The University of Michigan Protein Structure Facility Ann Arbor, MI 48109-5674 2560 MSRB II, Box 5674 1150 W. Medical Center Dr. Ann Arbor, MI 48109-5674 Telephone: (734) 763-6285 Fax: (734) 936-2633 hremmer@umich.edu Director: Henriette A Remmer, Ph.D. Peptide Synthesis Service Fees for MDRTC (effective January 1, 2008) Peptide Synthesis Small Scale Synthesis (5-40 mg crude peptide) Regular Peptides Repeat Orders* Long and Hydrophobic Peptides** Half Scale Synthesis (20-60 mg crude peptide) Regular Peptides Repeat Orders* Long and Hydrophobic Peptides** Medium Scale Synthesis (40-120 mg crude peptide) Regular Peptides Repeat Orders* Long and Hydrophobic Peptides** Full Scale Synthesis (100-300 mg crude peptide) Regular Peptides Repeat Orders* Long and Hydrophobic Peptides** Large Scale Synthesis (250-600 mg crude peptide) Regular Peptides Repeat Orders* Long and Hydrophobic Peptides** Fees per amino acid residue $7 $6 inquire $7 $6 inquire $9 $8 $11 $14 $13 $14 $22 $20 $22 * Peptides previously synthesized at the facility. **Peptides with >25 amino acids in length and/or sequence contains many (>50%) hydrophobic amino acids. Additional Peptide Synthesis Options Peptide Acetylation Peptide Amidation Amino Acid Mixture (synthesis of peptide library) Cyclization via Disulfide Bond Formation (air oxidation) Cyclization via Disulfide Bond Formation (I2 oxidation) Cyclization via Peptide Bond Formation* Freeze-Drying Multiple Antigenic Peptide (MAP) Synthesis Setup* N-Terminal Modification/Labeling* Peptide Aliquotation (2-10 aliquots) Peptide Conjugation to Carrier Protein** Phosphorylation (Ser, Thr, Tyr)* Resin Split 1 amino acid equivalent 1 amino acid equivalent $13 $50 $65 $63 $3 $11 $40 $3 $36 $35 $13 *Additional reagent costs apply ** Service offered via outsourcing fee includes shipping Peptide Purification Small Scale Half Scale Medium Scale Full Scale Large Scale 70% 90% 70% 90% 70% 90% 70% 90% 70% 90% purity purity purity purity purity purity purity purity purity purity Other Services Analytical HPLC Shipping and Handling Stock Peptides (for available sequences, please inquire) Guaranteed Minimum Yields* (purified Peptides) $59 $70 $59 $70 $68 $78 $71 $81 $119 $128 *Yields usually, but not always, exceed the guaranteed minimum. 2-12 mg 1-4 mg 6-18 mg 2-6 mg 12-36 mg 4-12 mg 30-90 mg 10-30 mg 75-180 mg 25-60 mg $8 $8 $24 per mg of peptide Policy: Samples will not be processed before request form has been completed and shortcode has been provided. Cancellations are not accepted after analysis, synthesis or preparation steps have been started. In case of an undesired result due to the nature of the submitted sample or peptide sequence, fees still apply. Note: Members of the University of Michigan Diabetes Research and Training Center (MDRTC), Rheumatic Disease Core Center (RDCC) and Michigan Gastrointestinal Peptide Research Center receive a discount on Protein Structure Facility services.