“CELLULAR INTERACTIONS IN INFLAMMATION AND CANCER” CENTRO DE INVESTIGACIONES BIOLOGICAS Madrid, December 3-4, 2007 Monday, December 3 9.15-9.30 Welcome FIRST SESSION: CELLULAR INTERACTIONS IN CANCER PROGRESSION Discussion Leader: Francisco Sánchez-Madrid 9.30-10.10 Margaret Frame A new role for focal adhesion kinase in linking integrins to the Arp2/3 complex. 10.10-10.30 Joaquin Teixidó Chemokines and metalloproteinases in melanoma metastasis 10.30-10.50 Miguel A. del Pozo Integrins and Caveolin-1 in Cell Migration, Endocytosis and Cell Growth Coffee break 11.20-12.00 John Collard The Par/Tiam complex and cell polarity 12.00-12.20 Amparo Cano Cooperation of Snail and lysyl oxidase like-2 (LOXL2) in tumour progression 12.20-12.40 Angeles García-Pardo Cellular interactions and function of MMP-9 in B-cell chronic lymphocytic leukemia 12.40-12.55 Stephanie Brooking (Senior Business Development specialist RNA Europe, Ambion-Applied Biosystems) siRNA AMBION New Generation 13.00-14.40 Lunch Discussion Leader: Paul Frenette 14.50-15.10 Miguel Quintanilla A role for the TGF- co-receptor endoglin as a suppressor of malignancy 15.10-15.30 Piero Crespo Site-specific Ras-ERK signals in the regulation of migration 15.30-15.50 María Montoya Rab8 involvement in cell migration and invasion. Role of Rho GTPases. 21.00 Dinner Tuesday, December 4 SECOND SESSION: CELLULAR INTERACTIONS IN HOMEOSTASIS AND INFLAMMATION. Discussion Leader: Margaret Frame 9.10-9.50 Reinhold Förster Control of homeostatic lymphocyte and dendritic cell trafficking by chemokine receptor CCR7 9.50-10.10 Mario Mellado Chemokine receptor dimerization: several faces of a single molecule 10.10-10.30 José Luis Rodríguez-Fernández Which is the function of the immunological synapse of dendritic cells? Coffee break 10.50-11.30 John Kehrl GPCR Signaling and B lymphocyte trafficking through lymph nodes 11.30-12.10 Paul Frenette Physiological trafficking of stem cells controlled by the nervous system 12.10-12.30 Santos Mañes Old and new players in chemoattractant-induced leukocyte polarization 12.30-12.50 Paloma Sánchez-Mateos Polarized clathrin-mediated endocytic dynamics at the uropod of moving lymphocytes 13.00-14.40 Lunch Discusión Leader: Xosé Bustelo 14.40-15.20 Francisco Sánchez-Madrid Nanoscale molecular interactions and dynamics of endothelial adhesive platforms in primary living cells 15.20-15.40 Miguel López-Botet NK cell receptors in the innate immune response to human cytomegalovirus infection 15.40-16.00 Angel Corbí RUNX factors contribute to macrophage activation and adhesion molecule expression 16.00-16.20 Alicia García-Arroyo MT1-MMP is required for macrophage fusion in osteoclasts and foreign body giant cells End of Meeting