Scientist DMPK

Scientist DMPK
Job Description
Primary duties include the determination of in vivo and in vitro metabolic pathways in
animals and humans, including identification and quantification of metabolites in
biological matrices (e.g., blood, excreta) using HPLC with radioactivity detection and/or
LC-MS/MS. The position requires expertise in sample preparation as well as subsequent
analysis, including metabolite structure elucidation. The position also includes conduct of
in vitro metabolism experiments for comparison of metabolic pathways across species
and to assess the potential for drug-drug interactions in humans (identification of
enzymes involved and inhibition studies). The determination of enzyme kinetic
parameters may also be required.
M.S. in Chemistry or Biochemistry or related field with a minimum of three years or B.S.
with five years of hands-on with HPLC and LC-MS/MS. Prior experience with
radioisotope handling (e.g., 3H, 14C), biochemical techniques and in vivo and in vitro
metabolism is required. The candidate should be capable of working independently under
moderate supervision and should possess good writing and verbal communication skills.
An excellent working knowledge of general laboratory techniques, HPLC and LCMS/MS operation, and troubleshooting and method development is essential. A strong
background in analytical problem solving is also required.
Novartis Institutes for Biomedical Research
East Hanover, NJ 07936
Please apply at requisition number 148724BR or at the link below