Supplementary Table 4: The top 10 biological process Gene Ontology (GO) categories
that are significantly over- or
under-represented near the mammalian CNCs. For each CNC, the nearest gene was
found without considering gene orientation. The first column (Key) shows the nested
relationship between GO categories. For example, 22_8 has level of 2 and is nested in
22, which has level of 1. The second column (Obs) is the observed count of genes near
CNCs in each category. The third column (Exp) is the expected count genes near CNCs
that are obtained based on the distribution of all human genes. The fourth column
indicates if each GO category is over- or under-represented. One-sided p-values are
computed using a chi-square test and are corrected by the Bonferroni criterion (p*values), using the number of the GO categories that are tested in each level.
Key
Obs
Exp +/- p*-value GO category
21_1_1
5
79.56 -
< 1030 olfaction
21_1
7
83.14 -
< 1030 chemosensory perception
1151 794.81 +
1021
developmental processes
22_8_1 385 220.78 +
1014
neurogenesis
22_8
253.8 +
1014
ectoderm development
1613 1301.61 +
1011
signal transduction
22_10
330 212.43 +
108
mesoderm development
12_2
458 329.78 +
106
intracellular signaling cascade
106
receptor protein tyrosine
22
12
427
12_1_2 148
80.75 +
kinase signaling pathway
18
304 210.84 +
106
neuronal activities