NAME
Wei Jia
BIOGRAPHICAL SKETCH
Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2.
Follow this format for each person. DO NOT EXCEED FOUR PAGES.
POSITION TITLE
Professor eRA COMMONS USER NAME (credential, e.g., agency login) weijia
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)
INSTITUTION AND LOCATION
Jiangnan University
DEGREE
(if applicable)
B.Sc.
YEAR(s)
1982-1986
FIELD OF STUDY
Analytical Chemistry
University of Missouri - Columbia M.S. 1989-1991 Radiopharmaceutical Chemistry
University of Missouri - Columbia Ph.D. 1992-1996 Radiopharmaceutical Chemistry
A. Positions and Honors:
1992-1994
1994-1996
Senior Project Specialist, University of Missouri Research Reactor Center.
Research Chemist, University of Missouri Research Reactor Center.
1996-1999
1999-2001
2001-2002
Senior Research Scientist, BEST Industries, Virginia.
Chief Scientific Officer, China Walfen Medical Company Limited., Hong Kong.
Professor, Natural Medicine Research Group, Associated Dean, School of Pharmaceutical
Science, Tianjin University, China.
2002-2008
2008-
Professor, Natural Medicine Research Group, Associated Dean, School of Pharmacy,
Shanghai Jiao Tong University, China.
Professor, Department of Nutrition, University of North Carolina at Greensboro, and
Co-Director, UNCG Center for Research Excellence in Bioactive Food Components.
Professional Activities:
Member, Editorial Board, Journal of Ethnopharmacology, 2007-present.
Member, Editorial Board, Chromatography, 2007-present.
Associate Editor, Chinese Medicine, 2007 – present.
Member, Editorial Board, Chinese Journal of Natural Medicine, 2004-present.
Member, Editorial Board, Journal of Chinese Materia Medica, 2002- present.
Member, Editorial Board, Chinese Traditional and Herbal Drugs, 2002 – present.
B. Selected publications from a total of over 130 peer-reviewed publications.
1. Jurisson, S., Berning, D., Jia, W.
, Ma, D. Coordination Compounds in Nuclear Medicine. Chem. Rev. 93, 3,
1137-1156, 1993.
2. Zhao, A., Xu, Z., Jia, W.
Immunosuppressive ent-Kaurene Diterpenoids from Isodon serra, Verlag Helv.
Chim. Acta Vol. 87, 3160-3166, 2004.
3. Chen, M., Zhao, L., Jia, W.
Metabonomic study on the biochemical profiles of a hydrocortisone induced animal model, J. Proteome Res. 4, (6) 2391-2396, 2005.
4. Zhang, Y., Liu, J., Jia, W.
, Zhao, A., Li, T., Distinct immunosuppressive effect by Isodon serra extracts. Int.
Immunopharm. 5, 1957-1965, 2005.
5. Chen, M., Su, M., Zhao, L., Cheng, J., Lai, Y., Liu, Y., Jia, W.
Metabonomic Study of Aristolochic Acid
Induced Nephrotoxicity in Rats, J. Proteome Res.
5, 4, 995-1002, 2006.

6. Ni, Y., Su, M., Qiu, Y., Chen, M., Liu, Y., Jia, W.
Metabolic profiling using combined GC-MS and LC-MS provides a systems understanding of aristolochic acid-induced nephrotoxicity in rat, FEBS Lett.
581, 4, 707-711, 2007.
7. Wang, X., Su, M., Qiu, Y., Ni, Y., Zhao, T., Zhou, M., Zhao, A., Yang, S., Jia, W.
Metabolic Regulatory
Network Alterations in Response to Acute Cold Stress and Ginsenoside Intervention, J. Proteome Res. 6
(9), 3449-3455, 2007.
8. Li, H., Ni, Y., Su, M., Qiu, Y., Zhou, M., Qiu, M., Zhao, A., Zhao, L., Jia, W.
Pharmaco-metabonomic phenotying reveals different responses to xenobiotic intervention in rats, J. Proteome Res. 6 (4) 1364-1370,
2007.
9. Qiu, Y., Su, M., Liu, Y., Chen, M., Gu, J., Zhang, J., Jia, W.
A GC-MS Based Analytical Method with ECF
Derivatization for Metabonomic Profiling, Anal. Chim. Acta 583, 277-283, 2007.
10. Wang, X., Zhao, T., Gao, X., Dan, M., Zhou, M., Jia, W.
Simultaneous Determination of Seventeen
Ginsenosides in Rat Urine by Ultra Performance Liquid Chromatography-mass Spectrometry with
Solid-phase Extraction, Anal. Chim. Acta 594, 265-273, 2007.
11. Xie, G., Su, M., Li, P., Gu, X., Yan, C., Qiu, Y., Jia, W.
Analysis of Urinary Metabolites for Metabolomic
Study by Pressurized Capillary Electrochromatography, Electrophoresis 28, 4459 － 4468, 2007.
12. Ni, Y., Su, M., Lin, J., Wang, X., Qiu, Y., Zhao, A., Chen, T., Jia, W.
Metabolic profiling reveals disorder of amino acid metabolism in various brain regions from a rat model of chronic unpredictable mild stress, FEBS
Lett. Vol. 582 (17), 2627-2636, 2008.
13. Jia, W.
, Li, H., Zhao, L., Nicholson, J.K. Gut microbiota: a potential new territory for drug targeting, Nat. Rev.
Drug Discov. Vol 7, 123-131, 2008.
14. Shen, Q., Li, X., Qiu, Y., Su, M., Liu, Y., Li, H., Wang, X., Zou, X., Yan, C., Yu, L., Li, S., Wan, C., He, L., Jia ,
W.
Metabonomic and Metallomic Profiling in the Amniotic Fluid of Malnourished Pregnant Rats, J. Proteome
Res. 7(5), 2151-2157, 2008.
15. Chen, M., Ni, Y., Duan, H., Qiu, Y., Guo, C., Jiao, Y., Shi, H., Su, M., Jia, W.
Mass Spectrometry-based
Metabolic Profiling of Rat Urine Associated with General Toxicity Induced by Multiglycoside of Tripterygium
Wilfordii Hook. F., Chem. Res. Toxicol. 21: 288-294, 2008.
16. Li, H., Xie, Z., Lin, J., Song, H., Wang, Q., Wang, K., Su, M., Qiu, Y., Zhao, T., Song, K., Wang, X., Zhou, M.,
Liu, P., Zhao, G., Zhang, Q., Jia, W.
Transcriptomic and metabonomic profiling of obesity-Prone and obesity-resistant rats under high fat diet, J. Proteome Res. 7(11), 4775-4783, 2008.
17. Xie, G., Ni, Y., Su, M., Zhang, Y., Zhao, A., Gao, X., Liu, Z., Long, X., Jia, W.
Application of ultra- performance LC-TOF MS metabolite profiling techniques to the analysis of medicinal Panax herbs,
Metabolomics 4: 248-260, 2008.
18. Dan, M., Su, M., Gao, X., Zhao, T., Zhao, A., Xie, G., Qiu, Y., Zhou, M., Liu, Z., Jia, W.
Metabolite profiling of
Panax notoginseng using UPLC-ESI-MS, Phytochem. 69, 2237-2244, 2008 .
19. Lin, J., Su, M., Wang, X., Qiu, Y., Hao, J., Long, X., Zhou, M., Yan, C., Jia, W.
Comprehensive Profiling of
Hydrophilic Metabolites in Rat Brain Tissues Using Gas Chromatography/Mass Spectrometry, J. Sep. Sci.
31: 2831-2838, 2008.
20. Xie, G., Plumb, R., Su, M., Xu, Z. Zhao, A., Qiu, M., Long, X., Liu, Z., Jia, W.
Ultra-performance LC/TOF MS analysis of medicinal Panax herbs for metabolomic research, J. Sep. Sci. 31, 1015-1026, 2008.
21. Li, M., Wang, B., Zhang, M., Rantlainen, M., Wang, S., Zhou, H., Zhang, Y., Shen, J., Pang, X., Zhang, M.,
Wei, H., Chen, Y., Lu, H., Zuo, J., Su, M., Qiu, Y., Jia, W.
, Xiao, C., Smith, L. M., Holmes, E., Tang, H., Zhao,
G., Yang, S., Nicholson, J. K., Li, L., Zhao, L. Symbiotic gut microbes modulate human metabolic phenotypes, Proc. Natl. Acad. Sci. USA. 105, 6, 2117-2122, 2008.

22. Bao, Y., Zhao, T., Wang, X., Qiu, Y., Su, M., Jia, W.
Metabonomic variations in the drug-treated type 2 diabetes mellitus patients and healthy volunteers, J. Proteome Res. Epub ahead of print, 2009.
C. Research Support:
Completed Research Support
Grant No. 2007CB914700: Jia, W. (Principal Investigator) 01/01/07-12/31/08
China National Key Basic Research Program (973), Chinese Ministry of Science and Technology
The Metabolomic Study of Metabolic Disorders ( ￥ 16,000,000.00)
The major goals of this project are to (1) establish metabolomic technology for clinical application, (2) determine the metabolic profile variations associated with obesity using metabolomic profiling approach, and (3) understand the alterations in key metabolic pathways involved in the development of obesity phenotypes.
Role: P.I.
Grant No. 2006DFA02700: Jia, W. (Principal Investigator) 01/01/06-12/31/08
International collaborative research project, China Ministry of Science and Technology
The Metabolism and Toxicological Study of FZHY Tablet for Liver Fibrosis ( ￥ 800,000.00)
The major goal of this project is to apply the metabolomic technology to the toxicological study of a State FDA approved drug product.
Role: P.I.
Grant No. 30572286: Jia, W. (Co- Investigator) 01/01/06 -12/31/08
National Science Foundation of China (NSFC)
The Metabolomic Study of Kidney Deficiency ( ￥ 250,000.00)
Role: Co-P.I.
Grant No. 06DZ19707: Jia, W. (Principal Investigator) 07/01/06-12/31/08
Shanghai Commission of Science and Technology
Development of Key Technology Platform for the Study of Traditional Chinese Medicine, Research Project for
Team of Excellence ( ￥ 2,500,000.00)
Role: P.I.
Grant No. T0301: Jia, W. (Principal Investigator) 07/01/05 -06/30/07
Key academic development project, Shanghai Educational Commission
The Systems Biology Research in TCM, Strategy and Methodology ( ￥ 12,000,000.00)
Role: P.I.
Grant No. 05DJ14009: Jia, W. (Principal Investigator) 10/01/05 – 09/30/07
Key Basic Research Project, Shanghai Commission of Science and Technology
The Metabolomic Study of Major Malignant Tumors in Shanghai Region ( ￥ 4,800,000.00)
The major goal of the research project was to initiate preliminary metabolic profiling study of two malignant tumors, liver and colorectal cancer, in Shanghai region, using mass spec-based analytical technology.
Role: P.I.

Grant No. 04DZ19843: Jia, W. (Principal Investigator) 10/01/04 – 09/30/06
Program for the modernization of traditional Chinese medicine, Shanghai Commission of Science and
Technology
Comprehensive Study of Four Traditional Chinese Herbal Medicines ( ￥ 1,790,000.00)
Role: P.I.
Grant No. 05DZ19733: Jia, W. (Co- Investigator) 10/01/05 – 09/30/07
Program for the modernization of traditional Chinese medicine, Shanghai Commission of Science and
Technology
Toxicological Study of Three Traditional Chinese Herbal Medicines ( ￥ 1,600,000.00)
Role: Co-P.I.