1
Supplemental File 1:
Detailed information for ‘Newly matched genes from association studies’:
The ‘newly matched genes’ (n=23) are listed under ‘Genes from association
studies’ in Table 1, together with the ‘initially matched’ genes. Here we provide
more detailed information and references that document how these ‘newly
matched genes’ were selected and matched to the criteria. Gene symbol and full
gene name are provided along with two studies defining the association with
schizophrenia. Then detailed information on the match based on the four criteria
is provided along with key reference papers. References related to this
Supplement are listed in alphabetical order.
2
Supplemental Table 1:
Association
Studies for
Schizophrenia
Yang et al., 2008;
Zhao et al., 2007
Criteria
Comments
References for
Criteria
VASC
Endothelial cell
tubulogenesis,
inflammation induced
angiogenesis
Claudin 5
Wei and
Hemmings, 2005;
Ye et al., 2005
VASC
DPYSL2
Dihydropyrimidinase-like 2
LIT
EGF
Epidermal growth
factor
GABRA1
Gamma-amino
butyric receptor,
alpha-1
Gamma-amino
butyric receptor,
beta-2
Glutamate
receptor,
ionotropic,
kainate 3
Melaninconcentrating
hormone receptor
Neurogenin 1
Hong et al., 2005;
Nakata et al.,
2003
Antilla et al.,
2004; Haenninen
et al., 2007
Ikeda et al.,
2005; Petryshen
et al., 2005
Betcheva et al.,
2009; Lo et al.,
2007
Begni et al.,
2002; Djurovic et
al., 2009
Expressed in brain
vasculature, bloodbrain barrier function,
angiogenesis
Hypoxia-ischemia in the
neonatal mouse brain
Malinda et al.,
1999;
Rathcke and
Vestergaard,
2006
Koto et al.,
2007
Gene
Symbol
Gene Name
CHI3LI
Chitinase-3 like 1
CLDN5
GABRB2
GRIK3
MCHR1
NEUROG1
NOS1
Nitric oxide
synthetase 1
NPY
Neuropeptide Y
OLIG2
Oligodendrocyte
lineage
transcription
factor 2
Phosphodiesterase 4B
PDE4B
PLA2G4A
Phospholipase
A2, group IVA
PLXNA2
Plexin A2
Zhou Y. et al.,
2008
LIT
Upregulated after brain
ischemia
Naylor et al.,
2005
IHR
gene
Moderate ischemia
Liverman et al.,
2004
IHR
gene
Focal brain ischemia
Lu et al., 2004
IHR
gene
Focal brain ischemia
Lu et al., 2004
Severinsen et al.,
2006; Miller et
al., 2009
Fanous et al.,
2007; Ho et al.,
2008
O’Donovan et al.,
2008; Reif et al.,
2006
Hall et al., 2007;
Doi et al. 2007
IHR
gene
Ischemia study
Bernaudin et
al., 2002
LIT
Expressed in progenitor
cells after brain
ischemia
Widely studied in brain
ischemia
Tonchev et al.,
2006
VASC
Multiple vascular
functions
Georgieva et al.,
2006; Huang et
al., 2008
LIT
Focal brain ischemia
ZukowskaGrojec et al.,
1998
Buffo et al.,
2005
Fatemi et al.,
2008; Kaehler et
al., 2009
Hudson et al.,
1996; Pae et al.,
2004
Mah et al., 2006;
Takeshita et al.,
2008
IHR
gene
Focal brain ischemia
Lu et al., 2003
IHR
gene
Global brain ischemia
Yabukov et al.,
2004
VASC
Neuropilin coreceptor
expressed in arteries
Herzog et al.,
2005
IHR
gene
Lu et al., 2004
3
PPP3CC
SNAP25
Protein
phosphatase 3,
catalytic subunit,
gamma isoform
Synaptosomalassociated
protein, 25-kD
Horiuchi et al.,
2007; Liu et al.,
2007
LIT
Regulated by hypoxia
Zhou D. et al.,
2008
Carroll et al.,
2009;
Kawashima et al.,
2008
Morita et al.,
2007; Yamada et
al., 2005
Chen et al., 2004;
Saviouk et al.,
2007
Ni et al., 2005;
Yang et al., 2004
IHR
gene
Focal brain ischemia
Raghavendra
Rao et al.,
2002
LIT
Delayed decrease after
brain ischemia
Wang and Zu,
2004
IHR
gene
Focal brain ischemia
Lu et al., 2004
IHR
gene
Focal and global brain
ischemia
Lu et al., 2004;
Yakubov et al.,
2004
Stenzel-Poor et
al., 2003
SRR
Serine racemase
SYN2
Synapsin II
TP53
Tumor protein
p53
UFD1L
Ubiquitin fusion
degradation 1like
X box-binding
protein 1
De Luca et al.,
2001; Xie et al.,
2008
Chen et al., 2004;
Kakiuchi et al.,
2004
IHR
gene
Focal brain ischemia
LIT
Tyrosine 3monooxygenase/
tryptophan 5monooxygenase
activation protein,
epsilon isoform
Wong et al.,
2005; Ikeda et
al., 2008
IHR
gene
Regulation of
endoplasmic reticulum
stress after brain
ischemia
Focal brain ischemia
XBP1
YWHAE
Abbreviations: HIF = related to HIF-1 pathway; IHR gene = ischemiahypoxia response gene from database; LIT = individual reference
documenting a link to ischemia-hypoxia response; VASC = vascular
factor.
Paschen et al.,
2003
Kim et al., 2004
4
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