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United States Patent 7,332,154
L'Oreal S.A. (Paris, FR)
-------------------------------------------------------------------------------Deodorant cosmetic composition (aerosol) comprising a combination of
zinc gluconate and an antiperspirant aluminum salt
Summary
The disclosure provides deodorant cosmetic compositions comprising: (a) zinc gluconate, and (b) at least
one antiperspirant aluminum salt; wherein the zinc gluconate/aluminum salt weight ratio ranges from 1/100
to 10/1. The disclosure also provides cosmetic processes for treating human perspiration and human
underarm odors with these compositions. In addition, the disclosure provides aerosol devises comprising
the compositions and a means for distributing the deodorant compositions.
The invention states that the use of zinc gluconate helps lower the whitening appearance of the
antiperspirant formulations.
Example 1 – Antiperspirant and Deodorant Sticks Preparation
Formulation 3, according to Example 1.4 of patent application WO2001099376, and formulation 4, in
accordance with the disclosure, were prepared as shown below.
Item No
1
2
3
4
5
6
7
8
9
10
11
12
13
Ingredients
Cyclopentasiloxane (DC245 Dow Corning)
Formulation 3
23 g
Formulation 4
32 g
Hexyldecyl stearate (Eutanol
G16S – Cognis)
PPG-14 butyl ether (Ucon
Fluid AP Amerchol)
Hydrogenated castor oil
(Cutina HR - Cognis)
Cetearyl alcohol (Lanette O
Cognis)
Cetearyl alcohol/Ceteareth- 30
80/20 (Sinnowax AO Cognis)
Talc
Aluminum chlorohydrate
(Micro Dry - Reheis)
Zinc gluconate (Govobio G
Zn- Seppic)
Stearyl alcohol
PEG-8 distearate (PEG 400 -distearate - Stearineries
Dubois)
C12-15 alkyl benzoate
(Finsolv TN - Witco)
Total
15 g
–
5g
10 g
6g
4g
8g
–
15 g
–
8g
20 g
2g
20 g
0.1 g
1g
14 g
2g
15 g
100.1
100.0
In a glass beaker, over a heating plate or using a heating mantle suitable to accommodate a glass beaker,
and under continuous mechanical agitation, mix the following ingredients: Weigh in and heat the
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cyclopentasiloxane to 65o C, item 1. The other ingredients (items 2, 3, 4, 5, 7, 11, 12 and 13) were added
one at a time and mixed until melt and homogeneous while maintaining the temperature between 65 and
70o C. The mixture was homogenized (transparent solution) for 15 minutes. The two deodorant active
agents (items 9 and 10), and the talc (item 8) were added. The resulting mixture was cooled to
approximately 55o C, a few degrees above the thickening point of the mixture, and cast into sticks. The
sticks were placed at 4o C. for 30 minutes.
The deposits of white residue of the sticks of Examples 3 and 4 after application were measured according
to the test described below.
Protocol
The measurements were performed using a Minolta CR300 machine. The products were applied in a
homogeneous manner until approximately 1 g of product per 40 cm2 was obtained on a Canson mid-tint
sheet black paper. The measurement was performed immediately after application. An average of two
measurements was reported.
The change in L was measured as follows: DELTA L=L*product-L*reference.
An L*reference of 19.45 was used for the Canson mid-tint sheet black paper.
A DELTA L of greater than or equal to 35 for a product is indicative of a cosmetically unacceptable
amount of whitening.
Results:
Formulation 3, DELTA L = 35,
Formulation 4, DELTA L = 6
It was found that composition 3 (according to the prior art) containing a zinc gluconate/aluminum
chlorohydrate combination in a 1/200 ratio produced a high level of white residue on the substrate, whereas
composition 4 produced very little white residue, comparable with deodorant sticks currently on the
market, such as the commercial products "Lady Speed Stick--Clean Glide" from Colgate and "Secret Clear
Dry" from Procter & Gamble.
Example 2 – Roll-on (Emulsion) Antiperspirant and Deodorant Preparation
Item
No.
1
2
3
4
5
6
7
8
Ingredients
Phase A
Aluminum chlorohydrate (50%
solution) (Chlorhydrol 50% USP)
Zinc gluconate (Govobio G ZnSeppic)
Phase B
Steareth-21 (Brij 721 - ICI)
Steareth-2 (Brij 2 - ICI)
Steareth-5 Stearate
PPG-15 stearyl ether (Arlamol E
- ICI)
Cyclopentasiloxane (DC245 Dow Corning)
Water
Total
Formulation 5
40 g
2g
2g
2g
1g
1.5 g
3.5 g C
48 g
100 g
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Phases (B) and (C) were heated separately to 70 o C. then mixed together using a Turrax stirrer (high shear
mixer) for 5 minutes and then cooled to 55 o C. with paddle stirring. Phase (A) was added slowly while
stirring. The mixture was homogenized for 1 to 3 minutes, and then cooled to 35 o C. with stirring. The
formulation was stable for 2 months at 45o C.
The amount of white residue was measured according to the test as described in Formulations 5, DELTA L
=2
Example 3 – Non-Aerosol Spray (Emulsion Obtained by Phase Inversion) Antiperspirant
and Deodorant Preparation
Item
No.
1
2
3
4
Ingredients
Aluminum chlorohydrate (50% solution)
(Chlorhydrol 50% USP)
Zinc gluconate (Govobio G Zn-Seppic)
Cetearyl isononanoate (and) Cetearyl alcohol
(and)
Ceteareth-20 (and) Glycerin (and) Glyceryl
stearate (and) Ceteareth-12 (and) cetyl
palmitate (Emulgade CM - Cognis)
Water
Total
Formulation 6
20 g
3g
15 g
62 g
100 g
The gluconate (item 2) was dissolved in water and Emulgade CM (item 3) was added with moderate
stirring. The aluminum salt solution was added with moderate stirring. The formulation was stable for 2
months at 45o C. The amount of white residue was measured according to the test described above,
DELTA L = 0.
Example 4 – Aerosol Antiperspirant and Deodorant Preparation
Item No.
1
2
3
4
5
6
7
8
Ingredients
Stearalkonium Bentonite (Tixogel MP 250 Sud Chemie Rheologicals United Catalysts
Inc.)
Aluminum chlorohydrate (Micro Dry Reheis)
Zinc gluconate (Govobio G Zn-Seppi)
C12-15 alkyl benzoate (Finsolv TN - Witco)
Isobutane
Triethyl citrate (Citroflex-Morflex)
Isopropyl palmitate
Cyclopentasiloxane (DC245 - Dow Corning)
Total
Formulation 7
0.5 g
7g
0.5 g
3g
80 g
1g
1g
7g
100 g
The solvents (items 4, 6, 7, and 8) and the hydrophobic-modified clay (item 1) were added and the mixture
was stirred using a Turrax stirrer until homogenized. The aluminum salt (antiperspirant active), item 2, and
the zinc gluconate (item 3) were then added with continued stirring. The mixture was placed in an aerosol
can, an aerosol cap was crimped on the can and finally the liquefied propellant (item 5) was charged in the
can in a suitable aerosol propellant filling station. (Warning! Liquid isobutane is an explosive and highly
flammable liquid)
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The level of white residue was measured according to the test above. DELTA = 4 was obtained for
formulation 7.
Laboratory Needs:
Formulation: Pyrex glass beakers , heat insulated gloves, safety goggles, pH indicator paper or probe,
spatulas, storage jars, aluminum foil and untreated virgin hair tresses.
Laboratory Equipment: A mechanical agitator with support and fastener, mixing blades to fit inside the
diameter of the glass beaker, thermometer and hot plate with temperature control, top load balance with
auto calibration and tare.
A mechanical agitator
Viscometer
Mixing blades
Thermometer and hot plate
top load balance
pH Meter
Warning: Read the material safety data sheets, MSDS, of all formulation ingredients to determine special
handling precautions. Prepare this formulation in a well ventilated laboratory:



This formulation may require handling heated or corrosive liquids and severe burning may occur.
Do not breath fumes
Wear gloves and goggles
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