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Exam II 2005 Multiple Choice Key
1.
A.
B.
C.
D.
E.
The initiating event in type I diabetes is now thought to be:
Fas induced apoptosis in beta cells in the pancreas
Inappropriate expression of MHC II by beta cells
Macrophage involvement leading to inflammation
A and B
A, B and C
2.
A.
B.
C.
D.
E.
VDR/RXR's are characterized and function as
Ligand activated receptors
Transcription Factors
Nuclear Receptors
A and B are correct
A, B and C are correct
3.
A.
B.
C.
D.
E.
Protein that is associated with Influenza type A virus attachment to target cell
Hemagglutinin
Neuraminidase
GP 120
A and B
A, B and C
4,
A.
B.
C.
D.
Absence of what proteins leads to antigenic variation in RNA viruses
Reverse transcriptase
DNA polymerase
RNA polymerase
RNA repair proteins
5.
A.
B.
C.
D.
E.
Differences between Influenza type A strains will be due to
Antigenic Drift
Antigenic Shift
RNA recombination
A and C
B and C
6.
A.
B.
C.
Differences between Influenza type A subtypes will be due to
Antigenic Drift
D. A and C
Antigenic Shift
E. B and C
RNA recombination
7.
A.
B.
C.
D.
E.
Mitogens
Will induce DNA mutations
Will induce non-specific activation of T and B cells
Induce tolerance
Protect cells from undergoing apoptosis
None of the above
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8.
A.
B.
C.
D.
E.
Failure in thymic development
results in severe immunodeficiency
can hinder clonal expansion of B cells
can cause inflammation
A and B are correct
A, B, and C are correct
9.
A.
B.
C.
D.
E.
T cell receptor complex is composed of
alpha and beta chains only
alpha and beta chains plus CD4 or CD8 molecules
alpha and beta chains plus CD3
alpha and beta chains plus CD28
none of the above
10. Two major cytokines secreted by T helper 1 cells are:
A. IL-1 and IL-6
B. IL-4 and IL-5
C. IL-2 and IFN-gamma
D. IL-10 and IL-12
E. TNF-alpha and GM-CSF
11. What T cell population will promote cytotoxic T cell expansion?
A. T helper 1 cells
B. T helper 2 cells
C. ThO cells
D. Tdh cells
E. A and B
12. CD28 is the ligand (exhibits specific binding) for
A. IL-1
B. MHC class II
C. antigen
D. B7
E. CD22
13. Superantigens are known to induce autoantibody diseases by binding to:
A. MHC class II molecules and TCR beta chain
B. MHC class I molecules and TCR alpha chain
C. MHC class I molecules and TCR beta chain
D. MHC class II molecules and TCR alpha chain
E. MHC class III molecules
14. Autoimmune diseases are described as
A. defects in the cell-mediated immune system
B. defects in the antibody-mediated immune system
C. an immune response against self-antigens
D. T cell deficiency
E. defects in thymus development
-315. The major cytokines secreted by T helper 2 cells are:
A. IL-4 and IL-5
B. IL-1 and IL-6
C. TNF-alpha and GM-CSF
D. IL-2 and IFN-gamma
E. IL-10 and IL-12
16. Aged red blood cells are removed by autoantibodies against
A. complement fragment
B. type O blood group
C. exposed band 3 protein
D. type A, B, and AB blood groups
E. B and D are correct
17. Which of the following is an example of tissue damage in autoimmunity due to "type III
hypersensitivity"?
A. peanut allergy in humans
B. autoimmune anemia
C. Graves' disease
D. Rheumatoid arthrytis
E. Myasthenia Gravis
18. Some autoimmune diseases may result from cross-reactions between immune responses
to microorganisms reacting with host tissues, a phenomenon called
A. molecular mimicry
B. antigenic variation
C. tissue sensitization
D. autosensitization
19. Autoimmune diseases
A. occur more often in females than males
B. are a heterogenous group of clinical and pathological diseases
C. can be described as organ specific or systemic
D. A and B are correct
E. A, B, and C are correct
20. Experimental autoimmune Myasthenia Gravis can be induced by injecting mice with
A. myelin basic proteins
B. thyroid hormones
C. acetylcholine receptors
D. antigens derived from nerve cells
E. antigens derived from T cells
21. NZB mice serve as a model for which autoimmune disease
A. Hayshimoto's thyroiditis
B. Insulin-dependent diabetes mellitus
C. multiple sclerosis
D. systemic lupus erythematosus
E. myasthenia gravis
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22. VDR knock out mice would have
A. Low levels of T helper 1 cell
B. High levels of T helper 1 cells
C. Would have an amplified cellular response
D. A and C are correct
E. B and C are correct
23. Which autoimmune disease tissue contains lymphocytic follicles and germinal centers?
A. brain tissue
B. spinal cord tissue
C. thyroid tissue
D. skeleton muscle
E. A and B are correct
24. Inadequate levels of vitamin B 12 is found in patients with
A. systemic lupus erythematosus
B. Pernicious anemia
C. Insulin-dependent diabetes mellitus
D. myasthenia gravis
E. multiple sclerosis
25. Which autoimmune disease is characterized by fetal cells in blood of females?
A systemic lupus erythematosus
B.Pernicious anemia
C Insulin-dependent diabetes mellitus
D Scleroderma
E Hayshimoto's thyroiditis
26. Rheumatoid factor is an
A. antinuclear antibody
B. antibody to synovial membranes
C. antibody to glomerular basement membrane
D. antibody to complement
E. antibody to IgG immunoglobulin
27. Systemic lupus erythematosus is most characteristically associated with
A. rheumatoid arthritis
B. amyloidosis
C. severe combined immunodeficiency
D. lymphoid cell tumors
E. antinuclear antibodies