Curriculum Vitae Personal information Name: Xiaoming ZHANG Sex: Male Date & Place: January 1977, Jiangsu, China Speciality: Immunology Contacts: Régulation Immunitaire et Vaccinologie, Institut Pasteur 25-28 Rue du Docteur Roux, 75724 PARIS Tel : 00 33 1 45 68 83 52 Fax : 00 33 1 45 68 85 40 E-mail: [email protected] Experience 2007.10 ~ 2007.9 PhD 2003.7 Master 2000.7 Bachelor Post-doctorate Régulation Immunitaire et Vaccinologie, Institut Pasteur, France Université Pierre et Marie Curie (Paris 6), France Yangzhou University, China Yangzhou University, China Nanjing Normal University/Nantong Medical College, China Research area: Human immunology Immune functions of human fresh pDC subsets, mDC subsets and B cell subsets. Mouse immunology 1 Anti Mycobacterial immunity 2 Regulation of neonatal innate immunity Vaccinology and Zoonosis 1 In vivo DC targeting by using C type lectin-specific sugar-based vaccines 2 Salmonella-based novel vaccines against important zoonotic pathogens such as avian influenza virus Awards: 2008 Prize for “Best oral presentation”, The Annual Meeting of the French Society for Immunology Patents: 1 A novel DNA vaccine vector without antibiotic resistance gene. China Patent No. ZL200310112640.3 2 A novel eukaryotic expression system regulated by magnesium concentration. China Patent Application No. 200710020573.0 Publications: 1 Zhang XM, Deriaud E, Jiao XA, Braun D, Leclerc C and Lo-Man R. Type I interferons protect neonates from acute inflammation through IL-10 producing B cells. J Exp Med, 2007, 204(5) :1107-1118. 2 Zhang XM, Jiao XA, Tang LH, Pan ZM and Liu XF. Construction and characterization of Salmonella typhimurium SL7207 SifA- mutant strain. Acta Microbiologica Sinica. 2005, 45(3) : 349-354. 3 Zhang XM, Jiao XA, Tang LH, Pan ZM and Liu XF. Enhanced stability of plasmid pcDNA3.1+ within Salmonella typhimurium by downregulation of the Ampicillin resistance gene expression. Chinese Microbiology, 2005, 32(5): 51-55. 4 Pan ZM*, Zhang XM*, Geng SZ , Cheng NN, Sun L, Liu BB, Huang JL and Jiao XA. Priming with a DNA vaccine delivered by attenuated Salmonella typhimurium and boosting with a killed vaccine confers protection of chickens against infection with the H9 subtype of avian influenza virus. Vaccine, 2009 (in press). (*: equal contribution) Submitted: Zhang XM, Majlessi L, Deriaud E, Ibrahim-Granet O, Leclerc C and Lo-Man R. Synergistic activation of MyD88 and dectin-1/Syk pathways activates regulatory properties of neutrophils in Mycobacterial infection. Talk summary: Bacteria contain several types of innate agonists. In contrast to monocytes/macrophages, murine neutrophils poorly contribute to inflammatory responses, but rather secrete high levels of IL-10 following bacterial (Mycobacteria, Escherichia coli and Shigella flexneri) stimulation. Co-triggering of TLR/MyD88 and dectin-1/Syk pathways, but not TLR alone, leads to sustained phosphorylation of p38 MAP and Akt (PI3K) kinases and affords murine neutrophils the capacity to produce high amount of anti-inflammatory cytokine IL-10. In vivo, IL-10-producing neutrophils play a regulatory role in both acute and chronic Mycobacterial infection models.