Maeda et al. Supplementary Table 1 Clinical and Immuno-histochemical Characteristics of DLBCL Patients POKEMON expression Variable Patients – no. Mean age – yr Age >60 – no. Sex – no. Male Female AAb stage – no. I or II III or IV IPIc – no. Low Low-Intermediate High-Intermediate High BM involvement – no. Yes No LDHd level – no. Normal Eleveted BCL2 – no. Positive Negative CD10 – no. Positive Negative BCL6 – no. Positive Negative MUM1 – no. Positive Negative GCB phenotypee – no. Yes No Ki67 – no. Low High Nc Negative Positive ( Moderate Strong ) 130 129 129 129 41 57 21 89 54 34 52 55 20 37 53 14 29 12 53 35 33 18 20 17 15 17 37 29 20 20 17 9 5 9 5 8 16 12 11 8 11 9 6 5 5 3 5 3 6 27 8 56 4 34 4 22 7 22 22 27 17 14 5 13 12 20 36 39 19 23 17 16 13 20 21 55 15 27 6 28 16 21 43 37 23 23 20 14 6 28 31 40 16 26 15 14 18 15 30 44 19 23 11 21 19 13 36 38 24 15 12 23 98 P Valuef 0.18 0.34 0.54 74 0.46 97 0.54 78 0.08 107 0.40 109 0.27 117 0.43 105 0.02 107 0.20 106 0.29 a. Number of cases with complete data b. Clinical stage according to Ann Arbor classification1,2 c. International Prognostic Index3 d. Lactate dehydrogenase e. Germinal Center B cell like4 f. Statistical analyses were performed to see the correlation between POKEMON expression and the indicated valuables. P-value was generated by a chi-square test. Supplementary Table 2 Clinical and Immuno-histochemical Characteristics of FL Patients POKEMON expression Variable Patients – no. Mean age – yr Age >60 – no. Sex – no. Male Female Gradea – no. 1 2 3 BM involvement – no. Yes No t(14;18) Yes No BCL2 – no. Positive Negative BCL6 – no. Positive Negative CD10 – no. Positive Negative Ki67 – no. Low High Nc Negative Positive ( Moderate Strong ) 290 256 256 258 42 58 15 248 57 98 143 56 56 105 58 42 22 16 111 109 64 66 47 43 12 16 13 50 86 103 39 57 43 11 29 60 6 32 41 179 26 104 15 75 27 11 166 51 98 30 68 21 30 10 197 48 114 28 83 20 14 26 153 84 74 63 79 21 30 12 162 83 97 45 65 38 38 1 181 59 123 16 58 43 280 P Valueb 0.49 0.49 0.31 258 0.81 255 0.54 285 0.39 277 <0.001 287 0.59 279 0.003 a. Pathological grade was determined according to WHO classification5 b. Statistical analyses were performed to see the correlation between POKEMON expression and the indicated valuables. P-value was generated by a chi-square test. References 1. 2. 3. 4. 5. Benzel, J. E. International conference on leukemia-lymphoma. Ann Arbor, Michigan, October, 1967. Del Med J 40, 78-81 (1968). Carbone, P. P., Kaplan, H. S., Musshoff, K., Smithers, D. W. & Tubiana, M. Report of the Committee on Hodgkin's Disease Staging Classification. Cancer Res 31, 1860-1 (1971). A predictive model for aggressive non-Hodgkin's lymphoma. The International Non-Hodgkin's Lymphoma Prognostic Factors Project. N Engl J Med 329, 987-94 (1993). Hans, C. P. et al. Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray. Blood 103, 275-82 (2004). Jaffe ES, H. N., Stein H and Vardiman JW. Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues ( IARC Press, Lyon, France, 2001).