SEXUALLY TRANSMITTED DISEASE AND HUMAN IMMUNODEFICIENCY VIRUS GENERAL INFORMATION FOR PATIENT SERVICES Purpose: The purpose of Sexually Transmitted Disease (STD) and Human Immunodeficiency Virus Counseling and Testing (HIVCT) Services is to prevent the spread and resultant sequelae of STDs, including Human Immunodeficiency Virus (HIV) infection. Under provisions of KRS Chapter 211, the Cabinet shall establish a network of voluntary HIV testing programs in every county of the state. The programs shall be conducted in each Local Health Department (LHD) and at selected other locations on an as need basis. Patients seeking services at HIVCT sites are given face-to-face pretest and post-test counseling by a qualified counselor trained in the HIV Counseling, Testing and Partner Notification Course instructed by personnel assigned to the STD and HIVCT programs or the AIDS Prevention Program staff. Anonymous counseling and testing services must be offered to persons who do not consent to confidential testing. Services must not be denied for those who choose confidential testing, but do not have the ability to pay. When it is necessary to test a patient for HIV-2 infection, contact the HIV Lab Testing Section at the Division of Laboratory Services, (502) 564-4446, ext. 4483, for instructions on specimen labeling. Services: Adequate examination with diagnosis and treatment services Face-to-face counseling for suspected infection, infection, and/or a contact to infection Rapid follow-up of positive laboratory results Rapid follow-up for contacts to STD or HIV Provide professional and public information and education Target Population: Persons presently infected or who have the potential for being infected with STD/HIV Pregnant and non-pregnant women High risk newborns and children Minorities Men who have sex with men Injecting drug users and their needle sharing and sexual partners Scope of Services: Disease Intervention Specialists (DIS) are assigned to four LHD locations: Louisville, Lexington, Bowling Green, and Florence. They are available to serve the STD/HIV needs of any county in Kentucky on short notice. The DIS perform priority STD interviews and assist with HIV counseling sessions at their assigned bases and in the counties within their jurisdiction. The interviewing process involves elicitation, location, and referral to examination of sexual and needle-sharing partners. Often field visits to the patient’s home are necessary. Investigative activities adhere to the rules of confidentiality. In addition to field staff, a manager, an assistant manager, and support staff are assigned to Frankfort. Service Sites: LHDs are required to provide STD/HIV services Louisville Metro Health Department Specialty Clinic is a clinic solely devoted to STD/HIV services Lexington-Fayette County Health Department operates a full-time HIVCT site Page 1 of 10 Kentucky Public Health Practice Reference Section: HIV/STD July 31, 2008 HIV COUNSELING/TESTING GUIDELINES Counseling and testing can only be done by persons who have attended the two day HIV Counseling and Partner Notification Course provided by the State STD Program or the AIDS Prevention Program. Types of Appointments: Client’s choice of confidential or anonymous for service. Confidential: Confidential client record initiated. Anonymous: No client record initiated. ID number used to identify testing and results. Court Ordered: No client record initiated. LHD involvement confined to specimen collection only and routing the specimen to the Division of Laboratory Services (DLS). Pre-Test Counseling Visit ACH 263 What You Should Know About HIV/AIDS Meaning of results: Positive, Negative, Indeterminate Review and plan for individual risk factor reduction Possibility of up to 6 months after exposure for antibody appearance Prognosis Prevention Review symptoms of other STDs, offer screening services Condom availability Explanation of HIV testing procedure Explain NO phone results given Must have ID number to obtain anonymous test results Written results will not be provided for test done anonymously Give appointment for Post-Test Counseling and results in two weeks with same provider, if feasible Initiate HIV Counseling and Testing Report Form Testing Procedure Submit 7-10 cc red stopper tube of whole blood to Virology Section of DLS, a green sticker which corresponds to the number of the lab slip, must be placed on the blood tube. Confidential Test: Name and ID number on lab form and specimen tube Anonymous Test: ID number only on lab form and specimen tube Court-Ordered Test: Name and ID number on lab form and specimen tube. Send Administrative Order of the Courts Form 499 to DLS with specimen OraSure or OraQuick testing Post-Test Counseling Visit for Negative Results Show results Explanation of no immunity to HIV Advise retest 6 months from last exposure incident Review risk factor reduction Review condom availability Review STD screening services Complete HIV Counseling and Testing Report Form* *Submit top copy of form to Kentucky STD Program. Retain bottom copy at local site for at least six months. If client does not return for Post-Test Counseling and results within two months, this form must still be completed, with top copy submitted, and bottom copy retained. Post-Test Counseling Visit for Positive Results Show results Assess coping ability Refer to KHCCP (Kentucky HIV Care Coordinator Program) Refer to area STD Program Supervisor for counseling and assistance Encourage anonymously tested clients to agree to confidential services Refer for nutritional counseling TB skin test (if not already done) Review symptoms of other STDs and offer screening services Review condom availability Review need to protect others from spread of infection Advise on need for notification of sex and needle sharing partners for testing Complete HIV Counseling and Testing Report Form* *Submit top copy of form to Kentucky STD Program. Retain bottom copy at local site for at least six months. If client does not return for Post-Test Counseling and results within two months, this form must still be completed, with top copy submitted, and bottom copy retained. Page 2 of 10 Kentucky Public Health Practice Reference Section: HIV/STD July 31, 2008 RYAN WHITE STATE FUNDED SERVICES PROGRAMS Overall intent of these services programs is to provide clients with a continuum of care utilizing existing community-based services to the greatest possible extent. Kentucky HIV Care Coordinator Program (KHCCP) Purpose: Facilitate provision of quality care services to HIV infected individuals and families in timely and consistent manner across a continuum of care. Provides Care Coordinators in six regional sites through arrangements with LHDs to aid the client in identifying and accessing needed services. KHCCP acts as umbrella program for other client assistance programs: Kentucky AIDS Drug Assistance Program (KADAP), Outpatient Health Care and Support Services, and the Kentucky Health Insurance Assistance Program (KHIAP). Following is a list of counties served by regions including Area Development Districts (ADDs): Barren River Region: Matthew 25, 411 Letcher Street, Henderson, KY 42420 Care Coordinator(s): 270-826-0200 ADDs: Barren River, Green River, and Lincoln Trail Counties: Allen, Barren, Breckinridge, Butler, Daviess, Edmonson, Grayson, Hancock, Hardin, Hart, Henderson, Larue, Logan, McLean, Marion, Meade, Metcalfe, Monroe, Nelson, Ohio, Simpson, Union, Warren, Washington, Webster Cumberland Valley Region: based in Cumberland Valley District Health Department Care Coordinator(s): 606-864-3776 ADDs: Lake Cumberland, Cumberland Valley, Kentucky River, and Big Sandy Counties: Adair, Bell, Breathitt, Casey, Clay, Clinton, Cumberland, Floyd, Green, Harlan, Jackson, Johnson, Knott, Knox, Laurel, Lee, Leslie, Letcher, Magoffin, Martin, McCreary, Owsley, Perry, Pike, Pulaski, Rockcastle, Russell, Taylor, Wayne, Whitley, Wolfe Lexington Region: based in Lexington-Fayette County Health Department Care Coordinator(s): 859-288-2362 ADDs: Bluegrass, Buffalo Trace, FIVCO, Gateway Counties: Anderson, Bath, Bourbon, Boyd, Boyle, Bracken, Carter, Clark, Elliott, Estill, Fayette, Fleming, Franklin, Garrard, Greenup, Harrison, Jessamine, Lawrence, Lewis, Lincoln, Madison, Mason, Menifee, Mercer, Montgomery, Morgan, Nicholas, Powell, Robertson, Rowan, Scott, Woodford Louisville Region: based in Volunteers of America, 850 Barret Avenue, Suite 302, Louisville, KY 40204 Care Coordinator(s): 502-574-0161 ADDs: KIPDA Counties: Bullitt, Henry, Jefferson, Oldham, Shelby, Spencer, Trimble Northern Kentucky Region: based in Northern Kentucky District Health Department Care Coordinator(s): 859-578-7660 ADDs: Northern Kentucky Counties: Boone, Campbell, Carroll, Gallatin, Grant, Kenton, Owen, Pendleton Purchase Region: Heartland Cares Inc., 3025 Clay Street, Paducah, KY 42002 Care Coordinator(s): 877-444-8183 (toll free) ADDs: Pennyrile, Purchase Counties: Ballard, Caldwell, Calloway, Carlisle, Christian, Crittenden, Fulton, Graves, Hickman, Hopkins, Livingston, Lyon, McCracken, Marshall, Muhlenberg, Todd, Trigg For more information, contact HIV Services Program Administrator 502-564-6539 Page 3 of 10 Kentucky Public Health Practice Reference Section: HIV/STD July 31, 2008 COMMON SEXUALLY TRANSMITTED DISEASES These guidelines reflect minimal services, and address the most common STDs currently presenting in the clinic setting in LHDs. LHDs with appropriate staff and capability to provide additional diagnostic and treatment services should add to or modify these guidelines. The guidelines included are based on the 2006 STD Treatment Guidelines and recent revisions, published by the Centers for Disease Control and Prevention (CDC). The treatment regimens described are for medications generally available for use in LHDs. Alternative regimens using medications not readily available are omitted for the sake of clarity. A copy of the 2006 (CDC) STD Treatment Guidelines must be available at each service site for reference and additional information. Copies of the Guidelines can be obtained from the Kentucky STD Control Program, Frankfort. Overall goals for providing STD services are to: Request area DIS for epidemiologic follow-up for 100% of suspected or diagnosed cases of priority STD (early syphilis and HIV infection), and darkfield microscopy. Assure that quality examination, diagnostic and treatment services are available to all females and males seeking or who are in need of such services. Include as a minimum for all patients evaluated for STD: o Examination for signs/symptoms of STD, to include visual examination of external genitalia for male and female patients and a speculum examination for female patients. o Appropriate screening test (gonorrhea [GC] and chlamydia tests [CT] from exposed site[s], Venereal Disease Research Laboratory [VDRL] rapid plasma regain [RPR], HIV antibody, etc.). A swab specimen will be collected from the urethra of males who are symptomatic. Urine samples will be collected from females without a cervix and for non-sexually active adolescent females and males. o Risk reduction counseling. Assessment for HIV risk. Counseling/testing offered to persons assessed to be at increased risk. Female patients suspected of having PID must be treated by the LHD or referred to another provider for management and care. Assure that patients with positive chlamydia and/or gonorrhea tests return for treatment within seven (7) days of receipt of laboratory report. Provide patients diagnosed with gonorrhea, male patients with urethritis (test results pending) and their sexual contacts with treatment effective against both gonorrhea and chlamydia. At time of original examination, provide epidemiologic/prophylactic treatment to all contacts exposed to gonorrhea within the past 60 days. At time of original examination provide epidemiologic/prophylactic treatment to all contacts to chlamydia, Nongonococcal Urethritis (NGU) and Mucopurulent Cervicitis who were exposed within the past 60 days. Provide face-to-face counseling/interviewing to public clinic patients diagnosed with chlamydia, gonorrhea, NGU or Mucopurulent Cervicitis. Interviews would be achieved in a timely manner, with the goal of obtaining an average of at least one contact elicited per case interviewed. This service should be available to privately diagnosed and treated patients upon request of their physician. Assure that contacts to chlamydia, gonorrhea, NGU, Mucopurulent Cervicitis named in interviews with infected patients are referred for medical evaluation in a timely manner. Assure reporting of suspected sexual abuse to the Department for Community-Based Services. Page 4 of 10 Kentucky Public Health Practice Reference Section: HIV/STD July 31, 2008 Overall goals for providing STD services are to: Provide all patients through counseling and/or printed material, adequate motivation that will: o Increase patients’ awareness of signs and symptoms of STDs and prompt patient to seek medical care immediately should evidence of symptoms occur. o Increase the number of sexual partners referred for evaluation by STD patients. o Increase patients’ rate of compliance with prescribed medication regimen. o Increase the practice of preventive behaviors in the patient population (use of condoms, selection of partners, etc.). Provide reporting vehicle to local private physicians and encourage voluntary reporting in order to more accurately determine the extent of the local STD problem. Should a clinician decide that a test-of-cure is needed, culture is the prescribed method but is unavailable through the DLS. A specimen can be collected for Gen-Probe testing by the DLS but a positive result may represent nonviable chlamydia remnants from the earlier infection. STD Offices by Area Developmental Districts (ADD) ADD STD Office 1–4 Warren County Health Dept., Bowling Green, KY 5–6 Specialty Clinic, Louisville, KY Northern Kentucky Independent District Health Dept., 7 Florence, KY 8–15 Fayette County Health Dept., Lexington, KY Page 5 of 10 Kentucky Public Health Practice Reference Section: HIV/STD July 31, 2008 Telephone (270) 781-2490, ext. 213 or ext. 214 (502) 574-6699 (859) 363-2060 (859) 255-6152 Guideline for Non-Occupational Post Exposure Prophylaxis (nPEP) In the case of exposure to blood, genital secretions, or other potentially infectious fluids of a known HIV+ person, a local health department, or other public health contracting agency or partner should: 1. If the client has the financial means or is medically insured, they should be recommended to go to their regular healthcare provider within 72 hours of exposure. 2. Otherwise, the client should be recommended to go to an emergency room within 72 hours of exposure. 3. Recommend HIV testing. Page 6 of 10 Kentucky Public Health Practice Reference Section: HIV/STD July 31, 2008 Protocols for Treatment of Common Sexually Transmitted Diseases Before treating a pregnant woman for a sexually transmitted disease, confer with the physician responsible for her maternity care. Generally, treatment for STD’s found in a pre-pubertal child should be managed by the child’s physician. Unless contraindicated (e.g., allergy or pregnancy), the first drug listed is the drug of choice. Condition Treatment Management of Sexual Follow-up Partner Chlamydia trachomatis* Do not need to retest Azithromycin 1g (two 500 mg All persons sexually for chlamydia after Confirmed infections tablets) p.o or exposed to Chlamydia completed therapy with laboratory test(s) trachomatis infections Doxycycline 100 mg p.o. BID x 7 unless symptoms within the previous 60 If there is a possibility days (not to be used if patient is persist or reinfection is days should be tested for of medical/legal pregnant, allergic to drug, or suspected. chlamydia, gonorrhea, considerations, patient under 8 years old) or and syphilis and should have a culture Erythromycin (base or stearate) promptly treated. done at a laboratory 500 mg p.o. QID x 7 days or certified to perform Amoxicillin 500 mg p.o. TID x 7 culture tests for to 10 days. May be substituted for chlamydia and erythromycin in pregnancy gonorrhea. Note: Symptomatic patients should also be treated for gonorrhea (see next page). Chlamydia–associated Syndromes NGU/NSU Male patients with urethral discharge and/or lab report on Gram stained smear of exudates indicates 4 or more polymorphonuclear leukocytes Azithromycin 1g (two 500 mg tablets) p.o. or Doxycycline 100 mg p.o. BID x 7 days or Erythromycin (base or stearate) 500 mg p.o. QID x 7 days may be used if patient cannot take doxycycline; i.e., allergy. Also treat for gonorrhea (see next page). Sex partners in the previous 60 days should be examined, tested for chlamydia, gonorrhea, and syphilis and treated at one sitting If no improvement repeat treatment x 1, then refer to private physician Advise patient to return to clinic if symptoms persist or recur. Sex partners in the past Advise patients to Azithromycin 1g (two 500 mg 60 days should be return to clinic if tablets) p.o. or examined and tested for symptoms persist or Doxycycline 100 mg p.o. BID x 7 chlamydia, gonorrhea recur. days (not to be used if patient is and syphilis and pregnant, allergic to drug, or promptly treated. under 8 years old) or Erythromycin (base or stearate) 500 mg p.o. QID x 7 days. Also treat for gonorrhea (see end of this section). *The Department for Public Health recommends that symptomatic male or female patients be treated with a regimen appropriate for both gonorrhea and chlamydia at the time of their initial visit. Mucopurulent Cervicitis Female patient with mucopurulent secretion from the endocervix which appears yellow/green on a white tipped swab (positive swab test) Note: Beginning in late June 2006, the STD Program began supplying Azithromycin in 500 mg. tablets only. Sites should use the 1 gram sachets previously supplied until their supply is exhausted and re-order 500 mg. tablets for future needs. Costs for filling pediatric prescriptions will be borne by the patient or LHD. ____________________________________ M.D. Signature Page 7 of 10 Kentucky Public Health Practice Reference Section: HIV/STD July 31, 2008 Date PROTOCOL FOR TREATMENT OF COMMON STDs (Continued) Condition Treatment GC Infections Male or female with positive genital or rectal test(s) for gonorrhea. Male with gram stained smear of urethral exudates indicating “Gram negative intracellular diplococci” should be presumed to have gonorrhea and should be treated. Oral and rectal specimens must be confirmed by culture results.* An important concern in the treatment of GC is coexisting chlamydial infection. Patient compliance with multiple-day treatment regimens can be a problem. To address these concerns a single dose regimen for gonorrhea should be administered in conjunction with the doxycycline or azithromycin regimen. This should be curative for both GC and chlamydial infections. If there is a possibility of medical/legal considerations, patients should have a culture done at a laboratory. Uncomplicated GC infections of the cervix, urethra, rectum, and pharynx in adults and adolescents: Ceftriaxone 125 mg IM in a single dose or Cefixime 400 mg, orally in a single dose (when available), except for GC infections of the pharynx Management of Sexual Partner All persons exposed to GC in the previous 60 days should be examined and tested for chlamydia, gonorrhea and syphilis and treated at one sitting. ALTERNATIVE REGIMEN FOR PATIENTS ALLERGIC TO CEPHALOSPORINS: Azithromycin 2 g, orally in a single dose Spectinomycin 2 g IM (when available) PLUS TREATMENT FOR CHLAMYDIA IF CHLAMYDIAL INFECTION IS NOT RULED OUT (unless the 2 g Azithromycin regimen is used) Uncomplicated GC Infections of the cervix, urethra, rectum, and pharynx in Pregnancy Drug regimens of choice: Ceftriaxone 125 mg IM in a single dose or Cefixime 400 mg, orally in a single dose (when available), except for GC infections of the pharynx Follow-up Follow-up tests are not indicated for persons with uncomplicated gonorrhea who are treated with one of the listed regimens. Individuals in whom symptoms persist after treatment should be reevaluated. Infections detected after treatment with one of the listed regimens more commonly occur because of reinfection rather than treatment failure, indicating a need for improved sex partner referral and patient information. The DPH recommends that symptomatic male or female patients be treated with a regimen appropriate for both gonorrhea and chlamydia at the time of their initial visit. *Testing of oral and rectal specimens by nucleic acid probe has not been approved by the FDA. __________________________________ M.D. Signature Date Page 8 of 10 Kentucky Public Health Practice Reference Section: HIV/STD July 31, 2008 PROTOCOL FOR TREATMENT OF COMMON STDs (continued) Condition GC Infections (continued) Treatment Management of Sexual Partner Follow-up ALTERNATIVE REGIMEN FOR PATIENTS ALLERGIC TO CEPHALOSPORINS: Azithromycin 2 g, orally in a single dose Spectinomycin 2 g IM (when available) PLUS TREATMENT FOR CHLAMYDIA IF CHLAMYDIAL INFECTION IS NOT RULED OUT (unless the 2 g Azithromycin regimen is used) Consult clinician responsible for patient’s maternity care prior to treatment if feasible and acceptable to patient.* Syphilis Due to complexity of diagnoses, written Partner contact Patients treated for orders should be obtained prior to referral will be primary, secondary, or treatment. Notify area STD coordinated by area early latent syphilis Primary, Secondary, or Early Latent (less representative STD should have blood test than one year duration) immediately for representative. (VDRL) 6 months and 12 treatment, Benzathine Penicillin G (Bicillin LA) Contacts exposed months post treatment. management and 2.4 million units deep IM at one to early syphilis Patients treated for follow-up. sitting (unless patient is allergic to within 90 days primary, secondary, or penicillin) before the patient’s early latent syphilis Doxycycline 100 mg p.o BID x 14 date of treatment should be offered testing days (total dose 2.8 Gm) should be given for HIV infection at time Latent Syphilis prophylactic of diagnosis of syphilis. (more than one year duration) treatment. If HIV infected, the Benzathine Penicillin G (Bicillin LA) patient should be retested 2.4 million units deep IM once a week for syphilis every 3 for a total of three injections. months up to one year. Patients allergic to penicillin who are Patients treated for latent pregnant or co-infected with syphilis should have HIV/AIDS should be desensitized and VDRL repeated at 6, 12, then treated with a penicillin regimen and 24 months. appropriate for the stage of syphilis infection. *OK to treat without consulting obstetric physician if patient objects or if contacting the physician will result in undue delay. ______________________________________ M.D. Signature Date Page 9 of 10 Kentucky Public Health Practice Reference Section: HIV/STD July 31, 2008 PROTOCOL FOR TREATMENT OF COMMON STDs (continued) Condition Syphilis (continued) Treatment Management of Sexual Partner Follow-up Late Manifest (Neurosyphilis, Cardiovascular, Benign) Consult CDC Guidelines Syphilis in Pregnancy Patients with syphilis who are pregnant should be treated with penicillin using the penicillin regimen appropriate for the woman’s stage of syphilis. If the patient is allergic to penicillin, arrangements should be made for desensitization and subsequent treatment with the penicillin regimen appropriate for the woman’s stage of syphilis. Consult physician responsible for patient’s maternity care prior to treatment and consult area STD representative for assistance. Condition Venereal Warts (Condylomata acuminata, Human Papillomavirus (HPV) visible or on Pap test report Herpes Simplex Pubic Lice (Crabs) Management/Treatment Test for chlamydia, gonorrhea and syphilis Refer to clinician for treatment or management of visible lesions Follow protocol for abnormal Pap test for HPV found on Pap test. When Herpes is suspected, test for chlamydia, gonorrhea, and syphilis Refer to clinician for management Test for chlamydia, gonorrhea and syphilis Recommend that the patient use one of the following over-the-counter treatments: permethrin 1%; i.e., Nix. Alternative: Pyrethins and Piperonyl Butoxide; i.e., RID, A-200, (over-the-counter preparations for which a second application one week later is recommended) __________________________________ M.D. Signature Medications available from the state for the treatment of STDs include: Amoxicillin (1 gram or 500 mg. tablets) Doxycycline Hyclate Azithromycin (500 mg. tablets) Erythromycin (250 mg. and 500 mg.) Benzathine Penicillin G (Bicillin LA) Ceftriaxone (Rocephin) 250mg Page 10 of 10 Kentucky Public Health Practice Reference Section: HIV/STD July 31, 2008 Date