- 107- The Origin of Life and Heisenberg's Uncertainty Principle Stefan Tallqvist Technical Research Centre of Finland (VTT) Espoo Abstract Heisenberg's uncertainty principle denies the possibility of distinguishing two particles if the difference in the momentum multiplied by the difference in position is less than Planck's constant. The same principle is valid for the product of energy and time. The difference between living and dead protoplasm is an example of systems with the same chemistry but different energy states of the constituent particles. A prerequisite for the condition that lifeless matter would be converted to a living cell involves the assumption that a very large quantity of particles (molecules, protons and electrons) at a certain moment of time would have the well defined energies to take their positions in the constituents of a living cell. An attempt is made based on Heisenberg's principle to indicate that the summation of uncertainties of simultaneous well defined locations and velocities of the particle constituents of the living cell leads to a probability approaching zero. Therefore a spontaneous formation of a living cell from any available constituent raw material is impossible. It is concluded that a protoplasmic cell must have either evolved over a very long period of chemical evolution or derives from previous extraterrestrial life that has been implanted on Earth by some intelligent agent. The age of life on Earth will also be briefly discussed. 1. Introduction The question about the origin of life is still one of the great problems of sciences that is open to controversial views and explanations. A review of the development of conceptions and theories about the origin of life from ancient myths of creation to modem scientific views will be presented. The key - 108transitions (Table 1) summarise the principal phases in the history of ideas on the origin of life on Earth (Table l): Table 1: Key transitions in conceptions about the origin of Life Ancient times Folkloric and religious Myths of creation conceptions _______________________________________________________________________ ca. 1700 Metaphysical conceptions Spontaneous generation ca. 1854 Darwin's theory Biological evolution ca. 1866 Mendel's experiments Classical genetic theory ca. 1887 Pasteur's experiments Refutation of spontaneous generation ca. 1915 Protoplasmic theories Biochemical theories ca. 1911 Morgan's theory Chemical genetics ca. 1936 Oparin's theory Chemical and geological evolution ca. 1950 Miller's Experiments Synthesis of amino acids ca. 1956 Crick and Watson The genetic code All ancient cultures and tribal peoples have had their conceptions and stories of creation of man and the world. The idea of growth or evolution of mankind from animals was held by civilised man much earlier than we use to think. Today it is obvious that many concepts which have been found for example among the old Greeks are actually already found among the still older being, eg (McCabe 1931) :"Some years ago we found in the ruins of what seems to have been a school library in ancient Nippur a clay tablet which showed that the Sumerians had a version of the evolution of man from lower animals." As water and fat is the surrounding in the cell in which the chemical processes take place it might also be noted that a Sumerian physician was an expert on the use of water "a-zu", on the use of oil or fat "i-zu" or on the use of active chemicals from plants "u-zu" (Tallqvist 1943). (There is a slight resemblance in those old Sumerian words to one of the first CETI-projects called Ozma which was led by Frank D. Drake in 1960. Drake was interested in the story of the Wizard from Oz where Ozma was the ruler of the mythical land of Oz. (Gardner 1966) Before the 1860s, the question was primarily of philosophical and religious interest. The situation changed radically when Darwin's theory of evolution implicitly raised the question of life's beginnings within an historical perspective of life on Earth. The main classes of 19th-century theories on the origin of life that were proposed as a result will be discussed briefly. It will be argued that these latter theories, although in the mainstream of historical development, were limited by the protoplasmic theory of life on which they were based. -109The next important step was the formulation of theories founded on biochemistry and genetics, respectively, when the sciences began to flourish in the early decades of the 20th century. A major landmark during this phase was the publication in 1936 of Oparin's classic theory of the origin of life. Oparins theory, with its strong roots in biochemistry, laid the experimental approaches that have characterised the field since the 1950s. Theories based strictly on a genetic interpretation of life had a somewhat later impact on experimental work relating to the problem. The first macroscopic animals, known as the Ediacaran fauna, did not appear until the end of the Proterozoic eon, some 85 percent of the way through the Earth's history. By sifting through ancient sediments, we have sought to understand the nature of life just before the Ediacaran animals appear in the fossil record and to identify environmental factors that may explain the timing of their appearance. We now know that the Ediacaran radiation was indeed abrupt and that the geologic floor to the animal fossil record is both real and sharp! The most recent eon is the Phanerozoic, which began with the expansion of skeleton-forming organisms 540 million years ago and continues to the present day. (Knoll 1991) The previously documented interdependency of inorganic and living worlds is consistent with the view that life is an important parameter in planetary evolution. According to the GAIA hypothesis life also regulates the terrestrial exogenic system for its own benefit. Life is also constrained by limits imposed by the interdependent populations. In the first instance, the development of a suitable planetary system is controlled by vagaries of stellar evolution. Secondly, geological evidence from this planet points out that tectonism, the hydrosphere and the atmosphere control the biosphere and to some extent vice versa. Hence, early this century, the view that vital processes are the outcome of the properties of a single substance became untenable and the question of the origin of life had to be reformulated. What had to be explained was the origin of systems composed of many different molecules acting in a concerted way to effect various vital functions. Not surprisingly, most biochemists at the time avoided this complex question. (Ferris 1988) 2. Conceptions about the Origin of Life in Darwin's Time The following lines of wisdom appear as the introductory words to Charles Darwin's book 7he Origin of Species By Means Of Natural Selection (Darwin 1928): But with regard to the material word, we can at least go so far as this - we can perceive that events are brought about not by -110insulated interpositions of Divine power, exerted in each particular case, but by establishment of general laws. Whewell, Bridgewater Treatise The only distinct meaning of the word "natural' is stated, fixed, or settled; since what is natural as much requires and presupposes an intelligent agent to render it so, i.e. to effect it continually or at stated times, as what is supernatural or miraculous does to effect it for once. Butler, Analogy of Revealed Religion. To conclude, therefore, let no man out of a weak conceit of sobriety, or an ill-applied moderation, think or maintain, that a man can search too far or be too well studied in the book of God's word, or in the book of God's works; divinity or philosophy; but rather let men endeavour an endless progress or proficiences in both. Bacon, Advancement of Learning. Such statements were typical for Darwin's time and when a scientific work is the result of one man's lifetime the statements are on their right place. It would certainly not decrease the quality of scientific papers even today if some more time were spent in the preparation of them and some philosophic wisdom would accompany them. In the concluding section of Darwin's work we find the following statements on the origin of life: "As Professor Asa Gray has remarked, the spores and other reproductive bodies of many of the lower algae may claim to have first a characteristically animal, and then an unequivocally vegetable existence. Therefore, on the principle of natural selection with divergence of character, it does not seem incredible that, from some such low and intermediate form, both animals and plants may have been developed; and, if we admit this, we must likewise admit that all the organic beings which have ever lived on this Earth may be descended from some one primordial form." "Hence we may look with some confidence to a secure future of great length. And as natural selection works solely by and for the good of each being, all corporeal and mental endowments will tend to progress towards perfection." "There is grandeur in this view of life, with its several powers, having been originally breathed by the Creator into a few forms or into one; and that, whilst this planet has gone cycling on according to the fixed law of gravity, - 111 from so simple a beginning endless forms most beautiful and most wonderful have been, and are being evolved." 3. Arrhenius' Theory of Panspermia The Swedish chemist Svante Arrhenius (Arrhenius 1959) took a vivid interest in the investigation of questions of the origin of life and other cosmological problems. His contemporaries among geologists and biologists generally favoured the Aristotelean idea of spontaneous generation (generatio spontanea or aequivoca) during an early stage of the history of the Earth. Arrhenius, however, starting from the concept of infinity of time, did not have any need for a hypothesis involving a singular event like the creation of life. Still it was necessary to find means for particles of living matter to travel through space. The idea of panspermian goes back to the Pythagorean school, but more definite statements regarding the mechanism of transport were not formulated until the 19th century, when meteorites were proposed as vehicles for primitive organisms. Arrhenius suggested that radiation pressure might be the driving force in transportation through space "spores" of living matter which had to have a size of the order of the wave length of light, to be able to escape from a solar system and to travel relatively rapidly through space. The critical questions concerned the surviving of living matter after exposure during thousands or ten thousands of years to low temperature and radiation in space. Pasteur showed that careful elimination of microbial contamination prevents the growth of bacteria in organic infusions. Especially after the discovery of bacterial spores in the early 1870s, and the design of sterilisation methods which prevented their germination, Pasteur and his followers could explain and predict the presence or absence of bacterial growth in infusions in a systematic manner. 4. The Urantia Papers The history of religion like the history of science (not to mention science fiction) is full of various kinds cosmogonies and fantastic stories and beliefs about the origin of man and life on Earth. All peoples and religions of the world have their myths of creation. Ancient Greek myths and philosophers explained origins of things in terms of chaos, water, fire, atoms etc. From the many later cosmographical conceptions we may mention monadology, the theory of infinitely nested worlds, inherited from Greek philosophy but propounded further by Leibniz. - 112Related conceptions have survived to the present time in various vitalistic, teleological and anthropic theories. Usually they are based on theological ideas and beliefs that are sometimes claimed to be divine revelations by their origin. One such text, dating from this century, is the Urantia Book (Urantia Foundation 1955) that will be briefly discussed in the following. Rarely does one find a book on theology or religion which seems to attempt shedding its wisdom in almost every area of human endeavour. In its two-thousand pages The Urantia Book presents an integrated picture of the universe which relates science, philosophy and religion in a holistic synthesis. Evaluated on the basis of spiritual insight, philosophical coherence and realitycenteredness, it presents, in the judgement of thousands of people who have critically examined it, one of the finest world views of religion available to contemporary humanity. (Sprunger 1985) The Urantia Papers, also called The Urantia Book, has been an object of my interest and at times intense study for almost 30 years. The text is an extraordinary piece of literature which comes close to being an extraterrestrial message. On page 737 of the Urantia Paper 65 are the lines which gave me the idea to present this paper: "It is impossible accurately to determine, simultaneously, the exact location and the velocity of a moving object; any attempt at measurement of either inevitably involves change in the other. The same sort of a paradox confronts mortal man when he undertakes the chemical analysis of protoplasm. The chemist can elucidate the chemistry of dead protoplasm, but he cannot discern either the physical organisation or the dynamic performance of living protoplasm. Ever will the scientist come nearer the secrets of life, but never will he find them and for no other reason than that he must kill protoplasm in order to analyse it. Dead protoplasm weighs the same as living protoplasm, but it is not the same." "In every living plant or animal cell, in every living organism, material or spiritual, there is an insatiable craving for the attainment of ever-increasing perfection of environmental adjustment, organismal adaptation, and augmented life realisation. These interminable efforts of all living things evidence the existence within them of an innate striving for perfection." "During the earlier time of universe materialisation the space regions are interspersed with vast hydrogen clouds, just such astronomic dust clusters as now characterise many regions throughout remote space. These vast hydrogen clouds are veritable cosmic chemical laboratories, harbouring all phases of evolving energy and metamorphosing matter. But none of these tremendous and far-flung energy activities of space exerts the last influence upon the phenomenon of organised life - the germ plasm of living things and beings." - 113The origin of life on our planet "Urantia" is described as follows: "We (the Life Carriers) organised and initiated the original life patterns of this world 550 million years ago and planted them in the hospitable waters of the realm. After the life patterns have been formulated and the material organizations have been duly completed, the supermaterial forces concerned in life propagation become forthwith active, and life is existent. All planetary life on our life experiment planet had its origin in our three original, identical, and simultaneous marine-life implantations. These three life implantations have been designed as: the central or Eurasian- African, the eastern or Australian, and the western, embracing Greenland and the Americas. These life implantations of marine vegetable life was made in the water filled cracks between the continental masses which were drifting apart from one large land mass. The bacteria, simple vegetable organisms of a very primitive nature, are very little changed from the early dawn of life; they even exhibit a degree of retrogression in their parasitic behaviour. Many of the fungi also represent a retrograde movement in evolution, being plants which have lost their chlorophyll making ability and have become more or less parasitic. The majority of disease-causing bacteria and their auxiliary virus bodies really belong to this group of renegade parasitic fungi. During the intervening ages all of the vast kingdom of plants has evolved from ancestors from which the bacteria have also descended. There has been discussion recently about the oldest trilobites from America and Siberia. They are distinctly different and must have taken a slightly different course of development at a very early stage." "From era to era radically new species of animal life arise. They do not evolve as the result of the gradual accumulation of small variations; they appear as full-fledged and new orders of life, and they appear suddenly. The sudden appearance of new species and diversified orders of living organisms is wholly biological, strictly natural. There is nothing supernatural connected with these genetic mutations." The time for the life implantation is determined by the geological evolution of the planet: "The Life Carriers had projected a sodium chloride pattern of life; therefore no steps could be taken toward planting it until the ocean waters had become sufficiently briny. The Urantia type of protoplasm can function only in a suitable salt solution." (Paper 58, page 664). (Sodium chloride solutions that are suitable for sustaining living cells are called Ringer's solutions) Also the atmosphere which later will be changed by the life processes is described: "The Earth's atmosphere is all but opaque to much of the solar radiation at the extreme ultraviolet end of the spectrum. Most of the short -114wave lengths are absorbed by a layer of ozone which exists throughout a level about ten miles above the surface of the Earth, and which extends spaceward for another ten miles. The ozone permeating this region, at conditions prevailing on the Earth's surface, would make a layer only one tenth of an inch thick; nevertheless, this relatively small and apparently insignificant amount of ozone protects Urantia inhabitants from the excess of these dangerous and destructive ultraviolet radiations present in sunlight. But were this ozone layer just a trifle thicker, you would be deprived of the highly important and health-giving ultraviolet rays which now reach the Earth's surface, and which are ancestral to one of the most essential of your vitamins." "The formation of the planetary system began 4500 million years ago and resulted in 12 (!) planets. There are five inner and five outer planets with Jupiter and Saturn in the middle. Of one of the inner planets only the asteroid belt is left today." It might be noted that recently at least one large planet like body has been found outside of Pluto's orbit. "2500 million years ago the planets had grown immensely in size. Urantia was a well-developed sphere about one tenth its present mass and was still growing rapidly by meteoric accretion." "1500 million years ago the Earth was two thirds its present size, while the moon was nearing its present mass. Earth's rapid gain over the moon in size enabled it to begin the slow robbery of the little atmosphere which its satellite originally had. Volcanic action is now at its height. The whole Earth is a veritable fiery inferno, the surface resembling its earlier molten state before the heavier metals gravitated toward the centre. This is the volcanic age. Nevertheless, a crust, consisting chiefly of the comparatively lighter granite, is gradually forming. The stage is being set for a planet which can someday support life." Conceptual developments in the field of the origin of life have been characterised by a rich interplay between philosophical assumptions regarding the nature of life, methodological issues concerning the investigation and explanation of vital behaviour and theoretical developments in the biological sciences. (Ferris 1988) Today it is known that 550 million years ago there happened a sudden explosion of life forms and the era that followed is sometimes called "the period of obvious life". Whatever the origin of the Urantia Papers is it represents a piece of text that belongs to at least to the history of religion and contains a lot of interesting material and ideas that can be studied like any other script whose origin is unknown to present day science. - 1155. Oparin's Theory of the Origin of Life The modem paradigm for scientific study of the origin of life was laid by Oparin's classic work "The Origin of Life", first published in 1936 in Russian and translated into English in 1938 (Kamminga 1988). Oparin gave substance to the notion of chemical and geological evolution by his very detailed consideration of the interaction between the environment and organic matter at successive stages of formation of the geological conditions on Earth and evolution of early life forms. Oparin was the first in the field to draw extensively on independent evidence from a wide range of scientific disciplines to establish the plausibility of his model. He presented a model that was partially testable. Geochemical studies, chemical and mineralogical analysis of meteorites and spectroscopic studies of stars, comets and planets suggested that the prebiotic Earth had a reducing atmosphere. As the organic molecules became more complex, colloidal reactions came into play and organic matter became concentrated locally in the form of individual colloidal bodies called coacervates. The most striking feature of the coacervates was their capacity to absorb and assimilate organic matter from the aqueous environment and utilise this material in reactions leading to their growth and development, a feature strongly reminiscent of metabolism. This idea of the fundamental unity of metabolism provided him with the focus of his theory. Oparin continued to extend and modify the theory for the rest of his life. 6. Present Life Forms Present-day life is divided into two great categories, whose distinctions are far more basic than are the differences between the plant and animal kingdoms. Bacteria and blue-green algae, collectively known as procaryotes, have cells that lack a chromosome-bearing nucleus to transmit messages for cell construction during reproduction. All other organisms, from single-celled plants and animals to oak trees and elephants, are made up of cells having such a nucleus. These nucleus-bearing organisms are collectively known as eucaryotes. Chemical traces of early life forms prior to the procaryotes are provided by complex carbon compounds extracted from Precambrian sediments. Recent development of very precise analytical techniques has led to the identification of many such compounds but their interpretation is difficult (MacAlester 1977). -1167. The Chemical Components of Life Chemically organisms are but endlessly varied combinations and permutations of five principal constituents (McAlester 1977): water, carbohydrates, fats, proteins and nucleic acids (Table 2). Table 2: Principal Basic Chemical Constituents of Life. Compound Function Composition ___________________________________________________________ Water Universal solvent Hydrogen, oxygen Carbohydrates Energy source Hydrogen, oxygen, carbon Fats Energy storage Hydrogen, oxygen, carbon Proteins Structural; facilitation Hydrogen, oxygen, carbon, of chemical reactions nitrogen, phosphorus, sulphur (organized into 20 amino acids "building blocks") Nucleic acids Patterns for protein Hydrogen, oxygen, carbon, (RNA, DNA) construction nitrogen, phosphorus (organized into 5 nucleotides "building blocks") ___________________________________________________________ Water is by far the most common of these constituents. It is a solvent for many substances within organisms, and it also enters directly into the molecular structure of other essential compounds. Carbohydrates (sugar and starches) and fats serve primarily as energy suppliers. In more advanced kinds of animals and plants nucleic acids are concentrated in the cell nucleus where they provide templates which serve as patterns for the manufacture of all the different proteins required by the cell. There are 92 chemical elements which occur naturally on Earth. Only 27 of these are essential components of life, and not all of these are essential to all living things. The first requirement for the origin of life, then, was a supply of these chemical elements in forms that might combine into proteins, nucleic acids, and the other components of living systems. There are suggestions that just such conditions may have existed early in the history of Earth as indicated by Miller's high-energy electrical spark experiments in 1953 at the University of Chicago. Miller's discovery opened a new field of investigation of experimental synthesis of the chemical constituents of life under "primitive Earth conditions". Spectroscopic analysis of sunlight, combined with chemical analysis of meteo-rites, provide means of calculating the relative abundance of the chemical elements in the Solar System. These calculations show that the four elements -117essential for life are among the most abundant in the Solar System today (Table 3): Table 3: Relative Abundance of elements in the Solar System. Rank Element Symbol Abundance _________________________________________ 1 Hydrogen H 2500000 2 Helium He 380000 3 Oxygen O 2500 4 Carbon C 930 5 Nitrogen N 240 6 Silicon Si 100 7 Magnesium Mg 91 8 Neon Ne 80 _________________________________________ All amino acids can be derived from alanine. Alanine can occur in two different forms. One in which the central carbon atom are arranged in a configuration that caused polarized light to be rotated in left-handed screw sense (L-alanine). The other in which polarized light would be rotated in the opposite sense (D-alanine). All amino acids found in proteins are L-amino acids. On Earth amino acids are overwhelmingly in the left-handed form. Why that should be so is a mystery, because chemically speaking the right- and left-handed forms are equally probable. Some meteorites showed D- and L-forms in essentially equal abundances. These amino acids are therefore very unlikely to have been biogenic contaminants. Biogenic molecules and molecules needed for existence of life therefore seem prevalent elsewhere. They occur naturally not just on Earth (Harwit 1973). 8. Quantum Physics and Life Living things are composed of lifeless molecules. When these molecules are isolated and examined individually, they conform to all the physical and chemical laws that describe the behaviour of inanimate matter. (Gribbin 1987) In 1897 (Joseph J. Thomson) electrons were discovered and identified as tiny negative charged particles. For the story of chemistry, all that is needed is an understanding of how electrons behave, because the electron cloud is the visible face that an atom shows to the world. It is the outermost electrons in that cloud that interact directly with other atoms when atoms join together to form molecules. Some of those molecules may contain tens of thousands, even -118hundreds of thousands of atoms. Each of those chemical compounds seems to have a specific role to play in the healthy functioning of the whole. The essence of life, ultimately due to the behaviour of those complex molecules working together, is the ability of living things to extract energy from their environment and to use that energy both to build up their own complex structures and to copy themselves (to replicate). For all life on the surface of the Earth, the ultimate source of that energy is sunlight, trapped in plants by photosynthesis. (Recently, however, organisms have been found in the hot springs and deep ocean, far from any source of sunlight; that derive energy from underwater volcanic hotspots and lead their lives quite cut off from the rest of the ecological web. Like us they, too, depend on an outside source of energy.) In the everyday world, the wave nature of matter is undetectable because the masses involved are so large compared with Planck's constant, h. But the smaller the mass of the particle involved, the more important its wave nature becomes, until for the massless particles of electromagnetic radiation, the photons, both facets of nature are equally important. In quantum physics, uncertainty is a definite thing. It was a German physicist, Werner Heisenberg, who came up with this concept in 1927. So Heisenberg deduced two things: for a small particle like an electron, it is impossible to measure its position and its momentum precisely. In theory, we can measure either quantity as accurately as we like, just short of absolute precision. It is a fundamental law of nature, which says that there is no such thing as a particle, which has a precisely defined position and a precisely defined momentum at the same time. And this uncertainty extends to other pairs of quantities, such as the time a fundamental event takes and the amount of energy involved in the event. In 1928 Linus Pauling developed the principle of resonance which says that if a molecule can be described in two (or more) equally acceptable ways, then the molecule has to be thought of as existing in both (or all) of those states simultaneously. The molecule is a hybrid of all the possible structures with the same lowest energy. Today quantum physics is combined with Schrodinger's modified wave equation to describe the behaviour of electrons and atoms. In the1940s Erwin Schroidinger wrote a little book titled 'What is Life" (Schrodinger 1944). Another physicist better known for his research in cosmology, George Gamow, brought the idea of a code analogous to the Morse code to the attention of molecular biologists in early 1950s, just after Watson and Crick had published their first two papers on the nature of DNA. Today there are projects underway to map the totality of the human genetic information. -119It is obvious that quantum physics and life processes are closely related. Manipulation of single atoms has recently been demonstrated by IBM using methods of nanotechnology, a first step towards molecular nanomachines and possibly synthesis of molecules of life. When the molecular level is reached scientists will either find that there is no difference between organic and inorganic chemistry or that a lifeless cell could not be brought to life without violating Heisenberg's uncertainty principle. The Heisenberg principle of uncertainty does not, however, preclude of complex chemical reactions, such as replication, protein synthesis, metabolism, photosynthesis etc., to take place at great precision under appropriate physicochemical conditions like those prevailing in a living cell, once these conditions and their self-regulation mechanisms have emerged. 9. Summary The Urantia Book contains interesting material on the origin of life, ancient cultures and many fundamental questions connected with SETI. Indeed, there might be intelligent civilizations in the universe, which are so advanced that they are able to manipulate particles with an accuracy that our knowledge of physics and the Heisenberg's principle would deny. To start life would need such a mysterious "spark of life". "You know, it would be sufficient to really understand the electron" Albert Einstein said. (Dehmelt 1990) 10. References 1. 2. 3. 4. 5. 6. 7. Arrhenius, S. (1959): Svante Arrhenius, till 100-arsminnet av hans fodelse, K. Svenska Vetenskapsakademiens Arsbok for ar 1959, bilaga, Almqvist & Wiksells Boktrycked AB, Stockholm Clarke A.C., ed., (1967): The Coming of the Space Age, Victor Gollancz Ltd, London Darwin C. (1928): The Origin of Species By Means Of Natural Selection, Sixth Edition, (first published 1859), Everyman's Library, J.M. Dent & Sons Ltd., London. Dehmelt H. (1990): Experiments with an isolated subatomic particle at rest, Reviews of Modem Physcics, Vol. 62, No. 3, July 1990 Dobzhansky T. (1937): Genetics and the Origin of Species, Columbia University Press, New York, U.S.A. Ehrensvard G. (1961): Liv - Ursprung och Utformning, Bokforlaget Aldus / Bonniers, Stockholm Ferris LP., ed., (1988): Papers from the 1986 ISSOL Meeting Berkeley, California (Part II), Origins of Life and Evolution of the Biosphere, Vol. 18, Nos. 1/2, D. Reidel Publishing Company, Dordrecht, Holland - 1208. Fisk L.A. (1990): NASA Research Announcement: Search for Extraterrestrial Inteligence, Microwave Observing Project, Life Sciences Division, National Aeronautics and Space Administration, Washington D.C. 9. Gardner M. (1966): Skapelsens symmetri (vanster-hoger och paritetslagens fall; Original title: "The Ambidextrous Universe"), Tema, Raben & Sjogren, Stockholm 10. Gardner M. (1990): The Great Urantia Mystery. Skeptical Inquirer, Vol. 14, Winter 1990 11. Gribbin J. (1987): In Search of the Double Helix (Quantum Physics and Life), Bantam Books, New York, U.S.A. 12. Harwit M. (1973): Astrophysical Concepts, John Wiley & Sons Inc., U.S.A 13. Hoyle F. (1965): Manniskor och vintergator, Svenska tryckeri bolagen STB AB, Stockholm 14. Kamminga H. (1988): Historical Perspective: The Problem of the Origin of Life in the Context of Developments in Biology. Origins of Life and Evolution of the Biosphere, Vol. 18, Nos 1/2, 1988 15. Kampis G. (1991): Self-Modifying Systems in Biology and Cognitive Science, Pergamon Press, England 16. Knoll A.H. (199l): End of the Proterozoic Eon, Scientific American, October 1991 17. McAlester A.L. (1977): The History of Life, second edition, Prentice-Hall Inc., New Jersey, U.S.A. 18. McCabe J. (1931): The New Science and the Story of Evolution, Hutchinson & Co. Ltd., London 19. Mustelin N. (1980): Liv bland miljarder stjarnor, Natur och Kultur, Lund, Sweden 20. Sagan C., ed,. (1973): Communication with Extraterrestrial Intelligence (CETI), 'The MIT press, Cambridge, Massachusetts and London, England 21. Schrodinger E. (1944): What is Life? Cambridge University Press, Cambridge 22. Sprunger J.M. (1985): The Urantia Book and Religious Studies, Paper presented at the American Academy of Religion meeting at Anaheim 11/25/85, Los Angeles, CA. 23. Tallqvist K. (1943): Sumererna och deras kultur, Foredrag vid finska vetenskaps-societetens sammantrade den 13 december 1943, Societas Scientiarum Fennica, Arsbok, Helsingfors 1944 24. Urantia Foundation (1955): The Urantia Book, Chicago, Illinois, U.S.A