Principal Investigator/Program Director (Last, First, Middle):
Castellanos, Francisco Xavier
BIOGRAPHICAL SKETCH
Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2.
Follow this format for each person. DO NOT EXCEED FOUR PAGES.
NAME
POSITION TITLE
Castellanos, Francisco Xavier
Professor of Child and Adolescent Psychiatry;
Professor of Radiology; Director of Research
eRA COMMONS USER NAME
FXCASTELLANOS
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)
INSTITUTION AND LOCATION
Vassar College, Poughkeepsie, NY
University of New Orleans, Louisiana
Louisiana State University Medical Center School
of Medicine in Shreveport
DEGREE
(if applicable)
A.B.
M.S.
M.D.
YEAR(s)
1975
1980
1986
FIELD OF STUDY
Linguistics
Experimental Psychology
Medicine
A. Positions and Honors.
Positions and Employment
1986-1991: “Triple Board” Resident – Combined Residency in Pediatrics, Psychiatry, and Child/Adolescent
Psychiatry, University of Kentucky, Lexington; 1991-1997: Child Psychiatry Research Fellow, Child Psychiatry
Branch, NIMH, Bethesda MD; 1997-2001: Staff Physician and Chief, ADHD Research Unit, Child Psychiatry
Branch, NIMH; 2001-present: Brooke and Daniel Neidich Professor of Child and Adolescent Psychiatry;
Director, Institute for Pediatric Neuroscience, NYU Child Study Center; Professor of Radiology, NYU School of
Medicine; 2003-present: Director of Research, NYU Child Study Center
Other Experience and Professional Memberships
1988-1991: Attending Pediatrician – Charter Ridge Hospital, Lexington, Kentucky; 1990-1991: Chief Resident
– Triple Board Program, University of Kentucky, Lexington; 1995-2001: Member, Institutional Review Board,
NIMH Intramural Research Program; 1997-2005: Member, Tourette Syndrome Association Scientific Advisory
Board; 1999-2001: Member, Ch.A.D.D. Professional Advisory Board; 2003-present: Member, American
College of Neuropsychopharmacology; 2005-present: Chair, Child Psychopathology & Developmental
Disability Initial Review Group, NIH Center for Science Review; 2006-present, Chair of DSM-V Work Group on
Externalizing and Learning Disorders
Honors
1980: Outstanding Graduate Student in Psychology, University of New Orleans; 1985: Alpha Omega Alpha
1986:Chancellor’s Award – Outstanding Medical Student LSUMC – Shreveport; 1990APA/NIMH Program for
Minority Research Training in Psychiatry Fellowships; 1990: Abraham Wikler MD Outstanding Psychiatry
Resident, University of Kentucky; 1992: New Investigator Award, New Clinical Drug Evaluation Unit, NIMH;
1992: NIMH Intramural Award for Excellence in Clinical Care and Research; 2000: ChADD Hall of Fame for
Outstanding Research on ADHD; 2004: Teacher of the Year, NYU Child Study Center Child/Adolescent
Psychiatry; 2005: NARSAD Distinguished Investigator Award; 2006: American Psychiatric Association Blanche
F. Ittleson Award for Research in Child/Adolescent Psychiatry
B. Peer-reviewed publications
(1) Castellanos FX, Sonuga-Barke EJS, Milham MP, Tannock R. Characterizing cognition in ADHD:
beyond executive dysfunction. Trends Cogn Sci 10:117-123, 2006.
(2) Castellanos FX, Glaser PE, Gerhardt GA. Towards a neuroscience of attention-deficit/hyperactivity
disorder: Fractionating the phenotype. J Neurosci Methods 151:1-4, 2006.
(3) Diaz Heijtz R, Castellanos FX. Differential effects of a selective dopamine D1-like receptor agonist on
motor activity and c-fos expression in the frontal-striatal circuitry of SHR and Wistar-Kyoto rats. Behav
Brain Funct 2:182006.
PHS 398/2590 (Rev. 09/04)
Page
1
Biographical Sketch Format Page
Principal Investigator/Program Director (Last, First, Middle):
Castellanos, Francisco Xavier
(4) Dickstein SG, Bannon K, Castellanos FX, Milham MP. The neural correlates of attention deficit
hyperactivity disorder: an ALE meta-analysis. J Child Psychol Psychiatry ePub 10-2006, 2006.
(5) Glaser PEA, Surgener SP, Grondin R, Gash CR, Palmer M, Castellanos FX, Gerhardt GA. Cerebellar
neurotransmission in attention-deficit/hyperactivity disorder: does dopamine neurotransmission occur in
the cerebellar vermis? J Neurosci Methods 15:62-67, 2006.
(6) Krain AL, Castellanos FX. Brain development and ADHD. Clin Psychol Rev 26:433-444, 2006.
(7) Krain AL, Wilson AM, Arbuckle R, Castellanos FX, Milham MP. Distinct neural mechanisms of risk and
ambiguity: a meta-analysis of decision-making. Neuroimage 32:477-484, 2006.
(8) Mulas F, Capilla A, Fernandez S, Etchepareborda MC, Campo P, Maestu F, Fernandez A, Castellanos
FX, Ortiz T. Shifting-related brain magnetic activity in attention-deficit/hyperactivity disorder. Biol
Psychiatry 59:373-379, 2006.
(9) Scheres A, Milham MP, Knutson B, Castellanos FX. Ventral striatal hyporesponsiveness during reward
anticipation in attention-deficit/hyperactivity disorder. Biol Psychiatry ePub 8-31/2006, 2006.
(10) Scheres A, Dijkstra M, Ainslie E, Balkan J, Reynolds B, Sonuga-Barke E, Castellanos FX. Temporal
and probabilistic discounting of rewards in children and adolescents: effects of age and ADHD
symptoms. Neuropsychologia 44:2092-2103, 2006.
(11) Shaw P, Lerch J, Greenstein D, Sharp W, Clasen L, Evans A, Giedd J, Castellanos FX, Rapoport J.
Longitudinal mapping of cortical thickness and clinical outcome in children and adolescents with
attention-deficit/hyperactivity disorder. Arch Gen Psychiatry 63:540-549, 2006.
(12) Bobb AJ, Castellanos FX, Addington AM, Rapoport JL. Molecular genetic studies of ADHD: 1991 to
2004. Am J Med Genet B Neuropsychiatr Genet 132:109-125, 2005.
(13) Bobb AJ, Addington AM, Sidransky E, Gornick MC, Lerch JP, Greenstein DK, Clasen LS, Sharp WS,
Inoff-Germain G, Wavrant-De Vrieze F, Arcos-Burgos M, Straub RE, Hardy JA, Castellanos FX,
Rapoport JL. Support for association between ADHD and two candidate genes: NET1 and DRD1. Am
J Med Genet B Neuropsychiatr Genet 134:67-72, 2005.
(14) Castellanos FX, Dickstein S. A computational thought experiment based on the pharmacology of
ADHD: commentary on Williams and Dayan. J Child Adolesc Psychopharmacol 15:157-159, 2005.
(15) Castellanos FX, Sonuga-Barke EJS, Scheres A, Di Martino A, Hyde C, Walters JR. Varieties of
attention-deficit/hyperactivity disorder-related intra-individual variability. Biol Psychiatry 57:1416-1423,
2005.
(16) Dickstein DP, Garvey M, Pradella A, Greenstein D, Sharp W, Castellanos FX, Pine D, Leibenluft E.
Neurologic examination abnormalities in children with bipolar disorder or attention-deficit/hyperactivity
disorder. Biol Psychiatry 58:517-524, 2005.
(17) Garvey MA, Barker CA, Bartko JJ, Denckla MB, Wassermann EM, Castellanos FX, Dell ML, Ziemann
U. The ipsilateral silent period in boys with attention-deficit/hyperactivity disorder. Clin Neurophysiol
116:1889-1896, 2005.
(18) Glaser PE, Thomas TC, Joyce BM, Castellanos FX, Gerhardt GA. Differential effects of amphetamine
isomers on dopamine release in the rat striatum and nucleus accumbens core. Psychopharmacology
178:250-258, 2005.
(19) Nicolson R, Craven-Thuss B, Smith J, McKinlay BD, Castellanos FX. A randomized, double-blind,
placebo-controlled trial of metoclopramide for the treatment of Tourette's disorder. J Am Acad Child
Adolesc Psychiatry 44:640-646, 2005.
(20) Seyffert M, Castellanos FX. Functional MRI in pediatric neurobehavioral disorders. Int Rev Neurobiol
67:239-284, 2005.
(21) Acosta MT, Castellanos FX. Use of the "inverse neuroleptic" metoclopramide in Tourette syndrome: an
open case series. J Child Adolesc Psychopharmacol 14:123-128, 2004.
(22) Arcos-Burgos M, Castellanos FX, Pineda D, Lopera F, David PJ, Guillermo PL, Rapoport JL, Berg K,
Bailey-Wilson JE, Muenke M. Attention-deficit/hyperactivity disorder in a population isolate: linkage to
Loci at 4q13.2, 5q33.3, 11q22, and 17p11. Am J Hum Genet 75:998-1014, 2004.
(23) Arcos-Burgos M, Castellanos FX, Konecki D, Lopera F, Pineda D, Palacio JD, Rapoport JL, Berg K,
Bailey-Wilson J, Muenke M. Pedigree disequilibrium test (PDT) replicates association and linkage
between DRD4 and ADHD in multigenerational and extended pedigrees from a genetic isolate. Mol
Psychiatry 9:252-259, 2004.
PHS 398/2590 (Rev. 09/04)
Page
Continuation Format Page
Principal Investigator/Program Director (Last, First, Middle):
Castellanos, Francisco Xavier
(24) Castellanos FX, Acosta MT. [The neuroanatomy of attention deficit/hyperactivity disorder]. Rev Neurol
38 Suppl 1:131-136, 2004.
(25) Castellanos FX, Acosta MT. [Tourette syndrome: an analysis of its comorbidity and specific treatment].
Rev Neurol 38 Suppl 1:124-130, 2004.
(26) Palacio JD, Castellanos FX, Pineda DA, Lopera F, Arcos-Burgos M, Quiroz YT, Henao GC, Puerta IC,
Ramirez DL, Rapoport JL, Bailey-Wilson J, Berg K, Muenke M. Attention-deficit/hyperactivity disorder
and comorbidities in 18 Paisa Colombian multigenerational families. J Am Acad Child Adolesc
Psychiatry 46:1506-1515, 2004.
(27) Reinblatt SP, Rifkin A, Castellanos FX, Coffey BJ. General psychiatry residents' perceptions of
specialized training in the field of mental retardation. Psychiatr Serv 55:312-314, 2004.
(28) Brotman LM, Gouley KK, Klein RG, Castellanos FX, Pine DS. Children, stress, and context: integrating
basic, clinical, and experimental prevention research. Child Dev 74:1053-1057, 2003.
(29) Castellanos FX, Sharp WS, Gottesman RF, Greenstein DK, Giedd JN, Rapoport JL. Anatomic brain
abnormalities in monozygotic twins discordant for attention deficit hyperactivity disorder. Am J
Psychiatry 160:1693-1696, 2003.
(30) Di Martino A, Castellanos FX. Functional neuroimaging of social cognition in pervasive developmental
disorders. A brief review. Ann N Y Acad Sci 1008:256-260, 2003.
(31) Keller A, Castellanos FX, Vaituzis AC, Jeffries NO, Giedd JN, Rapoport JL. Progressive loss of
cerebellar volume in childhood-onset schizophrenia. Am J Psychiatry 160:128-133, 2003.
(32) Sharp WS, Gottesman RF, Greenstein DK, Ebens CL, Rapoport JL, Castellanos FX. Monozygotic twins
discordant for attention-deficit/hyperactivity disorder: ascertainment and clinical characteristics. J Am
Acad Child Adolesc Psychiatry 42:93-97, 2003.
(33) Arcos-Burgos M, Castellanos FX, Lopera F, Pineda D, Palacio JD, Garcia M, Henao GC, Palacio LG,
Berg K, Bailey-Wilson JE, Muenke M. Attention-deficit/hyperactivity disorder (ADHD): Feasibility of
linkage analysis in a genetic isolate using extended and multigenerational pedigrees. Clin Genet
61:335-343, 2002.
(34) Bastain TM, Lewczyk CM, Sharp WS, James RS, Long RT, Eagen PB, Ebens CL, Meck JM, Chan WY,
Sidransky E, Rapoport JL, Castellanos FX. Cytogenetic abnormalities in attention-deficit/hyperactivity
disorder. J Am Acad Child Adolesc Psychiatry 41:806-810, 2002.
(35) Castellanos FX, Tannock R. Neuroscience of attention-deficit hyperactivity disorder: the search for
endophenotypes. Nat Rev Neurosci 3:617-628, 2002.
(36) Castellanos FX. Invited commentary: Proceed, with caution: SPECT cerebral blood flow studies of
children/adolescents with attention-deficit/hyperactivity disorder. J Nucl Med 43:1630-1633, 2002.
(37) Castellanos FX, Rapoport JL. Effects of caffeine on development and behavior in infancy and
childhood: a review of the published literature. Food Chem Toxicol 40:1235-1242, 2002.
(38) Castellanos FX, Acosta MT. El síndrome de déficit de atención con hiperactividad como expresión de
un trastorno funcional orgánico. Rev Neurol 35:1-11, 2002.
(39) Castellanos FX, Lee PP, Sharp W, Jeffries NO, Greenstein DK, Clasen LS, Blumenthal JD, James RS,
Ebens CL, Walter JM, Zijdenbos A, Evans AC, Giedd JN, Rapoport JL. Developmental trajectories of
brain volume abnormalities in children and adolescents with attention-deficit/hyperactivity disorder.
JAMA 288:1740-1748, 2002.
(40) Rapoport JL, Castellanos FX, Gogate N, Janson K, Kohler S, Nelson P. The scientific status of
attention deficit hyperactivity disorder (ADHD) - Reply. Aust N Z J Psychiatry 36:5632002.
(41) Asherson P, Barr C, Biederman J, Buitelaar J, Castellanos X, Curran S, Doyle A, Ebstein R, Eisenberg
J, Faraone SV, Gill M, Hay D, Holmes J, Hudziak J, Kennedy J, Kent L, Levy F, Manor I, Mick E, Price
T, Rohde LA, Rowe D, Sargeant J, Simonoff E, Spencer T, Swanson J, Taylor E, Todd R, Waldman I,
Yazgan Y. Report from the Second International Meeting of the Attention Deficit Hyperactivity Disorder
Molecular Genetics Network. Am J Med Genet 105:255-258, 2001.
(42) Castellanos FX. Neural substrates of attention-deficit/hyperactivity disorder, in Cohen D. J., Jankovic J.,
Goetz C. G., eds. Tourette Syndrome. Philadelphia, Lippincott Williams & Wilkins, 2001, pp 197-206.
(43) Castellanos FX, Giedd JN, Berquin PC, Walter JM, Sharp W, Tran T, Vaituzis AC, Blumenthal J,
Nelson J, Bastain TM, Zijdenbos A, Evans AC, Rapoport JL. Quantitative brain magnetic resonance
imaging in girls with attention-deficit/hyperactivity disorder. Arch Gen Psychiatry 58:289-295, 2001.
PHS 398/2590 (Rev. 09/04)
Page
Continuation Format Page
Principal Investigator/Program Director (Last, First, Middle):
Castellanos, Francisco Xavier
(44) Giedd JN, Blumenthal J, Molloy E, Castellanos FX. Brain imaging of attention deficit/hyperactivity
disorder. Ann N Y Acad Sci 931:33-49, 2001.
(45) Gould TD, Bastain TM, Israel ME, Hommer DW, Castellanos FX. Altered performance on an ocular
fixation task in attention-deficit/hyperactivity disorder. Biol Psychiatry 50:633-635, 2001.
(46) Greenhill LL, Pliszka S, Dulcan MK, Bernet W, Arnold V, Beitchman J, Benson RS, Bukstein O, Kinlan
J, McClellan J, Rue D, Shaw JA, Stock S, Kroeger K, Arnold LE, Biederman J, Cohen LG, Fritz G,
Castellanos FX. Summary of the practice parameter for the use of stimulant medications in the
treatment of children, adolescents, and adults. J Am Acad Child Adolesc Psychiatry 40:1352-1355,
2001.
(47) James RS, Sharp WS, Bastain TM, Lee PP, Walter JM, Czarnolewski M, Castellanos FX. A doubleblind placebo-controlled study of single-dose amphetamine formulations in ADHD. J Am Acad Child
Adolesc Psychiatry 40:1268-1276, 2001.
(48) Pineda DA, Lopera F, Henao GC, Palacio JD, Castellanos FX. [Confirmation of the high prevalence of
attention deficit disorder in a Colombian community]. Rev Neurologia 32:217-222, 2001.
(49) Rapoport JL, Castellanos FX, Gogate N, Janson K, Kohler S, Nelson P. Imaging normal and abnormal
brain development: new perspectives for child psychiatry. Aust N Z J Psychiatry 35:272-281, 2001.
(50) Asherson P, Barkley R, Barr C, Berg K, Biederman J, Castellanos X, Comings D, Curran S, Doyle A,
Ebstein R, Eisenberg J, Ergelen E, Faraone S, Freund L, Geller D, Gill M, Holmes J, Hudziak J,
Kennedy J, Kent L, Manor I, Mick E, Mitchell H, Navia B, Pato C, Pato M, Price T, Sargeant J, Simonoff
E, Smalley S, Spencer T, Swanson J, Waldman I, Wilens T, Yazgan Y. Collaborative possibilities for
molecular genetic studies of attention deficit hyperactivity disorder: report from an international
conference. Am J Med Genet 96:251-257, 2000.
(51) Castellanos FX, Marvasti FF, Ducharme JL, Walter JM, Israel ME, Krain AL, Pavlovsky C, Hommer
DW. Executive function oculomotor tasks in girls with ADHD. J Am Acad Child Adolesc Psychiatry
39:644-650, 2000.
(52) Nicolson R, Castellanos FX. Commentary: considerations on the pharmacotherapy of attention deficits
and hyperactivity in children with autism and other pervasive developmental disorders. J Autism Dev
Disord 30:461-462, 2000.
(53) Nopoulos P, Berg S, Castellanos FX, Delgado A, Andreasen NC, Rapoport JL. Developmental brain
anomalies in children with attention deficit hyperactivity disorder. J Child Neurol 15:102-108, 2000.
(54) Paule MG, Rowland AS, Ferguson SA, Chelonis JJ, Tannock R, Swanson JM, Castellanos FX.
Attention deficit/hyperactivity disorder: characteristics, interventions and models. Neurotoxicol Teratol
22:631-651, 2000.
(55) Castellanos FX. Stimulants and tic disorders - From dogma to data. Arch Gen Psychiatry 56:337-338,
1999.
(56) Castellanos FX, Lewczyk CM, Fernandez T, Koprivica V, Kashani A, Tayebi N, Ginns EI, Rapoport JL,
Sidransky E. Lack of an association between dopamine transporter (DAT1) & ADHD. Mol Psychiatry
4:S801999(Abstract).
(57) Castellanos FX, Lau E, Tayebi N, Lee P, Long RE, Giedd JN, Sharp WS, Marsh WL, Walter JM,
Hamburger SD, Ginns EI, Rapoport JL, Sidransky E. Sampling and analytic considerations in molecular
genetics studies of ADHD. The advantages of predicting phenotype from genotype in ADHD research Castellanos replies. Mol Psychiatry 4:4141999.
(58) Giedd JN, Blumenthal J, Jeffries NO, Castellanos FX, Liu H, Zijdenbos A, Paus T, Evans AC, Rapoport
JL. Brain development during childhood and adolescence: a longitudinal MRI study. Nat Neurosci
2:861-863, 1999.
(59) Giedd JN, Jeffries NO, Blumenthal J, Castellanos FX, Vaituzis AC, Fernandez T, Hamburger SD, Liu H,
Nelson J, Bedwell J, Tran L, Lenane M, Nicolson R, Rapoport JL. Childhood-onset schizophrenia:
progressive brain changes during adolescence. Biol Psychiatry 46:892-898, 1999.
(60) Giedd JN, Blumenthal J, Jeffries NO, Rajapakse JC, Vaituzis AC, Liu H, Berry YC, Tobin M, Nelson J,
Castellanos FX. Development of the human corpus callosum during childhood and adolescence: a
longitudinal MRI study. Prog Neuropsychopharmacol Biol Psychiatry 23:571-588, 1999.
(61) Sharp WS, Walter JM, Marsh WL, Ritchie GF, Hamburger SD, Castellanos FX. ADHD in girls: Clinical
comparability of a research sample. J Am Acad Child Adolesc Psychiatry 38:40-47, 1999.
PHS 398/2590 (Rev. 09/04)
Page
Continuation Format Page
Principal Investigator/Program Director (Last, First, Middle):
Castellanos, Francisco Xavier
(62) Berquin PC, Giedd JN, Jacobsen LK, Hamburger SD, Krain AL, Rapoport JL, Castellanos FX. The
cerebellum in attention-deficit/hyperactivity disorder: a morphometric study. Neurology 50:1087-1093,
1998.
(63) Castellanos FX, Lau E, Tayebi N, Lee P, Long RE, Giedd JN, Sharp WS, Marsh WL, Walter JM,
Hamburger SD, Ginns EI, Rapoport JL, Sidransky E. Lack of association between a dopamine-4
receptor polymorphism and attention-deficit/hyperactivity disorder: genetic and brain morphometric
analyses. Mol Psychiatry 3:431-434, 1998.
(64) Jacobsen LK, Giedd JN, Castellanos FX, Vaituzis AC, Hamburger SD, Kumra S, Lenane M, Rapoport
JL. Progressive reduction of temporal lobe structures in childhood onset schizophrenia. Am J
Psychiatry 155:678-685, 1998.
(65) Kumra S, Jacobsen LK, Lenane M, Zahn TP, Wiggs E, Alaghband-Rad J, Castellanos FX, Frazier JA,
McKenna K, Gordon CT, Smith A, Hamburger SD, Rapoport JL. "Multidimensionally impaired disorder":
is it a variant of very early-onset schizophrenia? J Am Acad Child Adolesc Psychiatry 37:91-99, 1998.
(66) Miller KJ, Castellanos FX. Management of attention-deficit/hyperactivity disorders. Pediatr Rev 19:373384, 1998.
(67) Swanson J, Castellanos FX, Murias M, LaHoste GJ, Kennedy J. Cognitive neuroscience of attention
deficit hyperactivity disorder and hyperkinetic disorder. Curr Opin Neurobiol 8:263-271, 1998.
(68) Casey BJ, Trainor RJ, Orendi JL, Schubert AB, Nystrom LE, Giedd JN, Castellanos FX, Haxby JV, Noll
DC, Cohen JD, Forman SD, Dahl RE, Rapoport JL. A developmental functional MRI study of prefrontal
activation during performance of a Go-No-Go task. J Cogn Neurosci 9:835-847, 1997.
(69) Casey BJ, Castellanos FX, Giedd JN, Marsh WL, Hamburger SD, Schubert AB, Vauss YC, Vaituzis
AC, Dickstein DP, Sarfatti SE, Rapoport JL. Implication of right frontostriatal circuitry in response
inhibition and attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 36:374-383,
1997.
(70) Castellanos FX, Giedd JN, Elia J, Marsh WL, Ritchie GF, Hamburger SD, Rapoport JL. Controlled
stimulant treatment of ADHD and comorbid Tourette's syndrome: effects of stimulant and dose. J Am
Acad Child Adolesc Psychiatry 36:589-596, 1997.
(71) Castellanos FX. Neuroimaging of attention-deficit hyperactivity disorder. Child and Adolescent
Psychiatric Clinics of North America 6:383-411, 1997.
(72) Castellanos FX. Toward a pathophysiology of attention-deficit/hyperactivity disorder. Clin Pediatr
36:381-393, 1997.
(73) Giedd JN, Castellanos FX, Rajapakse JC, Vaituzis AC, Rapoport JL. Sexual dimorphism of the
developing human brain. Prog Neuropsychopharmacol Biol Psychiatry 21:1185-1201, 1997.
(74) Lange N, Giedd JN, Castellanos FX, Vaituzis AC, Rapoport JL. Variability of human brain structure
size: ages 4 to 20. Psychiatry Res Neuroimaging 74:1-12, 1997.
(75) Mittleman BB, Castellanos FX, Jacobsen LK, Rapoport JL, Swedo SE, Shearer GM. Cerebrospinal fluid
cytokines in pediatric neuropsychiatric disease. J Immunol 159:2994-2999, 1997.
(76) Castellanos FX, Giedd JN, Hamburger SD, Marsh WL, Rapoport JL. Brain morphometry in Tourette's
syndrome: the influence of comorbid attention-deficit/hyperactivity disorder. Neurology 47:1581-1583,
1996.
(77) Castellanos FX, Ritchie GF, Marsh WL, Rapoport JL. DSM-IV Stereotypic Movement Disorder:
persistence of stereotypies of infancy in intellectually normal adolescents and adults. J Clin Psychiatry
57:116-122, 1996.
(78) Castellanos FX, Elia J, Kruesi MJP, Marsh WL, Gulotta CS, Potter WZ, Ritchie GF, Hamburger SD,
Rapoport JL, Kruesi MJ. Cerebrospinal homovanillic acid predicts behavioral response to stimulants in
45 boys with attention-deficit/hyperactivity disorder. Neuropsychopharmacology 14:125-137, 1996.
(79) Castellanos FX, Giedd JN, Marsh WL, Hamburger SD, Vaituzis AC, Dickstein DP, Sarfatti SE, Vauss
YC, Snell JW, Lange N, Kaysen D, Krain AL, Ritchie GF, Rajapakse JC, Rapoport JL. Quantitative
brain magnetic resonance imaging in attention-deficit/hyperactivity disorder. Arch Gen Psychiatry
53:607-616, 1996.
(80) Castellanos FX, Fine EJ, Kaysen D, Marsh WL, Rapoport JL, Hallett M. Sensorimotor gating in boys
with Tourette's syndrome and ADHD: preliminary results. Biol Psychiatry 39:33-41, 1996.
PHS 398/2590 (Rev. 09/04)
Page
Continuation Format Page
Principal Investigator/Program Director (Last, First, Middle):
Castellanos, Francisco Xavier
(81) Giedd JN, Rumsey JM, Rajapakse JC, Castellanos FX, Casey BJ, Kaysen D, Vaituzis AC, Vauss YC,
Hamburger SD, Rapoport JL. A quantitative MRI study of the corpus callosum in children and
adolescents. Brain Res Dev Brain Res 91:274-280, 1996.
(82) Jacobsen LK, Hommer DW, Hong WL, Castellanos FX, Frazier JA, Giedd JN, Rapoport JL. Blink rate in
childhood-onset schizophrenia: comparison with normal and ADHD controls. Biol Psychiatry 40:12221229, 1996.
(83) Jacobsen LK, Hong WL, Hommer DW, Hamburger SD, Castellanos FX, Frazier JA, Giedd JN, Gordon
CT, Karp BI, McKenna K, Rapoport JL. Smooth pursuit eye movements in childhood onset
schizophrenia: comparison with ADHD and normal controls. Biol Psychiatry 40:1144-1154, 1996.
(84) Arnold LE, Stoff DM, Cook EH, Jr., Cohen DJ, Kruesi MJP, Wright C, Hattab J, Graham P, Zametkin A,
Castellanos FX. Ethical issues in biological psychiatric research with children and adolescents. J Am
Acad Child Adolesc Psychiatry 34:929-939, 1995.
(85) Castellanos FX, Giedd JN, Eckburg P, Marsh WL, Vaituzis AC, Kaysen D, Hamburger SD, Rapoport
JL. Quantitative morphology of the caudate nucleus in attention deficit hyperactivity disorder. Am J
Psychiatry 151:1791-1796, 1994.
(86) Castellanos FX, Elia J, Kruesi MJP, Gulotta CS, Mefford IN, Potter WZ, Ritchie GF, Rapoport JL.
Cerebrospinal fluid monoamine metabolites in boys with attention-deficit hyperactivity disorder.
Psychiatry Res 52:305-316, 1994.
(87) Giedd JN, Castellanos FX, Casey BJ, Kozuch P, King AC, Hamburger SD, Rapoport JL. Quantitative
morphology of the corpus callosum in attention deficit hyperactivity disorder. Am J Psychiatry 151:665669, 1994.
(88) Castellanos FX, Rapoport JL. Etiology of attention-deficit hyperactivity disorder. Child and Adolescent
Psychiatric Clinics of North America 1:373-384, 1992.
(89) Little KY, Kearfott KS, Castellanos X, Rinker A, Whitley R. Increased detection of elevated TSH using
immunoradiometric assay. Can J Psychiatry 35:342-343, 1990.
(90) Little KY, Castellanos X, Humphries LL, Austin J. Altered zinc metabolism in mood disorder patients.
Biol Psychiatry 26:646-648, 1989.
(91) Shih WJ, Humphries L, Digenis GA, Castellanos FX, Domstad PA, DeLand FH. Tc-99m labeled
triethelene tetraamine polysterene resin gastric emptying studies in bulimia patients. Eur J Nucl Med
13:192-196, 1987.
(92) Porter RJ, Jr., Castellanos FX. Speech-production measures of speech perception: rapid shadowing of
VCV syllables. J Acoust Soc Am 67:1349-1356, 1980.
(93) Castellanos FX. Naloxone effects [letter]. Neurology 29:1318-1319, 1979.
(94) King BM, Castellanos FX, Kastin AJ, Berzas MC, Mauk MD, Olson GA, Olson RD. Naloxone-induced
suppression of food intake in normal and hypothalamic obese rats. Pharmacol Biochem Behav 11:729732, 1979.
(95) Olson GA, Olson RD, Kastin AJ, Castellanos FX, Kneale MT, Coy DH, Wolf RH. Behavioral effects of
D-Ala2-beta-endorphin in squirrel monkeys. Pharmacol Biochem Behav 9:687-691, 1978.
C.
Research Support:
ACTIVE
Agency
Grant
Grant Period:
Role on Project:
Goal:
PHS 398/2590 (Rev. 09/04)
Stavros S. Niarchos Foundation
Optical Imaging of Pediatric Neuropsychiatric Disorders
11/1/2001-8/31/2007
Principal Investigator
Near infrared spectroscopic imaging (NIRS) is performed in subjects with ADHD and
controls to validate this novel functional imaging paradigm and to test the hypothesis that
stimulants normalize abnormally low frequency oscillations in brain neuronal activity and
blood flow.
Page
Continuation Format Page
Principal Investigator/Program Director (Last, First, Middle):
Castellanos, Francisco Xavier
Agency
Grant
Grant Period:
Role on Project:
Goal:
National Institute of Mental Health
Cerebellar-Prefrontal-Striatal-Dysregulation in ADHD # R-21-MH066393
9/12/2002-8/31/2007
Principal Investigator
To establish an interdisciplinary network of basic and clinical scientists to test
hypotheses of cerebellar-striatal-prefrontal dysregulation in ADHD.
Agency
Grant
Grant Period:
Role on Project:
Goal:
National Institute of Mental Health
Research Training in Child and Adolescent Mental Health # 1T32 MH 067763
7/1/2003-6/30/2008
Principal Investigator
To establish a post-doctoral traineeship in child and adolescent mental health for child
and adolescent psychiatrists and child psychologists.
Agency
Grant
Grant Period:
Role on Project:
Goal:
National Institute on Drug Abuse
Childhood Stimulant Exposure Impact on Later Drug Abuse # 1R01-DA016979-01
9/30/2003-6/30/2008
Principal Investigator
To reevaluate probands and comparisons at mean age 39 for psychiatric and substance
abuse histories and to obtain high-resolution anatomic MRI scans to test the hypothesis
that age of first treatment is positively related to later substance use disorders.
Agency
Grant
Grant Period:
Role on Project:
Goal:
National Alliance for Research in Schizophrenia and Affective Disorders
Distinguished Investigator’s Award
5/1/2005-4/31/2007
Principal Investigator
To carry out non-linear multidimensional analyses of optical imaging and physiological
data in collaboration with Leslie Greengard of NYU Courant Institute of Mathematical
Sciences
PHS 398/2590 (Rev. 09/04)
Page
Continuation Format Page