(M/F)
Company : Specialized in the discovery and development of Nanobodies
®
Department: Pharmacology
Reporting to/hierarchy: Head of Bioanalytics and Immunogenicity
Our client is focused on the discovery and development of Nanobodies, a novel class of antibodyderived therapeutic proteins based on single-domain antibody fragments, for a range of serious lifethreatening human diseases. Our client is developing a portfolio of Nanobody-based therapeutic programs in a number of major disease areas, including inflammation, thrombosis, oncology and allergy. The unique properties of Nanobodies have allowed our client, and its partners, to pursue targets that are typically difficult to reach with conventional antibodies.
The Bioanalytics and Immunogenicity team mainly focuses on the pharmacokinetic and immunological assay development to support the preclinical and clinical development of the
Nanobodies.
Function details: The Scientific Team Leader will assess the immunogenicity of Nanobodies in preclinical and clinical setting, potentially supplemented with pharmacokinetic analysis of
Nanobodies including:
- development, optimization and validation of immunogenicity assays (ligand binding assays
(LBA), functional cellular assays such as neutralizing antibody assays)
- pharmacokinetic and immunogenicity analysis to support (pre)clinical studies in various species
- possibility to outsource assays to CRO’s (transfer and follow up).
In this role he/she will report to the pharmacology and multidisciplinary project team.
Expectations for this role include:
•
Design Immunogenicity Risk Assessment.
Page 1 of 3
ScienceCo BVBA
Jan Welterslaan 13
B-2100 Antwerpen (Deurne)
Tel. +32 2 400 75 10
Fax +32 2 400 75 13
Acknowledged office: VG.1345/B, W.RS.663, B-AB10.031
info@scienceco.eu www.scienceco.eu

•
Qualify and implement new methods and equipment.
•
Write and review development reports, validation plans/reports and procedures.
• Manage and technically guide a team of (senior) research associates.
Education and qualifications:
•
PhD (or master equivalent by experience) in (bio)chemistry, bio-engineering, pharmaceutical sciences… with minimum 3 years of experience preferably in a bio-therapeutic setting.
•
Strong background in immunology is a must.
• Technical expertise in cellular assays, ligand binding assay techniques (e.g. ELISA) and in assay development, optimization and assay validation.
•
Experience with bio-therapeutic immunogenicity assessment is strongly recommended
(experience with FDA, EMA, and regulatory submissions).
•
Experience in people and performance management.
•
Ability to work according to GLP guidelines is considered a plus.
Personality and mentality:
•
Highly quality oriented and accurate people manager.
•
Excellent communication skills with sense of initiative.
• Flexible and creative.
•
Team player, independent and self-motivated.
•
Driven by enthusiasm, commitment and dedication.
•
Sociable, ethical and trustworthy.
Languages: Fluent in English both oral and in writing. Dutch is a plus.
Mobility/travel: Limited travelling requirements.
Job specificities:
•
Full-time, permanent employment.
• Location: Flanders, Belgium.
•
Starting date: ASAP.
Offer:
• Compensation and title will depend on the level of experience.
•
Challenging job in a dynamic environment.
Page 2 of 3
ScienceCo BVBA
Jan Welterslaan 13
B-2100 Antwerpen (Deurne)
Tel. +32 2 400 75 10
Fax +32 2 400 75 13
Acknowledged office: VG.1345/B, W.RS.663, B-AB10.031
info@scienceco.eu www.scienceco.eu

•
Involvement in all the different areas of the research.
•
Help for visa and working license as well as help for house hunting can be discussed.
Available education/training: Possibilities for further education and training.
Career opportunities: Good career possibilities.
Interested?
You match the requested criteria for min. 90%?
Then send your application including publications and references to cv@scienceco.eu
, mentioning reference BE-R12JK
You have questions? Contact us, we are eager to help you! Tel.: +32 2 400 75 12
ScienceCo BVBA
Jan Welterslaan 13
B-2100 Antwerpen (Deurne)
Tel. +32 2 400 75 10
Fax +32 2 400 75 13
Acknowledged office: VG.1345/B, W.RS.663, B-AB10.031
Page 3 of 3 info@scienceco.eu www.scienceco.eu