TRAVIS P. REMARCHUK, PH.D.
Office: (650) 467-8834
Email: travisr@gene.com
Work Experience
05/15-Present Senior Scientist, Small Molecule Process Chemistry, Genentech (A Member of the Roche Group),
South San Francisco, CA.
2006–2015
Scientist, Small Molecule Process Chemistry, Genentech (A Member of the Roche Group), South
San Francisco, CA.
1995–1998
Research Associate, Process Chemistry, Agouron Pharmaceuticals, Inc. San Diego, CA.
1994-1995
Research Associate, Medicinal Chemistry, La Jolla Pharmaceuticals, Inc., San Diego, CA.
Education
2003–2006
1998-2003
1989-1994:
Postdoctoral Studies, Harvard University, Department of Chemistry and Chemical Biology,
Cambridge, MA. Advisor: Professor E. J. Corey (Nobel Laureate).
Ph.D. Organic Chemistry, University of California, Irvine, Irvine, CA. Advisor: Professor
Larry E. Overman, Distinguished Professor of Chemistry.
B.Sc. in Chemistry, University of Saskatchewan, Saskatoon, SK, Canada. Advisor: Professor
M. Majewski.
Publications
1. Dong, M. W.; Al-Sayah, M.; Goel, M.; Remarchuk, T. “HPLC Method Development Strategies for
Small Molecule Drug Candidates with Multiple Chiral Centers: A Case Study” J. Biomed.
Pharm. Anal. 2015. Manuscript Submitted.
2. Featured in Pharmaceutical Technology article titled: “Practical Approaches to Large-Scale
Heterocyclic Synthesis” December 1st, 2014 (Interview by Cynthia Challener).
3. Remarchuk, T. St-Jean, F.; Carrera, D.; Savage, S.; Yajima, H.; Wong, B.; Babu, S.; Deese, A.;
Stults, J.; Dong, M. W.; Askin, D.; Lane, J. W.; Spencer, K. L. "Synthesis of Akt Inhibitor
Ipatasertib. Part 2. Total Synthesis and First Kilogram Scale-up" Org. Process Res. Dev. 2014,
18, 1652–1666.
4. Lane, J. W.; Spencer, K. L.; Shakya, S. R.; Kallan, N. C.; Stengel, P. J.; Remarchuk, T. "Synthesis of
Akt Inhibitor Ipatasertib. Part 1. Route Scouting and Early Process Development of a
Challenging Cyclopentylpyrimidine Intermediate" Org. Process Res. Dev. 2014, 18, 1641–1651.
5. Remarchuk, T. P.; Babu, S.; Stults, J.; Zanotti-Gerosa, A.; Roseblade, S.; Yang, S.; Huang, P.; Sha,
C.; Wang, Y. “An Efficient Catalytic Asymmetric Synthesis of a  2-Amino Acid on MultiKilogram Scale” Org. Process Res. Dev. 2014, 18, 135–141. Highlighted in Synfacts, 2014.
6. Wigman, L.; Remarchuk, T.; Gomez, S. R.; Kumar, A.; Dong, M. W.; Medley, C. D.; Chetwyn, N. P.
“Byproducts of Commonly Used Coupling Reagents: Origin, Toxicological Evaluation and
Methods for Determination” Am. Pharm. Rev. (2014).
7. Lou, Y.; Remarchuk, T. P.; Corey, E. J. "Catalysis of Enantioselective [2+1]-Cycloaddition
Reactions of Ethyl Diazoacetate and Terminal Acetylenes Using Mixed-Ligand Complexes of
the Series Rh2(RCO2)n(L*4–n). Stereochemical Heuristics for Ligand Exchange and Catalyst
Synthesis" J. Am. Chem. Soc. 2005, 127, 14223–14230
8. Overman, L. E.; Remarchuk, T. "Catalytic Asymmetric Intramolecular Aminopalladation:
Enantioselective Synthesis of Vinyl-Substituted 2-Oxazolidinones, 2-Imidazolidinones and 2Pyrrolidinones" J. Am. Chem. Soc. 2002, 124, 12–13
1
TRAVIS P. REMARCHUK, PH.D.
9. Albizati, K. F.; Babu, S.; Birchler, A.; Busse, J. K.; Fugett, M.; Grubbs, A.; Haddach, A.; Pagan, M.;
Potts, B.; Remarchuk, T.; Rieger, D.; Rodriguez, R.; Shanley, J.; Tibbetts, T.; Whitten, K.; Borer, B.
C. "A Synthesis of the HIV-Protease Inhibitor Nelfinavir from D-Tartaric Acid" Tet. Lett. 2001,
42, 6481–6485
Patents
1. Angelaud, R.; Beaudry, D. R.; Carrera, D. E.; Malhotra, S.; Remarchuk, T.; St-Jean, F. “Process for
Making Benzoxazepin Compounds” Application# 14/205,634; Docket# P4974R1 (2014)
2. Remarchuk, T., Process for Making Amino Acid Compounds. PCT/US13/41687/2012
3. Askin, D.; Han, C.; Lane, J.; Remarchuk, T. P.; Shakya, S.; Sowell, G.; Spencer, K. L.; Stengel, P. J.
"Process for Making Hydroxylated Cyclopentylpyrimidine Compounds" PCT/US13/41666/2012
4. Babu, S.; Gosselin, F.; Ran, Y.; Remarchuk, T.; Savage, S.; Stults, J.; Yajima, H. "Process of
Making Hydroxylated Cyclopentylpyrimidine Compounds and Salts" PCT/US2013/041695
5. Lane, J.; Remarchuk, T.; Shakya, S.; Spencer, K.; Stengel, P. "Process for Making Hydroxylated
Cyclopentylpyrimidine Compounds" PCT/US13/41624/2012
6. Babu, S.; Borer, B. C.; Remarchuk, T. P.; Szendroi, R. J.; Whitten, K. R.; Busse, J. K.; Albizati, K.
F. "Methods of Making Intermediates for the Preparation of the HIV Protease Inhibitor
Nelfinavir" US/1999/5925759
7. Babu, S.; Borer, B. C.; Remarchuk, T. P.; Szendroi, R. J.; Whitten, K. R.; Busse, J. K.; Albizati, K.
F. "Preparation of Intermediates for the HIV-Protease Inhibitor Nelfinavir" US/1998/5705647
8. Tao, J.; Babu, S.; Dagnino, R., Jr.; Tian, Q.; Remarchuk, T. P.; McGee, K. S.; Nayyar, N. K.; Moran,
T. J. "Process for Preparation of Amidopentenoate Peptide Analog Rhinovirus Protease
Inhibitors" US/2001/99-150365
9. Tian, Q.; Nayyar, N., K.; Babu, S.; Tao, J.; Moran, T. J.; Dagnino, R., Jr.; Mitchell, L. J.;
Remarchuk, T. P.; Melnick, M. J.; Bender, S. L. "Synthetic Routes for the Preparation of
Rhinovirus Protease Inhibitors and Key Intermediates" US/2001/99-150368
Invited Presentations
Sept 2014
Aug 2014
June 2014
Sept 2013
July 2013
July 2012
Sabbatical lectures: “Process Development of PI3k -Sparing Inhibitor GDC-0032
(Taselisib)” (1) RIKEN, JP; (2) Chugai, JP; (3) LG Company, SK; (4) Korea Advanced
Institute of Science and Technology (KAIST), Daejeon, SK; (5) Busan National University,
Busan, SK; (6) Sungkyunkwan University (SKKU), Suwon, SK
248th ACS National Meeting August 10–14th. Presentation: Remarchuk, T. P. "Part II.
Development of a Manufacturing Route to PI3k -Sparing Inhibitor GDC-0032
(Taselisib)" San Francisco, CA
GRC, Heterocycles. Presentation: Remarchuk, T. P. "Process Route Development of PI3kSparing inhibitor GDC-0032 (Taselisib)"
246th ACS National Meeting & Symposium; Presentation: Remarchuk, T. P. "Route Selection
and Early Stage Process Development of AKT Inhibitor GDC-0068" Indianapolis, IN
NORM ‘13 Conference; Presentation: Remarchuk, T. P. "Route Selection and Early Stage
Process Development of AKT Inhibitor GDC-0068" Corvallis, OR
GRC, Organic Reactions and Processes. Presentation: Remarchuk, T. P. "Process
Development Toward a Manufacturing Route for the AKT Inhibitor GDC-0068"
2
TRAVIS P. REMARCHUK, PH.D.
April 2012
Sept 2012
June 2011
May 2011
May 2011
May 2011
May 2008
Sept 2006
July 1998
Mar 1994
14th Annual MINT (Meeting on Innovation and New Technology) Conference at Roche Basel,
Switzerland. Presentation: Remarchuk, T. P. & Savage, S. "gRED Small Molecule Process
Chemistry Innovation on GDC-0068 (RG7440)"
Asilomar Research Conference. Poster: "Acceleration of PI3K Beta-Sparing Inhibitor GDC0032 to Ph III “Speed to Discovery, Development and to Patients”" St. Jean, F., Angelaud,
R.; Askin, D. & Remarchuk, T.
Genentech Small Molecule Drug Discovery (SMDD) Offsite Meeting, South San Francisco
convention center. Presentation: Remarchuk, T. P. "Process Chemistry Development of AKT
Inhibitor GDC-0068"
Asilomar Research Conference. Poster: "Process Chemistry on the AKT Inhibitor GDC0068: Enabling Uninterrupted Clinical Supply" Han, C.; Gosselin, F.; Remarchuk, T.;
Carrera, D.; Savage, S.; Yajima, H.; & St. Jean, F.
Asilomar Conference: "Process Development and GMP Manufacturing of the PI3K BetaSparing Inhibitor GDC-0032" St-Jean, F.;* Wong, B.; Remarchuk, T.; & Askin, D.
Asilomar Research Conference. Poster: "Quality challenges of AKT inhibitor GDC-0068
API resupply campaigns: Transitioning complex candidates to clinic" Dong, M. W.;
Yazzie, D. T.; Remarchuk, T.; Chetwyn, N. P.
Asilomar Research Conference. Poster: "Scale-Up Strategy for Small Molecule APIs at
Genentech" Rogers, R.; Wong, B.; Yajima, H.; Savage, S.; Babu, S. and Remarchuk, T.*
Asilomar Research Conference. Poster: "Scale-Up Strategy for Small Molecule APIs at
Genentech" Remarchuk, T. P.;* Ha, E.;* Savage, S.; Yajima, H.; Cheng, K.; Tian, Q.; Stumpf,
A.; Babu, S. & Reynolds, M.
GRC, Organic Reactions and Processes, Henniker, NH
Poster: Remarchuk, T. P. "Recent Developments Towards the Synthesis of HIV Protease
Inhibitor Viracept® From D-(–)-Tartaric Acid"
Western Undergraduate Conference, Lethbridge, AB, Canada. Poster: Remarchuk, T. P.;
Lazny, R.; Majewski, M. "Synthesis of Chiral Amines as Reagents for Enantioselective
Deprotonations in the Asymmetric Synthesis of Tropane Alkaloids"
Conferences Attended
July 2014
July 2011
July 2010
July 2009
July 2008
July 2007
Aug 1997
July 1996
Oct 1995
Gordon Research Conference Organic Reactions and Processes, RI
Gordon Research Conference; Organic Reactions and Processes, RI
Baltic Organic Symposium (BOS) in organic chemistry; Riga, Latvia
Gordon Research Conference; Organic Reactions and Processes, RI
Gordon Research Conference; Organic Reactions and Processes, RI
Gordon Research Conference; Organic Reactions and Processes, RI
Gordon Research Conference; Organic Reactions and Processes, Henniker, NH
Gordon Research Conference; Organic Reactions and Processes, New Hampton School, NH
The 10th Annual William S. Johnson Symposium in Organic Chemistry, Stanford University
3