Disorders of Immunity, Module IIC, 4th year, Academic year 2011/12
Assoc Prof. P. Kucera - Head of the Course
The course description: The course is about pathophysiology mechanisms of diseases either originally from the error
of immunity either diseases when errors of immunity can contribute. Principles of immunopathology, typical basic
symptoms, typical laboratory findings and basic, general therapeutic approaches are discussed.
Requirements: The knowledge from the Module IB (Basic of Immunology of Cell) and Module IIA
(Immunopathology) is required. There is no room for extensive reviewing of these basics.
Structure: The course duration is 1 week; it consists from Seminars, Case studies discussions, Practicum demonstration of some clinical diagnostic procedures. Active participation of all students is essential
Topics:
Introduction, immune system and human diseases.
Immunology laboratory diagnostics, indication and interpretation of laboratory tests
Immunodeficiency primary and secondary
Autoimmune diseases organ nonspecific – rheumatic diseases, immunocomplex diseases, vasculitis.
Autoimmune diseases organ specific – endocrine, renal, GI, neuromuscular and reproductive diseases
Allergy diseases and anaphylaxis
Immunology of transplantation. Tumor immunology
Immunohematology and lymphoproliferation.
Basic principles of immunotherapy
Recommended resources, literature:
Medical Immunology. Parslow TG, Stites DP, Terr AI,. - 10th ed. - London: Mc Graw-Hill, 2001.
Essentials of Clinical Immunology, Chapel H, Haeney M et al. Blackwell Science, 5th ed. 2006
Primer on Allergic and Immunologic Diseases , Shearer WT, Li JT, J Allergy Clinical Immunology. 2003, 111, 2,
Supplement.
Seminar paper:
Short review from the literature of about 4-5 pages, appropriate structure, formal aspects and references (please start
with the textbook, than Medline search and fulltexts from the PC at school are available (SVI). The paper can be
written in pairs.
Topics are selected from the recommended areas. In special cases the student can discuss different topic with
teachers of the course on the course beginning. The paper has to be about immunology aspect of phenomenon, disease,
diagnostics test or therapy. The seminar paper due is the last day of the Course.
Recommended areas for paper:
Immunodeficiency primary (ID), humoral, combined, complement, phagocytic. Secondary ID. AIDS. Therapy of ID.
Autoimmune (AI) diseases – organ nonspecific –rheumatoid diseases. Organ specific AI diseases – various types.
Immune mediated infertility. Systemic vasculitis. Lymphoproliferation, immune cytopenias, immunohematology
diagnostics. Tumor immunotherapy. Immune aspects of transplantation. Bronchial asthma, pollen allergy, food
allergy, drug allergy. Specific allergen immunotherapy, allergy to animals. Skin allergy diseases. Anaphylaxis, latex
allergy, professional asthma. Immunosuppressive therapy, therapeutic use of monoclonal antibodies.
Credit:
1. The student will briefly present key features of the paper to the teacher to demonstrate the ability to discuss the
topic of the paper.
2. One - two questions from topics of the course
Terms and localization of credit examination will be posted on the Board of Dept Immunology (near Room 440 –
secretary) approx. few days after the course end.
Final exam Module IIC: The exam is commisional oral, on the basis of clinical cases. Immunology will not
necessary be examined.
Dept Immunology, 3rd Faculty of Medicine, CHU
18.2.2016
Doc. Kučera