Principal Investigator/Program Director (Last, First, Middle):
Lemmon, Vance, Paul
BIOGRAPHICAL SKETCH
Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2.
Follow this format for each person. DO NOT EXCEED FOUR PAGES.
NAME
POSITION TITLE
Vance P. Lemmon
Professor of Neurological Surgery, Walter G. Ross
Chair in Developmental Neuroscience, Univ. of
Miami, Miller School of Medicine
eRA COMMONS USER NAME
VLEMMON
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)
INSTITUTION AND LOCATION
Univ. of Calif, San Diego
Emory Univ., Atlanta
Washintgon Univ., St. Louis
DEGREE
(if applicable)
YEAR(s)
B.A.
Ph.D.
Post-Doc
1973
1978
78-81
FIELD OF STUDY
Biology
Anatomy
Neuroscience
Please refer to the application instructions in order to complete sections A, B, and C of the Biographical
Sketch.
A. Professional Experience:
1981-83 Assistant Professor, Dept. of Anatomy, Med. Univ. of S.C., Charleston, S.C.
1983-88 Assistant Professor, Dept. of Neurobiology, Anatomy and Cell Science, Univ. of Pittsburgh, PA
1988-95 Associate Professor with tenure, Dept. of Neurosciences, CWRU, Cleveland, OH
1995-03 Professor with tenure, CWRU
1997-8 Guest Professor, Institute of Biochemistry, Univ. of Zurich, Zurich, Switzerland
2000
Visiting Scientist, Tokyo Metro. Institute. of Gerontology, Tokyo, Japan
2001-03 Professor of Ophthalmology (secondary apt.), Member of CWRU Cancer Center
2003Walter G. Ross Chair in Developmental Neuroscience, Professor of Neurosurgery, Univ. of Miami
Honors and Positions:
1987-04 Ad hoc member, Neurology C, Neurology B2, MCD1, MCD7, Neurological Disorders ProgramProject, NIMH Conte Center study sections, and NIDDKD, NICHD, and NIDCD site visit teams
1992
Participant in Soc. for Neurosci/NBT Workshop on Neurosci Curriculum. Wake Forest Univ., N.C.
1993-95 NSF Developmental Neuroscience Advisory Panel
1993-96 Society for Neuroscience Committee on Neuroscience Literacy
1994-95 Organizer of "How to talk to children" workshops at Soc. for Neurosci. annual meeting
1995
Organizer of first International Meeting on L1 and X-linked Hydrocephalus
1997-01 Editorial Board, J. Neurosci, Res.
2000
RIKEN Brain Science Institute site visit team member
1997,99 Invited speaker Gordon Conference on Cell Contact and Adhesion
2001Member of "Faculty of 1000", an online reviewing service at PubMed Central
2001-3 CWRU IACUC member, Chair (2002-3)
2002-8 Editorial Board, J. Biological Chemistry
B. Publications: Selected from a total 68 peer-reviewed articles, 13 reviews and 8 book chapters
Lemmon, V., Pearlman, A.L. Does laminar position determine the receptive field properties of cortical neurons:
A study of corticotectal cells in area 17 of the normal mouse and reeler mouse. J. Neurosci. 1:83-93, 1981.
Lemmon, V., Gottlieb, D.I. Monoclonal antibodies selective for the inner portion of the chick retina. J.
Neurosci. 2:531-535, 1982.
Lemmon, V., McLoon, S. The appearance of an L1 like molecule in the chick primary visual pathway. J.
Neurosci. 6:2987-2994, 1986.
Lagenaur, C., Lemmon, V. A L1-like molecule, the 8D9 antigen, is a potent substrate for neurite extension.
Proc. Natl. Acad. Sci., USA 84:7753-7757, 1987.
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Biographical Sketch Format Page
Principal Investigator/Program Director (Last, First, Middle):
Lemmon, Vance, Paul
Lemmon, V., Farr, K., Lagenaur, C. L1 mediated axon outgrowth occurs via a homophilic binding mechanism.
Neuron, 2:1597-1603, 1989.
Drazba, J., Lemmon, V., The role of cell adhesion molecules in neurite outgrowth on Muller cells. Dev. Bio.
138:82-93, 1990.
Hlavin, M.L., Lemmon, V. Molecular structure and functional testing of human L1: an interspecies comparison.
Genomics, 11:416-423, 1991.
Cervello, M., Lemmon, V., Landreth, G., Rutishauser, U. Phosphorylation-dependent regulation of neurite
fasciculation. Proc. Natl. Acad. Sci., USA, 88:10548-10552, 1991.
Lemmon, V., Burden, S.M., Payne, H.R., Elmslie, G.J., Hlavin, M.L. Neurite growth on different substrates:
permissive versus instructive influences and the role of adhesive strength. J. Neurosci., 12:818-826, 1992.
Wong, E.V., Schaefer, A.W., Landreth, G. and Lemmon, V. Involvement of p90rsk in neurite outgrowth
mediated by the cell adhesion molecule L1. J. Biol. Chem. 271:18217-18233, 1996.
Yamasaki, M., Thompson, P., Lemmon, V. CRASH syndrome: mutations in the L1 gene correlate with severity
of the disease. Neuropediatrics, 28:175-178, 1997.
Kamiguchi, H., Hlavin, M.L., Yamasaki, M., Lemmon, V. Adhesion molecules and inherited diseases of the
nervous system. Ann. Rev. Neurosci., 21:97-125, 1998
Fransen, E., D’Hooge, R., Van Camp, G., Verhoye, M., Sijbers, J., Reyniers, E., Soriano, P., Kamiguchi, H.,
Willemsen, R., Koekkoek, S.K.E., De Zeeuw, C.I., P. De Deyn, P.P., Van der Linden, A., Lemmon, V.,
Frank Kooy, R.F., and Willems, P.J. L1 knockout mice show dilated ventricles, vermis hypoplasia and
impaired exploration patterns Hum. Mol. Genet, 7:999-1009, 1998
Kamiguchi, H., Long, K.E., Pendergast, M., Schaefer, A.W., Rapoport, I, Kirchhausen, T., Lemmon, V. The
neural cell adhesion molecule L1 interacts with the AP-2 adaptor and is endocytosed via the clathrinmediated pathway. J. Neurosci. 1998 18:5311-5321
Haney, C.A., Sahenk, Z., Li, C., Lemmon, V.P., Roder, J., Trapp, B.D. Heterophilic binding of L1 on
unmyelinated sensory axons mediates Schwann cell adhesion and is required for axonal survival. J. Cell
Biol. 146:1173-1183, 1999
Schaefer, A.W., Kamiguchi, H., Wong, E.V., Beach, C.M., Landreth, G., and Lemmon, V. Activation of the
MAPK Signal Cascade by the Neural Cell Adhesion Molecule L1 Requires L1 Internalization. J. Biol.
Chem. 274:37965-37973., 1999
Kamiguchi, H., Lemmon, V. Recycling of the Cell Adhesion Molecule L1 in Axonal Growth Cones J.
Neurosci., 15:3676-3686, 2000
De Angelis, E, Brümmendorf, T, Cheng, L, Lemmon, V, and Kenwrick, S. Alternative Use of a Mini Exon of the
L1 Gene Affects L1 Binding to Neural Ligands, J. Biol. Chem., 276 :32738-32742, 2001
Mechtersheimer S, Gutwein P, Agmon-Levin N, Stoeck A, Oleszewski M, Riedle S, Fogel M, Lemmon V,
Altevogt P. Ectodomain shedding of L1 adhesion molecule promotes cell migration by autocrine
binding to integrins. J Cell Biol. 2001 Nov 12;155(4):661-73.
Schaefer, A., Y. Kamei, H. Kamiguchi, E.V. Wong, I. Rapoport, T. Kirchhausen, C.M. Beach, G. Landreth,
S.K. Lemmon, and V, Lemmon. L1 endocytosis is controlled by a phosphorylation-dephosphorylation
cycle stimulated by outside-in signaling by L1. J Cell Biol. 157:1223–32, 2002
Itoh K, Cheng L, Kamei Y, Fushiki S, Kamiguchi H, Gutwein P, Stoeck A, Arnold B, Altevogt P, Lemmon V.
Brain development in mice lacking L1-L1 homophilic adhesion J Cell Biol. 165: 145-154, 2004
Cheng, L and Lemmon V. Pathological missense mutations of neural cell adhesion molecule L1 affect neurite
outgrowth and branching on an L1 substrate. Mol and Cell Neuroscience. 27:522-530, 2004
Cheng, L, Itoh, K. and Lemmon V L1 mediated branching is regulated by two ERM-binding sites, the YRSLE
motif and a novel juxtamembrane ERM-binding region,. J. Neuroscience. 25:395-403, 2005
Itoh, K., Shimono, K. and Lemmon V. Dephosphorylation and Internalization of Cell Adhesion Molecule L1
Induced by Theta Burst Stimulation in Rat Hippocampus. Mol Cell Neurosci., 29:245-249, 2005
Newpher TM, Smith RP, Lemmon V, Lemmon SK. In vivo dynamics of clathrin and its adaptor-dependent
recruitment to the actin-based endocytic machinery in yeast. Dev Cell. 2005 9:87-98, 2005
Itoh K, Fushiki S, Kamiguchi H, Arnold B, Altevogt P, Lemmon V. Disrupted Schwann cell-axon interactions in
peripheral nerves of mice with altered L1-integrin interactions. Mol Cell Neurosci. 30:131-6, 2005
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