CURRICULUM VITAE JAMES S.K. SHAM, Ph.D. School of Medicine, Johns Hopkins University I. CURRENT APPOINTMENT: Associate Professor of Medicine, Department of Medicine, Johns Hopkins School of Medicine Associate Professor of Physiology (Joint Appointment), Division of Physiology, Department of Environmental Health Sciences, Johns Hopkins School of Hygiene and Public Health. II. PERSONAL DATA: Address: Division of Pulmonary and Critical Care Medicine The Johns Hopkins Asthma & Allergy Center 5501 Hopkins Bayview Circle Baltimore, MD21224 Phone: (410) 550-7751 (Office) (410) 550-5208 (Lab) Fax: (410) 550-2612 E-mail: jsks@welchlink.welch.jhu.edu III. EDUCATION AND TRAINING: 1977-1981 B.Sc., Department of Biology, Chinese University of Hong Kong. 1981-1983 M.Phil., Department of Biology, Chinese University of Hong Kong. 1984-1989 Ph.D., Division of Physiology, School of Hygiene and Public Health, Johns Hopkins University. 1989-1992 Postdoctoral fellow, Department of Physiology, University of Pennsylvania. IV. PROFESSIONAL EXPERIENCE: 1983-1984, Assistant Lecturer, Department of Physiology, Chinese University of Hong Kong. 1982,84,85, summer Visiting Scientist, Department of Pharmacology, Texas Tech University. 1986, summer Visiting Scientist, Department of Physiology, University of Alberta. 1992-2000, Assistant Professor, Division of Pulmonary and Critical Care Medicine, Department of Medicine, School of Medicine, Johns Hopkins University. 1996-2000, Guest researcher, Laboratory of Cardiovascular Science, National Institutes of Ageing. 1998- present, Joint appointment, Division of Physiology, School of Hygiene and Public Health, Johns Hopkins University. 2001- present, Associate Professor, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University. 2009-2011, Honorary Associate Professor, Department of Pharmacology and Pharmacy, University of Hong Kong. 2009- 2014, Guest Professor, Department of Physiology and Pathophysiology, Fujian Medical University, P.R. China. V. Recent Publications 1. Becker P.M., J. Waltenberger, R. Yachechko, T. Mirzapoiazova, J.S.K. Sham, J.A. Elias and A.D. Verin. Neuropilin-1 regulates vascular endothelial growth factor-mediated endothelial permeability. Circ Res. 96:1257-65, 2005. 2. Spencer C.I., and J.S.K. Sham. Mechanisms underlying the effects of pyrethroid, tefluthrin, on action potential duration in isolated rat ventricular mycocytes. J. Pharmacol. Exp. Ther. 315:16-23, 2005. 3. Liu J.Q., E. Erbynn, I.N. Zelko, J.S.K. Sham and R.J. Folz. Hypoxic pulmonary hypertension: Role of superoxide and NADPH oxidases (gp91phox). Am J Physiol Lung Cell Mol Physiol 290:L2-L10, 2006. 4. Yang, X.R., M.J. Lin, L.S. McIntosh, and J.S.K. Sham. Functional Expression of Transient Receptor Potential Melastatin- (TRPM) and Vanilloid-Related (TRPV) Channels in Pulmonary Arterial and Aortic Smooth Muscle. Am J Physiol Lung Cell Mol Physiol 290(6):L1267-76, 2006. 5. Cao, C.M., Yan W.Y., J. Liu, K.W.L. Kam, S.Z. Zhang, J.S.K. Sham, T.M. Wong. Attenuation of mitochondrial, but not cytosolic, Ca2+ overload reduces myocardial injury by ischemia and reperfusion. Acta Pharmcol. Sin. 27(7):911-918, 2006. 6. Umesh, A., M.A. Thompson, E.N. Chini, K.P. Yip, and J.S.K. Sham. Integrin ligands mobilize intracellular Ca2+ from ryanodine receptor gated stores and lysosome-related acidic organelles in rat pulmonary arterial smooth muscle cells. J. Biol. Chem. 281:34312-34323, 2006. 7. Lin, M.J., X.R. Yang, and J.S.K. Sham. Hydrogen peroxide induced Ca2+ mobilization in Pulmonary Arterial Smooth Muscle Cells. Am. J. Physiol. Am J Physiol Lung Cell Mol Physiol, 292(6):L1598-608, 2007. 8. Balasubramanian L., A. Ahmed, C.-M. Lo, J.S.K. Sham and K.P. Yip. Integrin-mediated mechanotransduction in renal vascular smooth muscle cells: activation of calcium sparks. 9. Am J Physiol Regul Integr Comp Physiol 293(4):R1586-94, 2007.Balasubramanian L., J.S.K. Sham and K.P. Yip. Calcium signaling in vasopressin induced aquaporin-2 trafficking. Pfluger Archive: European Journal of Physiology 456(4): 747-754, 2008.