PUBLICATIONS - Zafar Nawaz, Ph.D., Associate Research Director,
Braman Family Breast cancer Institute
a. Books and Monographs:
1. N. J. McKenna, Z. Nawaz, S. Y. Tsai, and M.-J. Tsai. Coactivators and corepressors.
In Principles of molecular regulation, ed. Conn, P. M. and Means, A. R., Humana press.
pp.385-394, 2000.
2. Lonard, D. M., and Z. Nawaz, Coactivators and Corepressors. In Nuclear receptors
and genetic disease, ed. Burris, T. P. and McCabe, E., Academic Press Ltd. pp. 389-408,
2000.
b. Refereed Journal Articles:
1. S. Dhananjayan, O. Y. Khan and Z. Nawaz. Identification and characterization of
WW-domain binding proteins as E6-AP interacting proteins and their role in steroid
hormone receptor functions. MCB, 2005. (Under Revision).
2. S. Dhananjayan and Z. Nawaz. Ubiquitin and the control of transcription. Assays in
Biochem., 2005. (In Press).
3. A. Ismail and Z. Nawaz. Nuclear hormone receptor degradation and gene
transcription: An Update. IUBMB Life Sciences, 2005. (In Press).
4. O. Y. Khan, G. Fu, A. Ismail, S. Srinivasan, Y. Tu, S. Lu and Z. Nawaz. Multifunction
steroid receptor coactivator, E6-associated protein, E6-AP is involved in development of
the prostate gland. Mol. Endocrinology, 2005. (Under Revision).
5. X. Gao, S.K. Mohsin, Z. Gatalica, G. Fu, P. Sharma and Z. Nawaz. E6-associated
protein, E6-AP is involved in the carcinogenesis of human breast and prostate.
Endocrinology, 2005, 146:1707-1712.
6. S. Verma, A. Ismail, X. Li, B. W. O’Malley and Z. Nawaz. Ubiquitin-Conjugating
Enzyme, UBCH7 acts as a coactivator for steroid hormone receptors. MCB., 2004, 24:
8716-8726.
7. Z. Liu, H. Y. Shi, Z. Nawaz and M. Zhang. Tamoxifen induces the expression of
maspin through estrogen receptor-alpha. Cancer Lett., 2004, 209: 55-65.
8. Z. Nawaz and B. W. O’Malley. URBAN RENEWAL IN THE NUCLEUS: Is Protein
Turnover by Proteasomes Required for Transcription? Mol. Endo. Mol. Endo., 2004, 18:
493-499.
9. O. Y. Khan and Z. Nawaz. Nuclear hormone receptor co-regulators. Current Opinion
in Drug Discovery & Development, 2003, 6: 692-701.
10. F. Yan, X. Gao D. Lonard and Z. Nawaz. Specific ubiquitin-conjugating enzymes
promote degradation of specific nuclear receptor coactivators. Mol. Endo., 2003, 17:
1315-1331.
11. V. Pearce, Z. Nawaz, W. Xiao, D. Wiedenfled, N. Boyle and D. Smith. 4Ethoxymethylphenol: A novel estrogen that acts as an agonist for human estrogen
receptors. Steroid Biochem. And Mol. Biol., 2003, 84: 431-439.
12. X. Gao, B. W. Loggie and Z. Nawaz. The roles of sex steroid receptor coregulators in
cancer. Molecular Cancer, 2002, 1: 1-7.
13. X. Gao and Z. Nawaz. Role of steroid receptor coactivators and corepressors of
progesterone receptors in breast cancer. Breast Cancer Res., 2002, 4: 40-44.
14. C. L. Smith, D. G. DeVera, D. J. Lamb, Z. Nawaz, Y. H. Jiang, A. L. Beaudet and B.
W. O’Malley. Genetic Ablation of the Steroid Receptor Coactivator-Ubiquitin Ligase,
E6-AP, Results in Tissue-Selective Steroid Hormone Resistance and Defects in
Reproduction. Molecular and Cellular Biology, 2002, 22: 525-535.
15. A. P. Dennis, R. Ul Haq, and Z. Nawaz. Importance of the regulation of nuclear
receptor degradation. Front. Bioscience, 2001, d954-959.
16. H. Zhao, R. E. Herrera, E. Coronado-Heinsohn, M. C. Yang, J. H. Ludes-Meyers, K.
J. Seybold-Tilson, Z. Nawaz, D. Yee, F. G. Barr, S. G. Diab, P. H. Brown, S. A. W.
Fuqua, and C. K. Osborne. FKHR, A bifunctional nuclear protein: coactivator and
corepressor. J. Biol. Chem., 2001, 276: 27907-27912.
17. L. Sivaraman, Z. Nawaz, D. Medina, O. M. Conneely, and B. W. O’Malley. 2000.
The novel dual function steroid receptor coactivator/ubiquitin protein-ligase integrator
E6-AP is overexpressed in mouse mammary tumorigenesis. Breast Cancer Research and
Treatment, 62: 185-195
18. S. M. Hyder, J. C. Huang, Z. Nawaz, H. B. Tong, S. Makela, C. Chiappetta and G.
Stancel. The Regulation of vascular endothelial growth factor expression by estrogens
and progestins. Environmental Health Prospectives, 2000, 108 (5), 785-790.
19. J. Li, J. Wang, J. Wang, Z. Nawaz, J. M. Liu, J. Qin, and J. Wong. Both corepressors
SMRT and N-CoR proteins exist in large protein complexes containing HDAC3. EMBO,
2000, 19, 4342-4350.
20. D. M. Lonard*, Z. Nawaz*, C. L. Smith, and B. W. O’Malley. The 26S proteasome
is required for estrogen receptor- and coactivator turnover and for efficient estrogen
receptor- transactivation. Molecualr Cell, 2000, 5, 939-948.
*Equal contribution.
21. S. M. Hyder, Z. Nawaz, C. Chiappetta, and G. Stancel. Detection of classical and
atypical estrogen response elements in the untranslated regions of the rat VEGF gene.
Cancer Research, 2000, 60, 3183-3190.
22. N. J. McKenna, J. Xu, Z. Nawaz, S. Y. Tsai, M.-J. Tsai, and B. W. O’Malley.
Nuclear receptor coactivator: Multiple enzymes, multiple complexes, multiple functions.
J. Steroid Biochem. Mol. Bio., 1999, 69, 3-12.
23. C. E. Robinson, X. Wu, Z. Nawaz, S. A. Onate, and J. M. Gimble. A corepressor and
chicken ovalbumin upstream promoter transcription factor proteins modulate peroxisome
proliferator-activated receptor-gamma2/retinoid X receptor alpha-activated transcription
from the murine lipoprotein lipase promoter. Endocrinology, 1999, 140, 1586-1593.
24. Z. Nawaz, Lonard, D. M., Dennis, A. P., Smith, C. L., and B. W. O’Malley.
Proteasome-dependent degradation of the human estrogen receptor. Proc. Natl. Acad. Sci.
USA, 1999, 96, 1858-1862.
25. Z. Nawaz, G. M. Standcel, and S. M. Hyder. The pure antiestrogen ICI 182780
inhibits progestin-induce transcription. Cancer Res., 1999, 59, 372-376.
26. Z. Nawaz, D. Lonard, C. L. Smith, Efrat Lev-Lehman, Arthur L. Beaudet, S. Y. Tsai,
M.-J. Tsai, and B. W. O’Malley. The angelman syndrome-associated gene, E6-AP, is also
a coactivator for nuclear hormone receptor superfamily. Mol. Cell. Bio., 1999, 19, 11821189.
27. N. J. McKenna, Z. Nawaz, S. Y. Tsai, M.-J. Tsai, and B. W. O’Malley. Distinct
steady state nuclear receptor coregulator complexes exist in vivo. Proc. Natl. Acad. Sci.
USA, 1998, 95, 11697-11702.
28. H. Shibata, Z. Nawaz, S. Y. Tsai, B. W. O’Malley, and M.-J. Tsai. Gene silencing by
COUP-TFI is mediated by transcriptional corepressors N-CoR and SMRT. Mol. Endo.,
1997, 11, 714-724.
29. C. L. Smith, Z. Nawaz, and B. W. O’Malley. Transcriptional coregulators modulate
the relative ability of a mixed agonist/ antagonist, 4-hydroxytamoxifen to activate the
estrogen receptor. Mol. Endo., 1997, 11, 657-666.
30. J. Xu, Z. Nawaz, S. Y. Tsai, M. -J. Tsai and B. W. O’Malley. The extreme carboxylterminus of progesterone receptor contains a transcriptional repressor domain that
functions through a putative corepressor. Proc. Natl. Acad. Sci. USA., 1996, 93, 1219512199.
31. Z. Nawaz, M. -J. Tsai, and B. W. O’Malley. Specific mutations in the ligand binding
domain selectively abolish the silencing function of human thyroid receptor ß. Proc. Natl.
Acad. Sci. USA., 1995, 92, 11691-11695.
32. T. P. Burris, Z. Nawaz, M. J. Tsai and B. W. O'Malley. Interaction cloning of a
protein, TRUP, which inhibits transactivation by the thyroid hormone and retinoic acid
receptors. Proc. Natl. Acad. Sci. USA, 1995, 92, 9525-9529.
33. S. Hyder, Z. Nawaz, C. Chiappetta, K. Yokoyama and G. M. Stancel. Protooncogene
c-jun contains an unusual estrogen inducible enhancer within the coding sequences. J.
Biol. Chem., 1995, 270, 8506-8513.
34. C. Baniahmad, Z. Nawaz, A. Baniahmad, M. Gleeson, M. J. Tsai and B. W.
O'Malley. Enhancement of human estrogen receptor activity by SPT6: A potential Coactivator. Mol. Endo., 1995, 9, 34-43.
35. Z. Nawaz, C. Baniahmad, D. J. Stillman, T. Burris, B. W. O'Malley and M. J. Tsai.
The yeast SIN3 gene negatively regulates the activity of the human progesterone receptor
and positively regulates the activities of GAL4 and the HAP1 activator. Mol. General
Genetics, 1994, 245, 724-733.
36. S. A. W. Fuqua, D. C. Allred, R. M. Elledge, S. L. Krieg, M. G. Benedix, Z. Nawaz,
B. W. O'Malley, G. L. Green and W. L. McGuire. The ER-positive/ PgR-negative breast
cancer phenotype is not associated with mutations within the DNA binding domain.
Breast Cancer Res. and Treatment, 1993, 26, 191-202.
37. Z. Nawaz, G. M. Stancel, D. P. McDonnell and S. M. Hyder. Creation of an active
estrogen-responsive element by a single base change in the flanking sequence of a
cellular oncogene: A possible mechanism for hormonal carcinogenesis? Mol.
Carcinogenesis, 1993, 7, 76-82.
38. S. M. Hyder, G. M. Stancel, Z. Nawaz, D. P. McDonnell and D. S. Loose-Mitchell.
Identification of an estrogen response element in the 3'-flanking region of the murine cfos protooncogene. J. Biol. Chem., 1992, 267, 18047-18054.
39. Z. Nawaz, M. J. Tsai, D. P. McDonnell and B. W. O'Malley. Identification of novel
steroid responsive elements. Gene Expression, 1992, 2, 39-47.
40. S. A. W. Fuqua, S. D. Fitzgerald, D. C. Allred, R. M. Elledge, Z. Nawaz, D. P.
McDonnell, B. W. O'Malley, G. L. Green and W. L. McGuire. Inhibition of estrogen
receptor action by naturally occurring variant in human breast tumors. Cancer Res., 1992,
52, 483-486.
41. Z. Nawaz, D. W. Smith and D. P. McDonnell. Expression of functional vitamin D3
receptor in E. coli. In: Vitamin D; Gene Regulation, Structure-Function Analysis and
Clinical Application ( A. W. Norman, R. Bouillon and M. Thomasset, eds. ), 1991, pp.
50-51.
42. D. P. McDonnell, Z. Nawaz and B. W. O'Malley. In situ distinction between steroid
receptor binding and transactivation at a target gene. Mol. Cell. Bio., 1991, 11, 43504355.
43. D. P. McDonnell, Z. Nawaz, C. Densmore, N. L. Weigal, T. A. Pham, J. H. Clark
and B. W. O'Malley. High level expression of biologically active estrogen receptor in
Saccharomyces cerevisiae. J. Steroid Biol. and Mol. Biol, 1991, 39, 291-297.
44. T. A. Pham, J. F. Elliston, Z. Nawaz, D. P. McDonnell, M. J. Tsai and B. W.
O'Malley. Antiestrogen can established nonproductive receptor complexes and alter
chromatin structure at target enhancers. Proc. Natl. Acad. Sci. USA., 1991, 88, 31253129.
45. S. A. W. Fuqua, S. D. Fitzgerald, G. C. Chamness, A. K. Tandon, D. P. McDonnell,
Z. Nawaz, B. W. O'Malley and W. L. McGuire. Variant human breast tumor estrogen
receptor with constitutive transcriptional activity. Cancer Res., 1991, 51, 105-109.
46. D. Santiso-Mere, Z. Nawaz, D. P. McDonnell and B. W. O'Malley. The development
of Saccharomyces cerevisiae as a host system for steroid hormone action studies: In:
Hormone Action and Molecular Endocrinology, 15th edition (M. R. Huges, W. T.
Schrader and B. W. O'Malley eds.). Houston biological associates inc., 1991, pp. 23-123-24.
47. J. L. Witliff, L. L. Wenz, J. Dong, Z. Nawaz and T. R. Butt. Expression and
characterization of an active human estrogen receptor as a ubiquitin fusion protein from
Escherichia coli. J. Biol. Chem., 1990, 265, 22016-22022.
48. S. Riazuddin, A. Sohail and Z. Nawaz. Isolation of temperate bacteriophage phi R7
specific for Pseudomonas aeruginosa. Pak. J. of Zool., 1987, 19(3), 290-298.
49. A. Raufa, Z. Nawaz, S. Riazuddin and A. R. Shakoori. Isolation, characterization and
genetic studies of Rhizobium meliloti. Pak. J. of Zool., 1987, 19(2), 120-124.
50. M. Neelam, Z. Nawaz and S. Riazuddin. Hydrocarbon Biodegradation: Biochemical
characterization of bacteria isolated from local soils. Pak. J. of Sci. and Indus., 1987, Res.
30, 282-285.
51. M. Neelam, Z. Nawaz, A. R. Shakoori and S. Riazuddin. Isolation and
characterization of R- factor (plasmids) from antibiotic resistant strains collected from
local hospitals. Pak. J. of Zool., 1987, 19(1), 17-26.
52. Z. Nawaz and N. Ahmad. Isolation and characterization of Rhizobium species as
nitrogen fixing symbionts in Guar (Cymopsis tetragonoloba (L) Taub). Pak. J. of Zool.,
1987, 19(1), 9-15.
53. S. Riazuddin, A. R. Shakoori and Z. Nawaz. Mutagenicity testing of children,s
consumables. Pak. J. of Zool., 1986, 18(3), 325- 334.
c. Abstracts:
1. Nawaz, Z. 2004. Ubiquitin-Conjugating Enzyme, UBCH7 Modulates Steroid
Hormone Receptor Functions. 2nd Ubiquitin Conference.
2. Seema Verma, Ayesha Ismail, Xiatao Li, Bert W. O’Malley and Nawaz, Z. 2004.
Ubiquitin-Conjugating Enzyme, UBCH7 modulates steroid hormone receptor function by
forming a multiprotein complex with SRC-1 and E6-AP. Key Stone Symposia on
Nuclear hormone receptors.
3. Brian W. Loggie, Nawaz, Z., Zoran Gatalica, Edward Silvaand, and Ghada A El-Ella.
2004. Inhibition of Mucin 2 production: Implications for treatment of Pseudomyxoma
Peritonei. The Surgical Society of Oncology.
4. Ghada A El Ella, Zoran Gatalica and Nawaz, Z. 2004. Inhibition of Mucin production:
Implications for treatment of breast cancer. AACR Meeting.
5. Shazia Zafar, Xiuhua Gao, Mohsin Khalid, Zoran Gatalica and Nawaz, Z. 2004. E6associated protein, E6-AP is involved in the carcinogenesis of human breast and prostate.
AACR Meeting.
6. Brian W. Loggie, Ghada A El-Ella, Zoran Gatalica, Edward Silvaand and Nawaz, Z.
2003. Promising new strategies for treatment of Pseudomyxoma Peritonei. The Surgical
Society of Oncology.
7. Nawaz, Z. 2003. Steroid hormone receptor coregulators. Nuclear Receptors as Drug
Targets.
8. S. Verma1, X. Li, B. W. O’Malley and Nawaz, Z. 2003. Ubiquitin Conjugating
Enzyme, UBCH7 Act As a Coactivator For Steroid Hormone receptors. The Endocrine
Society.
9. Nawaz, Z. 2003. Role of Ubiquitin-Proteasome Pathway Enzymes in Steroid Hormone
Receptors Transactivation. NIH meeting on Ubiquitin and Ubiquitin like pathways.
10. Riaz Ul Haq and Nawaz, Z. 2002. Identification and characterization of WWdomain binding proteins as E6-AP interacting proteins and their role in steroid hormone
receptor functions. The Endocrine Society.
11. Xiuhua Gao, Syed K. Mohsin, Thomas M. Weeler, Feng Yan and Nawaz, Z. 2002.
E6-associated protein, E6-AP, is involved in the tumorigenesis of both mammary gland
and prostate gland. The Endocrine Society.
12. Seema Verma, Zheng Liu, Riaz Haq, Bert W. O’Malley and Nawaz, Z. 2002.
UBCH7, an E2 ubiquitin-comjugating enzyme: Its possible role in the steroid receptor
transactivation. The Key Stone Symposia.
13. Torsten A. Hopp, Chenguang Wang, Richard G. Pestell, Nawaz, Z., Mingyue Wang,
and Suzanne A.W. Fuqua. 2001. A hypersensitive mutation of estrogen receptor a
occurring in premalignant breast disease influences co-activator binding, receptor
acetylation, and stability. The Endocrine Society.
14. Xiuhua Gao and Nawaz, Z., 2001. The nuclear hormone receptor coactivator, E6-AP
is overexpressed in human mammary tumors. The Endocrine Society.
15. Torsten Hopp, D. Craig Allred, Sue Hilsenbeck, Syed Mohsin, Nawaz, Z., Peter
O’Connell, Richard G. Pestell, and Suzanne A.W. Fuqua. 2000. A Hypersensitive
16. .Bert W. O’Malley, Jamin Xu, Nawaz, Z., Ranier Lanz, Niall Barron, Zeng Liu,
Brian Rowen, Indreas Cavarretta, Carolyn Smith, Jamieng Wong, Sophia Tsai and Ming
Jer Tsai. 2000. In vivo roles of steroid receptor coactivators in gene regulation. The
Endocrine Society.
17. Niall Barron, Nawaz, Z., Jun Qin and Bert W. O’Malley. 2000. Effects of the
Ccr4/Not complexes on steroid receptor-dependent transcription. The Endocrine Society.
18. Carolyn Smith, Darryii De Vera, Nawaz, Z., Yong-Hui Jiang, Arthur L. Beaudet and
Bert W. O’Malley. 2000. A null mutation of thew steroid receptor coactivator/ubiquitin
ligase E6-AP, negatively impact selected tissues of the male and female reproductive
tract in mice. . The Endocrine Society.
19. Andrew Dennis, Nawaz, Z. and Bert W. O’Malley. 2000. Characterization of UBA3:
A novel type of nuclear hormone receptor coactivator. The Endocrine Society.
20. Nawaz, Z., David M. Lonard, Carolyn L. Smith and Bert W. O’Malley. 2000.
Regulation of Gene Expression by the Nuclear Hormone Receptor-Coactivator Complex
Requires the Ubiquitin-Proteasome Pathway. The Endocrine Society.
21. Bert W. O’Malley, Jamin Xu, Nawaz, Z., Ranier Lanz, Ray Wu, David M. Leonard,
Zeng Liu, Indreas Cavarretta, Carolyn Smith, Jamieng Wong, Sophia Tsai and Ming Jer
Tsai. 2000. Roles of steroid receptor co-activators in transcriptional regulation in vitro
and in vivo. The Key Stone Symposia.
22. George W. Cox, Nawaz, Z. and Gail V. W. Johnson. 2000. Analysis of a unique
nuclear transglutaminase (TGase) substrate expressed in macrophages. American
Association of Immunology Meeting.
23. Lonard, D. M., C. L. Smith, Nawaz, Z. and B. W. O’Malley. 2000. Ligand-mediated
down-regulation of estrogen receptor-alpha dependes upon intact AF-2 coactivatorbinding surfaces, The Key Stone Symposia.
24. Nawaz, Z. and Bert W. O’Malley. 2000. The Nuclear Hormone Receptor
Coactivators are Targets of the Ubiquitin-Proteasome Pathway. The Key Stone
Symposia.
25. O’Malley, B. W., Lanz, R., Xu, J., Nawaz, Z., Lonard, D., Smith, C. L., Tsai, S. Y.,
and Tsai, M. J. 1999. Role of steroid receptor coactivators in transcriptional regulation.
The Endocrine Society.
26. Hyder, S. Nawaz, Z., and Stancel, G. 1999. A novel antiprogestin activity associated
with the pure antiestrogen ICI 182,780: Inhibition of progesterone receptor mediated
gene expression. The Endocrine Society.
27. Hyder, S. M., Chiappetta, Nawaz, Z., and Stancel, G. 1999. Detection of two
estrogen receptor binding sites located in the 5’ and 3’ untranslated regions of the VEGF
gene. The Endocrine Society.
28. H. H. Zhao, E. C. Heinsohn, K. S. Tilson, M. C. Yang, J. H. Ludes-Meyers, Z.
Nawaz, R. E. Herrera, D. Yee, P. H. Brown, S. G. Diab, F. G. Barr, B. W. O’Malley, S.
W. A. Fuqua and K. Osborne. 1999. FKHR, a bifunctional nuclear receptor intermediary
protein, inhibits estrogen-dependent human breast cancer cell growth. The Endocrine
Society.
29. Z. Nawaz, Lonard, D. M., Dennis, A. P., Smith, C. L., and B. W. O’Malley 1999.
Proteasome-dependent degradation of the human estrogen receptor. The Endocrine
Society.
30. H. H. Zhao, E. C. Heinsohn, K. S. Tilson, M. C. Yang, Z. Nawaz, R. E. Herrera, D.
Yee, P. H. Brown, S. G. Diab, F. G. Barr, B. W. O’Malley, S. W. A. Fuqua and K.
Osborne. 1999. FKHR, a novel nuclear receptor interacting protein that functions as both
a coactivator and corepressor. AACR Meeting (The Steroid Receptor Superfamily).
31. D. M. Lonard, Z. Nawaz, C. L. Smith, and B. W. O’Malley. 1999. Involvement of
ubiquitin-proteasome mediated protein degradation in steroid receptor function. AACR
Meeting (The Steroid Receptor Superfamily).
32. S. Hyder, Z. Nawaz, G. M. Stancel. 1999. The pure antiestrogen ICI182,780 exhibits
a novel antiprogestin activity and inhibits progesterone receptor dependent gene
expression. AACR Annual Meeting.
33. E. L. Lehman, Z. Nawaz, C. Benton, D. Dicks, and A. Beaudet. 1998. Analysis of
mutations causing Angelman Syndrome: mRNA stability and UBA3 activity. American
Society of Human Genetics.
34. Z. Nawaz, D. Lonard, C. L. Smith, S. Y. Tsai, M.-J. Tsai, and B. W. O’Malley, 1998.
The angelman syndrome-associated gene, E6-AP, is a coactivator for nuclear hormone
receptor superfamily. The Endocrine Society.
35. D. Lonard, Z. Nawaz, C. L. Smith, S. Y. Tsai, M.-J. Tsai, and B. W. O’Malley. 1998.
The ubiquitin-protein ligase E6-AP, mutated in angelman syndrome, is a steroid receptor
coactivator. The Key Stone Symposia.
36. Z. Nawaz, D. Lonard, C. L. Smith, S. Y. Tsai, M.-J. Tsai, and B. W. O’Malley, 1998.
The angelman syndrome-associated gene, E6-AP, is a coactivator for nuclear hormone
receptor superfamily. The Key Stone Symposia.
37. C. L. Smith, Z. Nawaz, and B. W. O’Malley. 1997. Transcriptional coregulators
modulate the relative ability of a mixed agonist/ antagonist, 4-hydroxytamoxifen to
activate the estrogen receptor. The Endocrine Society.
38. H. Shibata, Z. Nawaz, S. Y. Tsai, B. W. O’Malley, and M.-J. Tsai. 1997. Gene
silencing by COUP-TFI mediated by transcriptional corepressors N-CoR and SMRT. The
Endocrine Society.
39. H. Shibata, Z. Nawaz, M. -J. Tsai, and B. W. O’Malley. 1996. Cloning of
corepressors for the thyroid hormone receptor with yeast two-hybrid system. The
Endocrine Society.
40. Z. Nawaz, M. -J. Tsai, and B. W. O’Malley. 1996. Specific mutations in the ligand
binding domain selectively abolish the silencing function of human thyroid receptor ß.
The Key Stone Symposia.
41T. P. Burris, Z. Nawaz, S. Y. Tsai, M. J. Tsai and B. W. O'Malley, 1995. Interaction
cloning of a protein, TRIP, which inhibits transactivation by the thyroid hormone and
retinoic acid receptors. The Endocrine Society.
42. C. Chiappetta, Z. Nawaz, G. M. Stancel, and S. M. Hyder, 1994. Different nucleotide
requirements for estrogen receptor binding and hormone dependent transcriptional
activation defines a novel estrogen responsive element within the coding sequence of cjun. IX International Congress on Hormonal Steroids.
43. Z. Nawaz, D. Stillman, T. Burris, B. W. O'Malley, and M. J. Tsai, 1994. The yeast
SIN3 gene negatively regulates the transcriptional activity of the human progesterone
receptor and positively regulates the activities of GAL4 and the HAP1 activator. The
Endocrine Society.
44. S. M. Hyder, Z. Nawaz and G. M. Stancel, 1993. A single base change in the
flanking sequence of a cellular oncogene creates an active estrogen response element- A
possible mechanism of hormonal carcinogenesis? The Endocrine Society.
45. C. Baniahmad, Z. Nawaz, M. J. Tsai and B. W. O'Malley, 1992. Identification and
isolation of co-activator for steroid hormone receptors using a yeast host system. Santa
Cruiz Summer Conference.
46. S. M. Hyder, D. S. Loose-Mitchell, Z. Nawaz and G. M. Stancel, 1992. A 32 base
pair deoxyoligonucleotide derived from murine c-fos protooncogene binds estrogen
receptor. The Endocrine Society.
47. S. A. W. Fuqua, D. C. Allred, D. P. McDonnell, Z. Nawaz, B. W. O'Malley, G. L.
Green and W. L. McGuire, 1992. A dominant-positive variant estrogen receptor conferes
resistance to endocrine therapy in human breast cancer cells. The Endocrine Society.
48. N. Paslidis, C. Baniahmad, Z. Nawaz, D. P. McDonnell, M.-J. Tsai and B. W.
O'Malley, 1992. Identification of an 102 KDa protein which interacts with the estrogen
receptor in yeast. American Association of Cancer Research.
49. Z. Nawaz, M.-J. Tsai, D. P. McDonnell and B. W. O'Malley, 1992. A system to
identify novel steroid response elements. ASBMB/Biophysical Society.
50. S. A. W. Fuqua, D. C. Allred, M. Qui, S. D. Fitzgerald, M. G. Benedix, S. L. Krieg,
D. P. McDonnell, Z. Nawaz, B. W. O'Malley, G. Green and W. L. McGuire, 1991.
Transcriptionally active estrogen-independent variant estrogen receptors in human breast
tumors. Breast Cancer Symposium.
51. Z. Nawaz, D. P. McDonnell and B. W. O'Malley, 1991. A novel system to identify
steroid responsive elements. Eight Workshop on Vitamin D.
52. Z. Nawaz, D. W. Smith, D. P. McDonnell and B. W. O'Malley, 1991. Expression of
functional vitamin D3 receptor in E. coli. Eight Workshop on Vitamin D.
53. S. A. W. Fuqua, D. C. Allred, R. M. Elledge, G. L. Green, Z. Nawaz and W. L.
McGuire. Estrogen receptor mRNA variants in breast cancer. The Endocrine Society.
54. D. P. McDonnell, Z. Nawaz and B. W. O'Malley, 1991. In situ distinction between
steroid receptor binding and transactivation at a target gene. The Endocrine Society.
55. C. L. Densmore, D. P. McDonnell, Z. Nawaz and J. H. Clark, 1990. Expression and
characterization of human estrogen receptor in yeast Saccharomyces cerevisiae. The Cell
Biology Society.
56. S. A. W. Fuqua, D. P. McDonnell, Z. Nawaz, B. W. O'Malley and McGuire, 1990.
Variant estrogen receptor RNA transcripts in breast tumors. The Endocrine Society.
57. T. R. Butt, D. P. McDonnell, Z. Nawaz, L. Bowdin, G. Green and D. Drutz, 1989.
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