GUIDELINE FOR THE MANAGEMENT OF PATIENTS WITH DIABETES HAVING WEIGHT LOSS SURGERY Version 1 Name of responsible (ratifying) committee Surgical and Cancer Governance committee Date ratified 3rd April 2014 Document Manager (job title) Bariatric Practitioner Date issued 16th May 2014 Review date 15th May 2015 Electronic location Clinical Guideline Related Procedural Documents Diabetes guideline Key Words (to aid with searching) Bariatric, Diabetes, Weight loss surgery Version Tracking Version Date Ratified Brief Summary of Changes Management of Diabetic Patients Having Weight Loss Surgery Issue date 16/05/2014 (Review date May 2015 Author Version 1 Page 1 of 6 CONTENTS 1. INTRODUCTION.......................................................................................................................... 3 2. PURPOSE ................................................................................................................................... 3 3. SCOPE ........................................................................................................................................ 3 4. DEFINITIONS .............................................................................................................................. 3 5. PROCESS ................................................................................................................................... 4 6. TRAINING REQUIREMENTS ...................................................................................................... 4 7. REFERENCES AND ASSOCIATED DOCUMENTATION ............................................................ 5 8. MONITORING COMPLIANCE ..................................................................................................... 5 9. EQUALITY IMPACT ASSESSMENT ............................................................................................ 8 Management of Diabetic Patients Having Weight Loss Surgery Issue date 16/05/201 (Review date May 2015 Page 2 of 11 Version 1 ) 1. INTRODUCTION This guideline has been developed to provide a framework for the postoperative management of diabetic patients who have had weight loss surgery. Patients who are having weight loss surgery are more likely to have hypoglycaemic episodes as they lose weight rapidly and in gastric bypass surgery have altered absorption and reduced calorie intake, therefore affecting the amount of medication they need, if any. 2. PURPOSE The purpose of this guideline is to ensure that all patients who have diabetes and have had weight loss surgery are managed appropriately using the attached algorithm to avoid hypoglycaemic events during their weight loss journey. 3. SCOPE This guideline will apply to adult inpatients that have Type 1 or Type 2 diabetes requiring management decisions on treatment for their diabetes post operatively and on discharge. To be used in conjunction with the trust guideline for Hypoglycaemia. 4. DEFINITIONS Weight Loss Surgery Any surgical procedure that produce weight loss by restricting food intake and/or interfering with nutrition through malabsorption. Diabetes There are two major types of diabetes: Type 1: an autoimmune disease characterised by hyperglycaemia resulting from absolute deficiency of insulin affecting a heterogeneous group of people. (1) Type 2: a metabolic disease characterised by hyperglycaemia resulting from relative insulin deficiency and insulin resistance affecting a heterogeneous group of people. (1) Hypoglycaemia Hypoglycaemia results from an imbalance between glucose supply, glucose utilization, and insulin levels resulting in more insulin than is needed at that time (3) Hypoglycaemia is defined as a blood glucose level being equal or less than 4mmols/l, with or without symptoms (1). Hypoglycaemia can occur not only with people who are requiring insulin treatment, but also those who are taking oral anti-diabetic tablets such as gliclazide or Pioglitazone (1). Insulin and Sulphonylureas (such as gliclazide) tablets give most risk of hypoglycaemic events. Hypoglycaemic events are common but should not be a daily normality. Hypoglycaemia is a side effect of treatment for diabetes and therefore is unlikely to occur in people treated with diet and exercise alone. Risk of Hypoglycaemic events after bariatric surgery Gastric restrictive procedures such as Laparoscopic adjustable gastric banding, Sleeve gastrectomy and Vertical gastroplasty limit gastric volume and therefore restrict the intake of calories by inducing satiety (4) Malabsorptive procedures such as Roux en Y bypass and Gastric switch surgery promote weight loss by interrupting the digestive process causing food to be poorly digested and absorbed. Hence diabetes remits within days, even before the patient has lost much weight.(4) Therefore requiring reduced or no diabetes medication. Management of Diabetic Patients Having Weight Loss Surgery Issue date 16/05/201 (Review date May 2015 Page 3 of 11 Version 1 ) PROCESS Post Operative Therapy for Diabetes Following Bariatric Surgery Type 2 Diabetes Therapy Type 1 Diabetes Therapy It is sometimes difficult to decide if a patient has type 1 or type 2 diabetes, as either type can be on Insulin. However, if a patient is thought to be type 2 and is in fact type 1, and their insulin is stopped inappropriately, serious events such as DKA can be caused. So if unsure, treat as type 1 by withdrawing insulin slowly as the blood sugars will allow. Using the algorithm below. Dietary and Lifestyle Monitor glucose levels GP follow up Oral Therapy GLP - 1 Planned procedure: Gastric Bypass or Sleeve gastrectomy, discontinue Insulin < 20units total / day and Oral Therapy Discontinue Planned procedure: adjustable gastric band, continue with GLP – 1 once eating, discontinue insulin or oral therapy Insulin > 20units total / day Discontinue unless (a) Type 1 or (b) Type 2 administering more than 20 units total daily dose pre procedure and then follow type 1 diabetes therapy (See right) Post procedure: patient to monitor glucose levels pre and 2 hrs post meals (min two tests per day). See GP at two weeks to review glucose levels If taking metformin pre procedure recommence at two weeks in all cases, regardless of glucose level, start at 500mg with evening meal If 50% of results are > 10 mmols/l after 4 weeks then recommence pre procedure medication, in the following order starting at minimal doses and titrate upwards according to response: a) Oral Therapy in addition to Metformin b) GLP – 1 c) Insulin therapy (to contact diabetes centre and discuss with DSNs Anita Thynne and Joanne Buchanan) Insulin Do Not Discontinue Confirm diagnosis: Type 1 = started on Insulin at diagnosis Type 2 = diet/lifestyle changes and/or tablets at diagnosis Re-commence insulin at 25% of original dose administered pre commencing the milk diet Monitor capillary blood glucose pre-meal and 2 hrs post meals. If 50% of results are >10mmols/l to titrate insulin up in the usual manner Diabetes centre follow up . 5. TRAINING REQUIREMENTS All staff involved in clinical care of inpatients who have diabetes and are having weight loss surgery should read this guideline and use the algorithm as a guide to managing their diabetes. Management of Diabetic Patients Having Weight Loss Surgery Issue date 16/05/201 (Review date May 2015 Page 4 of 11 Version 1 ) 6. REFERENCES AND ASSOCIATED DOCUMENTATION 1) Diabetes UK (2011) [online] Monitoring Your Health / Glucose Levels. www.diabetes.org.uk TEL: 020 73231531 2) British National Formulary 60.Section 6.1, Drugs Used In Diabetes. London BMJ Group. 3) Turner H and Wass JA (2007). Oxford Handbook of Diabetes. Oxford University Press. Oxford 4) Kashyap, S., Gastmaitan, P., Brethauer, S. (2010). ‘Bariatric surgery for type 2 diabetes: Weighing the impact for obese patients’. Cleveland Clinic Journal of Medicine. vol 77,.No 7, Pg 468-476. 7. MONITORING COMPLIANCE This policy will be monitored as follows: Management of patients with diabetes who are having weight loss surgery and who are suffering from hypoglycaemia episodes despite the use of the algorithm will be referred to the diabetes specialist nurse. Specialist diabetes team will discuss unfavourable hypoglycaemia management issues and the suitability of the algorithm. Annual audits will capture hypoglycaemia management. Results of the audit will be considered by the specialist diabetes and Endocrinologist team and any educational needs will be identified and addressed by the Bariatric nurse practitioner/team. 8. EQUALITY IMPACT ASSESSMENT Portsmouth Hospitals NHS Trust is committed to ensuring that, as far as is reasonably practicable, the way we provide services to the public and the way we treat our staff reflects their individual needs and does not discriminate against individuals or groups on any grounds. This guideline has been assessed accordingly Management of Diabetic Patients Having Weight Loss Surgery Issue date 16/05/201 (Review date May 2015 Page 5 of 11 Version 1 ) Management of Diabetic Patients Having Weight Loss Surgery Issue date 16/05/201 (Review date May 2015 Page 6 of 11 Version 1 )