Embargo 19th Jan 2016 16.00 London Time (GMT)
Ancient genomes reveal that the English are one third Anglo-Saxon
DNA from ancient British skeletons reveals immigrant history
For the first time, researchers have been able to directly estimate the Anglo-Saxon ancestry of the
British population from ancient skeletons, showing how Anglo-Saxon immigrants mixed with the
native population.
Human remains excavated from burial sites near Cambridge provided the material for the first wholegenome sequences of ancient British DNA. Using a new analysis method to compare these ancient
genomes with modern-day sequences, researchers have estimated that approximately a third of British
ancestors were Anglo-Saxon immigrants.
What was the scale of the Anglo-Saxons migrations, how did they mix with the native population and
how did they contribute to British ancestry? This has been a long-standing topic of debate amongst
historians and archaeologists. Recently excavated skeletons dating to the late Iron Age and from the
Anglo-Saxon period gave researchers the opportunity to solve this question with genomics.
“By sequencing the DNA from ten skeletons from the late Iron Age and the Anglo-Saxon period, we
obtained the first complete ancient genomes from Great Britain,” said Dr Stephan Schiffels, first
author from the Wellcome Trust Sanger Institute, Cambridgeshire and the Max Plank Institute in
Germany. “Comparing these ancient genomes with sequences of hundreds of modern European
genomes, we estimate that 38% of the ancestors of the English were Anglo-Saxons. This is the first
direct estimate of the impact of immigration into Britain from the 5th to 7th Centuries AD and the
traces left in modern England.”
Previous DNA studies have relied entirely on modern DNA and suggested anything between 10% and
95% contribution to the population. One such study suggested that Anglo Saxons didn't mix with the
native population, staying segregated. However, this newly published study uses ancient genetic
information and disproves the earlier idea, showing just how integrated the people of Britain were.
The ancient skeletons from Cambridgeshire were carbon dated, proving they were from the late Iron
Age (approximately 50BC) and from the Anglo-Saxon era (around 500-700 AD). Complete genome
sequences were then obtained for selected DNA samples to determine the genetic make-up of these
Iron Age Britons and Anglo-Saxons.
“Combining archaeological findings with DNA data gives us much more information about the early
Anglo-Saxon lives. Genome sequences from four individuals from a cemetery in Oakington indicated
that, genetically, two were migrant Anglo-Saxons, one was a native, and one was a mixture of both.
The archaeological evidence shows that these individuals were treated the same way in death, and
proves they were all well integrated into the Oakington Anglo-Saxon Community despite their
different biological heritage.” said Dr Duncan Sayer, archaeologist and author on the paper from
University of Central Lancashire.
Modern British and continental European genomes from the UK10K project and the 1000 Genomes
Project were compared with the genomes from the ancient skeletons. Researchers discovered that the
Anglo-Saxon immigrants were genetically very similar to modern Dutch and Danish, and that they
contributed 38% of the DNA of modern people from East England, and 30% for modern Welsh and
Scottish. The Anglo-Saxons first settled in the South East of England so this pattern is consistent with
their migration pattern.
The genomes of northern European populations are similar and it is difficult to accurately distinguish
between them. To help solve this problem, the study developed a sensitive new method, called
rarecoal, which could identify subtle genetic traces in individuals, using rare genetic variants
identified in hundreds of present-day people. Earlier methods of mapping ancient DNA looked at
common genetic variants from the very distant past, which are present in most people. The new
rarecoal method did exactly the opposite, allowing researchers to map more recent events and unravel
very closely related populations.
“We wanted to determine where ancient DNA samples would fit with respect to a modern population
model and to map individuals into that model. This study, using whole-genome sequencing, allowed
us to assign DNA ancestry at extremely high resolution and accurately estimate the Anglo-Saxon
mixture fraction for each individual,” said Richard Durbin, senior author at the Sanger Institute.
“More full genome sequences and further improvements in methodology will allow us to resolve
migrations in even more detail in the future.”
Ends
Contact details:
Dr Samantha Wynne
Press Office
Wellcome Trust Sanger Institute
Cambridge, CB10 1SA
Phone: 01223 492368
Email: press.office@sanger.ac.uk
Notes to Editors:
Publication
Iron Age and Anglo-Saxon genomes from East England reveal British migration history.
Stephan Schiffels et al. (2016) Nature Communications DOI: 10.1038/ncomm10326
Funding:
The Oakington excavations were funded by the Oakington Parish Council, the Institute for Field Research (IFR)
and the University of Central Lancashire (UCLan). This work was funded by Australian Research Council grant
DP130102158, by the University of Adelaide’s Environment Institute, and by Wellcome Trust Grant 098051.
Participating centres:
 Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK
 Australian Centre for Ancient DNA, School of Biological Sciences, University of Adelaide, SA 5005,
Australia.
 Oxford Archaeology East, 15 Trafalgar Way, Bar Hill, Cambridge, CB23 8SQ, UK
 Oxford Archaeology South, Janus House, Osney Mead, Oxford, OX2 0ES, UK
 University of Central Lancashire, Preston, PR1 2HE, UK


Max Planck Institute for the Science of Human History, Department for Archaeogenetics, Kahlaische
Strasse 10, 07745 Jena, Germany
The Genome Analysis Centre, Norwich Research Park, Norwich, NR4 7UH, UK
Selected Websites:
Australian Centre for Ancient DNA (ACAD)
A leading ancient DNA research facility at the University of Adelaide specialising in the analysis of
evolutionary processes, human evolution, and the impacts of environmental and climate change through time.
Hosts the Online Ancient Genome Repository (OAGR) of ancient human genomes and
microbiomes. https://www.adelaide.edu.au/acad/
The University of Adelaide
The University of Adelaide is one of Australia’s leading research-intensive universities and is consistently
ranked among the top 1% of universities in the world. Established in 1874, it is Australia’s third oldest
university with a strong reputation for research and teaching excellence, and producing graduates that make an
impact on the world. http://www.adelaide.edu.au/
Oxford Archaeology
Oxford Archaeology is one of the largest independent archaeological and heritage practices in Europe, with over
250 specialist staff working out of offices in Oxford, Lancaster and Cambridge. Founded in 1973, we have over
40 years of experience in professional archaeology, and a tradition of quality, innovation and service on projects
ranging in scale from domestic extensions to international transport infrastructure. We are also an Institute for
Archaeologists Registered Organisation and, as a registered educational charity, we help people to discover and
enjoy their heritage through our publications and outreach. Across the country, we have welcomed many
thousands of visitors to our sites on open days, regularly provide presentations and information panels, and
volunteers of all ages have participated in our wide variety of excavation and survey projects that span all
periods of human history. www.oxfordarchaeology.com
University of Central Lancashire
The University of Central Lancashire (UCLan) in Preston was founded in 1828 as the Institution for the
Diffusion of Knowledge. Since those early days it has grown into one of the UK's largest universities with a
staff and student community approaching 38,000 and an employment-focused course portfolio containing over
350 undergraduate programmes and nearly 250 postgraduate courses. The University has an established research
reputation with world-leading or internationally excellent work taking place within the areas of Business,
Health, Humanities and Science.
https://www.uclan.ac.uk/
The Wellcome Trust Sanger Institute
The Wellcome Trust Sanger Institute is one of the world's leading genome centres. Through its ability to conduct
research at scale, it is able to engage in bold and long-term exploratory projects that are designed to influence
and empower medical science globally. Institute research findings, generated through its own research
programmes and through its leading role in international consortia, are being used to develop new diagnostics
and treatments for human disease. http://www.sanger.ac.uk/
The Wellcome Trust
The Wellcome Trust is a global charitable foundation dedicated to achieving extraordinary improvements in
human and animal health. We support the brightest minds in biomedical research and the medical humanities.
Our breadth of support includes public engagement, education and the application of research to improve health.
We are independent of both political and commercial interests. http://www.wellcome.ac.uk/