Cape Breton University
Animal Use Protocol
ANIMAL CARE COMMITTEE
Schedule 12 - BREEDING COLONIES/GENETICALLY MODIFIED ANIMALS
Section I.
Species:
Strain:
Source of Animals (please specify if derived on site, donated, purchased from commercial
supplier, etc.):
yes [ ] no [ ]
Are the animals being used as part of a breeding colony?
An affirmative answer requires the completion of Section II.
yes [ ] no [ ]
Are these animals genetically modified?
An affirmative answer requires the completion of Section III.
yes [ ] no [ ]
Is biological containment required?
An affirmative answer requires the completion of Section IV.
Section II.
(a) Are the animals available from a commercial supplier?
yes [ ] no [ ]
If yes, why is it necessary to breed animals at Cape Breton University?
(b) Name of person managing the colony:
Telephone Number
FAX
E-Mail
(c) Approximately how many female breeders will be needed in one year?
(d) Approximately how many male breeders will be needed in one year?
(e) Approximately how many offspring will be produced in one year?
(f) How does this relate to your anticipated use?
(g) If more animals are produced than required for your experimental protocol(s), what
happens to the excess animals?
(h) Will the animals produced be used in protocols other than this one? yes [ ] no [ ]
If yes, list all the protocols:
Section III.
(a) List and describe the genetic alterations to be induced or which have been characterized in
the animal model you are using.
(b) What known traits will affect breeding and/or lifespan?
(c) Describe the expected phenotypic expression of the alterations.
(d) If morbidity develops due to genetic alteration, please describe steps to be taken to reduce
pain and distress to the animals.
(e) What criteria will be used for early removal from the study or euthanasia of animals?
Section IV.
(a) State reasons and level of containment.
(b) Describe containment and security procedures.
(c) How will a breach of containment be dealt with?
(d) Will there be any risks to human health, wild populations or the environment if
containment fails?