Robert E. Anderson, MD, PhD
CURRICULUM VITAE
ANDERSON, Robert Eugene
Born on October 5, 1940, in Livingston, Texas; married to Elizabeth (Ozan); three children: Nick, David, and
Susan; four grandchildren: Ashley, Alexander, Taylor, and Ian.
ADDRESS
(Home)
1621 E. Glendale Drive
Edmond, OK 73034
(Work)
Dean A. McGee Eye Institute
Department of Ophthalmology
608 Stanton L. Young Blvd
Oklahoma City, OK 73104
Telephone
405-340-4999
Telephone
FAX
E-Mail
405-271-8250
405-271-8128
robert-anderson@ouhsc.edu
EDUCATION
Texas A & M University, College Station, TX, 1958-63, Bachelor of Arts in Mathematics.
Texas A & M University, College Station, TX, 1963-65, Master of Science in Biochemistry.
Texas A & M University, College Station, TX, 1965-68, Doctor of Philosophy in Biochemistry.
Oak Ridge Associated Universities, Medical Division, Oak Ridge, TN, 1968, AEC Postdoctoral Fellowship.
Baylor College of Medicine, Houston, TX, 1972-75, Doctor of Medicine.
ACADEMIC AFFILIATIONS
George Lynn Cross Research Professor, University of Oklahoma Health Sciences Center, Oklahoma City, OK.
June 1, 2005 – present.
Dean A. McGee Professor of Ophthalmology, Department of Ophthalmology, University of Oklahoma Health
Sciences Center, Oklahoma City, OK. July 1, 1998 – present.
Director of Research, Dean A. McGee Eye Institute, July 1, 1998 – present.
Professor and Chair, Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma
City, OK. May 1, 1998 – July 31, 2007.
Adjunct Professor of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK.
January 1, 1998 - present.
Director, Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, Oklahoma City,
OK. January 1, 1995 - March 1, 1999.
Adjunct Professor of Biochemistry & Molecular Biology, University of Oklahoma Health Sciences Center,
Oklahoma City, OK. January 1, 1995 - present.
Professor of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, OK. January 1,
1995 – July 1, 1998.
Professor of Biochemistry, Departments of Ophthalmology and Biochemistry and Division of Neuroscience,
Baylor College of Medicine, Houston, TX. July 1, 1981 - January 31, 1995.
Visiting Professor, Department of Medical Biochemistry, Kurume University School of Medicine, Kurume, Japan.
September 1988 - present.
Associate Professor of Biochemistry, Departments of Ophthalmology and Biochemistry, Baylor College of
Medicine, Houston, TX. March, 1976 - June, 1981.
Assistant Professor of Biochemistry, Departments of Ophthalmology and Biochemistry, Baylor College of
Medicine, Houston, TX. January, 1969 - March, 1976.
Postdoctoral Fellow, Oak Ridge Associated Universities, Medical Division, Oak Ridge, Tennessee. January,
1968 - January, 1969.
OTHER AFFILIATIONS
Member, Scientific Advisory Board, The Foundation Fighting Blindness (formerly the National Retinitis
Pigmentosa Foundation), Hunt Valley, MD, 1985 – present
Member, Scientific Advisory Board, Retina Foundation of the Southwest, Dallas, TX, 1993 – 2000.
Member, Executive Board, Texas Society to Prevent Blindness, Houston, TX, 1983 – 1995.
Medical Director and Chief Financial Officer, Insta-Medic Home Health Care, Inc., Houston, TX, 1984 - 1990.
Medical Director and Chief Financial Officer, Insta-Medic Home Health Care II, Inc., Houston, TX, 1986 - 1990.
Chief Financial Officer, ContinueCare Home Health, Inc., Houston, TX, 1990 - 1992.
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Robert E. Anderson, MD, PhD
Member, Board of Directors, FHJ Scientific, Inc., Nacogdoches, Tx, 1985 - 2000.
Member, Board of Directors, Docosa Foods, Ltd., Columbus, OH, 1997 – 2005.
HONORS, AWARDS, and SERVICE
Proctor Award, Association for Research in Vision and Ophthalmology (ARVO), to be awarded in 2011
Fellow (Gold level), Association for Research in Vision and Ophthalmology (ARVO), 2009
Past-President, International Society for Eye Research, January, 2007 – December, 2009
Visiting Professor, West China School of Medicine, Sichuan University, Chengdu, China, April 13, 2007
Honorary Professorship, Xi’an Jiaotong University, Xi’an, China, June 12, 2007
Honored Speaker, Peking University Global Ophthalmology Forum, Beijing, June 22-24, 2007
Visiting Professor Pro Tempore, Cleveland Clinic Education Foundation, Cleveland, OH, May 18, 2007
Honorary Professor of Sichuan Medical Science Academy, Sichuan Provincial People’s Hospital, Sichuan,
China, May 26, 2006
George Lynn Cross Research Professor, OUHSC, April, 2005
Memorial Lecture, American College of Veterinary Ophthalmologists, Nashville, October 15, 2005
Scientific Advisory Panel, Research to Prevent Blindness, 10/2005 – 9/2008
Dean’s Lecture, Louisiana State University College of Medicine, January 27, 2005
Anne Gibson Memorial Lecture, Institute of Brain Chemistry and Human Nutrition, London- July 6, 2004
President, International Society for Eye Research, January, 2004 – December, 2008
Distinguished Lecturer, Creighton University, June 18, 2003
Visiting Lecturer Pro Tempore, Cole Eye Institute, Cleveland Clinic Foundation, May 15, 2003
Honoree, Huntington’s Disease Society of Oklahoma, February, 2003
President Elect, International Society for Eye Research, July 2002 – December, 2003
Editorial Board, Experimental Eye Research, 1991 - 2002
Japanese Society for the Promotion of Science, Travel Award, March – April, 2001
Roy Steinberg Memorial Lecture, UCSF, March, 2000
Special Recognition Award, Association for Research in Vision and Ophthalmology (ARVO), 1996 – 1997
Vice-President, ARVO, May, 1998
Senior Scientific Investigator’s Award, Research to Prevent Blindness, Inc., 1997
Marjorie W. Margolin Prize, Retina Research Foundation, 1994
Editorial Board, Neurochemistry International, 1994-1997
Treasurer, International Society for Eye Research, 1992 - 1995
Trustee, Association for Research in Vision and Ophthalmology (ARVO), Biochemistry and Molecular Biology
Section, 1991 - 1997
Senior Scientific Investigator's Award, Research to Prevent Blindness, Inc., 1990
Editorial Board, Current Eye Research, 1988 - 1993
Counselor, International Society for Eye Research, 1988 - 1992
Editorial Board, Journal of Neuroscience Research, 1986 - 1992
Program Committee, Seventh International Congress of Eye Research, 1986
Program Committee, Winter Conference on Brain Research, 1985 - 1987
Alcon Research Institute Award for Outstanding Contributions in the Field of Vision Research, 1985
Board of Scientific Counselors, National Eye Institute, July, 1983 - 1987; Chairman, 1985-1987
Faculty, Section I, The Basic and Clinical Science Series, American Academy of Ophthalmology, 1984 - 1992
Editorial Board, Investigative Ophthalmology and Visual Science, 1982 - 1987
Program Committee, Retinal Cell Biology Section, ARVO, 1984-85; Chairman, 1985
Program Committee, Biochemistry Section, ARVO, 1982-1984; Chairman, 1984
Dolly Green Special Scholar Award, Research To Prevent Blindness, Inc., 1982
Sam and Bertha Brochstein Award for Outstanding Achievement in Retina Research, 1980
Vision Research Program Committee of the National Eye Institute, July 1, 1977 - June 30, 1981
American Society of Biological Chemists, 1975
AEC Postdoctoral Fellow, 1968
MacGee Award, American Oil Chemists' Society, 1965
Sigma Xi, 1964
PROFESSIONAL SOCIETIES
American Association for the Advancement of Science
American Society for Cell Biology
American Society for Neurochemistry
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Robert E. Anderson, MD, PhD
Association for Research in Vision and Ophthalmology (ARVO)
FASEB (American Society for Biochemistry and Molecular Biology)
International Society for Eye Research
International Society for Neurochemistry
International Society for the Study of Fatty Acids and Lipids
Society for Neuroscience
MEDICAL LICENSURE
Texas- August, 1975-2006.
Oklahoma- November, 1996-present
COMMITTEE SERVICE, STATE OF OKLAHOMA
Alzheimer’s Research Advisory Council (Chairman) (Appointed by Gov. Frank Keating on Dec. 20, 1996)
COMMITTEE SERVICE AT THE UNIVERSITY OF OKLAHOMA
Faculty Board, 1998-2007
Executive Committee, 1999-2005
Vice chairman, 2000-2002
Department of Ophthalmology
Search Committee, Molecular Biologist, 1996-97
Tenure and Promotions Committee, 1999 - present
Department of Biochemistry & Molecular Biology
Advisory committee, 1997-1999
Graduate Admissions and Student Recruitment Committee, 1997-98
MD/PhD Program Steering committee, 1999 – 2003; 2004-present
Search Committee (Chairman), OUHSC (Dean, College of Pharmacy) 2007
Institutional Review Board, 1997-98
Search Committee, Department of Anatomical Sciences (Asst/Assoc. Prof), 1996 - 1997
Search Committee, Department of Neurosurgery (Prof and Chair), 1997
Ad hoc reviewer, Presbyterian Health Foundation, 1995 - present
First Year Curriculum Task Force, 1995 - 1996
Committee to establish Regional Primate Center, 1995 - 1997
Medical Neuroscience Task Force (Chairman), 1995 – 1996
Mouse Users Committee (ad hoc), Chairman, 2002 - 2007
Student thesis committee as mentor
Dana Rundle, PhD, Dept. Biochemistry & Molecular Biology (completed December 2000)
Zhong Huang, PhD, Dept. Cell Biology (completed June 2000)
Gwen Li, PhD student, Dept. Cell Biology (completed August 2007)
Martin Paul Agbaga, PhD student, Dept. Cell Biology (completed May 2009)
Sreemathi Logan, PhD student, Dept. Cell Biology (started June, 2008)
Summer Undergraduate Research Committee (SURE)- Selection Committee, 1995
COMMITTEE SERVICE AT BAYLOR COLLEGE OF MEDICINE (HOUSTON, TX)
Admissions Committee, College of Medicine 1985 - 1995
Committee on Recruitment, Chairman 1988 - 1989
Executive Committee, 1988 - 1989
Animal Protocol Review Committee, 1988 - 1992
Committee on Scientific Integrity, 1993 - 1995
Faculty Awards Committee, 1988 - 1992
Faculty Research and Fellowship Support Committee, 1982 - 1986
Medical Scientist Training Program
Operating Committee, 1979 - 1995
Steering Committee, 1979 - 1995
Nutrition Education Sub-Committee, 1986
Patent and Copyright Committee, 1987 - 1989
Program in Neuroscience
Admissions Committee, 1981 - 1989
Advisory Subcommittee, 1986 - 1989
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Robert E. Anderson, MD, PhD
Education Committee, 1983 - 1986
Steering Committee, 1979 - 1989
Student thesis committee as a member (numerous)
Student thesis committee as mentor
Hong Gwan Choe, PhD
Dan Browder
Department of Ophthalmology
Chairman's Advisory Committee for Faculty Appt. and Prom., 1983 - 1995
Chairman, ad hoc Committee on Conduct in Research, 1988 - 1995
Chairman, Faculty Retreat Planning Committee, 1987 - 1995
Chairman, Awards Committee, 1988 - 1995
Resident Selection Committee, 1993 - 1995
Resident Lecture Committee, 1989 - 1995
Department of Biochemistry
Course director, Biochemistry for Allied Health Professionals, 1992- 1995
Student thesis committee as a member (numerous)
Student thesis committee as mentor
Peter A. Dudley, PhD
Alan P. Tarver, PhD
Muna I. Naash, PhD
Ann M. Stinson, MD, PhD
Huiming Chen, PhD
Nan Wang, PhD
James DeMar, PhD
Michael Bell, PhD
PUBLICATIONS
1.
Anderson, R.E. and H. Rakoff (1965). Gas-liquid chromatography of the positional isomers of methyl
nonynoate. J. Amer. Oil Chem. Soc. 42:1102.
2.
Bottino, N.R., R.E. Anderson, and R. Reiser (1965). Dietary fatty acids: Their metabolic fate and influence on
fatty acid biosynthesis. J. Amer. Oil Chem. Soc. 42:1124.
3.
Anderson, R.E. (1965). The inability of rats to synthesize linoleic acid from cis-2-octenoic acid. Thesis, Texas A
& M University.
4.
Anderson, R.E. and R. Reiser (1966). Cis-2-octenoic acid administration and essential fatty acid synthesis.
Lipids 1:233.
5.
Anderson, R.E., N.R. Bottino, and R. Reiser (1967). Pancreatic lipase hydrolysis as a source of digylcerides for
the steorospecific analysis of triglycerides. Lipids 2:440.
6.
Anderson, R.E. (1968). Species differences among animal endogenous triglycerides. Dissertation, Texas A &
M University.
7.
Anderson, R.E., R.E. Cumming, M. Walton, and F. Snyder (1969). Lipid metabolism in cells grown in tissue
culture: O-alkyl, O-alk-1-enyl and acyl moieties of L-M cells. Biochim. Biophys. Acta 176:491-501.
8.
Anderson, R.E. and F. Snyder (1969). Quantitative collection of 14CO2 in the presence of labeled short-chain
acids. Anal. Biochem. 27:311-314.
9.
Anderson, R.E., R.D. Garrett, M.L. Blank, and F. Snyder (1969). The quantitative production of aldehydes from
O-alk-1-enyl glycerols. Lipids 4:327-330.
10.
Anderson, R.E., N.R. Bottino, and R. Reiser (1970). Animal endogenous triglycerides: I. Swine adipose tissue.
Lipids 5:161-164.
11.
Bottino, N.R., R.E. Anderson, and R. Reiser (1970). Animal endogenous triglycerides: II. Rat and chicken
adipose tissue. Lipids 5:165-170.
12.
Anderson, R.E., N.R. Bottino, L.J. Cook, and R. Reiser (1970). Animal endogenous triglycerides: III. Swine, rat
and chicken liver. Lipids 5:171-179.
13.
Anderson, R.E., M.B. Maude, and G.L. Feldman (1969). Lipids of ocular tissue: I. The phospholipids of mature
rabbit bovine lens. Biochim. Biophys. Acta 187:345-353.
14.
Anderson, R.E., L.S. Feldman, and G.L. Feldman (1970). Lipids of ocular tissues: II. The phospholipids of
bovine and rabbit retinas. Biochim. Biophys. Acta 202:367-373.
15.
Anderson, R.E., M.B. Maude, and G.L. Feldman (1970). Lipids of ocular tissues: III. The phospholipids of
mature bovine iris. Exp. Eye Res. 9:281-284.
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Anderson, R.E. and G.L. Sansone (1970). On the biosynthesis of glycerol ethers in mitochondria. Lipids 5:577578.
Anderson, R.E. (1970). Is retinal-phosphatidyl ethanolamine the chromophore of rhodopsin? Nature 277:954955.
Anderson, R.E. and M.B. Maude (1970). Phospholipids of bovine rod outer segments. Biochemistry 9:36243628.
Anderson, R.E. (1970). Lipids of ocular tissues: IV. A comparison of the phospholipids of six mammalian
species. Exp. Eye Res. 10:339.
Hoffman, R.T., M.O. Hall, and R.E. Anderson (1971). Linkage of retinal to opsin. Nature New Biology 229:249250.
Anderson, R.E., M.D. Kuns, and M.H. Dresden (1971). Collagenase activity in the alkali-burned cornea. Ann.
Ophthalmol. 3:619.
Anderson, R.E. and L. Sperling (1971). Lipids of ocular tissues: VII. Positional distribution of the fatty acids in
the phospholipids of bovine retina rod outer segments. Arch. Biochem. Biophys. 144:673-677.
Anderson, R.E. (1972). Solubility of rod outer segment protein in acidic organic solvents. Biochemistry 11:12241228.
Anderson, R.E. and M.B. Maude (1972). Lipids of ocular tissues: VII. The effects of essential fatty acid
deficiency on the phospholipids of the photoreceptor membranes of rat retina. Arch. Biochem. Biophys.
151:270-276.
Landis, D.J., P.A. Dudley, and R.E. Anderson (1973). Alterations of disc formation in the photoreceptor of rat
retina. Science 182:1144-1146.
Benolken, R.M., R.E. Anderson, and T.G. Wheeler (1973). Membrane fatty acids associated with the electrical
response in visual excitation. Science 182:1253-1254.
Anderson, R.E. and M. Risk (1974). Lipids of ocular tissues: IX. The phospholipids of frog photoreceptor
membranes. Vis. Res. 14:129-131.
Anderson, R.E., R.M. Benolken, P.A. Dudley, D.J. Landis, and T.G. Wheeler (1974). Polyunsaturated fatty acids
of photoreceptor membranes. Exp. Eye Res. 18:205-213.
Maude, M.B., R.E. Anderson, K.J. Armstrong, and J.E. Stoffer (1974). Membrane phospholipids and hormone
sensitive lipolysis in fat cells. Arch. Biochem. Biophys. 161:628-631.
Dudley, P.A. and R.E. Anderson (1975). The separation of polyunsaturated fatty acids by argentation thin-layer
chromatography. Lipids 10:113-115.
Hsieh, W-C. and R.E. Anderson (1975). Quantitation of stained proteins in SSA-polyacrylamide gels using
lysozyme as internal standard. Anal. Biochem. 69:331-338.
Anderson, R.E., M.B. Maude, and W. Zimmerman (1975). Lipids of ocular tissues: X. Lipid composition of
subcellular fractions of bovine retina. Vis. Res. 15:1087-1089.
Wheeler, T.G., R.M. Benolken, and R.E. Anderson (1975). Visual membranes: Specificity of fatty acid
precursors for the electrical response to illumination. Science 188:1312-1314.
Dudley, P.A., D.J. Landis, and R.E. Anderson (1975). Further studies on the chemistry of photoreceptor
membranes of rats fed an essential fatty acid deficient diet. Exp. Eye Res. 21:523-530.
Benolken, R.M., R.E. Anderson, and M.B. Maude (1975). Lipid composition of Limulus photoreceptor
membranes. Biochim. Biophys. Acta 413:234-242.
Anderson, R.E., P.A. Dudley, and D.J. Landis (1976). Essential fatty acid deficiency and renewal of rod outer
segments in the albino rat. Invest. Ophthalmol. Vis. Sci. 15:232-236.
Benolken, R.M., M.B. Maude, and R.E. Anderson (1976). Photopigments of the lateral eye of Limulus. J. Comp.
Phys. 107:339-347.
Anderson, R.E., P.M. Lissandrello, M.B. Maude, and M.T. Matthes (1976). Lipids of bovine retinal pigment
epithelium. Exp. Eye Res. 23:149-157.
Plante, E.O., M.B. Maude, and R.E. Anderson (1977). Regeneration of rhodopsin: Effect of quaternary
ammonium salt detergents. Exp. Eye Res. 24:377-382.
Anderson, R.E., R.M. Benolken, M.B. Jackson, and M.B. Maude (1977). The relationship between membrane
fatty acids and the development of the rat retina. In Function and Biosynthesis of Lipids, edited by N.G. Bazan,
R.R. Breener and N.M. Giusto, Plenum Press (New York), pp. 547-559.
Anderson, R.E. (1978). Lipid-rhodopsin interactions in photoreceptor membranes. In Frontiers in Visual
Science, edited by S.J. Cool and E.L. Smith III, Springer-Verlag (New York), pp. 54-62.
Anderson, R.E., R.M. Benolken, P.A. Kelleher, M.B. Maude, and R.D. Wiegand (1978). Chemistry of the
photoreceptor membranes of squid. Biochim. Biophys. Acta 510:316-326.
Dudley, P.A. and R.E. Anderson (1978). Phospholipid transfer protein from bovine retina with high activity
towards retinal disc membranes. FEBS Letters 95:57-60.
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Anderson, R.E. (1979). Essential fatty acid deficiency and photoreceptor membrane renewal - a reappraisal.
Invest. Ophthalmol. Vis. Sci. 17:1102-1104.
Anderson, R.E., P.A. Kelleher, M.B. Maude, and T.M. Maida (1980). Synthesis and turnover of lipid and protein
components of frog retinal rod outer segments. Neurochemistry J. 1:29-42.
Anderson, R.E., M.B. Maude, P.A. Kelleher, S.F. Basinger, and T.M. Maida (1980). Metabolism of phosphatidylcholine in the frog retina. Biochim. Biophys. Acta 620:212-226.
Anderson, R.E., P.A. Kelleher, and M.B. Maude (1980). Metabolism of phosphatidylethanolamine in the frog
retina. Biochim. Biophys. Acta 620:227-235.
Anderson, R.E., M.B. Maude, and P.A. Kelleher (1980). Metabolism of phosphatidylinositol in the frog retina.
Biochim. Biophys. Acta 620:236-246.
Anderson, R.E. and P.A. Kelleher (1981). Biosynthesis of retinal phospholipids by base exchange reactions.
Exp. Eye Res. 32:729-736.
Anderson, R.E., J.G. Hollyfield, and G.E. Verner (1981). Regional effects of sodium aspartate and sodium
glutamate on protein synthesis in the retina. Invest. Ophthal. Vis. Sci. 21:554-562.
Prager, T.C., D.J. Wilson, D. Avery, J.H. Merritt, C.A. Garcia, G. Hopen, and R.E. Anderson (1981). Vitreous
fluorophotometry. Identification of sources of variability. Invest. Ophthalmol. Vis. Sci. 21:854-864.
Anderson, R.E. and J.G. Hollyfield (1981). Light stimulates the incorporation of inositol into phosphatidylinositol
in the retina. Biochim. Biophys. Acta 665:619-622.
Anderson, R.E. and L.D. Andrews (1982). Biochemistry of retinal photoreceptor membranes in vertebrates and
invertebrates. In Visual Cells in Evolution, edited by J. Westfall, Raven Press (New York), pp. 1-22.
Anderson, R.E. (1982). Renewal of lipids in rod outer segments. In Methods in Enzymology. Vol. 81. Visual
Pigments and Purple Membranes, edited by L. Packer, Academic Press, Inc. (New York), pp. 800-806.
Wiegand, R.D. and R.E. Anderson (1982). Determination of molecular species of rod outer segment phospholipids. In Methods in Enzymology. Vol. 81. Visual Pigments and Purple Membranes, edited by L. Packer,
Academic Press (New York), pp. 297-304.
Hollyfield, J.G., M.E. Rayborn, G.E. Verner, M.B. Maude, and R.E. Anderson (1982). Membrane addition to rod
photoreceptor outer segments: Light stimulates membrane assembly in the absence of increased membrane
biosynthesis. Invest. Ophthalmol. Vis. Sci. 22:417-427.
Prager, T.C., H. Chu, C.A. Garcia, and R.E. Anderson (1982). The influence of vitreous change on fluorophotometry. Arch. Ophthalmol. 100:594-596.
Wiegand, R.D., N.M. Giusto, and R.E. Anderson (1982). Lipid changes in albino rat rod outer segments
following constant illumination. In Problems of Normal and Genetically Abnormal Retinas, edited by R. Clayton,
J. Haywood, H. Reading and A. Wright, Academic Press (New York), pp. 121-128.
Rapp, L.M., R.D. Wiegand, and R.E. Anderson (1982). Ferrous ion-mediated retinal degeneration: Role of rod
outer segment lipid peroxidation. In Problems of Normal and Genetically Abnormal Retinas, edited by R.
Clayton, J. Haywood, H. Reading and A. Wright, Academic Press (New York), pp. 109-119.
Hollyfield, J.G. and R.E. Anderson (1982). Retinal protein synthesis in relationship to environmental lighting.
Invest. Ophthalmol. Vis. Sci. 23:631-639.
Chu, H.H., T.C. Prager, C.A. Garcia, and R.E. Anderson (1982). Vitreous fluorophotometry: I. Factors which
influence the result in normals. Chinese J. Ophthal. 18:147-152.
Fliesler, S.J. and R.E. Anderson (1983). Chemistry and metabolism of lipids in the vertebrate retina. In
Progress in Lipid Research, edited by R.T. Holman, Pergamon Press (Elmsford, NY) 22:79-131.
Prager, T.C., H. Chu, C.A. Garcia, R.E. Anderson, J.B. Field, E.A. Orzeck, and J.P. Comstock (1983). The use
of vitreous fluorophotometry to distinguish between diabetics with and without observable retinopathy: Effect of
vitreous abnormalities on the measurement. Invest. Ophthalmol. Vis. Sci. 24:57-65.
Pu, G.A-W. and R.E. Anderson (1983). Alteration of choline metabolism in an experimental photoreceptor cell
degeneration. Invest. Ophthalmol. Vis. Sci. 24:288-293.
Wiegand, R.D. and R.E. Anderson (1983). Neutral lipids of frog and rat rod outer segments. Exp. Eye Res.
36:389-396.
Wiegand, R.D. and R.E. Anderson (1983). Phospholipid molecular species of frog rod outer segment
membranes. Exp. Eye Res. 37:159-173.
Wiegand, R.D., N.M. Giusto, L.M. Rapp and R.E. Anderson (1983). Evidence for rod outer segment lipid
peroxidation following constant illumination of the rat retina. Invest. Ophthal. Vis. Sci. 24:1433-1435.
Anderson, R.E., M.B. Maude, P.A. Kelleher, M.E. Rayborn, and J.G. Hollyfield (1983). Phosphoinositide
metabolism in the retina: Localization to horizontal cells and regulation by light and divalent cations. J.
Neurochem. 41:764-771.
Anderson, R.E. (1983). Chemistry of photoreceptor outer segments. In Biochemistry of the Eye, edited by R.E.
Anderson, American Academy of Ophthalmology (San Francisco), pp. 164-170.
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Anderson, R.E. (1983). Synthesis and turnover of photoreceptor outer segments. In Biochemistry of the Eye,
edited by R.E. Anderson, American Academy of Ophthalmology (San Francisco), pp. 171-177.
Anderson, R.E. and L.M. Rapp (1983). Visual pigment dynamics and the vitamin A cycle. In Biochemistry of
the Eye, edited by R.E. Anderson, American Academy of Ophthalmology (San Francisco), pp. 189-195.
Anderson, R.E. and J.G. Hollyfield (1983). Biochemical correlates in retinal disease. In Biochemistry of the
Eye, edited by R.E. Anderson, American Academy of Ophthalmology (San Francisco), pp. 243-255.
Fliesler, S.J., M.B. Maude, and R.E. Anderson (1983). Lipid composition of photoreceptor membranes from
goldfish retinas. Biochim. Biophys. Acta 734:144-152.
Pu, G.A-W. and R.E. Anderson (1983). Ethanolamine accumulation by photoreceptor cells of the rabbit retina.
J. Neurochem. 42:185-191.
Anderson, R.E., L.M. Rapp, and R.D. Wiegand (1983). Lipid peroxidation and retinal degeneration. Curr. Eye
Res. 3:223-227.
Anderson, R.E. and J.G. Hollyfield (1984). Inositol incorporation into phosphoinositides in retinal horizontal cells
of Xenopus laevis: Enhancement by acetylcholine, inhibition by glycine. J. Cell Biol. 99:686-691.
Wiegand, R.D., J.G. Jose, L.M. Rapp, and R.E. Anderson (1984). Free radicals and damage to ocular tissues.
In Free Radicals in Molecular Biology Aging and Disease, edited by D. Armstrong, et al., Raven Press (New
York), pp. 317-354.
Brown, J.E., L.J. Rubin, A.J. Ghalayini, A.P. Tarver, R.F. Irvine, M.J. Berridge, and R.E. Anderson (1984). Myoinositol polyphosphate may be a messenger for visual excitation in Limulus photoreceptors. Nature (London)
311:160-163.
Naash, M.I. and R.E. Anderson (1984). Characterization of glutathione peroxidase in frog retina. Curr. Eye
Res. 4:1299-1304.
Ghalayini, A.J. and R.E. Anderson (1984). Phosphatidylinositol 4,5-bisphosphate: Light-mediated breakdown in
the vertebrate retina. Biochem. Biophys. Res. Comm. 124:503-506.
Anderson, R.E., M.B. Maude, and J.C. Nielsen (1985). Effect of lipid peroxidation on rhodopsin regeneration.
Curr. Eye Res. 4:65-71.
Fliesler, S.J., P.A. Kelleher, and R.E. Anderson (1985). Catabolism of myo-inositol to precursors utilized for de
novo glycerolipid biosynthesis. J. Neurochem. 44:171-174.
Anderson, R.E., M.B. Maude, G.A-W. Pu, and J.G. Hollyfield (1985). Effect of light on the metabolism of lipids
in the rat retina. J. Neurochem. 44:773-778.
Anderson, R.E. and J.G. Hollyfield (1985). The phosphatidylinositol effect in the retina: Role of light and
neurotransmitters. In Inositol and Phosphoinositides: Metabolism and Regulation, edited by J.E. Bleasdale et
al., Humana Press (Clifton, N.J.), pp. 299-312.
Rapp, L.M., M.I. Naash, R.D. Wiegand, C.D. Joel, J.C. Nielsen, and R.E. Anderson (1985). Morphological and
biochemical comparisons between retinal regions having differing susceptibility to photoreceptor degeneration.
In Retinal Degeneration: Contemporary Experiments and Clinical Studies, edited by M.M. LaVail, J.G. Hollyfield,
and R.E. Anderson, Alan R. Liss, Inc. (New York), pp. 421-438.
Waloga, G. and R.E. Anderson (1985). Effects of inositol 1,4,5-trisphosphate injections into salamander rods.
Biochem. Biophys. Res. Comm. 126:59-62.
Nielsen, J.C., M.B. Maude, H. Hughes, and R.E. Anderson (1986). Rabbit photoreceptor outer segments
contain high levels of docosapentaenoic acid. Invest. Ophthalmol. Vis. Sci. 27:261-264.
Wiegand, R.D., C.D. Joel, L.M. Rapp, J.C. Nielsen, M.B. Maude, and R.E. Anderson (1986). Polyunsaturated
fatty acid and vitamin E in rat rod outer segments during light damage. Invest. Ophthalmol. Vis. Sci. 27:727733.
Fliesler, S.J. and R.E. Anderson (1986). In vivo incorporation of 2-3H-myo-inositol into frog opsin. Biochem.
Biophys. Res. Comm. 136:815-821.
Baker, B.N., M. Moriya, M.B. Maude, R.E. Anderson, and T.P. Williams (1986). Oil droplets of the retinal
epithelium of the rat. Exp. Eye Res. 42:547-557.
Ghalayini, A.J. and R.E. Anderson (1986). Light activation of phospholipase C in frog outer segments. In Pineal
and Retinal Relationships, edited by P.J. O'Brien and D.C. Klein, Academic Press, Inc. (Orlando, FL), pp. 431435.
Anderson, R.E. (1986). Critique: Phosphoinositide metabolism in photoreceptor cells. Neurochem. Internat.
9:235-237.
Anderson, R.E., M.B. Maude, R.A. Lewis, D.A. Newsome, and G.A. Fishman (1987). Abnormal plasma levels
of polyunsaturated fatty acid in autosomal dominant retinitis pigmentosa. Exp. Eye Res. 44:155-159.
Penn, J.S., M.I. Naash, and R.E. Anderson (1987). Effect of light history on retinal antioxidants and light
damage susceptibility in the rat. Exp. Eye Res. 44:779-788.
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95.
96.
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109.
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120.
Penn, J.S. and R.E. Anderson (1987). Effect of light history on rod outer segment membrane composition in the
rat. Exp. Eye Res. 44:767-778.
Anderson, R.E., R.D. Wiegand, L.M. Rapp, M.B. Maude, M.I. Naash, and J.S. Penn (1987). Studies on
biochemical mechanisms of retinal degeneration. In Cell and Developmental Biology of the Eye. Vol. 6: The
Microenvironment and Vision, edited by J.B. Sheffield and S.R. Hilfer, Springer Verlag, pp. 159-168.
Anderson, R.E. and J.S. Penn (1987). The role of vitamin E in retinal degenerative diseases. Vitamins (Jap)
61:237-244.
Smith, C.V. and R.E. Anderson (1987). Methods for determination of lipid peroxidation. Free Rad. Biol. Med.
3:341-344.
Ghalayini, A.J. and R.E. Anderson (1987). Activation of bovine rod outer segment phospholipase C by ATP and
GTP. Neurosci. Res. Commun. 1:119-127.
Nielsen, J.C., M.I. Naash, and R.E. Anderson (1988). The regional distribution of vitamins E and C in mature
and premature human infant retinas. Invest. Ophthalmol. Vis. Sci. 29:22-26.
Naash, M.I. and R.E. Anderson (1988). Regional distribution of glutathione peroxidase and glutathione-Stransferase in adult and premature human retinas. Invest. Ophthalmol. Vis. Sci 29:149-152.
Tarver, A.P. and R.E. Anderson (1988). Phospholipase C activity and substrate specificity in frog
photoreceptors. Exp. Eye Res. 46:29-35.
Rapp, L.M., L.A. Thum, and R.E. Anderson (1988). Synergism between environmental lighting and taurine
depletion in causing photoreceptor cell degeneration. Exp. Eye Res. 46:229-238.
Tarver, A.P. and R.E. Anderson (1988). Detection of inositol 1,4,5-trisphosphate kinase in retina: A direct
demonstration of phosphorylation of inositol 1,4,5-trisphosphate by ATP. Biochem. J. 250:891-895.
Newsome, D.A., R.E. Anderson, J.G. May, T.A. McKay, and M.B. Maude (1988). Clinical and serum lipid
findings in a large family with autosomal dominant retinitis pigmentosa. Ophthalmology 95:1691-1695.
Anderson, R.E. and J. Brown (1988). Phosphoinositides in the retina. In Progress in Retinal Research, Vol. 8,
edited by N. Osborne and G. Chader, Pergamon Press (New York), pp. 211-228.
Louie, K., R.D. Wiegand, and R.E. Anderson (1988). Docosahexaenoate-containing molecular species of
glycerophospholipids from frog retinal rod outer segments show different rates of biosynthesis and turnover.
Biochemistry 27:9014-9020.
Ho, M.T.P., J.B. Massey, H.J. Pownall, R.E. Anderson, and J.G. Hollyfield (1988). Mechanism of vitamin A
movement between rod outer segments, interphotoreceptor retinoid-binding protein, and liposomes. J. Biol.
Chem. 264:928-935.
Naash, M.I., and R.E. Anderson (1989). Glutathione-dependent enzymes in intact rod outer segments of rats.
Exp. Eye Res. 48:309-318.
Choe, H.G., R.D. Wiegand, and R.E. Anderson (1989). Quantitative analysis of retinal glycerolipid molecular
species acetylated by acetolysis. J. Lipid Res. 30:454-457.
Wetzel, M.G., C. Fahlman, M.B. Maude, R.A. Alvarez, P.J. O'Brien, G.M. Acland, G.D. Aguirre, and R.E.
Anderson (1989). Fatty acid metabolism in normal miniature poodles and those affected with progressive rodcone degeneration (PRCD). In Inherited and Environmentally Induced Retinal Degenerations, edited by J.G.
Hollyfield, R.E. Anderson, and M.M. LaVail, Alan R. Liss, Inc. (New York), pp. 427-439.
Naash, M.I., M.M. LaVail, and R.E. Anderson (1989). Factors affecting the susceptibility of the retina to light
damage. In Inherited and Environmentally Induced Retinal Degenerations, edited by J.G. Hollyfield, R.E.
Anderson, and M.M. LaVail, Alan R. Liss, Inc. (New York), pp. 513-522.
Choe, H.G. and R.E. Anderson (1990). Unique molecular species composition of glycerolipids of frog rod outer
segments. Exp. Eye. Res. 51:159-165.
Choe, H.G., A.J. Ghalayini, and R.E. Anderson (1990). Phosphoinositide metabolism in frog rod outer
segments. Exp. Eye. Res. 51:167-176.
Stinson, A.M., R.D. Wiegand, and R.E. Anderson (1991). Fatty acid and molecular species compositions of
phospholipids and diacylglycerols from rat retinal membranes. Exp. Eye. Res. 52:213-218.
Stinson, A.M., R.D. Wiegand, and R.E. Anderson (1991). Metabolism of lipid molecular species in rat rod outer
segments. Exp. Eye. Res. 52:219-227.
Anderson, R.E., M.B. Maude, R.A. Alvarez, G.M. Acland, and G.D. Aguirre (1991). Plasma lipid abnormalities in
the miniature poodle with progressive rod-cone degeneration. Exp. Eye. Res. 52:349-355.
Ghalayini, A.J., A.P. Tarver, W.M. Mackin, C.A. Koutz, and R.E. Anderson (1991). Identification and immunolocalization of phospholipase C in bovine rod outer segments. J. Neurochem. 57:1405-1412.
Louie, K., W.F. Zimmerman, S. Keys, and R.E. Anderson (1991). Phospholipid molecular species from isolated
bovine rod outer segments incorporate exogenous fatty acids at different rates. Exp. Eye. Res. 53:309-316.
Anderson, R.E., M.B. Maude, S.E.G. Nilsson, and K. Narfström (1991). Plasma lipid abnormalities in the
Abyssinian cat with a hereditary rod-cone degeneration. Exp. Eye. Res. 53:415-417.
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121. Wetzel, M.G., J. Li, R.A. Alvarez, R.E. Anderson, and P.J. O'Brien (1991). Metabolism of linolenic acid and
docosahexaenoic acid in rat retinas and rod outer segments. Exp. Eye Res. 53:437-446.
122. Wiegand, R.D., C.A. Koutz, A.M. Stinson, and R.E. Anderson (1991). Conservation of docosahexaenoic acid in
rod outer segments of rat retinas during n-3 and n-6 fatty acid deficiency. J. Neurochem. 57:1690-1699.
123. Naash, M.I., E. Izbicka, and R.E. Anderson (1991). Rat retina has an active and stable ubiquitin-protein
conjugating system. J. Neurosci. Res. 30:433-441.
124. Anderson, R.E. (1991). Metabolism and photochemistry of the retina. In Duane's Foundations of Clinical
Ophthalmology, Vol. 2, edited by E.A. Jaeger and W. Tasman, J.B. Lippincott Co. (Philadelphia, PA), Chap. 12,
pp. 1-12.
125. Stinson, A.M., R.D. Wiegand, and R.E. Anderson (1991). Recycling of docosahexaenoic acid in rat retinas
during n-3 fatty acid deficiency. J. Lipid Res. 32:2009-2017.
126. Anderson, R.E., M.B. Maude, R.A. Alvarez, S.E.G. Nilsson, K. Narfstrom, G.M. Acland, and G. Aguirre (1991).
Plasma lipid abnormalities in prcd-affected miniature poodles and Abyssinian cats. In Retinal Degenerations,
edited by R.E. Anderson, J.G. Hollyfield, and M.M. LaVail. CRC Press (Boca Raton, FL), pp.131-142.
127. Penn, J.S. and R.E. Anderson (1992). Effects of light history on the rat retina. In Progress in Retinal Research,
Vol. 11, edited by N. Osborne and G. Chader, Pergamon Press (New York), pp. 75-98.
128. Anderson, R.E., P.J. O'Brien, R.D. Wiegand, C.A. Koutz, and A.M. Stinson (1992). Conservation of docosahexaenoic acid in the retina. In Neurobiology of Essential Fatty Acids, edited by N. Bazan, M. Marfi, and G.
Tossano, Plenum Press (New York), pp. 285-294.
129. De La Paz, M. and R.E. Anderson (1992). Lipid peroxidation in rod outer segments: role of hydroxyl radical and
lipid hydroperoxides. Invest. Ophthalmol. Vis. Sci. 33:2091-2096.
130. Wang, N., R.D. Wiegand, and R.E. Anderson (1992). Uptake of 22-carbon fatty acids into rat retina and brain.
Exp. Eye Res. 54:933-940.
131. Chen, H., R.D. Wiegand, and R.E. Anderson (1992). Decreased docosahexaenoic acid levels in retina and
pigment epithelium of frogs fed crickets. Exp. Eye Res. 54:885-892.
132. Chen, H., R.D. Wiegand, C.A. Koutz, and R.E. Anderson (1992). Docosahexaenoic acid increases in frog
retinal pigment epithelium following rod photoreceptor shedding. Exp. Eye Res. 55:93-100.
133. Wang, N. and R.E. Anderson (1992). Enrichment of polyunsaturated fatty acids from rat retinal pigment
epithelium to rod outer segments. Curr. Eye Research 8:783-791.
134. De La Paz, M. and R.E. Anderson (1992). Region and age-dependent variation in susceptibility of the human
retina to lipid peroxidation. Invest. Ophthalmol. Vis. Sci. 33:3497-3499.
135. Ghalayini, A.J. and R.E. Anderson (1992). Activation of bovine rod outer segment phospholipase C by arrestin.
J. Biol. Chem. 267:17977-17982.
136. Chen, H. and R.E. Anderson (1992). Quantitation of phenacyl esters of retinal fatty acids by high-performance
liquid chromatography. J. Chromatography 578:124-129.
137. Chen, H. and R.E. Anderson (1992). Lipids of frog retinal pigment epithelium: comparison with rod outer
segments, retina, plasma, and red blood cells. Curr. Eye Research 8:793-800.
138. Anderson, R.E., M.B. Maude, R.A. Alvarez, M.G. Wetzel, P.J. O'Brien, G.M. Acland, G. Aguirre (1992). Role of
docosahexaenoic acid in inherited retinal degenerations. In Proceedings of The Third International Congress on
Essential Fatty Acids and Eicosanoids, edited by A. Sinclair and R. Gibson, AOCS, Champaign, IL. pp.96-99.
139. Wang, N., C.A. Koutz, R.D. Wiegand, and R.E. Anderson (1993). A method for the isolation of retinal pigment
epithelial cells from adult rats. Invest. Ophthalmol. Vis. Sci. 34:101-107.
140. Gülcan, H.G., R.A. Alvarez, and R.E. Anderson (1993). Lipids of human retina, retinal pigment epithelium, and
Bruch's membrane/choroid. Comparison of macular and peripheral regions. Invest. Ophthalmol. Vis. Sci.
34:3187-3193.
141. Day, N.S. and R.E. Anderson (1993). Inositol-1,4,5-trisphosphate receptors in the vertebrate retina. Curr. Eye
Research 12:981-992.
142. Wang, N. and R.E. Anderson (1993). Transport of 22:6n-3 in the plasma and uptake into retinal pigment
epithelium and retina. Exp. Eye Res. 57:225-233.
143. Wang, N. and Anderson, R.E. (1993). Synthesis of docosahexaenioc acid by retina and retinal pigment
epithelium. Biochemistry. 32:13703-13709.
144. Chen, H. and Anderson, R.E. (1993). Differential incorporation of docosahexaenoic and arachidonic acids in
frog retinal pigment epithelium. J. Lipid Res. 34:1943-1955.
145. Chen, H. and Anderson, R.E. (1993). Metabolism in frog retinal pigment epithelium of docosahexaenoic and
arachidonic acids derived from rod outer segment membranes. Exp. Eye Res. 57:369-377.
146. Chen, H. and Anderson, R.E. (1993). Comparison of uptake and incorporation of docosahexaenoic and
arachidonic acids by frog retinas. Current Eye Res. 12:851-860.
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147. Ghalayini, A.J., Koutz, C.A., Wetsel, W.C., Hannun, Y.A., and Anderson, R.E. (1994). Immunolocalization of
PKC in rat photoreceptor inner segments. Current Eye Res. 13:145-150.
148. Anderson, R.E., Chen, H., Wang, N., and Stinson, A. (1994). The accretion of docosahexaenoic acid in the
retina. In The Proceedings of the First International Society for the Study of Fats and Other Lipids, ed. C. Galli.
pp 124-127.
149. Anderson, R.E, Maude, M.B., Acland, G., and Aguirre, G.D. (1994). Plasma lipid changes in prcd-affected and
normal miniature poodles given oral supplements of linseed oil. Indications for the involvement of N-3 fatty
acids in inherited retinal degenerations. Exp. Eye Res. 58:129-137.
150. Anderson, R.E., Chen, H., Wiegand, R.D., and Stinson, A.M. (1994) Metabolism and function of n-3 fatty acids
in the retina. Proceedings From the Scientific Conference on Omega-3 Fatty Acids in Nutrition, Vascular
Biology, and Medicine. pp 193-199.
151. Alvarez, R.A., Aguirre, G.D., Acland, G.M., and Anderson, R.E. (1994). Docosapentaenoic acid is converted to
docosahexaenoic acid in the retinas of normal and prcd-affected miniature poodle dogs. Invest. Ophthalmol.
Vis. Sci. 35:402-408.
152. Simopoulos, A.P., Koletzko, B., Anderson, R.E., Hornstra, G., Mensink, R.P., Weksler, B.B., Harris, W.S., De
Caterina, R., Muggli, R., and Sprecher, H. (1994). The 1st Congress of the International Society for the Study
of Fatty Acids and Lipids (ISSFAL): fatty acids and lipids from cell biology to human disease. J. Lipid Res.
35:169-173.
153. Anderson, R.E., Kretzer, F., and Rapp, L.M. (1994). Role of free radicals in ocular disease. In Free Radicals in
Diagnostic Medicine: A Systems Approach to Laboratory Technologies, Clinical Correlations, and Antioxidant
Therapy. ed. D. Armstrong, Plenum Press (New York), pp 73-86.
154. Wiegand, R.D., Koutz, C.A., Chen, H., and Anderson, R.E. (1995). Effect of dietary fat and environmental
lighting on the phospholipid molecular species of rat photoreceptor membranes. Exp. Eye Res. 60:291-306.
155. Koutz, C.A., Anderson, R.E., Rapp, L.M., and Wiegand, R.D. (1995). Effect of dietary fat and environmental
lighting on the response of the rat retina to chronic and acute light stress. Exp. Eye Res. 60:307-316.
156. Ghalayini, A.J. and Anderson, R.E. (1995). Light adaptation of bovine retinas in situ stimulates phosphatidylinositol synthesis in rod outer segments in vitro. Current Eye Research. 14:1025-1029.
157. Day, N. and Anderson, R.E. (1995). Inositol hexakisphosphate binding proteins in bovine retinal membranes.
Current Eye Res. 14:851-855.
158. Alvarez, R.A., Xu, P., Hardcastle, A., Bhattacharya, S., Rao, P.N., Pettenati, M., Bowden, D.W., Anderson, R.E.,
and Baehr, W. (1995). cDNA sequence of the human retinal phosphoinositide-specific phospholipase C4 and
chromosomal localization of its gene. Genomics 29: 53-61.
159. Jensen, C.L., Chen, H., Fraley, J.K., Anderson, R.E., and Heird, W.C. (1996). Biochemical effects of dietary
linoleic/-linolenic acid ratio in term infants. Lipids 31:107-113.
160. DeMar Jr., J.E., Wensel, T.G., and Anderson, R.E. (1996). Biosynthesis of the unsaturated 14-carbon fatty
acids found on the N-termini of photoreceptor specific proteins. J. Biol. Chem. 271:5007-5016.
161. Anderson, R.E., Alvarez, R.A., Guo, X.X., Nordquist, R.E., Baehr, W., and Ghalayini, A.J. (1996). Genes
encoding enzymes involved in phosphoinositide metabolism are candidate genes for inherited retinal
degenerations in humans. In Retinal Degeneration and Regeneration, ed S. Kato, N.N. Osborne, and M. Tamai.
Kugler Publications (Amsterdam). pp. 81-88.
162. Sauerwald, T.U., Hachey, D.L., Jensen, C.L., Chen, H., Anderson, R.E., and Heird, W.C. (1996). Effect of
dietary -linolenic acid intake on incorporation of docosahexaenoic and arachidonic acids into plasma
phospholipids of term infants. Lipids 31:S131-S135.
163. Heird, W.C., Prager, T.C., and Anderson, R.E. (1997). Docosahexaenoic acid and the development and
function of the infant retina. Curr. Opin. Lipidol. 8:12-16.
164. Delton-Vandenbroucke, I., Grammas, P., and Anderson, R.E. (1997). Polyunsaturated fatty acid metabolism in
retinal and cerebral microvascular endothelial cells. J. Lipid Res. 38:147-159.
165. Sauerwald, T.U., Hachey, D.L., Jensen, C.L., Chen, H., Anderson, R.E., and Heird, W.C. (1997). Intermediates
in endogenous synthesis of C22:6n-3 and C20:4n-6 by term and preterm infants. Pediat. Res. 41:183-187.
166. Anderson, R.E., Maude, M.B., Narfström, K., and Nilsson, S.E.G. (1997). Lipids of plasma, retina, and retinal
pigment epithelium in Swedish Briard dogs with a slowly progressive retinal dystrophy. Exp. Eye Res. 64:181187.
167. Guo, X.X., Ghalayini, A.J., Chen, H., and Anderson, R.E. (1997). Phosphatidylinositol 3-kinase in bovine rod
outer segments. Invest. Ophthalmol. Vis. Sci. 38:1873-1882.
168. Jensen, C.L., Prager, T.C., Fraley, J.K., Anderson, R.E., and Heird, W.C. (1997). Functional effects of dietary
linoleic/-linolenic acid ratio in term infants. J. Pediatr. 131:200-209.
169. Aguirre, G.D., Acland, G.M., Maude, M.B., and Anderson, R.E. (1997). Diets enriched in docosahexaenoic acid
fail to correct progressive rod-cone degeneration (prcd) phenotype. Invest. Ophthalmol. Vis. Sci. 38:2387-2407.
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170. DeMar Jr., J.C. and Anderson, R.E. (1997). Identification and quantitation of the fatty acids comprising the CoA
ester pool of bovine retina, heart, and liver. J. Biol. Chem. 272:31362-31368.
171. Naash, M.I., Al-Ubaida, M.R., and Anderson, R.E. (1997). Light-exposure induces ubiquitin-conjugation and
degradation activities in the rat retina. Invest. Ophthalmol. Vis. Sci. 38:2344-2354.
172. Ghalayini, A.J., Guo, X.X., Koutz, C.A., and Anderson, R.E. (1998). Light stimulates tyrosine phosphorylation of
rat rod outer segments in vivo. Exp. Eye Res. 66:817-821.
173. Delton-Vandenbroucke, I., Grammas, P., and Anderson, R.E. (1998). Regulation of n-3 and n-6 fatty acid
metabolism in retinal and cerebral microvascular endothelial cells by high glucose. J. Neurochem. 70:841-849.
174. Maude, M.B., Anderson, E.O., and Anderson, R.E. (1998). Polyunsaturated fatty acids are lower in blood lipids
of Ushers Type I, but not Ushers Type II. Invest. Ophthalmol. Vis. Sci. 39:2164-2166.
175. Yuan, C., Chen, H., Anderson, R.E., Kuwata, O., and Ebrey, T.G. (1998). The unique lipid composition of gecko
(Gekko Gekko) photoreceptor outer segment membranes. Comp. Biochem. Physiol. Part B 120:785-789
176. Delton-Vandenbroucke, I., Maude, M.B., Chen, H., Aguirre, G.D., Acland, G.M., and Anderson, R.E. (1998).
Effect of dietary modifications of the fatty acid and molecular species composition of the dog retina. Lipids
33:1187-1193.
177. Ghalayini, A.J., Weber, N.R., Rundle, D.R., Koutz, C.A., Lambert, D., Guo, X.X., and Anderson, R.E. (1998).
Phospholipase Cgamma1 in bovine rod outer segments: immunolocalization and light-dependent binding to
membranes. J. Neurochem. 70: 171-178.
178. Anderson, R.E., Maude, M.B., Alvarez, R.A., Acland, G., and Aguirre, G.D. (1999). Inherited retinal
degenerations-role of polyunsaturated fatty acids. Les Seminaires Ophthalmologiques d’IPSEN, ed Y. Christen,
M. Doly, and M.-T. Droy-Lefaix. Irvinn (Paris). pp. 57-65.
179. Anderson, R.E., Maude, M.B., Alvarez, R.A., Acland, G., and Aguirre, G.D. (1999). A hypothesis to explain the
reduced blood levels of docosahexaenoic acid in inherited retinal degenerations caused by mutations in genes
encoding retina-specific proteins. Lipids. 34:S235-238.
180. Prager, T.C., Zou, Y.L., Jensen, C.L., Fraley, J.K., Anderson, R.E., and Heird, W.C. (1999). Evaluation of
methods for assessing visual function of infants. Am. Assoc. Ped. Ophthalmol. Strabis. 3:275-282.
181. DeMar, J.C., Rundle, D.R., Wensel, T.G., and Anderson, R.E. (1999). Heterogeneous N-terminal acylation of
retinal proteins. Progress in Lipid Research 38:49-90.
182. Chen, H, Ray, J. Scarpino, V. Acland, G.M., Aguirre, G.D., and Anderson, R.E. (1999). Synthesis and release of
docosahexaenoic acid by the RPE cells of prcd-affected dogs. Invest. Ophthalmol. Vis. Sci. 40:2418-2422.
183. Jensen, C.L., Prager, T.C., Zou, Y., Fraley, J.K., Maude, M., Anderson, R.E., and Heird, W.C. (1999). Effects of
maternal docosahexaenoic acid supplementation on visual function and growth of breast-fed term infants. Lipids
34:S225.
184. Delton-Vandenbroucke, I., Grammas, P., and Anderson, R.E. (1999). A role for cerebral and retinal endothelial
cells in the supply of docosahexaenoic acid to the brain and the retina? Lipids 34:S117.
185. Jensen, C.L., Maude, M., Anderson, R.E., and Heird, W.C. (2000). Effect of docosahexaenioc acid
supplementation of lactating women on the fatty acid composition of breast milk lipids and maternal and infant
plasma phospholipids. Amer. J. Clin. Nutr. 71:292S-299S.
186. Guo, X.X., Huang, Z., Bell, M.W., Chen, H., Ghalayini, A.J., and Anderson, R.E. (2000). Tyrosine
phosphorylation is involved in light-mediated phosphatidylinositol 3-kinase activation in bovine rod outer
segments. Mol. Vision. 6:216-21.
187. Huang, Z., Ghalayini, A.J., Guo, X.X., Alvarez, K.M., and Anderson, R.E. (2000). Light-mediated activation of
diacylglycerol kinase in rat and bovine rod outer segments. J. Neurochem. 75:355-362
188. Huang, Z., Guo, X.X., Bell, M.W., Chen, H., and Anderson, R.E. (2001). Regulation of type II
phosphatidylinositol phosphate kinase by tyrosine phosphorylation in bovine rod outer segments. Biochemistry
40:4550-4559.
189. Li, F., Chen, H., and Anderson, R.E. (2001). Biosynthesis of docosahexaenoate-containing glycerolipid
molecular species in the retina. J. Mol. Neurosci. 16:205-214.
190. Ranchon, I., Chen, S., Alvarez, K., and Anderson, R.E. (2001). Systemic administration of phenyl N-tertbutylnitrone (PBN) protects retinal rod photoreceptor cells from light damage. Invest. Ophthalmol. Vis. Sci.
42:1375-1379.
191. Calvert, P.D., Govardovskii, V.I., Krasnoperova, N., Anderson, R.E., Lem, J., and Makino, C.L. (2001). Effect of
rhodopsin membrane density on the speed of rod phototransduction. Nature 411:90-94.
192. Rajala, R.VS. and Anderson, R.E. (2001). Interaction of the insulin receptor -subunit in the activation of
phosphatidylinositol 3-kinase in bovine ROS. Invest. Ophthalmol. Vis. Sci., 42: 3110-3117.
193. Hoffman, D.R., DeMar, J.C., Heird, W.C., Birch, D.G., and Anderson, R.E. (2001). Impaired synthesis of
docosahexaenoic acid (DHA) in patients with X-linked retinitis pigmentosa (XLRP). J. Lipid Res. 42:1395-1401.
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194. Li, F., Cao, W., and Anderson, R.E. (2001). Protection of photoreceptor cells in adult rats from light-induced
degeneration by adaptation to bright cyclic light. Exp. Eye Res. 73:569-577.
195. Anderson, R.E., Maude, M.B., and Bok, D. (2001). Low docosahexaenoic acid levels in rod outer segment
membranes of mice with rds/peripherin and P216L peripherin mutations. Invest. Ophthalmol. Vis. Sci., 42:17151720
196. Watkins, P., Hamilton, J.A., Leaf, A., Spector, A., Moore, S.A., Anderson, R.E., Moser, H.W., Noetzel, M.J., and
Katz, R. (2001). Brain uptake and utilization of fatty acids. J. Mol. Neurosci. 16:87-92.
197. Ranchon, I., White, J., Chen, C., Alvarez, K., and Anderson, R.E. (2001). Chronic administration of phenyl Ntert-butylnitrone protects the retina against light damage. In New Insights into Retinal Degenerative Diseases,
edited by R.E. Anderson, J.G. Hollyfield, and M.M. LaVail. Plenum Press (New York), p. 95-103.
198. Anderson, R.E., Sieving, P.A., Maude, M.B., and Naash, M.I. (2001). Mice with G90D rhodopsin mutations have
lower DHA in rod outer segment membranes than control mice. New Insights into Retinal Degenerative
Diseases, edited by R.E. Anderson, J.G. Hollyfield, and M.M. LaVail. Plenum Press (New York), p. 235-245.
199. Anderson, R.E., Maude, M.B., McClellan, M., Matthes, M.T., Yasumura, D., and LaVail, M.M. (2002). Low
docosahexaenoic acid levels in rod outer segments of rats with P23H and S334ter rhodopsin mutations.
Molecular Vision 8:351-358.
200. Martin, R.E., Hopkins, S.A., Brush R.S., Williamson, C., Chen, H., and Anderson, R.E. (2002).
Docosahexaenoic, arachidonic, palmitic, and oleic acids are differentially esterified into phospholipids of frog
retina. Prostaglandins Leukot Essent Fatty Acids 67:105-11.
201. Rundle, D.R., Alvarez, R.A., Rajala, R.VS., and Anderson, R.E. (2002). Characterization of Type I and Type II
myristoyl-CoA:protein N-myristoyltransferase with the acyl-CoAs found in heterogeneously acylated retinal
proteins. Exp. Eye Res. 75:87-97.
202. Rajala, R.VS., McClellan, M.E., Ash, J.D., and Anderson, R.E. (2002). In vivo regulation of phosphoinositide 3kinase in retina through light induced tyrosine phosphorylation of the insulin receptor -subunit. J. Biol.
Chem.277:43319-43326.
203. Ranchon, I., LaVail, M.M., Kotake, Y. and Anderson, R.E. (2003). Free radical phenyl-N-tert-butylnitrone protects
against light damage but does not rescue P23H and S334ter rhodopsin transgenic rats from inherited retinal
degeneration. J. Neurosci. 23:6050-6057.
204. Káldi, I., Dittmar, M., Pierce, P. and Anderson, R.E. (2003). L-NAME protects against acute light damage in
albino rats, but not against retinal degeneration in P23H and S334ter transgenic rats. Exp. Eye Res. 76:453461.
205. Rajala R.VS., McClellan, M.E., Ash, J.D., and Anderson, R.E. (2003). Regulation of retinal phosphoinositide 3kinase activity in p85 -subunit knockout mice. In Retinal Degenerations: Mechanisms and Experimental
Therapy, edited by M.M. LaVail, J.G. Hollyfield, and R.E. Anderson. Kluwer Academic/Plenum Publishers (New
York). Pp. 369-376.
206. Cao, W. Rajala, R.VS., Li, F., Anderson, R.E., Wei, N., Soliman, C.E., and McGinnis, J.F. (2003).
Neuroprotective effect of estrogen upon retinal neurons in vitro. In Retinal Degenerations: Mechanisms and
Experimental Therapy, edited by M.M. LaVail, J.G. Hollyfield, and R.E. Anderson. Kluwer Academic/Plenum
Publishers (New York). Pp. 395-402.
207. Li, F., Cao, W., and Anderson, R.E. (2003). Adaptation of adult albino rat to bright cyclic light alleviates constant
light-induced photoreceptor degeneration. Invest. Ophthalmol. Vis. Sci. 44:4968-1975.
208. Rajala, R.VS. and Anderson, R.E. (2003). Light regulation of the insulin receptor in the retina. Molec. Neurobiol.
28:123-138.
209. Al-Ubaidi, M.R. and Anderson, R.E. (2003). Metabolism and photochemistry of the retina. In Duane's
Foundations of Clinical Ophthalmology on CD-ROM, Foundation Volume 2, Chapter 12, edited by E.A. Jaeger
and W. Tasman, J.B. Lippincott Co. (Philadelphia, PA).
210. Káldi, I, Martin, R.E., Huang, H., Brush, R.S., Morrison, K., and Anderson, R.E (2003). Bright cyclic rearing
protects albino mouse retina against acute light-induced apoptosis. Molec. Vis. 9:337-344.
211. Martin, R.E. Ranchon, I. Brush, R.S. Williamson, C.R., Hopkins, S.A. Feng Li, and Anderson R.E. (2004). P23H
and S334ter opsin mutations: Increasing photoreceptor outer segment n-3 fatty acid content does not affect the
course of retinal degeneration. Molec. Vis. 10:199-207.
212. Rundle, D.R., Rajala, R.VS., Alvarez, R.A., and Anderson, R.E. (2004). Kinetic parameters of Type I and Type II
myristoyl-CoA:protein N-myristoyltransferases: human liver, bovine liver, and bovine retina enzymes with the
acyl-CoAs found on heterogeneously acylated retinal proteins. Molecular Vision 10:177-185.
213. Huang, H., Li, F., Alvarez, R.A., Ash, J.D., and Anderson, R.E. (2004). Down-regulation of a mitochondrial
transcript encompassing ATPase-6, cytochrome C oxidase-III, and NADH-dehydrogenase-3 by bright cyclic light
in the rat retina. Invest. Ophthalmol. Vis. Sci. 45:2489-2496
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214. Yu, X., Rajala, R.VS., McGinnis, J.F., Li, F., Anderson, R.E., Yan, X., Li, S., Elias, R.V., Knapp, R.R., Cao, W.
(2004). Involvement of insulin/PI3K/Akt signal pathway in 17beta-estradiol-mediated neuroprotection. J. Biol.
Chem. 279:13086-13094.
215. Rajala, R.VS., McClellan, M.E., Tsiokas, L., and Anderson, R.E. (2004). Direct interaction of retinal insulin
receptor -subunit with p85 subunit of phosphoinositide 3-kinase. Biochemistry 43:5637-5650.
216. Le, Y-Z., Ash, J.D., Al-Ubaidi, M.R., and Anderson, R.E. (2004). Targeted expression of Cre recombinase to
cone photoreceptor cells in transgenic mice. Molecular Vision 10:1011-1018.
217. Anderson, R.E. and Penn, J.S. (2004). Environmental light and heredity provoke adaptive changes in retinal
DHA levels that affect retinal function Lipids. 39:1121-1124.
218. Tomita, H., Kotake, Y. and Anderson, R.E. (2005). Mechanism of protection from light-induced retinal
degeneration by the synthetic antioxidant phenyl N-tert-butylnitrone. Invest. Ophthalmol. Vis. Sci. 46:427-434.
219. Jensen, C.L., Voigt, R.G., Prager, T.C., Zou, Y.L., Fraley, J.K., Rozelle, J., Turcich, M., Llorente, A.,
Anderson, R.E., and Heird, W.C. (2005). Effects of maternal docosahexaenoic acid (DHA) intake on visual
function and neurodevelopment of breast-fed term infants. Amer. J. Clin. Nutr. 82:125-32..
220. Huang, H., Frank, M.B., Dozmorov, I, Cao, W., Cadwell, C., Knowlton, N., Centola, M., and Anderson, R.E.
(2005). Identification of Mouse Retinal Genes Differentially Regulated by Dim and Bright Cyclic Light Rearing.
Exp. Eye Res. 80:727-739.
221. Martin, R.E., Elliott M.H., Brush, R.S., and Anderson, R.E. (2005). Detailed characterization of the lipid
composition of detergent-resistant membranes from photoreceptor rod outer segment membranes. Invest.
Ophthalmol. Vis. Sci. 46:1147-1154.
222. Martin, R.E., Fliesler, S.J., Brush, R.S., Richards, M.J. Hopkins, S.A. and Anderson, R.E. (2005). Lipid
differences in rod outer segment membranes of rats with P23H and S334ter opsin mutations. Molecular Vision
11:338-346.
223. Tanito, M, Elliott, M.H., Kotake, Y., and Anderson, R.E. (2005). Protein modifications by 4-hydroxynonenal and
4-hydroxyhexenal in light-exposed rat retina. Invest. Ophthalmol. Vis. Sci. 46:3859-3868.
224. Tanito, M. and Anderson, R.E. (2006). Bright cyclic light rearing-mediated retinal protection against damaging
light exposure in adrenalectomized mice. Exp Eye Res 83:697-701. PMID: 16635489
225. Le, Y.-Z., Zheng, L., Zheng, W., Ash, J.D., Agbaga, M.-P., Zhu, M. and Anderson, R.E. (2006) Mouse opsin
promoter directed Cre recombinase expression in transgenic mice. Mol Vis 12:389-398. PMID: 16636658
226. Makino, C.L., X.-H. Wen, Michaud, M., Peshinko, I.V., Pawlyk, B., Brush, R.S., Soloviev, M., Liu, X., Woodruff,
M.L., Calvert, P.D., Savchenko, A.B., Anderson, R.E., Fain, G.L., Li, T., Sandburg, M.A, Dizhoor, A.M. (2006).
PMID: 16639031 Effects of low AIP1L1 expression on phototransduction in rods. Invest. Ophthalmol. Vis. Sci.
47:2185-2194.
227. Tanito, M., Kaidzu, S., and Anderson, R.E. (2006). Protective effects of soft acrylic yellow filter against blue lightinduced retinal damage in rats. Exp.Eye Res. 83:1493-1504. PMID: 16997296
228. Kasus-Jacobi, A., Birch, D.G., and Anderson, R.E. (2006). Photoreceptor retinol dehydrogenases: An attempt to
characterize the function of Rdh11. In Retinal Degenerations, edited by J.G. Hollyfield, R.E. Anderson, and M.M.
LaVail. Kluwer Academic/Plenum Publishers (New York). Pp. 505-511. PMID: 17249616
229. Le, Y-Z, Ash, J.D., Al-Ubaidi, M.R., Chen, Y., Ma, J-X., Anderson, R.E. (2006). Conditional gene knockout
system in cone photoreceptors. In Retinal Degenerations, edited by J.G. Hollyfield, R.E. Anderson, and M.M.
LaVail. Kluwer Academic/Plenum Publishers (New York). Pp. 173-178. PMID: 17249572
230. Rajala, R.V.S, Elliott, M.H., McClellan, M.E., and Anderson, R.E. (2006). Localization of the insulin receptor and
phosphoinositide 3-kinase in detergent-resistant membrane rafts of rod photoreceptor outer segments. In
Retinal Degenerations, edited by J.G. Hollyfield, R.E. Anderson, and M.M. LaVail. Kluwer Academic/Plenum
Publishers (New York). Pp. 491-497. PMID: 17249614
231. Fox, T.E., Han, X., Kelly, S., Merrill Jr, A.H., Martin, R.E., Anderson, R.E., Gardner, T.W., and Kester, M. (2006).
Diabetes alters sphingolipid metabolism in the retina: a potential mechanism of cell death in diabetic retinopathy.
Diabetes 55:3573-3580. PMID: 17130506
232. Zheng, L., Anderson, R.E., Agbaga, M.-P., Rucker III, E., and Le, Y.-Z. (2006) Loss of BCL-XL causes increased
rod photoreceptor susceptibility to bright light damage. Invest. Ophthalmol. Vis. Sci. 47:5583-5589. PMID:
17122152
233. Tanito, M., Haniu, H., Elliott, M.H., Singh, A.K., Matsumoto, H., and Anderson, R.E. (2006). Identification of 4HNE-modified retinal proteins induced by photooxidative stress prior to retinal degeneration. Free Radical
Biology & Medicine 41:1847-1859. PMID: 17157187
234. Tanito, M., Agbaga, M.-P., and Anderson, R.E. (2007). Upregulation of thioreodoxin system via Nrf-2-antioxidant
responsive element pathway in bright cyclic light rearing-mediated retinal protection in vivo and in 4hydroxynonenal-mediated adaptive response in vitro. Free Radicals Biology & Medicine 42:1838-1850. PMID:
17512463
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235. Tanito, M., Li, F., Elliott, M.H., Dittmar, M., and Anderson, R.E. (2007). Protective effect of TEMPOL derivatives
against light-induced retinal damage in rats. Invest. Ophthalmol. Vis. Sci. 48:1900-1905. PMID: 17389526
236. Tanito, M., Kaidzu, S., and Anderson, R.E. (2007). Delayed loss of cone photoreceptor cells due to impairment
of choroidal circulation following acute light exposure in rats. Invest. Ophthalmol. Vis. Sci. 48:1864-1872. PMID:
17389522
237. Rajala, A., Anderson, R.E., Ma, J-X., Al-Ubaidi, M.R., Lem, J., and Rajala, R.VS. (2007). G protein-coupled
receptor rhodopsin regulates the phosphorylation of retinal insulin receptor. J. Biol. Chem. 282:9865-9873.
PMID: 17272282
238. Ford, D.A., Monda, J.K, Brush, R.S., Anderson, R.E., Richards, M.J. and Fliesler, S.J. (2008). Lipidomic analysis
of the retina in a rat model of Smith-Lemli-Opitz Syndrome: Alterations in docosahexaenoic acid content of
phospholipid molecular species. J Neurochem. 105:1032-47. PMID: 18182048
239. Anderson, R.E., Tanito, M., Kaidzu, S., and Ohira, A. (2007). Mechanisms of adaptation of the retina to oxidant
stress. Biol. Skr. Dan. Vid. Selsk. 56:33-41.
240. Li, G., Anderson, R.E., Tomita, H., Adler, R., Liu, X., Zack, D.J., and Rajala, R. VS. (2007). Non-redundant role
of Akt2 for neuroprotection of rod photoreceptor cells from light-induced cell death. J. Neuroscience 27:203211. PMID: 17202487
241. Le Y., Zheng L., Le, Y., Rucker III E.B., Anderson R.E. (2008). Role of BCL-XL in rod and cone photoreceptor
survival. Adv Exp Med Biol 613: 69-74. PMID: 18188930
242. Le, Y.-Z., Zheng. W., Rao, P.-C., Anderson, R.E., Esumi, N., Zack, D.J., and Zhu, M. (2008). Inducible
expression of Cre recombinase in the retinal pigmented epithelium. Invest. Ophthalmol. Vis. Sci. 42:1248-1253.
PMID: 18326755
243. Rajala, R.VS. and Anderson, R.E. (2008). Probing the interactions between the retinal insulin receptor and its
downstream effectors. In Signal Transduction in the Retina, edited by S.J. Fliesler and A. Kesolov. Taylor &
Francis/CRC Press, Pp. 237-266.
244. Li, G., Rajala, A., Dilly, A.K., Wiechmann, A.F., Anderson, R.E., and Rajala, R.V.S. (2008). Light-dependent
generation of phosphoinositides regulates the activation and membrane binding of retinal PKBα/Akt1. J
Neurochem. 107:1382-1397. PMID: 18823366
245. Karpac, J., Czyzewska, K., Kern, A., Brush, R., Anderson, R., Hochgeschwender, U. (2008). Failure of adrenal
corticosterone production in pro-opiomelanocortin deficient mice results from lack of integrated effects of POMC
peptides on multiple factors. Am J Physiol Endocrinol Metab. 295:E446-455. PMID: 18559987
246. Agbaga, M.-P., Brush, R.S., Mandal, M.N.A., Henry, K., Elliott, M.H., and Anderson, R.E. (2008) Role of
Stargardt-3 macular dystrophy protein (ELOVL4) in the biosynthesis of very long chain fatty acids. Proc. Natl.
Acad. Sci. USA 105:12843-12848. PMID: 18728184
247. Boesze-Battaglia, K., Damek-Poprawa, M., Mitchell, D.C., Greeley, L., Brush, R.S., Anderson, R.E., Richards,
M.J., and Fliesler, S.J. (2008). Alteration of retinal rod outer segment membrane fluidity in a rat model of SmithLemli-Opitz Syndrome. J. Lipid Res. 49:1488-99. PMID: 18344409
248. Tanito, M., Kaidzu, S., Ohira, A., and Anderson, R.E. (2008). Topography of retinal damage in light-exposed
albino rats. Exp. Eye Res. 87:292-295. PMID: 18586030
249. Mandal, M.N., Patlolla, J.M., Zheng, L., Agbaga, M.-P., Tran, J.T., Wicker, L., Kasus-Jacobi, A., Elliott, M.H.,
Rao, C.V., and Anderson, R.E. (2009). Curcumin protects retinal cells from light-and oxidant stress-induced cell
death. Free Radic Biol Med. 46:672–679. PMID: 19121385
250. Tanito, M., Elliott, M.H., Brush, R.S., Wicker, L.D., Henry, K.R., and Anderson, R.E. (2009). High levels of retinal
membrane DHA increase susceptibility to stress-induced degeneration. J. Lipid Res. 50:807-19 Nov 20. [Epub
ahead of print]. PMID: 19023138
251. Wen, S-H., Brush, R.S., Michaud, N., Al-Ubaidi, M.R., Lem, J., Anderson, R.E., and Makino, C.L. (2009). Overexpression of rhodopsin alters the structure and photoresponse of rod photoreceptors. Biophysical Journal
96:939-50. PMID: 19186132
252. Li, F., Marchette, L.D., Brush, R.S., Elliott, M.H., Henry, K.A., Anderson, A.G., Zhao, C., Sun, X., Zhang, K., and
Anderson, R.E. (2009). DHA does not protect ELOVL4 transgenic mice from retinal degeneration. Molecular
Vision 15:1185-1193.
253. Tanito, M. and Anderson, R.E. (2009). Dual roles of polyunsaturated fatty acids in retinal physiology and
pathophysiology associated with retinal degeneration. Clinical Lipidology 4:821-827.
254. Mandal, NA, Anderson, RE, and Ash, JD (2010). Injury and repair: light damage. In Encyclopedia of the Eye,
edited by Darlene A. Dartt. Oxford: Academic Press, Vol 2, pp. 392-399.
255. Tanito, M., Brush, R.S., Elliott, M.H., Wicker, L.D., Henry, K.R., and Anderson, R.E. (2010). Correlation between
tissue docosahexaenoic acid levels and susceptibility to light-induced retinal degeneration. Adv Exp Med Biol
664:567-573.
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256. Agbaga, M.-P., Brush, R.S., Al-Ubaidi, M.R., Mandal, M.N.A., and Anderson, R.E. (2010). Role of ELOVL4
protein in the biosynthesis of docosahexaenoic acid. Adv Exp Med Biol 664:233-242.
257. Roqueta-Rivera, M., Stroud, C.K., Haschek, W.M., Akare, S.J., Segre, M., Brush, R.S., Agbaga, M-P.,
Anderson, R.E., Hess, R.A., and Nakamura, M.T. (2010). Docosahexaenoic acid supplementation fully restores
fertility and spermatogenesis in male delta-6 desaturase knockout mice. J. Lipid Res. 51:360-367
258. Rajala, R.VS. and Anderson, R.E. (2010). Rhodopsin-regulated insulin receptor signaling pathway in rod
photoreceptor neurons. Molec. Neurobiol. 42:39-47, Apr 21. [Epub ahead of print]
259. Huang, Z. Anderson, R.E., Cao, W, Wiechmann, A.F., and Rajala, R.VS. (2010). Light-induced tyrosine
phosphorylation of rod outer segment membrane proteins regulates the translocation, membrane binding and
activation of Type II alpha phosphatidylinositol-5-phosphate 4-kinase. Neurochem. Res. Mar 5. [Epub ahead of
print]
260. Kanan, Y., Matsumoto, H., Song, H., Sokolov, M., Anderson, R.E., and Rajala, R.VS. (2010). Insulin receptor
signaling regulates the activity of retinal serine/threonine phosphatases, PHLPP and PHLPPL. J. Neurochem.
113:477-488. Epub 2010 Jan 20.
261. Ivanovic, I., Rajala, A., Gupta, V.K., Anderson, R.E, and Rajala, R.V.S. (2010). Phosphoinositide 3-kinase
signaling in retinal rod photoreceptor functions. Submitted to J. Biol. Chem.
262. Ivanovic, I., Anderson, R.E., Le, Y.Z., Fliesler, S.J., Sherry, D.M., and Rajala, R.V.S. (2010). Importance of
phosphoinositide 3-kinase pathway for cone survival. Submitted to J. Neurosci.
263. Agbaga, M.-P., Mandal, M.N.A., and Anderson, R.E. (2010). Retinal very long chain polyunsaturated fatty acids:
new insights from studies on ELOVL4 protein. J. Lipid Res, 51:1624-42, Mar 18. [Epub ahead of print]
264. Al-Ubaidi, M.R. Sherry, D.M., and Anderson, R.E. (2010). Metabolism and photochemistry of the retina. In
Duane's Foundations of Clinical Ophthalmology on CD-ROM, Foundation edited by E.A. Jaeger and W.
Tasman, J.B. Lippincott Co. (Philadelphia, PA), in press.
265. Li, F., Marchette, L.D., Brush, R.S., Elliott, M.H., Davis, K.A., Anderson, A.G., and Anderson, R.E. (2010). High
levels of retinal docosahexaenoic acid do not protect photoreceptor degeneration in VPP transgenic mice.
Molecular Vision 16:1669-1679.
266. Tanito, M., Li, F., and Anderson, R.E. (2010). Protection of retinal pigment epithelium by OT-551 and its
metabolite TEMPOL-H against light-induced damage in rats. Exp. Eye Res 91:111-4, Apr 28 [Epub ahead of
print].
267. Rajala, R.VS. and Anderson, R.E. (2010). Focus on Molecules: Phosphatidylinositol-4,5-bisphosphate (PIP2).
Exp. Eye Res. 91:324-325 May 8. [Epub ahead of print]
268. Anderson RE. (2010). Introducing Joe G. Hollyfield, the 2009 Recipient of the Proctor Medal. Invest Ophthalmol
Vis Sci 51:1275.
269. Tanito, M., Li, F., and Anderson, R.E. (2010). Intravitreal injection of erythropoietin glycosylation analogs does
not protect rod photoreceptor cells from light-induced damage. Submitted to Adv Exp Med Biol.
270. Rajala, R.VS., Anderson, R.E., Ueki, Y., and Ash, J.D. (2010). Neuroprotective survival signaling pathways in
light stress and preconditioning. Submitted to Progress in Retina and Eye Research.
271. Jensen, C.L., Voigt, R.G., Llorente, A.M., Peters, S.U., Prager, T.C., Zou, Y.L., Rozelle, J.C., Turcich, M., Fraley,
J.K., Anderson, R.E., and Heird, W.C. (2010). Effects of early maternal docosahexaenoic acid (DHA) intake on
later neuropsychological status and visual function of former breast-fed term infants J. Pediatr 157:900-5. Jul
22. [Epub ahead of print].
272. Fox, T.E., Bewley, M.C., Unrath, K.A., Pedersen, M.M., Anderson, R.E., Bronson, S.K., Flanagan, J.M., Kester,
M. (2010). Circulating sphingolipid biomarkers in models of Type 1 diabetes. J. Lipid Res., accepted.
BOOKS
1.
Anderson, R.E. (coordinating editor). Biochemistry of the Eye. American Academy of Ophthalmology (San
Francisco) 1983.
2.
LaVail, M.M., J.G. Hollyfield, and R.E. Anderson (editors). Retinal Degeneration: Experimental and Clinical
Studies. Alan R. Liss, Inc. (New York) 1985.
3.
Hollyfield, J.G., R.E. Anderson, and M.M. LaVail (editors). Progress in Clinical and Biological Research, Vol.
247. Degenerative Retinal Disorders: Clinical and Laboratory Investigations. Alan R. Liss, Inc. (New York)
1987.
4.
LaVail, M.M., R.E. Anderson, and Hollyfield, J.G. (editors). Inherited and Environmentally Induced Retinal
Degenerations, Alan R. Liss, Inc. (New York) 1989.
5.
Anderson, R.E., J.G. Hollyfield, and M.M. LaVail (editors). Retinal Degenerations, CRC Press, Inc. (Boca Raton
FL) 1991.
15
Robert E. Anderson, MD, PhD
6.
7.
8.
9.
10.
11.
12.
13.
14.
Hollyfield, J.G., R.E. Anderson, and M.M. LaVail (editors). Retinal Degenerations. Clinical and Laboratory
Manifestations. Plenum Press (New York) 1993.
Anderson, R.E., J.G. Hollyfield, and M.M. LaVail (editors). Degenerative Diseases of the Retina. Plenum Press
(New York) 1995.
LaVail, M.M., R.E. Anderson, and Hollyfield, J.G. (editors).Retinal Degenerative Diseases. Plenum Press (New
York), November, 1997.
Hollyfield, J.G., R.E. Anderson, and M.M. LaVail (editors). Retinal Degenerations. Clinical and Laboratory
Manifestations. Plenum Press (New York) 1999.
Anderson, R.E., J.G. Hollyfield, and M.M. LaVail (editors). New Insights into Retinal Degenerative Diseases.
Plenum Press (New York) 2001.
LaVail, M.M., J.G. Hollyfield, and R.E. Anderson (editors). Advances in Experimental Medicine and Biology, Vol.
553, Retinal Degenerations: Mechanisms and Experimental Therapy. Kluwer Academic/Plenum Publishers
(New York) 2003.
Hollyfield, J.G., R.E. Anderson, and M.M. LaVail (editors). Advances in Experimental Medicine and Biology, Vol.
572, Retinal Degenerations. Springer (New York) 2006.
Anderson, R.E., M.M. LaVail, and J.G. Hollyfield (editors). Advances in Experimental Medicine and Biology, Vol.
613, Recent Advances in Retinal Degeneration. Springer (New York) 2008.
Anderson, R.E., M.M. LaVail, and J.G. Hollyfield (editors). Advances in Experimental Medicine and Biology, Vol.
664, New Insights into Retinal Degeneration. Springer (New York) 2010.
GRANTS, AWARDS, and CONTRACTS: (PI except as indicated by *. Current funding is in bold print).)
1.
GRS P-70-14: The Chemistry and Metabolism of Retina Rod Outer Segments. (Jan 1 - Dec 31, 1970) - $5,000.
2.
NIH EY00244-09/13: Retina: The Chemistry of Photoreceptor Membranes. (June 1, 1970 - May 31, 1975) $210,765.
3.
NIH EY00871-01/03: Retina: The Metabolism of Polyunsaturated Fatty Acids. (Feb 1, 1972 - Jan 31, 1975) $109,241.
4.
NIH EY42162: Development of a Method for Large Scale Preparation of Rod Outer Segments. (May 6, 1974 June 30, 1975) - $26,175.
5.
Retina Research Foundation: Studies on the Control of Photoreceptor Membrane Biosynthesis by Essential
Polyunsaturated Fatty Acids. (Mar 13, 1974 - Dec 31, 1976) - $63,902.
6.
Retina Research Foundation: The Management of Retinitis Pigmentosa and its Relationship to Photoreceptor
Renewal. (Mar 13, 1974 - Dec 31, 1976) - $62,296.
7.
Research to Prevent Blindness Manpower Award: The Management of Retinal Degeneration of the RCS Rat.
(July 1, 1975) - $7,500.
8.
*National Retinitis Pigmentosa Foundation: Special award to support studies on the effect of dimethylsulfoxide
on the progress of retinal degeneration in the RCS rat. (June 25, 1976) - $3,000.
9.
NIH EY00871-04/06: The Metabolism of Visual Cells. (Feb 1, 1975 - Jan 3, 1978) - $184,416.
10. Retina Research Foundation: Experimental Retinal Vasculopathies. (Jan 1 - Dec 31, 1977)- $28,922.50.
11. Retina Research Foundation: Studies on Diabetic Retinopathy. (Jan 1 - Dec 31, 1978) - $25,029.75.
12. NIH EY00871-07/11: Chemistry and Metabolism of Retina Lipids. (Feb 1, 1978 - Jan 31, 1983) - $694,099.
13. NIH EY07001-01/05: Research Training in Visual Sciences. (July 1, 1977 - June 30, 1980) - $229,553.
14. NIH EY07001-03S1: Supplement to Research Training In Visual Sciences. (July 1, 1977 - June 30, 1980) $140,974.
15. Retina Research Foundation: Studies on Diabetic Retinopathy. (Jan 1 - Dec 31, 1979) - $21,150.80.
16. *NIH EY02520-01/05: Center for Research on the Structure and Function of the Visual System. (July 1, 1979 June 30, 1984) - $600,099.
17. *Retinitis Pigmentosa Center Grant. (July 1, 1979 - June 30, 1982) - $272,272.
18. Retina Research Foundation: Studies on Diabetic Retinopathy. (Jan 1 - Dec 31, 1980) - $11,247.
19. *Retina Research Foundation: The Effect of Vitamin E on the Retinas of Premature Infants. (Jan 1 - Dec 31,
1980) - $12,937.50.
20. NIH EY07001-06/10: Research Training in Visual Sciences. (July 1, 1980 - June 30, 1985) - $514,806.
21. Retina Research Foundation: Biochemical Studies of Retinal Degenerations. (Jan 1 - Dec 31, 1981) - $25,300.
22. Retina Research Foundation: Studies on Retinal Degenerations. (Jan 1 - December 31, 1982) - $35,926.
23. NIH EY04149-01/03: Role of Lipid Peroxidations in Retinal Degenerations. (Apr 1, 1982 - Sep 29, 1985)$261,100.
24. Research to Prevent Blindness, Inc.: Dolly Green Special Scholar Award. (July 1, 1982 - June 30, 1984) $60,000.
25. *Retinitis Pigmentosa Center Grant. (July 1, 1982 - June 30, 1986) - $522,532.
16
Robert E. Anderson, MD, PhD
26.
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46.
47.
48.
49.
50.
51.
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53.
54.
55.
56.
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58.
59.
60.
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Retina Research Foundation: Studies on Retinal Degenerations. (Jan 1 - Dec 31, 1983) - $22,149.
NIH EY00871-12/16: Chemistry and Metabolism of Retina Lipids. (Feb 1 - Jan 31, 1988) - $657,197.
Retina Research Foundation: Studies on Retinal Degenerations. (Jan 1 - Dec 31, 1984) - $21,150.
*NIH EY02520-06/10: Center for Research on the Structure and Function of the Visual System. (July 1, 1984 June 30, 1989) - $677,816.
NIH EY07001-11/15: Research Training in Visual Sciences. (July 1, 1985 - June 30, 1991) - $895,742.
Alcon Research Institute. (Sep 1, 1985) - $25,000.
NIH EY04149-04/08: Role of Lipid Peroxidations in Retinal Degenerations. (Sep 30, 1986 - Sep 29, 1991) $597,404.
Retina Research Foundation: Studies on Retinal Degenerations. (Jan 1 - Dec 31, 1986) - $16,500.
*Retinitis Pigmentosa Foundation Center Grant. (July 1, 1986 - June 30, 1991) - $1,016,734.
Retina Research Foundation: Biochemical Studies on Retinopathy of Prematurity. (Jan 1 - Dec 31, 1987) $13,630.
NIH EY00871-17/21: Chemistry and Metabolism of Retina Lipids. (Feb 1, 1988 - June 30, 1993) - $1,023,521.
*NIH EY02520-11/15: Center for Research on the Structure and Function of the Visual System. (July 1, 1989 June 30, 1994) - $750,000.
Retinitis Pigmentosa Foundation Fighting Blindness: Docosahexaenoic Acid in Retinitis Pigmentosa. (July 1,
1989 - June 30, 1990) - $74,671.
Retina Research Foundation: Role of Long Chain Polyunsaturated Fatty Acids in the Retina. (Jan 1- Dec 31,
1990) - $31,213.
Research to Prevent Blindness, Inc., Senior Scientific Investigators Award. (Jan 1, 1990) - $40,000.
Retinitis Pigmentosa Foundation Fighting Blindness: Docosahexaenoic Acid in Retinitis Pigmentosa. (July 1,
1990 - June 30, 1991) - $77,191.
NIH EY04149-09/13: Role of Essential Fatty Acids in Retinal Degenerations. (Sep 30, 1990 - Sep 29, 1995) $1,058,671.
Retina Research Foundation: Role of Long Chain Polyunsaturated Fatty Acids in the Retina. (Jan 1- Dec 31,
1991) - $26,951.
NIH EY07001-16/20: Research Training in Visual Sciences. (Feb 1,1991 - Jan 31, 1996) - $572,833.
Retinitis Pigmentosa Foundation Fighting Blindness: Lipid Studies in Retinitis Pigmentosa. (July 1, 1991 - June
30, 1992) - $60,455.
Retina Research Foundation: Role of Long Chain Polyunsaturated Fatty Acids In the Retina. (Jan 1 - Dec 31,
1992) - $30,000.
*Retinitis Pigmentosa Foundation Fighting Blindness: Initiative on Macular Degeneration. (July 1, 1991 - June
30, 1992) - $100,000.
*Retinitis Pigmentosa Foundation Fighting Blindness: Initiative on Macular Degeneration. (July 1, 1992 - June
30, 1993) - $106,000.
Retinitis Pigmentosa Foundation Fighting Blindness: Lipid Studies in Retinitis Pigmentosa. (July 1, 1992 - June
30, 1993) - $64,082.
Retina Research Foundation: Biochemical Studies on Age-Related Macular Degeneration. (Jan 1 - Dec 31,
1993) - $16,000.
*Retinitis Pigmentosa Foundation Fighting Blindness: Initiative on Macular Degeneration. (July 1, 1993 - June
30, 1994) - $112,000.
Retinitis Pigmentosa Foundation Fighting Blindness: Lipid Studies in Retinitis Pigmentosa. (July 1, 1993 - June
30, 1994) - $67,927.
NIH EY00871-22/25: Role of Second Messengers in the Retina. (July 1, 1993 - Oct 31, 1996) - $582,158.
Retina Research Foundation: Biochemical Studies on Age-Related Macular Degeneration. (Jan 1 - Dec 31,
1994) - $11,353.
Retinitis Pigmentosa Foundation Fighting Blindness: Lipid Studies in Retinitis Pigmentosa. (July 1, 1994 - June
30, 1995) - $65,166.
Retinitis Pigmentosa Foundation Fighting Blindness: Lipid Studies in Retinitis Pigmentosa. (July 1, 1995 - June
30, 1996) - $66,733.
NIH EY04149-15/18: Lipid Metabolism in the Retina. (Sep 30, 1995 - Sep 29, 1999) - $982,560.
Retinitis Pigmentosa Foundation Fighting Blindness: Lipid Studies in Retinitis Pigmentosa. (July 1, 1996 - June
30, 1997) - $69,402.
Presbyterian Health Foundation: Role of Second Messengers in the Retina. (July 1, 1996 - Nov 30, 1997) $45,000.
NIH EY00871-26/30: Second Messengers in the Retina. (Dec 1, 1996 - Nov 30, 2001) - $1,152,706.
Foundation Fighting Blindness: Long Chain Fatty Acid Biosynthesis in X-Linked Retinitis Pigmentosa. (May 1,
1997 - April 30, 1998) - $91,940.
17
Robert E. Anderson, MD, PhD
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81.
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83.
84.
85.
86.
87.
88.
89.
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91.
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93.
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Research to Prevent Blindness, Inc., Senior Scientific Investigators Award. (Jan 1, 1997) - $55,000.
Foundation Fighting Blindness: Lipid Studies in Retinitis Pigmentosa. (July 1, 1997 - June 30, 2000) - $248,770.
*Foundation Fighting Blindness: FFB Southwest Regional Research Center. (July 1, 1999 - June 30, 2004) $2,129,562. (Co-PI; $472,457 awarded to REA at OUHSC)
NIH EY12190-1/5: Core Vision Center (July 1, 1999 - June 30, 2004) - $1,374,459.
NIH EY04149-19A: Lipid Metabolism in the Retina. (Sept 30, 1999 – Nov 30, 1999) - $42,283.
NIH R01 EY04149-19/23: Lipid Metabolism in the Retina. (Dec 1, 1999 – Nov 30, 2004) - $1,361,807.
Japanese Society for the Promotion of Science. Travel Grant (Mar 10 - Apr 8, 2001)
Presbyterian Health Foundation: Equipment grant to establish frog transgenic and embryo freezing cores. (Nov
1, 2001 – Oct 31, 2002) - $70,000.
NIH R01 EY00871-31/34: Second Messengers in the Retina. (Dec 1, 2001 - Nov 30, 2007) - $1,702,000.
*OCAST-OARS (Subcontract through Kotake-OMRF): Therapeutic Potential of New Antioxidants (Jan 1, 2002
– Dec 31, 2003) - $36,108
NIH R13 EY13974-01: Retinal Degeneration Conference. (Aug 1, 2002-July 31, 2003). $86,250.
NIH COBRE P20-RR17703-01/05: Mentoring Vision Research in Oklahoma. (Sep 16, 2002 – June 30, 2007) $11,389,397.
Warren Pharmaceuticals- (Nov 1, 2002 – July 31, 2003) - $90,072.
NIH COBRE P20-RR1770-02S1: Supplement for Functional Genomics Core (RR17703). (Sep 1, 2003 – June
30, 2004). $500,000.
NIH 1U13EY015299-01: Retinal Degeneration Conference. (July 1, 2004-June 30, 2005). $94,233.
*Foundation Fighting Blindness: FFB Southwest Regional Research Center. (July 1, 2004 - June 30, 2007) $1,039,214. (Co-PI; $367,391 awarded to OUHSC).
NIH P30 EY12190-6/10S1: Core Vision Center (July 1, 2004 - June 30, 2010) - $2,930,000.
NIH R01 EY04149-24/27: Lipid Metabolism in the Retina. (Dec 1, 2004 – Nov 30, 2009) - $1,905,140.
Merck Pharmaceuticals- (Dec. 1, 2004 – Nov. 31, 2005). $101,615.
Alcon Labs: (June 1, 2005 – May 31, 2006). $30,000.
Othera Pharmaceuticals: (June 1, 2005 – May 31, 2006). $97,250.
Regena-Vue, Inc-. (May 1, 2005 – April 30, 2006). $20,000.
Amgen, Inc.: (Oct. 17, 2005 – Oct. 16, 2006). $137,500.
Pfizer, Inc (Mar 15, 2006 – Mar 14, 2008). $276,885.
NIH 1 U13 EY017489-01: Retinal Degeneration Conference. (July 1, 2006-June 30, 2008). $70,336.
NIH R01 EY00871-35/38: Second Messengers in the Retina. (Dec 1, 2007 - Nov 30, 2011) - $1,465,000.
Foundation Fighting Blindness: FFB Southwest Regional Research Center. (July 1, 2007 - June 30,
2012) - $3,154,992. (Co-PI; $1,442,497 awarded to OUHSC).
NIH COBRE P20-RR17703-06/10: Mentoring Vision Research in Oklahoma. (July 1, 2007 – June 30,
2012) - $10,920,989.
NIH 3R01EY004149-27S1: Lipid Metabolism in the Retina. (Dec 1, 2007 – Nov 30, 2009) - $63,571.
NIH 1R13EY018977-01: Retinal Degeneration Conference. (Jul 1, 2008 – Jun 30, 2010) - $68,280.
Pfizer, Inc (May 15, 2009 – Feb 14, 2011). - $590,595.
NIH R01 EY04149-28/32: Lipid Metabolism in the Retina. (Jul 1, 2009 – Jun 31, 2014) - $2,555,887.
NIH 1R13 EY020686-01: Retinal Degeneration Conference. (Apr 1, 2010-Mar 31, 2011). $69,258.
18