fall 2015 - GENE EXPRESSION (5143)
Rayford Auditorium Room 106-2
Biomedical Research Center II
Tuesdays & Thursdays
9:00 am – 11:00 am
Course Director: Patricia Wight
DATE
Tue,
08/18/15
Thurs, 08/20/15
Tue,
08/25/15
Thurs, 08/27/15
Tue,
09/01/15
Thurs, 09/03/15
LECTURE
INSTRUCTOR
Prokaryotic Genome Organization
Mark Smeltzer
Operons
Mark Smeltzer
Regulation of prokaryotic transcription
Kevin Raney
Prokaryotic transcription
Chia Lee
Prokaryotic replication, repair and recombination
Chia Lee
EXAM 1 (9:00 – 11:30 AM)
Includes lectures from 8/18/15 - 9/01/15
09/08/15
Eukaryotic Genome Organization
Helen Benes
Thurs, 09/10/15
Eukaryotic replication and repair
Kevin Raney
Tue,
Eukaryotic replication and repair
Robert Eoff
Tue,
09/15/15
Thurs, 09/17/15
Tue,
09/22/15
Thurs, 09/24/15
Tue,
09/29/15
Thurs, 10/01/15
Tue,
10/06/15
Eukaryotic RNA Polymerases and their promoters
Patricia Wight
Eukaryotic Transcription; RNAPII
Promoters/Enhancers
Patricia Wight
Eukaryotic Transcription Factors
Patricia Wight
LCR, insulators, DNA methylation, and noncoding
RNAs
Patricia Wight
Eukaryotic Gene Regulation
Helen Benes
EXAM 2 (9:00 – 11:30 AM)
Includes lectures from 9/08/15 - 10/01/15
Genetic Recombination
Wayne Wahls
Posttranscriptional processing
Xuming Zhang
Thurs, 10/15/15
RNA splicing
Xuming Zhang
Tue,
RNA splicing
Xuming Zhang
Thurs, 10/08/15
Tue,
10/13/15
10/20/15
Thurs, 10/22/15
Tue,
10/27/15
Thurs, 10/29/15
Tue,
11/03/15
CAREER DAY
Reverse transcription
Xuming Zhang
EXAM 3 (9:00 – 11:30 AM)
Includes lectures from 10/08/15 - 10/27/15
Prokaryotic & Regulation of Prokaryotic translation Angus MacNicol
DATE
LECTURE
Thurs, 11/05/15
Eukaryotic translation
Tue,
11/17/15
Thurs, 11/19/15
Angus MacNicol
VETERAN’S DAY HOLIDAY
11/10/15
Regulation of Eukaryotic translation
Thurs, 11/12/15
Tue,
INSTRUCTOR
Eukaryotic Differentiation & Development as an
Integrated Overview of Gene Regulation
EXAM 4 (9:00 – 11:00 AM)
Angus MacNicol
Mari Davidson
Includes lectures from 11/03/15 – 11/17/15
Prerequisites:
It is recommended that students have taken an undergraduate
course in biochemistry and/or molecular biology.
Objectives:
The goal of this course is for students to acquire a working
knowledge of the various methods by which gene expression can
be controlled. A side-by-side comparison of these mechanisms for
both prokaryotes and eukaryotes will be explored. It is anticipated
that at the end of this course, students will become proficient at
reading the primary literature relevant to gene expression.
Course Structure:
The course is 3 credit hours which meet twice a week for 2 hours
per session. The course will be conducted by didactic lectures, as
well as, class discussion of current reviews and primary papers.
The students will be assigned a grade solely based on exams,
which will be in the format of short answer/essay questions.
Grades will scaled, with the class average typically set at a B.
Plus/minus grades will be given in the course, but please note that
the graduate school records only solid grades (no +/).
Reading Material:
Readings will mainly consist of recent reviews and primary articles
as assigned by the individual Instructors. Lewin’s Genes XI is
recommended as a text for general background. A copy of the text
has been placed on Reserve in the main library (2 hour intervals).
Course Evaluation: The course will be evaluated by the students as per standard
UAMS procedures. Each Instructor will also be evaluated by the
students.