Mendelian Genetics This section will deal with the study of inheritance, and the work of Gregor Mendel, who first understood how characteristics are passed on from one generation to the next. A) Web site name: Mendel’s Genetics Web URL: http://anthro.palomar.edu/mendel/mendel_1.htm 1) Which invention in the 1890s helped scientists to understand sexual reproduction? _________________________________________________ 2) When did Gregor Mendel publish his results? ___________________ 3) Explain the 19th century “blending theory” in your own words: _____________________________________________________________ _____________________________________________________________ _____________________________________________________________ _____________________________________________________________ 4) What is the name of the male sex structure in flowers? ________________ 5) Mendel’s “units” or “factors” of inheritance are now called: ___________ 6) What is meant by “homozygous”? _____________________________________________________________ _____________________________________________________________ 7) Explain Mendel’s “principle of segregation”: _________________________ _____________________________________________________________ _____________________________________________________________ 8) When does the segregation of alleles occur? _____________________________________________________________ 9) Which principle explains why inheriting a particular eye color has no effect on the likelihood of having 6 fingers on each hand ? _____________________________________________________________ B) Web site name: Mendel Web Web site address: http://www.mendelweb.org/MWpeaslee.html Read “In the Footsteps of Mendel” 10) Why did Mendel join a monastery? ________________________________ 11) Why are begonias now planted in Mendel’s garden and not peas? ________ _____________________________________________________________ 12) According to Pasteur “Chance favors ______________________________” 13) What subject, apart from natural history, did Mendel teach at the Technical College (Brno Modern School) ? __________________________________ 14) Mendel donated money to his birthplace. What was the money for? _____________________________________________________________ C) Web site name: Arizona State University Web site address: http://askabiologist.asu.edu/punnett-squares Read “Solving a genetic mystery” 15) What was Reginald Punnett’s profession? _________________________ _ 16) What are “alleles”? _____________________________________________ 17) What does “phenotype” refer to?__________________________________ ____________________________________________________________ 18) In the first example that is shown, which allele does Capital “A” represent? __________________________________________ 19) Does the order of the letters in a Punnett square make a difference? _______ 20) What does “heterozygous” mean? _______________________ _____________________________________________________________ 21) Explain why the yellow pea phenotype is called dominant: ______________ _____________________________________________________________ 22) In the second generation, why was it strange that some of the offspring had green seeds? _________________________________________________ ____________________________________________________________ D) Web site name: Science Daily Web URL: http://www.sciencedaily.com/releases/2014/06/140601150924.htm 23) Apart from humans, what other animal does David Kingsley study? _______________________________ 24) What is the name of the protein that affects hair color? _________________ 25) What happens when this genetic change is introduced into laboratory mice? _____________________________________________________________ _____________________________________________________________ 26) On which human chromosome does this single nucleotide change take place? ______________________________ 27) What does the KITLG gene alter by about 20 percent? _________________________________________ 28) Give examples of how the stickleback adapts to changes in its environment: _____________________________________________________________ _____________________________________________________________ _____________________________________________________________ 29) Which human population is particularly associated with blond hair? ___________________________________ 30) Why did Kingsley conclude that the change that causes blond hair is only skin deep? ____________________________________________________ _____________________________________________________________ E) Web site name: Science Nordic Web URL: http://sciencenordic.com/edible-vaccines-can-be-grown-everywhere One idea to improve vaccines is to take human genes, and add them to the DNA of plants and animals so that these plant cells produce human proteins. Read “Edible vaccines can be grown everywhere” 31) What is the problem with current vaccines, particularly in poor countries? ____________________________________________________________ ____________________________________________________________ 32) How does a vaccine work? _______________________________________ _____________________________________________________________ _____________________________________________________________ _____________________________________________________________ 33) How are vaccines traditionally produced? _____________________________________________________________ _____________________________________________________________ _____________________________________________________________ 34) What happens after scientists splice gene sequences into the genome of a plant? _______________________________________________________ ____________________________________________________________ 35) Which main food plants are scientists working on to make edible vaccines? ___________________________________________________________ ___________________________________________________________ 36) What are the five main diseases that researchers are trying to develop edible vaccines against ? ____________________________________________________________ _____________________________________________________________ _____________________________________________________________ _____________________________________________________________ F) Web site name: IFL Scince Web URL: http://www.iflscience.com/health-and-medicine/pig-hearttransplants-humans-could-be-their-way Read “Pig heart transplants for humans could be on their way” 37) What is the biggest problem with transplants using animal organs? _____________________________________________________________ _____________________________________________________________ 38) Which genes in the pigs were removed (or knocked out)? _____________________________________________________________ 39) How long have the hearts survived in the baboons? _____________________________________________________________ 40) What problem may be solved by using animal parts? _____________________________________________________________ 41) What potential problems can you see with this technique of transplanting organs from other species into humans? _____________________________ _____________________________________________________________ _____________________________________________________________ _____________________________________________________________ 42) If you needed a heart transplant, would you prefer to stay on a mechanical assist device until a human heart was available, or would you accept a pig heart? Explain your answer. _____________________________________________________________ _____________________________________________________________ _____________________________________________________________ _____________________________________________________________ _____________________________________________________________