Synthesis of specific nanoparticles for targeting tumor angiogenesis using electron-beam irradiation
Ecole Polytechnigue
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Author(s): Deshayes S (Deshayes, Stephanie)1,2, Maurizot V (Maurizot, Victor), Clochard MC (Clochard,
Marie-Claude)2, Berthelot T (Berthelot, Thomas)2, Baudin C (Baudin, Cecile)2, Deleris G (Deleris, Gerard)
Source: RADIATION PHYSICS AND CHEMISTRY Volume: 79 Issue: 3 Pages: 208-213 Published:
MAR 2010
Times Cited: 0 References: 16
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Conference Information: 8th International Symposium on Ionizing Radiation and Poymers
Angra dos Reis, BRAZIL, OCT 12-17, 2008
Abstract: Angiogenesis plays a critical role in both growth and metastasis of tumors. Vascular endothelial
growth factor (VEGF) is an endogenous mediator of tumor angiogenesis. Blocking associations of the VEGF
with its corresponding receptors (KDR) have become critical for anti-tumor therapy. A cyclo-peptide (CBOP11), derived from VEGF, able to inhibit the interaction between the growth factor and its receptor, was
synthesized in our laboratory to provide a target for angiogenesis. We have prepared biocompatible
poly(vinylidene fluoride) (PVDF) nanoparticles in order to obtain long blood circulating systems. Electron-beam
(EB) irradiation was used to activate the PVDF nanoparticles. From electron paramagnetic resonance (EPR)
measurements, we studied the radical stability in order to optimize the radio-grafting of acrylic acid (AA).
Further functionalization of PVDF-g-PAA nanoparticles with the cyclo-peptide via a spacer arm was also
possible by performing coupling reactions. High resolution magic angle spinning nuclear magnetic resonance
(HRMAS NMR) and MALDI mass spectrometry allowed us to follow each chemical step of this peptide
immobilization. We designed a new nanodevice suggesting a great potential for targeting angiogenesis. 772721-1 (C) 2009 Elsevier Ltd. All rights reserved.
Document Type: Proceedings Paper
Language: English
Author Keywords: Angiogenesis; Nanoparticles; Irradiation; PVDF
KeyWords Plus: POLY(VINYLIDENE FLUORIDE); SURFACE; RADIATION; PVDF; POLYMERIZATION; FILM
Reprint Address: Deshayes, S (reprint author), Univ Bordeaux, Chim Bioorgan Lab, CNRS, CNAB,UMR 5084,
146 Rue Leo Saignat, F-33076 Bordeaux, France
Addresses:
1. Univ Bordeaux, Chim Bioorgan Lab, CNRS, CNAB,UMR 5084, F-33076 Bordeaux, France
2. Ecole Polytech, CEA, CNRS, Solides Irradies Lab,UMR 7642, F-91128 Palaiseau, France
E-mail Addresses: stephanie.deshayes@u-bordeaux2.fr
Publisher: PERGAMON-ELSEVIER SCIENCE LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON,
OXFORD OX5 1GB, ENGLAND
IDS Number: 561EI
ISSN: 0969-806X
DOI: 10.1016/j.radphyschem.2009.09.007