Principal Investigator/Program Director (Last, First, Middle): Mao, Jianren
BIOGRAPHICAL SKETCH
Provide the following information for the key personnel and other significant contributors.
Follow this format for each person. DO NOT EXCEED FOUR PAGES.
NAME
POSITION TITLE
Hans C. Breiter, M.D.
Assistant Professor of Psychiatry
Director of Motivation Emotion Neuroscience
Collaboration, Radiology
eRA COMMONS USER NAME
HCBREITER
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)
INSTITUTION AND LOCATION
DEGREE
(if applicable)
St. Andrews University, Scotland
YEAR(s)
FIELD OF STUDY
1982-1983
Honors Logic & Metaphys.
Northwestern University, Chicago, IL
BSc
1983
Honors Program Med. Ed.
Northwestern University Medical School (NUMS)
Pharmaceutical Manufacturers Association
Foundation, NUMS
Salem Hospital, MA
Massachusetts General Hospital (MGH), MA
MGH Psychiatric Neuroscience Fellowship Program
Ethel Dupont-Warren Research Fellow, Harvard Univ.
NIH Postdoctoral Fellowship in NMR Research, MGH
DANA Foundation Fellowship in Neurobiology, MGH
MD
1988
Medicine
Res Fellow
1987-1988
Pharmacokinetic Modeling
Intern
Resident
Res Fellow
Res Fellow
Res Fellow
Res Fellow
1988-1989
1989-1992
1991-1992
1992-1993
1992-1995
1994-1995
Internal Medicine
Adult Psychiatry
Neuroanatomy
Psychiatric Morphometry
FMRI & Exper. Psychology
Addiction Neurobiology
A. Positions and Honors.
Professional Experience
1994-1999
Instructor, Harvard Medical School
1993Clinical Assistant in Psychiatry, MGH
1999Assistant Professor, Harvard Medical School
2002
Co-Founder, Descartes Therapeutics, Inc., Boston, MA
2002Director, Motivation and Emotion Neuroscience Collaboration (MENC), MGH-NMR
Center, MGH
2003Director, Phenotype Genotype Project on Addiction and Depression, Departments of
Radiology, Psychiatry and Neurology, MGH
Honors and Awards
1987
Pharmaceutical Manufacturers Association Foundation Research Fellowship Award
1989
Honorable Mention, Eighth Annual SOHO International Art Competition
1992
(a) Society of Biological Psychiatry, Dista Fellowship Award; (b) Livingston Fund Award;
(c) Dupont-Warren Fellowship Award; (d) Stanley Cobb Award; (e) Thomas P. Hackett
Award
1993
(a) Stanley Cobb Award; (b) Neal Alan Mysell Award
1995
(a) Young Investigator Award, NARSAD; (b) Scientist Development Award (K21)
1996
Klerman Award (for developing fMRI as a tool for psychiatric research), NARSAD
B. Selected peer-reviewed publications
1. Breiter HC, Craig RM, Levee G, Atkinson AJ. Use of kinetic methods to evaluate D-xylose malabsorption in
patients. J Lab Clin Med 1988;112:533-543.
2. Atkinson AJ, Ruo TI, Piergies AA, Breiter HC, Connelly TJ, Sedek GS, Juan D, Hubler GL, Hsieh AM:
Pharmacokinetics of N-acetylprocainamide in patients profiled with a stable isotope method. Clin
Pharmacol Ther 1989;46:182-189.
3. Brown H, Kosslyn SM, Breiter HC, Baer L, Jenike MC: Can patients with obsessive-compulsive disorder
discriminate between percepts and mental images? A signal detection analysis. J Abnorm Psych
1994;103:445-454.
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4. Breiter HC, Filipek PA, Kennedy DN, Baer L, Pitcher D, Renshaw P, Caviness VS, Jenike MA. Brain white
matter abnormalities in patients with obsessive-compulsive disorder. Arch Gen Psych 1994;51:663-664.
5. Rauch SL, Jenike MA, Alpert NM, Baer L, Breiter HC, Fischman AJ: Regional
cerebral blood flow
determination during symptom provocation in obsessive- compulsive disorder using 15O-labelled CO2
and positron emission tomography. Arch Gen Psych 1994;51:62-70.
6. Sutton JP, and Breiter HC. Neural scale invarience: An integrative model with implications for
neuropathology. World Congress on Neural Networks, 1994;4:667-672.
7. Rauch SL, Savage CR, Alpert NM, Miguel EC, Baer L, Breiter HC, Fischman AJ, Manzo PA, Moretti C,
Jenike MA. A positron emission tomography study of simple phobic symptom provocation. Arch Gen Psych
1995;52:20-28.
8. Huang-Hellinger FR, Breiter HC, McCormack G, Cohen MS, Kwong KK, Sutton JP, Savoy RL, Weisskoff
RM, Davis TL, Baker JR, Belliveau JW, Rosen BR: Simultaeous functional magnetic resonance imaging
and electrophysiological recording. Hum Brain Mapping 1995;3:13-23.
9. Jenike MA, Breiter HC, Baer L, Kennedy DN, Savage CR, Olivares MJ, O'Sullivan RL, Shera DM, Rauch
SL, Keuthen N, Rosen BR, Caviness VS, Filipek PA. Cerebral structural abnormalities in obsessivecompulsive disorder. A quantitative morphometric magnetic resonance imaging study. Arch Gen
Psychiatry. 1996;53(7):625-632.
10. Breiter HC, Rauch SL, Kwong KK, Baker JR, Weisskoff RM, Kennedy DN, Kendrick AD, Davis TL, Jiang A,
Cohen MS, Stern CE, Belliveau JW, Baer L, O’Sullivan RM, Savage CR, Jenike MA, Rosen BR. Functional
magnetic resonance imaging of symptom provocation in obsessive compulsive disorder. Arch Gen Psych
1996;53:595-606.
11. Cohen MS, Kosslyn SM, Breiter HC, DiGirolamo GJ, Thompson WL, Anderson AK, Bookheimer SY, Rosen
BR, Belliveau JW. Changes in cortical activity during mental rotation. A mapping study using functional
MRI. Brain 1996;119:89-100.
12. Breiter HC, Etcoff NL, Whalen PJ, Kennedy WA, Rauch SL, Buckner RL, Strauss MM, Hyman SE, Rosen
BR. Response and habituation of the human amygdala during visual processing of facial expression.
Neuron 1996;17:875-887.
13. O’Sullivan RL, Rauch SL, Breiter HC, Grachev ID, Baer L, Kennedy DN, Keuthen NJ, Savage CR, Manzo
PA, Caviness VS, Jenike MA. Reduced basal ganglia volumes in trichotillomania measured via
morphometric MRI. Biol Psychiatry 1997;42:39-45.
14. Breiter HC, Gollub RL, Weisskoff RM, Kennedy DN, Makris N, Berke JD, Goodman JM, Kantor HL,
Gastfriend DR, Riorden JP, Mathew RT, Rosen BR, Hyman SE. Acute effects of cocaine on human brain
activity and emotion. Neuron 1997;19:591-611.
15. Borsook D, Fishman S, Becerra L, Edwards A, Stojanovic M, Ramachandran VS, Gonzalez G, Breiter H.
Acute plasticity in the human somatosensory cortex following amputation. NeuroReport 1998;8:371-376.
16. Grachev ID, Breiter HC, Rauch SL, Savage CR, Baer L, Shera DM, Kennedy DN, Makris N, Caviness VS,
Jenike MA. Structural abnormalities of frontal neocortex in obsessive-compulsive disorder. Arch Gen Psych
1998;55(2):181-182.
17. Seidman LJ, Breiter HC, Goodman JM, Goldstein JM, Woodruff PW, O'Craven K, Savoy R, Tsuang MT,
Rosen BR. A functional magnetic resonance imaging study of auditory vigilance with information
processing demands. Neuropsychology 1998;12(4):505-518.
18. Gollub RI, Breiter HC, Kantor H, Kennedy D, Gastfriend D, Mathew RT, Makris N, Guimaraes A, Riorden J,
Campbell T, Foley M, Hyman SE, Rosen B, Weisskoff R. Cocaine decreases cortical cerebral blood flow
but does not obscure region in functional magnetic resonance imaging in human subjects. J Cereb Blood
Flow Metab. 1998;18(7):724-734.
19. Becerra LR, Breiter HC, Stojanovic M, Fishman S, Edwards A, Comite AR, Chang I-W, Berke JD,
Gonzalez RG, Borsook D. Human brain activation to controlled thermal stimulation and habituation to
noxious heat: an fMRI study. Magn Reson Med 1999;41:1044-1057
20. Breiter HC, Rosen BR. Functional magnetic resonance imaging of brain reward circuitry in the human. Ann
NY Acad Sci 1999;877:523-547.
21. Elman I, Breiter HC, Gollub RL, Krause S, Kantor HL, Baumgartner WA, Gastfriend DR, Rosen BR:
Depressive symptomatology and cocaine-induced pituitary-adrenal axis activation in individuals with
cocaine dependence. Drug Alcohol Depend 1999;56:39-45.
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Principal Investigator/Program Director (Last, First, Middle): Mao, Jianren
22. Elman I, Krause S, Breiter HC, Gollub R, Heintges J, Baumgartner W, Rosen B, Gastfriend D. Validity of
self-reported drug use in non-treatment seeking individuals with cocaine dependence: Correlation with
biochemical assays. Amer J on Addictions 2000;9(3):216-221.
23. Breiter, HC, Aharon I, Kahneman D, Dale A, Shizgal P. Functional Imaging of Neural Responses to
Expectancy and Experience of Monetary Gains and Losses. Neuron 2001; 30:619-639.
24. Aharon I, Etcoff N, Ariely D, Chabris CF, O’Connor E, and Breiter, HC. Beautiful faces have variable
reward value: fMRI and behavioral evidence. Neuron 2001; 32:537-551.
25. Becerra L, Breiter HC, Wise R, Gonzalez RG, Borsook D. Reward circuitry activation by noxious thermal
stimuli. Neuron 2001; 32:927-946.
26. Elman I, Karlsgodt KH, Gastfriend DR, Chabris CF, and Breiter HC. Cocaine-primed craving and its
relationship to depressive symtomatology in individuals with cocaine dependence. J Psychopharamacology
2002;16:163-167.
27. Elman I., Lukas SE, Karlsgodt KH, Gasic GP, and Breiter HC. Acute cortisol administration triggers craving
in individuals with cocaine dependence. Psychopharmacol Bull. 2003;37:84-89.
28. Thermenos HW, Seidmn LJ, Breiter H, Goldstein JM, Goodman JM, Poldrack R, Faraone SV, Tsuang MT.
Functional magnetic resonance imaging during auditory verbal working memory in nonpsychotic relatives
of persons with schizophrenia: a pilot study. Biol Psychiatry 2004; 55(5):490-500.
29. Makris N, Gasic GP, Seidman LJ, Goldstein JM, Gastfriend DR, Elman I, Albaugh MD, Hodge SM, Ziegler
DA, Sheahan FS, Caviness VS, Tsuang MT, Kennedy DN, Hyman SE, Rosen BR, and Breiter HC.
Decreased absolute amygdala volume in cocaine addicts. Neuron 2004; 44:729-740.
30. Strauss MM, Makris N, Aharon I, Vangel MG, Goodman J, and Kennedy DN, Gasic GP, Breiter HC. FMRI
of sensitization to angry faces. NeuroImage 2005; 26(2): 389-413.
C. Research Support
Ongoing Research Support
DABK39-03-0098 Breiter (PI)
10/01/03 - 10/09/08
Agency: US Army/ONDCP
ADVANCE Army- Phenotyping and Genotyping of Heritable Components Leading to Cocaine Addiction
This project aims to use genetic analysis of phenotypes defined by high-field functional and structural MRI to
identify genes involved in cocaine addiction and depression.
Role: Program Director and Principal Investigator of project involving 80 investigators and staff.
The Brain Architecture Project Mitra (PI)
08/01/06-07/30/09
Agency: Keck Foundation Award
The Brain Architecture Project
The goal of this project is to produce a comprehensive draft of the connectivity matrix of the human brain as
well as drafts of major functional subsystems or pathways, along with analytical and visualization tools.
Role: Co-Principal Investigator.
Completed Support
RO1DA14118 Breiter (PI)
09/01/01 - 08/30/07
Agency: NIH/NIDA
Cocaine Addiction: Mapping Alterations in Reward Circuitry
This project is focused on two topics: (a) the development of novel neuroeconomic paradigms to test the
common function of reward/aversion circuitry, and (b) the use of these novel methods to study cocaine
dependent subjects and understand the alterations in reward/aversion circuitry.
Role: Principal Investigator.
RIS-EMR-4021 Evins (PI)
10/01/05-09/30/06
Agency: Janssen Medical Affairs
Clinical and Brain Reward Circuitry Effects of Risperdal Consta in Active Cocaine Dependence
The goal of this project is to assess Risperdal Consta effects on drug craving behavior and brain activity, and
to quantify any changes in brain structure or function the relate to successful drug therapy.
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Principal Investigator/Program Director (Last, First, Middle): Mao, Jianren
Role: Co-Principal Investigator.
MIND Institute Project Rosen (PI)
01/01/06-12/31/06
Agency: MIND Institute Foundation Contract
Spatiotemporal Activation maps of Human Cortex
This is a grant that provides core support for functional neuroimaging with regard to neuro psychiatric
disorders.
Role: Investigator.
5PO1DA09467 Rosen (PI)
9/30/94-6/30/04
Agency: NIH/NIDA
Functional Brain Mapping of Cocaine Action
The goal of this grant was to develop novel imaging procedures to visualize drug actions in the brain, and to
understand drug effects in the human and animal brain.
Role: Project 1 Principal Investigator
ONDCP 7T Contract Rosen (PI), Breiter (Co-PI)
07/01/98-06/30/03
Agency: US Army/ONDCP
Joint Proposal between ONDCP and MGH NMR Center for a 7T MRI System for Functional Studies of
Substance Abuse
The goal of this project was to build a 7T human magnet for functional and structural studies of substance
abuse.
Role: Co-Principal Investigator
K21DA00265 Breiter (PI)
09/01/95-06/30/00
Agency: NIH/NIDA
FMRI Studies of Brain Reward and Emotion
The goal of this scientist development award was to acquire experimental psychology skills applied to fMRI
and mMRI to study reward/aversion circuitry in the human brain.
Role: Principal Investigator
RO1DA012581 Borsook (PI)
07/01/01-08/30/02
Agency: NIH/NIDA
CNS Reward/Aversion Circuitry Activated by Pain & Opioids
The goal of this project was to understand the role of reward/aversion systems in the reponse to pain and to
analgesic medications.
Role: Co-Principal Investigator
Foundation Contract Breiter (PI)
070/1/97-06/30/99
Agency: Scottish Rite Research Program
Emotional Processing in Negative vs Positive Symptom Schizophrenia
The goal of this project was to quantify reward circuitry differences in distinct subtypes of schizophrenia using
fMRI.
Role: Principal Investigator
Foundation Contract Breiter (PI)
07/01/99-06/30/01
Agency: National Center for Responsible Gaming
Functional MRI of Neural Responses to Monetary Gains, Losses, and Prospects in Pathological Gamblers and
Normal Subjects
The goal of this project was to investigate the neural substrates of normative responses to expectancies and
outcomes from games of risk.
Role: Principal Investigator
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