AMOXICILLIN DEGRADATION PRODUCTS IN VARIOUS AQUATIC
ENVIRONMENTS
Igal Gozlan1/2, Adi Mayer1 & Dror Avisar1
1
2
Hydrochemistry Laboratory, Tel Aviv University, Israel
TAMI (IMI) Ltd., Institute for Research & Development, Haifa, Israel 26111
Gozlan@tami-imi.icl-ip.com
This study examined the chemical behavior of selected antibiotic, amoxicillin (AMX), in variable aquatic
environmental conditions in order to determine its degradation products. HPLC–UV-MS/MS and NMR
were used to detect and quantify these compounds. These analytical tools were followed up by sample
preparation methods such as liquid-liquid extraction, SPE and preparative HPLC. The AMX, which was
kept on natural environmental conditions, showed degradation products such as: penicilloic acid,
penilloic acid, diketopiperazine amoxicillin, amoxicillin oxide and 3-(4-hydroxyphenyl) pyrazin-2-ol.
Subsequently, several of these degradation products were detected in the aquatic environment
(wastewater, effluent and groundwater) at levels of ppb's.
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