CARDIOLOGY
1. HYPERTENSION
ß-Blockers
1. List the selective and non-selective beta-blockers available (include eye
drops).
2. How does selectivity affect the pharmacological action, indications and side
effects of the above?
3. List the most common side effects of beta-blockers.
4. What affect can beta-blockers have on lipids?
5. What conditions are beta-blockers contraindicated in?
6. What affect can beta-blockers have in diabetic patients?
7. List the common drug interactions of beta-blockers.
8. Describe the role (and mechanism of action) of beta-blockers in angina.
9. for SOTACOR 160mg : 1 bd
List:
generic name
drug class
appropriateness of the dose / usual dose range
indication/s
contraindications
main side effects
10. List the ancillary labels needed and any food specifications for all betablockers.
11. What is timolol used for? How does it work in this condition?
12. Discuss:
Rx
Cosopt 1 bd
Ventolin inhaler 1-2 qid pm
lntal Forte
1 qid
13. Discuss:
Rx
Tenormin
Isoptin 240
1 d ud
1 d ud
ACE Inhibitors & Angiotenson Receptor Antagonists
List the generic and brand names of all the ACEl and AIlRA's available.
1. Describe the differences in MOA between ACEI and AIl antagonists. Are
there any advantages to AIl antagonist? Can they be used together?
2. What are the common side effects? What ancillary labels are needed and
why?
3. List the drug interactions of these 2 classes.
4. Does the side effect profile differ between the individual ACEI? Does it
differ between ACEI and AIl antagonists?
5. for Teveten Plus 600mg / 12.5mg : 1 bd
List:
generic name
drug class
appropriateness of the dose / usual dose range
indication/s
contraindications
main side effects
6.Comment:
Rx
Tritace 5mg 1 daily
Moduretic
1 mane
7. Comment:
Rx
Capoten 25mg
1 tds ac
Eryc 250mg
1 qid pc
Rikodeine
8ml n pm pt
Calcium Antagonists
List all the calcium antagonists and brand names available.
1. Describe the pharmacological difference between selective and nonselective calcium antagonists.
2. Describe the role of calcium antagonists in angina prophylaxis.
3. What are the major side effects associated with the calcium antagonists?
Are there any differences between the selective and non-selective? Are there
any differences between the various selective agents?
4. What are the main drug interactions of calcium antagonists?
6. Comment:
Rx
Isoptin 240mg 1 d
Lanoxin PG 2 mane
Lasix 40mg 1.5 mane
Slow K 1 b pc
7. Comment:
Rx
Anpec 240mg
1d
Renitec 20mg
1d
Coloxyl with Senna 2 nocte
8. Discuss grapefruit juice and calcium antagonists? Is there an interaction
and is it clinically important? What is the mechanism of the interaction?
9. for Vasocardol 360mg : 1 d
List:
- generic name
- drug class
- appropriateness of the dose / usual dose range
- indication/s
- contraindications
- main side effects
Diuretics
List the loop, thiazide and potassium sparing diuretics with brand names
available.
1. What are the drug interactions of the loop, thiazide and potassium sparing
diuretics?
2. What is unique about spironolactone? What are its uses and main side
effects?
3. What are the main side effects of the other diuretics?
4. What are the uses of diuretics in general?
5. Are there any practical differences between the various thiazide agents?
What about the various loop diuretics?
6. for Inspra 50mg: daily
List:
generic name
drug class
appropriateness of the dose / usual dose range
indication/s
contraindications
main side effects
Other Antihypertensives
List the indications, MOA, side effects, drug interactions, doses and ancillary
labels for:
1. Prazosin
2. Methyldopa
3. Clonidine
2. CHOLESTEROL
List all drugs and brand names available for the treatment of high cholesterol.
1. What are the target values for cholesterol and triglycerides? Are they the
same for everyone?
2. Describe the role of diet in cholesterol lowering. What recommendations
would you make? What about "cholesterol lowering" margarines?
3. List the various statins available (generic and brand names). What are
their food specifications and standard doses?
4. What are the common side effects experienced by patients on Zocor?
5. How do pravastatin and atorvastatin differ from other HMG-CoA
Reductase Inhibitors?
6. for Crestor 40mg : 1 d
List:
generic name
drug class
appropriateness of the dose / usual dose range
indication/s
contraindications
main side effects
6. Describe the role of nicotinic acid in hyperlipidaemia. List the dose, major
side effects and counselling.
7. What is Ezetrol? How does it work and when is it indicated?
8. What is the mechanism of action of Questran? How can it be
administered? What are the interactions and side effects?
9. Discuss the following:
Rx Questran 4g
Zocor 20mg 1 n
Betaloc 100mg 1 bd
10. Discuss the following:
Rx Zocor 20mg 1 n
Lopid 600mg 1 bd
11. Describe the role of oestrogen in lipid lowering in post-menopausal
women.