Gomathi Ramanoudjame
SUMMARY
Over ten years of experience in research with experience in teaching for first year and second year
masters students.
EDUCATION AND CREDENTIALS
Ph.D. in Organic Chemistry, from Annamalai University, India, May 2004
M.Phil. in Chemistry, from Annamalai University, India, Nov 2000
M.Sc. in Organic Chemistry, from Annamalai University, India, May 1999
B.Sc. in Chemistry, from Anna Adharsh College, University of Madras, India, May 1997
EXPERIENCE
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Teaching Chemistry for first year and second year College students.
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Total 10 years’ Experience in Research and Development in the field of Organic Chemistry.
EMPLOYMENT HISTORY
 Organic Chemist, Department Of Biochemistry and Molecular Biology, The University Of Texas
Medical Branch, Galveston, Texas
- Jun 2008 - Mar 2012
 Actively worked in a project of synthesis of novel polymers (to be patented) for use in two
dimensional electrophoresis.
 Extensive experience in organic synthesis in finding out a novel organic compound to be
used in polymerization.
 Accomplished monopolymer synthesis and identification through spectroscopic methods.
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Application of the polymer onto glass plates to create a surface bonded initiator. Optimized
the chemistry and the coating processes
Foundation coating procedures were established in capillaries to produce plates without
endo-osmotic flow
The capping of the foundation coating eliminated the endo-osmotic flow and proteinfoundation coating interaction.
 Postdoctoral Fellow, Department of Integrative Biology and Pharmacology, The University of
Texas Health Science Center, Houston , Texas
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- May 2005 – July 2007
Worked on a class of membrane protein called glutamate receptors, which are the main
excitatory neurotransmitter in the central nervous system.
FRET based probe was designed and developed in our lab to study the degree of cleft closure
in the ligand-binding core of the glutamate receptors.
Have experience in Fourier transform infrared spectroscopy to monitor the changes in the
ligand: protein interactions.
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A set of mutants that exhibit a wide spectrum of activation were expressed in the bacterial
cells and the contributions of specific ligand: protein interactions towards mediating
conformational changes in the isolated LBD of the glutamate receptors were studied.
Worked on organic synthesis of fluorophores to be used in fluorescence resonance energy
experiments.
Gained experience in making mutations, protein expression, western blot analysis, and gel
analysis.
 Teaching Assistant, Department of Chemistry, Annamalai University, Annamalai Nagar, Tamil
Nadu, India.
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- Jan 2001 – Oct 2003
Taught introduction to classes for first-year college students.
Conducted conferences with students for each major paper assignment.
Emphasized research as an on-going process of discovery and growth, encouraging
students to see research and inquiry as activities central to daily life.
Teach students to conduct research and to critically evaluate the quality of sources.
Worked with a diverse population of students, including many international students.
PUBLICATIONS
Biochemistry.2008, Volume 47, Issue 37, Pages 9803-9810. Overexpression and functional
characterization of the extracellular domain of the human alpha 1 glycine receptor.
Zhenyu Liu, Gomathi Ramanoudjame, Deqian Liu, Robert Fox, Vasanthi Jayaraman, Maria Kurnikova
and Michael Cascio.
Biochemistry.2007, Volume 46, Issue 5, Pages 1343-1349. Role of the Chemical Interactions of the
Agonist in Controlling -Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Receptor Activation.
Kimberly A. Mankiewicz, Anu Rambhadran, Mei Du, Gomathi Ramanoudjame, and Vasanthi
Jayaraman.
Proceedings of the National Academy of Sciences of the United States of America.2006, Volume
103, Number 27, Pages 10473-10478. Allosteric mechanism in AMPA receptors: a FRET-based
investigation of conformational changes. Gomathi Ramanoudjame, Mei Du, Kimberly.A. Mankiewicz,
and Vasanthi Jayaraman
Nature Chemical Biology.2005, Volume 1, Number 6, Pages 329-332.Evolution of glutamate
interactions during binding to a glutamate receptor. Qing Cheng, Mei Du, Gomathi Ramanoudjame,
and Vasanthi Jayaraman.
Magnetic Resonance in Chemistry.2005, Volume 43, Issue 5, Pages 430-434. Synthesis and NMR
spectral study of some t (3)-aryl-r (2), c (4)-bisethoxycarbonyl-t (5)-hydroxy-c (5)methylcyclohexanones. K. Pandiarajan, R. T. Sabapathy Mohan, R. Gomathi, and G. Muthukumaran.
PRESENTATIONS
 Investigation of the mutant Y450F in glutamate receptor ligand binding site
 Presentation at the Cell and Regulatory Biology meeting, Camp Allen, Texas, May 2005
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Extend of cleft closure versus activation in AMPA receptors.
 Poster presentation at 50th Biophysical Society Annual Meeting at Salt Lake city, Utah, Feb
2006.
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Fluorescence resonance energy transfer to probe cleft closure in the ligand binding
domain of the Glutamate receptors.
o Presentation at the Cell and Regulatory Biology meeting, Texas, April 2006
Overexpression and functional characterization of a mutated form of the extracellular
domain of human glycine α 1 subunit.
o Poster presentation at 51st Biophysical Society Annual Meeting at Baltimore,
Maryland, March 2007.
CERTIFICATIONS
Basic Safety in the Research and Clinical Laboratory Environment.
COMPUTER SKILLS
MS office Word, Excel and PowerPoint
TRAINING
Indira Gandhi Center for Atomic Research