Disorders of Immunity, Module IIC, 4th year – Course Description
Assoc Prof. Petr Kucera. - Head of the Course
The course description: The course is about pathophysiology mechanisms of diseases either
originally from the error of immunity either diseases when errors of immunity can contribute.
Principles of immunopathology, typical basic symptoms, typical laboratory findings and basic, general
therapeutic approaches are discussed.
Requirements: The knowledge from the Module IB (Basic of Immunology of Cell) and Module IIA
(Immunopathology) is required. There is no room for extensive reviewing of these basics.
Structure: The course duration is 1 week; it consists from Seminars, Case studies discussions,
Practicum - demonstration of some clinical diagnostic procedures. Active participation of all students
is essential
Topics:
Introduction, immune system and human diseases. Immunology laboratory diagnostics, indication and
interpretation of laboratory tests.
Immunodeficiency primary and secondary
Autoimmune diseases organ nonspecific, systemic – rheumatic diseases, immunocomplex diseases,
vasculitis. Autoimmune diseases organ specific – endocrine, renal, GI, neuromuscular and
reproductive diseases. Immunology of solid organ and bone marrow transplantation. Tumor
immunology, Immunohematology and lymphoproliferation.
Allergy diseases and anaphylaxis, clinical tests in allergy. Basic principles of immunotherapy
Recommended resources, literature:
Medical Immunology. Parslow TG, Stites DP, Terr AI,. - 10th ed. - London: Mc Graw-Hill, 2001.
Essentials of Clinical Immunology, Chapel H, Haeney M et al. Blackwell Science, 5th ed. 2006
Primer on Allergic and Immunologic Diseases , Shearer WT, Li JT, J Allergy Clinical Immunology.
2003, 111, 2, Supplement.
Seminar paper:
Short review from the literature of about 4-5 pages, appropriate structure, formal aspects and
references (please start with the textbook, than Medline search and peer-reviewed journals fulltexts
from the PC at school are available (SVI). The paper can be written in pairs.
Topics are selected from the recommended areas. In special cases the student can discuss
different topic with the head of the course on the course beginning. The paper has to be about
immunology aspect of phenomenon, disease, diagnostics test or therapy. The seminar paper due is the
last day of the Course.
Recommended areas for paper:
Immunodeficiency primary (ID), humoral, combined, complement, phagocytic. Secondary ID. AIDS.
Therapy of ID. Autoimmune (AI) diseases – organ nonspecific –rheumatoid diseases. Organ specific
AI diseases – various types. Immune mediated infertility. Systemic vasculitis. Lymphoproliferation,
immune cytopenias, immunohematology diagnostics. Tumor immunotherapy. Immune aspects of
transplantation. Bronchial asthma, pollen allergy, food allergy, drug allergy. Specific allergen
immunotherapy, allergy to animals. Skin allergy diseases. Anaphylaxis, latex allergy, professional
asthma. Immunosuppressive therapy, therapeutic use of monoclonal antibodies.
Credit:
1. The student will briefly present key features of the paper to the teacher to demonstrate the ability
to discuss the topic of the paper.
2. Two questions from immunology, related to topics of the course
Terms and localization of credit examination will be posted on the board of Dept Immunology (near
Room 440 – secretary) few days after the course end.
Final exam Module IIC: The exam is commisional oral, on the basis of clinical cases. Immunology
will not necessary be examined.