SOM Table 1: Previously associated phenotypes and references for the variants genotyped in this study. SNP Phenotype Study Ref rs6541281 MDD 1 rs3738401 MDD 1 rs12044355 LOAD 2 rs1340982 MDD 1 rs1538979 BPD, SCZ 3 rs2492367 MDD 4 rs1322784 ASP 5 rs6675281 MDD 4 rs1000731 MDD 4 rs999710 SCZ 6 rs967433 MDD 1 rs821577 MDD; BPD, SCZ 1,3 rs821597 MDD 1,4 rs821616 MDD 1 rs821633 BPD, SCZ 3 rs2806465 MDD 1 rs3737597 SCZ 6 Abbreviations: BPD, bipolar disorder; MDD , major depressive disorder; SCZ, schizophrenia; ASP, Asperger’s syndrome; LOAD late onset Alzheimer’s disease. SOM Table 1 references: 1. Hashimoto R, Numakawa T, Ohnishi T, Kumamaru E, Yagasaki Y, Ishimoto T, Mori T, Nemoto K, Adachi N, Izumi A, Chiba S, Noguchi H, Suzuki T, Iwata N, Ozaki N, Taguchi T, Kamiya A, Kosuga A, Tatsumi M, Kamijima K, Weinberger DR, Sawa A, Kunugi H. Impact of the DISC1 Ser704Cys polymorphism on risk for major depression, brain morphology and ERK signaling. Hum Mol Genet. 2006 Oct 15;15(20):3024-33. 2. Beecham GW, Martin ER, Li YJ, Slifer MA, Gilbert JR, Haines JL, Pericak-Vance MA. Genomewide association study implicates a chromosome 12 risk locus for late-onset Alzheimer disease. Am J Hum Genet. 2009 Jan;84(1):35-43. 3. Hennah W, Porteous D. The DISC1 pathway modulates expression of neurodevelopmental, synaptogenic and sensory perception genes. PLoS One. 2009;4(3):e4906. 4. Schosser A, Gaysina D, Cohen-Woods S, Chow PC, Martucci L, Craddock N, Farmer A, Korszun A, Gunasinghe C, Gray J, Jones L, Tozzi F, Perry J, Muglia P, Owen MJ, Craig IW, McGuffin P. Association of DISC1 and TSNAX genes and affective disorders in the depression case-control (DeCC) and bipolar affective case-control (BACCS) studies. Mol Psychiatry. 2010 Aug;15(8):844-9. 5. Kilpinen H, Ylisaukko-Oja T, Hennah W, Palo OM, Varilo T, Vanhala R, Nieminen-von Wendt T, von Wendt L, Paunio T, Peltonen L. Association of DISC1 with autism and Asperger syndrome. Mol Psychiatry. 2008 Feb;13(2):187-96. 6. Allen NC, Bagade S, McQueen MB, Ioannidis JP, Kavvoura FK, Khoury MJ, Tanzi RE, Bertram L. Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database. Nat Genet. 2008 Jul;40(7):827-34.