Senior Design Project Data Sheet
Project #
Project Name
Project Track
Project Family
09054
Ex Vivo Rodent Lung
Deposition
Biomedical Systems
and Technologies
Medical Device
Technology
Start Term
Team Guide
Project Sponsor
Doc. Revision
082
John Wellin
American Cancer
Society
Project Description
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Lung chamber.
All systems must be able to be tested
independently.
Project Background:
Expected Project Benefits:
The goal of this project is to create an
experimental apparatus that can be used to verify
the numerical deposition predictions developed at
RIT to predict particle dose on the cells that line
the airway walls. The apparatus must precisely
simulate inflation and deflation of an actual
excised rodent lung in a pressurized and
controlled chamber. Past projects in this area
were P06215 and P07041.
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Problem Statement:
The apparatus must reproduce the biological
conditions of the lung’s environment and
functionality. The apparatus must also provide
the user with the ability to vary pressure and flow
conditions to study different particle deposition
scenarios.
Objectives/Scope:
1.
2.
3.
4.
Achieve aerosolization of dry particles.
Perform lung expansion and contraction
using techniques and under environmental
conditions that will mimic in-vivo lung
operation.
Use fluorescent probe technology developed
by Todd Pagano of NTID to measure particle
input and output to gain knowledge of
deposition within the lung.
Create a system that is cleanable or
desposable.

Support bioengineering program at RIT.
Validate research done by Dr. Robinson.
Gain support for future development and
testing of artificial lungs.
Gain support and funding from American
Cancer Society
Core Team Members:
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Matt Moore (IE)
David Kosla (ME)
David Sorensen (ME)
Ben Kahler (ME)
Matt Bliss (EE)
Tuan Pham (EE)
Strategy & Approach
Assumptions & Constraints:
1.
2.
3.
4.
5.
Benchmarking and validation is based on
research by Dr. Robinson and Edward
Harding.
Uniform pressure distribution.
Replication of in vivo conditions.
Easily reproducible excision procedure.
Use one or two probes.
Issues & Risks:
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Deliverables:
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Gain understanding of team roles and values.
Aerosol generator and static chamber.
Control system to prime air to in-vivo
conditions before entering lung.
Surgery process.
Aerosolizing dry particles and keeping
air static.
Minimizing particle deposition
throughout in the tubing.
Lungs must be quickly transplanted into
the system from the rodent.