NUS Institutional Animal Care and Use Committee
000/15
Date revised: Jun 2015
Form expiry date: 31 Dec 2015
Appendix 1
Changes in animal species / strains* / type**
* Including change in genetically modified animals and mutants
**Example of change in type: from female to pregnant female, adult to newborn
Check the appropriate box(es) and complete only the relevant Section(s).
1. Removing species/strains/types from the study
2. Replacing the species/strains/types of approved protocol
3. Adding new species/strains/types to approved protocol
Complete the relevant section(s) applicable.
Attach Procedure C form if the new species/strains are genetically modified animals and the
source is not from your own breeding protocol.
1. Removing species/strains/types from the study
1.1
Name the species/strains/types to be deleted:
1.2
Explain why the change is required:
2. Replacing the species/strains/types of approved protocol
2.1
Identify the new species/strains/types required and the species/strains/types
to be replaced.
Attach Procedure C form if the new species/strains are genetically modified animals and the
source is not from your own breeding protocol.
2.2
Explain why the change is required and justify the choice of the new
species/strains/types.
2.3
Will there be any change in the approved animal numbers?
Yes. Some of the approved species/strains/types have been used. Complete Appendix 2
No. Animals to be replaced have not been used (or provide explanation below):
2.4
Continue to complete Section 4 below.
3. Adding new species/strains/types to approved protocol
3.1
Name the new species/strains/types to be added (please use proper
nomenclature). Complete Appendix 2 for the number of animals that will be
used for each species / strain / type.
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NUS Institutional Animal Care and Use Committee
000/15
Attach Procedure C form if the new species/strains are genetically modified animals and the
source is not from your own breeding protocol.
3.2
Explain why the new species/strains/types are required.
3.3
Will there be any change in procedure?
Yes. Please complete Appendix 3
No. Please answer the following:
If you are adding new species/strains/types without changing the procedure, please
justify the need to conduct the same experiment in multiple species/strains/types.
3.4
Continue to complete Section 4 below.
4. Scientific justification and other information for new species / strains
/ types requested
4.1
Is there any change in the animal housing and use location?
Yes. Please complete Appendix 5.
No. Please indicate the housing location:
4.2
Source of animals
Please note that CM and/or IACUC have to be informed prior to any movement of animals into
or out of NUS, including research laboratories (e.g., importation, transfer from another
institution, delivery by local suppliers to the labs, etc).
Sources obtained through CM. Species/strains:
My own approved breeding protocol No:
Species/stains:
Other PI’s approved breeding protocol No:
Species/stains:
Other sources obtained directly by PI. (Only for species caught from the wild by
researches. All laboratory animals including fish and frog should be obtained through
CM)
Please indicate the species/strains and source, including the names and addresses of
the suppliers, if applicable:
4.3
Describe other features of the species (e.g., anatomic, physiologic, genetic,
etc) that make it desirable for this model.
5. Occupational Health and Safety
Please note that OSHE requires Principal Investigator to submit an Amendment to Risk Assessment
if there are significant changes in the protocol, practices, material, personnel or environment that
would require additional risk controls.
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NUS Institutional Animal Care and Use Committee
5.1
000/15
Have you submitted an amendment of risk assessment to OSHE for the above
changes in animal species / strains / type?
Yes, approved. The approved Risk Assessment Amendment number (e.g., FOXo-123R1) is:
Yes, submitted. The amendment of the approved Risk Assessment (No:
submitted to OSHE. .
) has been
No, amendment of the Risk Assessment is not required. Please explain:
(e.g., change in strains but not species; change in rodent species (mouse and rat)
only)
-- End of Appendix 1 --
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Appendix 1