NUMERICAL COMPARISON AMONG WATER DISTILLATION COLUMN PROCESS, MONOTHERMAL AND BITHERMAL H2/H2O- ISOTOPIC EXCHANGE COLUMN PROCESS PRODUCING D- DEPLETED WATER M. Shimizu1, K. Takeshita2 1 2 Japan - Isotope Science Laboratory, Japan Tokyo Institute of Technology, Deuterium- depleted (D- depleted) water is said to be a new anti-tumor veterinary medicine for treating cats and dogs. G. Somlyai reported the biological effect of D- depleted water which is a new possibility in cancer therapy. The authors tried to estimate numerically the size of plants producing D- depleted water, namely, (1) Water distillation column process, (2) Monothermal H2/H2O- isotopic exchange column process, (3)Bithermal H2/H2O- isotopic exchange column process, excluding H2 or H2O/NH3- isotopic exchange and H2O/H2S- isotopic exchange process from a sanitary point of view of drink water. D- depleted water, as a by product of heavy water production by means of bithermal H2/H2Oisotopic exchange process, may be considered to be the cheapest, but in this paper the authors tried to estimate an independent and non- parasite producing D- depleted water. As the result, the water distillation column process was found to be a favourable process for the production of a cheaper D- depleted water.