Proof for the 2012-2013 Duke University Bulletin of Undergraduate Instruction, p. 1
RETURN PROOF BY MAY 25th to sarah.kibler@duke.edu
__________________________________________________________________________
This is the final, optional proof for the 2012-2013 Bulletin of Undergraduate Instruction.
No new revisions can be made to the bulletin at this time. This proof is intended solely to
correct production errors. You do not need to respond if the information is correct.
However, if we have made an error, or not made a correction that you indicated on a
previous proof, please contact the Publications Coordinator, Sarah Kibler, as soon as
possible, but not later than Friday, May 25, 2012. No changes will be accepted after this
date.
This file should be in track-change mode (if it isn’t, please type [Ctrl]+[Shift]+e).
Medicine (School)—Graduate (School) Basic Science Courses Open to
Undergraduates
Qualified students in arts and sciences may select courses from the following offered by the graduate departments
associated with the School of Medicine.
A major is not offered to undergraduates in any of the departments listed below.
For permission to register for these courses and for further information, see Professors Spicer (biochemistry),
Endow (cell biology), Marchuk (University Program In Genetics), Dawson (immunology), Valdivia (molecular
genetics and microbiology), Beese (structural biology and biophysics), W. C. Hall (neurobiology), Abraham
(pathology), and Schwartz-Bloom (pharmacology and cancer biology).
BIOCHEMISTRY (BIOCHEM)
301. Introductory Biochemistry I: Intermediary Metabolism. Chemistry of the constituents of proteins, lipids,
carbohydrates, and nucleic acids and their metabolic interrelationships. Prerequisite: two semesters of organic
chemistry. Instructors: Coggins and staff. One course.
302. Introductory Biochemistry II. Structure, function, and biosynthesis of biological macromolecules and
regulation of their synthesis. Intermediary metabolism and metabolic utilization of energy. Biochemistry of
biological membranes, receptors, and signal transduction via membrane receptors. Prerequisite: organic chemistry
and Biochemistry 301. Instructors: Been and staff. One course.
593. Research Independent Study. R Individual research in a field of special interest, under the supervision of a
faculty member, the major product of which is a substantive paper or written report containing significant analysis
and interpretation of a previously approved topic. Designed for students interested in either a laboratory or a library
project in biochemistry. One course for undergraduate students. One to twelve units for graduate students.
Instructor: Staff. Variable credit.
622. Structure of Biological Macromolecules. R Computer graphics intensive study of some of the biological
macromolecules whose three-dimensional structures have been determined at high resolution. Emphasis on the
patterns and determinants of protein structure. Two-hour discussion session each week along with computer-based
lessons and projects. Instructors: D. Richardson and J. Richardson. One course. C-L: Structural Biology and
Biophysics 622, Computational Biology and Bioinformatics 622
658. Structural Biochemistry I. Principles of modern structural biology. Protein-nucleic acid recognition,
enzymatic reactions, viruses, immunoglobulins, signal transduction, and structure-based drug design described in
terms of the atomic properties of biological macromolecules. Discussion of methods of structure determination with
particular emphasis on macromolecular X-ray crystallography NMR methods, homology modeling, and
bioinformatics. Students use molecular graphics tutorials and Internet databases to view and analyze structures.
Prerequisites: organic chemistry and introductory biochemistry. Instructors: Beese and staff. Half course. C-L: Cell
and Molecular Biology 658, Cell Biology 658, University Program in Genetics 658, Immunology 658, Structural
Biology and Biophysics 658, Computational Biology and Bioinformatics 658
659. Structural Biochemistry II. Continuation of Biochemistry 658. Structure/function analysis of proteins as
enzymes, multiple ligand binding, protein folding and stability, allostery, protein-protein interactions. Prerequisites:
Biochemistry 658, organic chemistry, physical chemistry, and introductory biochemistry. Instructors: Hellinga and
staff. Half course. C-L: Cell Biology 659, Immunology 659, Computational Biology and Bioinformatics 659,
Structural Biology and Biophysics 659, University Program in Genetics 659
Proof for the 2012-2013 Duke University Bulletin of Undergraduate Instruction, p. 2
RETURN PROOF BY MAY 25th to sarah.kibler@duke.edu
__________________________________________________________________________
667. Biochemical Genetics I: DNA and Genome Stability. Chromosome structure, replication, repair, genetic
recombination, mutation and chromosome rearrangement. Minicourse, 1st half-semester. Instructor: Kreuzer and
staff. Half course.
668. Biochemical Genetics II: From RNA to Protein. Mechanisms of transcription, splicing, catalytic RNA, RNA
editing, mRNA stability and translation. Mini-course, 2nd half semester. Instructors: Steege and Staff. Half course.
C-L: Cell Biology 668, Immunology 668, University Program in Genetics 668
681. Physical Biochemistry. A structure-based introduction to the role of thermodynamic driving forces in biology.
An overview of experimental sources of structural and dynamic data, and a review of the fundamental concepts of
thermodynamics. Both concepts are combined to achieve a structural and quantitative mechanistic understanding of
allosteric regulation, and of coupled ligand binding and conformational change. Statistical thermodynamics is used
to develop ensemble models of protein and nucleic acid dynamics. This treatment leads into specific examples and
general principles of how to interpret structural and dynamic information toward the purposes of other research.
Instructor consent required. Instructor: Oas. One course. C-L: Structural Biology and Biophysics 681
695. Macromolecular Structure Determination by NMR Spectroscopy and X-ray Crystallography. Theoretical
and experimental principles of nuclear magnetic resonance (NMR) spectroscopy and macromolecular x-ray
crystallography. Topics of NMR cover theory, data collection and interpretation of macromolecular NMR
experiments, including 1D, 2D, and multidimensional NMR data collection and interpretation, chemical exchange,
protein dynamics, residual dipolar couplings, and solution structure determination. Emphasis on crystal symmetry,
space group determination, diffraction theory, and a practical understanding of macromolecular crystallization, x-ray
intensity data collection, macromolecular structure determination, refinement, and analysis. Prerequisites:
Undergraduate physical chemistry, undergraduate biochemistry, and one year of calculus. Instructor consent
required. Instructor: Schumacher. One course.
CELL BIOLOGY (CELLBIO)
493. Research Independent Study. R Individual Research in a field of special interest under the supervision of a
faculty member, the central goal of which is a substantive paper or written report containing significant analysis and
interpretation of a previously approved topic. Consent of instructor required. Instructor: Staff. One course. C-L:
Marine Sciences
503. Introduction to Physiology. Modern organ physiology; cellular physiology, organ system physiology
including cardiovascular, respiratory, renal gastrointestinal, endocrine, reproductive, muscle and nervous. Mini
course. Prerequisite: elementary biology. Instructors: Jakoi and Vigna. One course.
658. Structural Biochemistry I. Half course. C-L: see Biochemistry 658; also C-L: Cell and Molecular Biology
658, University Program in Genetics 658, Immunology 658, Structural Biology and Biophysics 658, Computational
Biology and Bioinformatics 658
659. Structural Biochemistry II. Half course. C-L: see Biochemistry 659; also C-L: Immunology 659,
Computational Biology and Bioinformatics 659, Structural Biology and Biophysics 659, University Program in
Genetics 659
668. Biochemical Genetics II: From RNA to Protein. Half course. C-L: see Biochemistry 668; also C-L:
Immunology 668, University Program in Genetics 668
CELL AND MOLECULAR BIOLOGY (CMB)
658. Structural Biochemistry I. Half course. C-L: see Biochemistry 658; also C-L: Cell Biology 658, University
Program in Genetics 658, Immunology 658, Structural Biology and Biophysics 658, Computational Biology and
Bioinformatics 658
UNIVERSITY PROGRAM IN GENETICS AND GENOMICS (UPGEN)
533. Genetic Epidemiology. This course will cover traditional genetic epidemiologic methods such as study design,
linkage analysis and genetic association. Instructor: Ashley-Koch. One course.
658. Structural Biochemistry I. Half course. C-L: see Biochemistry 658; also C-L: Cell and Molecular Biology
658, Cell Biology 658, Immunology 658, Structural Biology and Biophysics 658, Computational Biology and
Bioinformatics 658
659. Structural Biochemistry II. Half course. C-L: see Biochemistry 659; also C-L: Cell Biology 659,
Immunology 659, Computational Biology and Bioinformatics 659, Structural Biology and Biophysics 659
668. Biochemical Genetics II: From RNA to Protein. Half course. C-L: see Biochemistry 668; also C-L: Cell
Biology 668, Immunology 668
Proof for the 2012-2013 Duke University Bulletin of Undergraduate Instruction, p. 3
RETURN PROOF BY MAY 25th to sarah.kibler@duke.edu
__________________________________________________________________________
IMMUNOLOGY (IMMUNOL)
493. Research Independent Study. R Individual research and reading of the primary literature in a field of special
interest, under the supervision of a faculty member, the major product of which is a substantive paper or written
report containing significant analysis and interpretation of a previously approved topic. Consent of instructor
required. Instructor: Staff. One course.
494. Research Independent Study. R Individual research and reading of the primary literature in a field of special
interest, under the supervision of a faculty member, the major product of which is a substantive paper or written
report containing significant analysis and interpretation of a previously approved topic. Consent of instructor
required. Instructor: Staff. One course.
523S. Computational Immunology. One course. C-L: see Computational Biology and Bioinformatics 523S
544. Principles of Immunology. NS, R An introduction to the molecular and cellular basis of the immune response.
Topics include anatomy of the lymphoid system, lymphocyte biology, antigen-antibody interactions, humoral and
cellular effector mechanisms, and control of immune responses. Prerequisites: Biology 220 or Biology 201L.
Instructors: Zhang and Immunology Faculty. One course. C-L: Biology 515
658. Structural Biochemistry I. Half course. C-L: see Biochemistry 658; also C-L: Cell and Molecular Biology
658, Cell Biology 658, University Program in Genetics 658, Structural Biology and Biophysics 658, Computational
Biology and Bioinformatics 658
659. Structural Biochemistry II. Half course. C-L: see Biochemistry 659; also C-L: Cell Biology 659,
Computational Biology and Bioinformatics 659, Structural Biology and Biophysics 659, University Program in
Genetics 659
668. Biochemical Genetics II: From RNA to Protein. Half course. C-L: see Biochemistry 668; also C-L: Cell
Biology 668, University Program in Genetics 668
MOLECULAR GENETICS AND MICROBIOLOGY (MGM)
521. Computational Gene Expression Analysis. QS C-L: see Computational Biology and Bioinformatics 521; also
C-L: Statistical Science 505
522. Critical Readings in Genetics and Genomics. One course. C-L: University Program in Genetics 522
552. Virology. Molecular biology of mammalian viruses, with emphasis on mechanisms of replication, virus-host
interactions, viral pathogenicity, and the relationship of virus infection to neoplasia. Instructor: Cullen and staff. One
course.
582. Microbial Pathogenesis. Modern molecular genetic approaches to understanding the pathogenic bacteria and
fungi. Underlying mechanisms of pathogenesis and host-parasite relationships that contribute to the infectious
disease process. Instructor: McCusker, Abraham, and staff. One course.
593. Research Independent Study. R Independent research in Molecular Genetics and Microbiology. Instructor:
Staff. One course.
NEUROBIOLOGY (NEUROBIO)
193FS. Neurobiology of Mind. NS Introduction to the fundamental principles of brain organization and
mechanisms. Open only to students in the Focus Program. Instructor: Hall. One course. C-L: Psychology 193FS,
Neuroscience 193FS
195FS. Neuroeconomics: The Neurobiology of Decision Making. NS, SS Emerging ideas in neuroeconomics
research. Topics include basic structural and functional organization of the brain, strengths and limitations of
techniques in neuroscience, introduction of concepts from economics into neuroscience, and impact of neuroscience
on economics models. Open only to students in the Focus Program. Instructor: Huettel. One course. C-L:
Neuroscience 195FS
198S. The Origin of Species. A chapter-by-chapter discussion and analysis of Charles Darwin's The Origin of
Species (1859). Permission of instructor required. Instructor: Hall. Half course.
393. Research Independent Study. R Individual research and reading of the primary literature in a field of special
interest, under the supervision of a faculty member, the major product of which is a substantive paper or written
report containing significant analysis and interpretation of a previously approved topic. Consent of instructor
required. Instructor: Staff. One course.
541. Introduction to Theoretical Neuroscience. NS, QS Mathematical introduction to the biophysics and circuits
underlying biological and neural computation. Topics covered include neural coding at single cell and population
level. Reverse correlation and kernel estimation, coordinate transformations, Bayesian decoding and information
Proof for the 2012-2013 Duke University Bulletin of Undergraduate Instruction, p. 4
RETURN PROOF BY MAY 25th to sarah.kibler@duke.edu
__________________________________________________________________________
theory. Introduction to Hodgkin-Huxley and other related models of neural excitability. Phase-plane analysis of
single and coupled neural oscillators. Models of synaptic transmission and plasticity. Biophysical basis of working
memory. Hopfield and related models of long term memory. Stochastic chemical reactions in small volumes.
Biochemical computation in single cells. Instructor: Raghavachari. One course.
557. Vision. Understanding the machinery of vision and its perceptual consequences. How we see brightness, color,
form, motion, depth; the integration of visual and auditory information to generate unified multimodal
representations; using vision to probe cognitive aspects of brain function; exploring visual aesthetics. The course is
designed for advanced undergraduates and beginning graduate students. Instructor: Fitzpatrick and Purves. One
course.
559. The Biological Basis of Music. Examine how and why we hear what we do, from intra-species communication
to music. Consider the biological basis of music, in particular the relationship between music and speech.
Comparison between the operating principles of the auditory system with what is presently known about vision.
Limited inquiry into the neurobiology of aesthetics. Instructor: Purves. One course. C-L: Philosophy 559,
Psychology 580
PATHOLOGY (PATHOL)
201T. Tutorial in Sports and Medicine. Reading course focusing on a series of books highlighting the relationship
between sports and medicine. Substantial analytical paper required to be submitted at the end of the semester.
Consent of instructor required. Instructor: Friedman. One course.
202T. Tutorial in Human Disease. Reading course focusing on a series of books highlighting different areas of
medicine. Substantial analytical paper required to be submitted at the end of semester. Consent of instructor
required. Instructor: Friedman. One course.
293. Research Independent Study. R Individual research and reading of the primary literature in a field of special
interest, under the supervision of a faculty member, the major product of which is a substantive written report or oral
presentation containing significant analysis and interpretation of a previously approved topic. Consent of instructor
required. Instructor: Staff. One course.
PHARMACOLOGY AND CANCER BIOLOGY (PHARM)
190FS. Chemistry of the Brain: Sex, Eating, and Addiction. NS, R The neurochemistry of the brain. The basic
mechanisms, focus on how the brain causes three kinds of behavior: sex, eating, and addiction. Topics such as, how
drugs affect the brain, why people get fat, and why anorectic drugs not work over the long run. The neurobiological
basis of sexual behavior and sexual differentiation of the brain. Different models of addiction: i.e. a neurochemical
adaptation in the brain, a disease, or a moral weakness. Open only to students in the Focus Program. Instructor:
Kuhn. One course.
293. Research Independent Study in Science Education. R Individual research in a field of science education
(with reference to pharmacology) at the precollege level, under the supervision of a faculty member, resulting in a
substantive paper or written report containing significant analysis and interpretation of study results. Open to
(juniors and seniors) with consent of supervising instructor. Prerequisite: Biology 25L; Chemistry 21L or 23L.
Instructor: Schwartz-Bloom. One course.
294. Research Independent Study in Science Education. R Continuation of Pharmacology 293. Open to juniors
and seniors with consent of supervising instructor. Prerequisites: Biology 25L; Chemistry 21L or 23L;
Pharmacology 293. Consent of instructor required. Instructor: Schwartz-Bloom. One course.
350. Pharmacology: Drug Actions and Reactions. Mechanisms of drug action, concepts of drug toxicity,
resistance, tolerance, and drug interactions. Examples of how drugs affect the autonomic and central nervous
systems, the cardiovascular and endocrine systems, and how drugs treat infection and cancer. This course is
designed for both science and nonscience majors, but preference will be given to junior biology majors
concentrating in pharmacology. Prerequisite: introductory biology (Biology 25L) and chemistry (Chemistry 11L,
12L). Instructor: Schwartz-Bloom. One course. C-L: Neuroscience 350
360. Drugs, Brain, and Behavior (B). NS Mechanisms by which psychoactive drugs act. Changes that occur with
chronic use of drugs; drug abuse and dependence. Social and legal implications of psychoactive drugs. Designed for
both science and nonscience majors. Emphasis on the reasoning, research designs, and methods for understanding
drug effects. Prerequisite: introductory biology (Biology 25L) and chemistry (Chemistry 11L, 12L). Instructor:
Kuhn. One course. C-L: Psychology 274, Neuroscience 360
370S. Pharmacogenomics and Personalized Medicine. NS Introduction to human genetic and genomics and how
the topics relate to modern medicine and treatment. Special emphasis placed on principles of human genomics
Proof for the 2012-2013 Duke University Bulletin of Undergraduate Instruction, p. 5
RETURN PROOF BY MAY 25th to sarah.kibler@duke.edu
__________________________________________________________________________
(including human genome organization, complex disease and large scale genomic analysis) and how they relate to
the field of translational genomics (bridging human genetics to drug design). Discussion of ethical and societal
issues concerning personalized medicine as well as future implications to modern health care. Current journal
articles highlighting new genomic treatments will be presented and discussed. Prerequisite: Biology 201L.
Instructor: Staff. One course.
393. Research Independent Study. R Individual research in a pharmacology-related area under the supervision of a
faculty member, resulting in a substantive paper or written report containing significant analysis and interpretation
of the study results. Open to first-year students and sophomores with consent of supervising instructor. Instructor:
Staff. One course.
394. Research Independent Study. R Individual research in a pharmacology-related area under the supervision of a
faculty member, resulting in a substantive paper or written report containing significant analysis and interpretation
of the study results. Open to first-year students and sophomores with consent of supervising instructor. Instructor:
Staff. One course.
471S. Reward and Addiction (B). NS One course. C-L: see Psychology 471S; also C-L: Neuroscience 471S
493. Research Independent Study. R Individual research in a pharmacology-related area under the supervision of a
faculty member, resulting in a substantive paper or written report containing significant analysis and interpretation
of the study results. Open to juniors and seniors with consent of supervising instructor. Instructor: Staff. Variable
credit.
494. Research Independent Study. R Individual research in a pharmacology-related area under the supervision of a
faculty member, resulting in a substantive paper or written report containing significant analysis and interpretation
of the study results. Open to juniors and seniors with consent of supervising instructor. Instructor: Staff. One course.
495. Research Independent Study. R Individual research in a pharmacology-related area under the supervision of a
faculty member, resulting in a substantive paper or written report containing significant analysis and interpretation
of the study results. Open to juniors and seniors who have already taken Pharmacology 493 and 494, with consent of
supervising instructor. Instructor: Staff. One course.
533. Essentials of Pharmacology and Toxicology. Drug absorption, distribution, excretion, and metabolism.
Structure and activity relationships; drug and hormone receptors and target cell responses. Consent of instructor
required. Prerequisite: introductory biology; Chemistry 201DL; Mathematics 21 and 122. Instructor: Slotkin and
staff. One course. C-L: Neuroscience 533
534. Interdisciplinary Approach to Pharmacology. Several model systems (cancer, immunological disorders, and
infectious diseases) will be used to explore the molecular, biochemical, and physiological basis of drug action.
Consent of instructor required. Instructors: Rathmell, Wang, or Whorton. One course.
535. Interdisciplinary Approaches to Pharmacology Part II. NS Several model systems (CNS, cardiovascular,
and infectious diseases) will be used to explore the molecular biochemical, and physiological basis of drug action.
Consent of instructor required. Instructor: Whorton. One course.
554. Mammalian Toxicology. Principles of toxicology as related to humans. Emphasis on the molecular basis for
toxicity of chemical and physical agents. Subjects include metabolism and toxicokinetics, toxicologic evaluation,
toxic agents, target organs, toxic effects, environmental toxicity, management of poisoning, epidemiology, risk
assessment, and regulatory toxicology, Prerequisite: introductory biology, and Chemistry 201DL, or consent of
instructor. Instructor: Abou-Donia and staff. One course.
673S. Computer Models and the Treatment of Psychiatric Disorders. NS, QS One course. C-L: see Psychology
673S; also C-L: Computer Science 673S, Information Science and Information Studies 673S
693. Research Independent Study in Science Education. R Individual research in a field of science education
(with reference to pharmacology) at the precollege/college level, under the supervision of a faculty member,
resulting in a substantive paper or written report containing significant analysis and interpretation of study results.
Open to all qualified seniors and graduate students with consent of supervising instructor. Instructor: SchwartzBloom. One course.
694. Research Independent Study in Science Education. R Individual research in a field of science education
(with reference to pharmacology) at the precollege/college level, under the supervision of a faculty member,
resulting in a substantive paper or written report containing significant analysis and interpretation of study results.
Open to all qualified seniors and graduate students with consent of supervising instructor. Instructor: SchwartzBloom. One course.
Proof for the 2012-2013 Duke University Bulletin of Undergraduate Instruction, p. 6
RETURN PROOF BY MAY 25th to sarah.kibler@duke.edu
__________________________________________________________________________
STRUCTURAL BIOLOGY AND BIOPHYSICS (SBB)
622. Structure of Biological Macromolecules. R One course. C-L: see Biochemistry 622; also C-L: Computational
Biology and Bioinformatics 622
659. Structural Biochemistry II. Half course. C-L: see Biochemistry 659; also C-L: Cell Biology 659,
Immunology 659, Computational Biology and Bioinformatics 659, University Program in Genetics 659