Table 1S—[Section 1.0] PICO Questions
Section
Pancoast
tumors
Section
Surgery
for
T3N0M0
NSCLC
(one or
more
nodules in
the same
lobe)
Section
M1a
lesions
(nodules
in
ipsilateral
lung but
different
lobe) vs. a
synchrono
us primary
NSCLC
Informal
Questions
In a patient
with a Pancoast
tumor, does
induction
chemoradiation
therapy
improve
complete
resection rates
and improve 5year survival?
Informal
Questions
Does the new
T3N0M0
classification
(for this subset
of T3 lesions)
have similar
survival to M1a
disease (M1a
by ipsilateral
NSCLC in
another lobe)?
Informal
Questions
How to
determine if the
lesion is a
synchronous
primary
NSCLC or
M1a lesion and
does it matter?
PICO Question
Population
Patients with a
Pancoast tumor
Intervention (s)
Induction
chemo-radiation
therapy
Comparator
None or
Adjuvant
therapy
Study
Methods
Outcome
Improve
complete
resection rates
and 5-year
survival.
PICO Question
Population
Bx-proven
NSCLC with
other nodules
in the same
lobe or
ipsilateral lobes
Intervention (s)
Chest CT
FDG-PET
Needle biopsy
Surgery
Comparator
Chemotherap
y or
Non-surgical
intervention
Study
Methods
Outcome
Yield
Accuracy
Dx thinking
Treatment plan
Complications
Unnecessary or
futile surgery
Mortality
Costeffectiveness
PICO Question
Population
Multiple
nodules
identified
during
evaluation of
dominant
nodule
Intervention (s)
Chest CT
FDG-PET
Needle biopsy
Navigational
bronchoscopy
Surgery
Comparator
Chemothera
py or
Nonsurgical
intervention
RCT
Cohort
Case-control
Case series
Cohort
Case-control
Case series
Study
Methods
Outcome
Yield
Accuracy
Dx thinking
Treatment plan
Complications
Unnecessary or
futile surgery
Survival
Mortality
Costeffectiveness
Cohort
Case-control
Case series